Search results for "ILF"
showing 10 items of 35 documents
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
2019
Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction and premature entry into cellular senescence. Recently, we reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which control the DNA damage response (DDR) at dysfunctional telomeres. Here we show that progerin-induced telomere dysfunction induces the transcription of tncRNAs. Their functional inhibition by sequence-specific telomer…
Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations
2016
This work was supported by Spanish Ministry of Economy and Competitiveness (MINECO) Grants SAF2010-16044 and SAF2013-46663-R (to V.A.), SAF2011-30312 and SAF2014-58286-C2-1-R (to L.H.-M.), SAF2011-30088 (to E.D.), and SAF2014-52413-R (to C.L.-O.) and Fondo de Investigación Sanitaria del Instituto de Salud Carlos III Grants RD12/0042/0028 (to V.A.), RD12/0042/0011 (to J.T.), and RD12/0042/0002 (to L.H.-M.), with cofunding from the Fondo Europeo de Desarrollo Regional and the Progeria Research Foundation. J.A.G. is the recipient of a U-Mobility Grant from the Marie Curie cofunding of Regional, National and International Programme (Grant 246550). The Instituto Universitario de Oncología is sup…
Torah, Temple, Land
2021
Veröffentlicht auf Englisch. Dieser Band widmet sich den Erscheinungsformen, in denen das Judentum in der Antike Gestalt annahm. Bekanntlich war das antike Judentum eine Religion in ständigem Wandel, mit unterschiedlichen Perspektiven auf zentrale Kategorien wie Tora, Tempel und Heiliges Land. Was als »Judentum« oder »jüdisch« angesehen wurde, stand demnach nicht einfach fest, sondern musste stets neu verhandelt werden.
Liability for wilful misconduct in the familiar relations
2016
La posible aplicación del art. 1.902 C.c. español para indemnizar los daños entre familiares ha sido una cuestión muy discutida. En los últimos quince años los Tribunales españoles se han enfrentado a un novedoso grupo de casos, el de los daños derivados de la ocultación de la verdadera paternidad biológica, concediendo indemnización y dando así entrada a la responsabilidad civil en el ámbito de las relaciones familiares, exigiendo, en la mayoría de las ocasiones, la culpa grave o el dolo como criterio de imputación. The possible application of the article 1.902 Spanish Civil Code to compensate the damages between relatives has been a very controversial question. In the last fifteen years t…
Conductas adictivas y trastorno por déficit de atención con hiperactividad en adultos
2009
El trastorno por déficit de atención con hiperactividad (TDAH) es un trastorno de inicio en la infancia, con una prevalencia del 1.2 7.3% en población general adulta. La frecuencia de trastornos comórbidos es elevada en los pacientes con TDAH. Las conductas adictivas o trastornos por uso de sustancias (TUS) son de los que mayor relevancia tienen en este sentido. La comorbilidad TDAH y TUS destaca por las dificultades diagnósticas, terapéuticas y de pronóstico que puede significar su asociación. Los psicoestimulantes, como el metilfenidato, son el tratamiento de primera elección en pacientes con TDAH. A pesar de ello, existen controversias sobre el uso de este tipo de medicamentos en pacient…
Randomised phase II evaluation of irinotecan plus high-dose 5-fluorouracil and leucovorin (ILF) vs 5-fluorouracil, leucovorin, and etoposide (ELF) in…
2005
An open-label randomised comparison of efficacy and tolerability of irinotecan plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) (ILF) with etoposide plus 5-FU/LV (ELF) in patients with untreated metastatic or locally advanced gastric cancer. One cycle of ILF comprised six once-weekly infusions of irinotecan 80 mg m(-2), LV 500 mg m(-2), 24-h 5-FU 2000 mg m(-2), and ELF comprised three once-daily doses of etoposide 120 mg m(-2), LV 300 mg m(-2), 5-FU 500 mg m(-2). In all, 56 patients received ILF and 58 ELF. Median age was 62 years, Karnofsky performance 90%, and disease status was comparable for both arms. The objective clinical response rates after 14 weeks treatment (primary end p…
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study.
2015
Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The…
Aortic root dilation in associated with the reduction in capillary density observed at nailfold capillaroscopy in SSc patients
2020
Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction and fibroblasts activation. Microvascular disease may be easily observed by means of nailfold capillaroscopy. Recent evidences emphasized also the involvement of large-medium arteries in SSc, mainly in terms of increased stiffness of the vessel wall. The study aims to measure aortic root diameter in a cohort of SSc patients and to correlate echocardiographic findings with the capillaroscopic pictures. We analyzed the clinical records of 125 consecutive SSc patients (M/F 14/111, mean age 55 ± 12.7 years, median disease duration 11 years) referring in 3 second-level rheumatology centers. All subjects un…
Demographic Analysis of Bucharest-Ilfov Region
2013
Abstract This paper aims to achieve a study was to research, analyze and interpret statistical data, in conjunction with theoretical aspects that allowed assessment of regional information on population structure in the Bucharest-Ilfov. Bucharest-Ilfov region's population (2,264,865 inhabitants in 2012) is distributed inversely proportional to the size of two administrative entities (Bucharest - the capital of Romania - Ilfov county). Bucharest is the largest urban agglomeration in Romania, its population being 1,924,299 inhabitants, representing about 85% population of the region, more than 16.4% of the urban population of the country, or around 9% of the total population of Romania and ha…
Acte clair doktrīna Eiropas Savienības tiesībās
2020
Līguma par Eiropas Savienības darbību 267.panta trešajā daļā ir noteikts Eiropas Savienības dalībvalstu pēdējo instanču tiesu pienākums vērsties Eiropas Savienības tiesā pēc prejudiciāla nolēmuma, ja lietā nepieciešama Eiropas Savienības tiesību interpretācija. Atkāpes no šī pienākuma Eiropas Savienības tiesa noteikusi CILFIT spriedumā. Vislielāko uzmanību sev pievērsusi tieši šajā spriedumā adaptētā Acte clair doktrīna, kas tiesām atļauj nevērsties Eiropas Savienības tiesā, ja Eiropas Savienības tiesību piemērošana ir tik acīmredzama, ka tā neatstāj vietu nekādām saprātīgām šaubām. Jau no doktrīnas ieviešanas brīža Eiropas Savienības tiesībās tā juristu vidū ir izpelnījusies kritiku par tā…