Search results for "Imine"
showing 10 items of 2850 documents
Tutkimuksellisuus luonnontieteissä ja sen yhteys luonnontieteelliseen osaamiseen Suomessa
2018
Social information use by predators : expanding the information ecology of prey defences
2022
Social information use is well documented across the animal kingdom, but how it influences ecological and evolutionary processes is only just beginning to be investigated. Here we evaluate how social transmission may influence species interactions and potentially change or create novel selection pressures by focusing on predator-prey interactions, one of the best studied examples of species coevolution. There is extensive research into how prey can use social information to avoid predators, but little synthesis of how social transmission among predators can influence the outcome of different stages of predation. Here we review evidence that predators use social information during 1) encount…
Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery
2016
(1) Background: A new family of nanosystems able to discern between normal and tumor cells and to release a therapeutic agent in controlled way were synthetized by e-beam irradiation. This technique permits to obtain biocompatible, sterile, carboxyl-functionalized polyvinylpyrrolidone (PVP-co-acrylic acid) nanogels (NGs); (2) Methods: Here, we performed a targeting strategy based on the recognition of over-expressed proteins on tumor cells, like the folate receptor. The selective targeting was demonstrated by co-culture studies and flow cytometry analysis, using folate conjugated NGs. Moreover, nanoparticles were conjugated to a chemotherapeutic drug or to a pro-apoptotic siRNA through a gl…
Parents' causal attributions concerning their children's academic achievement
2007
Katja Natale seurasi väitöstutkimuksessaan vanhempien lastensa koulumenestystä koskevien kausaaliattribuutioiden eli syyselitysten muotoutumista lasten siirtyessä esikoulusta kouluun. Hän tutki kuinka tärkeinä vanhemmat pitivät kykyä, yrityksen määrää, tehtävien vaikeustasoa ja lapsen saamaa ohjausta selittämässä lasten onnistumista ja epäonnistumista koulussa. - Koulunsa aloittavien lasten vanhempia voisi neuvoa viestimään lapsilleen, että heillä on kykyjä onnistua haastavissakin koulutehtävissä. Tällainen viesti vaikuttaa positiivisesti lasten koulutaitojen kehitykseen ja minäkuvan muuttumiseen realistisemmaksi, Natale suosittaa.Onnistuminen kyvykkyyttä, epäonnistuminen yrityksen puutetta…
Surrogate-assisted evolutionary biobjective optimization for objectives with non-uniform latencies
2018
We consider multiobjective optimization problems where objective functions have different (or heterogeneous) evaluation times or latencies. This is of great relevance for (computationally) expensive multiobjective optimization as there is no reason to assume that all objective functions should take an equal amount of time to be evaluated (particularly when objectives are evaluated separately). To cope with such problems, we propose a variation of the Kriging-assisted reference vector guided evolutionary algorithm (K-RVEA) called heterogeneous K-RVEA (short HK-RVEA). This algorithm is a merger of two main concepts designed to account for different latencies: A single-objective evolutionary a…
A Surrogate-assisted Reference Vector Guided Evolutionary Algorithm for Computationally Expensive Many-objective Optimization
2018
We propose a surrogate-assisted reference vector guided evolutionary algorithm for computationally expensive optimization problems with more than three objectives. The proposed algorithm is based on a recently developed evolutionary algorithm for many-objective optimization that relies on a set of adaptive reference vectors for selection. The proposed surrogateassisted evolutionary algorithm uses Kriging to approximate each objective function to reduce the computational cost. In managing the Kriging models, the algorithm focuses on the balance of diversity and convergence by making use of the uncertainty information in the approximated objective values given by the Kriging models, the distr…
On Dealing with Uncertainties from Kriging Models in Offline Data-Driven Evolutionary Multiobjective Optimization
2019
Many works on surrogate-assisted evolutionary multiobjective optimization have been devoted to problems where function evaluations are time-consuming (e.g., based on simulations). In many real-life optimization problems, mathematical or simulation models are not always available and, instead, we only have data from experiments, measurements or sensors. In such cases, optimization is to be performed on surrogate models built on the data available. The main challenge there is to fit an accurate surrogate model and to obtain meaningful solutions. We apply Kriging as a surrogate model and utilize corresponding uncertainty information in different ways during the optimization process. We discuss…
Multiobjective shape design in a ventilation system with a preference-driven surrogate-assisted evolutionary algorithm
2019
We formulate and solve a real-world shape design optimization problem of an air intake ventilation system in a tractor cabin by using a preference-based surrogate-assisted evolutionary multiobjective optimization algorithm. We are motivated by practical applicability and focus on two main challenges faced by practitioners in industry: 1) meaningful formulation of the optimization problem reflecting the needs of a decision maker and 2) finding a desirable solution based on a decision maker’s preferences when solving a problem with computationally expensive function evaluations. For the first challenge, we describe the procedure of modelling a component in the air intake ventilation system wi…
Hyperspectral imaging reveals spectral differences and can distinguish malignant melanoma from pigmented basal cell carcinomas : A pilot study
2021
Pigmented basal cell carcinomas can be difficult to distinguish from melanocytic tumours. Hyperspectral imaging is a non-invasive imaging technique that measures the reflectance spectra of skin in vivo. The aim of this prospective pilot study was to use a convolutional neural network classifier in hyperspectral images for differential diagnosis between pigmented basal cell carcinomas and melanoma. A total of 26 pigmented lesions (10 pigmented basal cell carcinomas, 12 melanomas in situ, 4 invasive melanomas) were imaged with hyperspectral imaging and excised for histopathological diagnosis. For 2-class classifier (melanocytic tumours vs pigmented basal cell carcinomas) using the majority of…
Evaluation of the potential therapeutic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of endometri…
2015
Objective To assess the therapeutic potential of polyinosine-polycytidylic acid, a double-stranded RNA molecule with selective proapoptotic and antiangiogenic activity, complexed with polyethyleneimine (pIC PEI ) in treating endometriosis. Design A heterologous mouse model of endometriosis was created by injecting human endometrial fragments into the peritoneum. Endometrial fragments were engineered to express the fluorescent protein mCherry as a reporter to monitor status over the course of the 4-week study. Setting University-affiliated infertility center. Animal(s) Ovariectomized and hormone-replaced nude mice (n = 30) injected with fluorescent-labeled human endometrial fragments at 4–6 …