Search results for "INFARCTUS"
showing 10 items of 12 documents
Study of leurocyte telomere lenght and transcription in patients in the acute phase of myocardial infarction
2011
Atherosclerosis with cardiovascular complications remains today one of the leading causes of death in developed countries. In this context, development of new biomarkers of atherosclerosis has an important place. Objectives of these biomarkers are: • to identify populations most at risk of developing cardiovascular complications, • to stratify patient groups to optimize their clinical management and therapeutic, • to reveal new therapeutic targets in the treatment of the disease. In this context, we identified three biomarkers of interest, leukocyte telomere length (LTL) and level of expression of leukocyte genes c-Fos (involved in inflammatory processes and oxidative) and OGG1 (necessary r…
Travail posté et maladies cérébro- et cardiovasculaires : revue critique et synthèse des preuves épidémiologiques
2013
National audience; Une revue critique de la littérature a été menée sur le lien entre travail posté (TP) et survenue de maladies cérébro- et cardiovasculaires (MCCV). Dans plusieurs études de bonne qualité, le TP est associé à une augmentation modeste mais significative du risque de maladies cardiaques ischémiques fatales et non fatales. Les conclusions sont moins claires pour le lien avec la mortalité cardiovasculaire ischémique et les pathologies cérébrovasculaires. Sur le plan de la causalité, des biais de sélection difficiles à prendre en compte sur le plan méthodologique ne peuvent être écartés pour expliquer ces associations observées. Lien causal ou marqueur socio-économique ? Cette …
Silent and symptomatic atrial fibrillation,during the acute phase of myocardial infarction : determinants and role of arginine methylated and oxidati…
2015
Atrial fibrillation (AF) is a frequent complication of acute myocardial infarction (AMI) with a poorer prognosis. Silent atrial fibrillation has been suggested to be frequent after AMI. However, most part of the studies has targeted only paroxysmal or persistent AF. Thus, Reduced Nitric Oxide availability and endothelial dysfunction has been recently recognized as a possible contributor to altered prognosis in AF. Asymmetric dimethylarginine (ADMA) can inhibit nitric oxide synthase and leads to endothelial dysfunction, inflammation and oxidative stress in multiple cardiovascular diseases. However, any study has addressed the relationship between ADMA levels and the occurrence of AF in AMI.W…
Epidemiological approach of type 2 myocardial infarction : Etiologies, characteristics, treatment and prognosis.
2020
Introduction: Type 2 Myocardial infarction (MI)has been recently defined as an imbalance between oxygen supply and demand, in the absence of atherothromthrombosis. This work aimed to describe the main etiolgies as well as epidemiological, clinical and prognostic characteristics.Method: Data from patients with type 2 MI were collected from the RICO cohort (Observatoire des Infarctus de Cote d'Or). In a complementary work, we analyzed the retrospective data of the emergency department of Dijon University Hospital.Results: Among 4,436 consecutive patients hospitalized for MI in Dijon emergency department over 3 years, 947 (21%) had type 2 MI (median age: 81 years). In the RICO cohort, 4,572 co…
Cardiac rehabilitation and 5-year mortality after acute coronary syndromes: The 2005 French FAST-MI study.
2016
IF 2.271; International audience; Background. - Clinical studies have shown a beneficial effect of cardiac rehabilitation (CR) on mortality.Objective. - To study the effect of CR prescription at discharge on 5-year mortality in patients with acute myocardial infarction (AMI).Methods. - Participants, from the 2005 French FAST-MI hospital registry, were 2894 survivors at discharge, divided according to AMI type: ST-segment elevation myocardial infarction (STEMI; n=1523) and non-STEMI (NSTEMI; n=1371). The effect of CR prescription on mortality was analysed using a Cox proportional hazards model.Results. - At discharge, 22.1% of patients had a CR prescription. Patients referred to CR were youn…
In-hospital outcomes and 5-year mortality following an acute myocardial infarction in patients with a history of cancer: Results from the French regi…
2019
Summary Background Cancer and acute myocardial infarction (AMI) have important prognostic consequences. Treatment of some cancers may affect coronary artery disease, myocardial function and/or AMI management. Whether the early and long-term mortality of patients with AMI differ according to their history of cancer remains questionable. Aims To determine in-hospital outcomes and 5-year mortality following AMI according to patient history of cancer. Methods The FAST-MI registry is a nationwide French survey collecting data on characteristics, management and outcomes of 3670 consecutive patients admitted for AMI during October 2005. Results Overall, 246/3664 patients (6.7%) admitted for an AMI…
Deep learning architectures for automatic detection of viable myocardiac segments
2021
Thesis abstract: Deep learning architectures for automatic detection of viable myocardiac segmentsAccurate myocardial segmentation in LGE-MRI is an important purpose for diagnosis assistance of infarcted patients. Nevertheless, manual delineation of target volumes is time-consuming and depends on intra- and inter-observer variability. This thesis aims at developing efficient deep learning-based methods for automatically segmenting myocardial tissues (healthy myocardium, myocardial infarction, and microvascular obstruction) on LGE-MRI. In this regard, we first proposed a 2.5D SegU-Net model based on a fusion framework (U-Net and SegNet) to learn different feature representations adaptively. …
Incidences de l’ischémie cérébrale sur la fonction et la sensibilité cardiaques à l’ischémie
2019
For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes in cardiovascular function.The aim of this study was to evaluate how prior cerebrovascular lesions affect myocardial function and signaling in vivo and ex vivo, and how they influence cardiac vulnerability to ischemia-reperfusion injury and the expression of cardiac genes and proteins involved in cardioprotective pathways.Thus, in our work, we studied cardiac function in a rat stroke model induced by cerebral embolization.The main results show that experimental stroke 1/ impaired …
Infarctus cérébral et plasticité : focus sur le BDNF
2011
Functional recovery after ischemic stroke largely involves brain plasticity and more accurately its ability to reorganize the neuronal networks spared by the infarct. Studies conducted on animals using different ischemic stroke models have demonstrated that plastic changes are induced by BDNF (Brain-Derived Neurotrophic Factor). Hence, increasing levels of BDNF in the brain is considered a promising therapeutic strategy to reduce post-stroke impairments. In this context, our work had 2 aims: 1) In a rat model, to identify cells involved in the over-production of BDNF and to evaluate the pertinence of the measurement of circulating BDNF levels to estimate brain BDNF levels; 2) In ischemic st…
Soins ambulatoires et facteurs associés à la réhospitalisation précoce des sujets âgés (65+) après un infarctus du myocarde : étude observationnelle …
2017
Etat de la question Les rehospitalisations precoces (RHP), dans les 30 jours suivant la sortie d’hospitalisation, sont frequentes chez les sujets âges, notamment apres un infarctus du myocarde (IDM). Elles augmentent la morbi-mortalite et les depenses de sante. Il a ete demontre qu’une meilleure organisation de la sortie d’hospitalisation reduit significativement le risque de RHP. Neanmoins, il n’existe aucune recommandation sur le suivi ambulatoire en sortie d’hospitalisation. L’objectif de l’etude etait d’analyser les soins ambulatoires post-hospitaliers et les facteurs associes a la RHP des sujets âges apres un IDM. Materiel et methodes Etude observationnelle retrospective a partir des d…