Search results for "LSP"
showing 10 items of 71 documents
Maternal and fetal genetic contribution to gestational weight gain
2018
Background: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. Participants and methods: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspri…
Variants associated with HHIP expression have sex-differential effects on lung function
2021
Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10-8) interactions with sex …
La terminologie du vin au prisme des corpus oraux de dégustation/présentation (français-allemand) : entre émotions, culture et sensorialité
2017
International audience; Cet article vise à interroger et illustrer les apports de larges corpus oraux authentiques pour l'étude de la terminologie d'un domaine « flou », celui de l'oenologie, dans une approche contrastive français-allemand. D'un point de vue théorique, il s'agit tout d'abord de s'arrêter sur la nécessaire redéfinition de plusieurs principes de la terminologie traditionnelle en interrogeant le rôle de l'usage des termes, leur construction prototypique et leurs dimensions extra-techniques. D'un point de vue pratique, on discute ensuite, à partir du cas spécifique des données mobilisées, les contraintes pesant sur la collecte d'un corpus approprié. La dernière partie propose t…
Monitoring Cropland Phenology on Google Earth Engine Using Gaussian Process Regression
2021
Monitoring cropland phenology from optical satellite data remains a challenging task due to the influence of clouds and atmospheric artifacts. Therefore, measures need to be taken to overcome these challenges and gain better knowledge of crop dynamics. The arrival of cloud computing platforms such as Google Earth Engine (GEE) has enabled us to propose a Sentinel-2 (S2) phenology end-to-end processing chain. To achieve this, the following pipeline was implemented: (1) the building of hybrid Gaussian Process Regression (GPR) retrieval models of crop traits optimized with active learning, (2) implementation of these models on GEE (3) generation of spatiotemporally continuous maps and time seri…
Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis
2019
Background: Thyroid hormone is essential for optimal fetal brain development. Evidence suggests that both low and high maternal thyroid hormone availability may have adverse effects on child neurodevelopmental outcomes, but the effect on behavioral problems remains unclear. We studied the association of maternal thyrotropin (TSH) and free thyroxine (fT4) concentrations during the first 18 weeks of pregnancy with child attention-deficit hyperactivity disorder (ADHD). Methods: A total of 7669 mother-child pairs with data on maternal thyroid function and child ADHD were selected from three prospective population-based birth cohorts: INfancia y Medio Ambiente (INMA; N = 1073, Spain), Generation…
La recherche en langues de spécialité comme analyse de discours :réflexions théorico-méthodologiques dans la recherche francophone
2017
International audience; La communication posera la question des conséquences théoriques, mais surtout méthodologiques, du postulat aujourd’hui largement admis selon lequel les langues de spécialité (selon la dénomination traditionnelle) ne sont nullement isolables en système (par exemple au travers d’une terminologie), mais seulement en discours, à travers des usages, des acteurs, des communautés discursives et des textes où c’est un système linguistique dans toute sa complexité qui est mis en oeuvre. Ce tournant de la recherche, dans l’espace francophone et au delà, peut être borné par la redéfinition de l’objet d’étude par Lerat (1995 : 20), qui envisage la ‘langue de spécialité’ comme « …
Plasmonic Nanosensor Array for Multiplexed DNA-based Pathogen Detection
2019
In this research we introduce a plasmonic nanoparticle based optical biosensor for monitoring of molecular binding events. The sensor utilizes spotted gold nanoparticle arrays as sensing platform. The nanoparticle spots are functionalized with capture DNA sequences complementary to the analyte (target) DNA. Upon incubation with the target sequence, it will bind on the respectively complementary functionalized particle spot. This binding changes the local refractive index, which is detected spectroscopically as the resulting changes of the localized surface plasmon resonance (LSPR) peak wavelength. In order to increase the signal, a small gold nanoparticle label is introduced. The binding ca…
Glucosylsphingosine (Lyso-Gb1) as a reliable biomarker in Gaucher disease: a narrative review
2023
Abstract Background Gaucher disease (GD) is a rare, inherited, autosomal recessive disorder caused by a deficiency of the lysosomal enzyme, acid β-glucosidase. Its diagnosis is achieved via measurements of acid β-glucosidase activity in either fresh peripheral blood leukocytes or dried blood spots, and confirmed by identifying characteristic mutations in the GBA1 gene. Currently, several biomarkers are available for disease monitoring. Chitotriosidase has been used over the last 20 years to assess the severity of GD, but lacks specificity in GD patients. Conversely, the deacylated form of glucosylceramide, glucosylsphingosine (also known as lyso-Gb1), represents a more reliable biomarker ch…
Les composantes émotionnelles et culturelles des descripteurs sensoriels : enjeu pour l’équivalence terminologique en traduction
2017
International audience; [Problématique] Largement indexée sur les sciences de l’ingénieur, la théorie générale de la terminologie développée par Wüster ne laissait que peu de place aux dimensions non strictement objectivables du sens terminologique. Même si les évolutions ultérieures, de la socioterminologie (Gaudin) à la terminologie cognitive (Temmermann) en passant par la théorie communicationnelle de la terminologie (Cabré), ont permis de grandes avancées en la matière, en particulier en s’attaquant à des domaines aux contours moins stricts (soft domains), la terminologie sensorielle – construite à l’intersection entre sciences du goût, analyse sensorielle et sémantique lexicale – a peu…
Why we need TI-Oriented Language Learning and Teaching
2021
The teaching of foreign languages to students in Translation and Interpreting (TI) programmes should be framed within the field of Language for Specific Purposes (LSP). This would make it possible to pinpoint specific curricular content and methodological traits that contribute to the enhancement of the communicative competence and initial development of TI competences. This paper analyses the students’ perspectives on L2 teaching in a TI programme and how it should be undertaken to best comply with the linguistic demands imposed by translation and interpreting. A thematic analysis of 117 open questionnaires returned by students from Austria, Slovenia and Spain identified five areas to whic…