Search results for "Moiety"
showing 10 items of 621 documents
Palladium-catalyzed domino C-H/N-H functionalization: an efficient approach to nitrogen-bridged heteroacenes.
2015
Palladium-catalyzed domino C-H/N-H functionalization for the synthesis of novel nitrogen-bridged thienoacenes and 10H-benzo[4,5]thieno[3,2-b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial C-H functionalization of the benzo[b]thiophene moiety, followed by Buchwald-Hartwig coupling. This transformation is also useful for the synthesis of highly π-extended compounds.
Conformation of the umifenovir cation in the molecular and crystal structures of four carboxylic acid salts
2014
The umifenovir salts of maleic, salicylic, glutaric, and gentisic acid as well as the chloroform solvate of the salicylate were prepared. Single crystals of the five compounds were obtained and their molecular and crystal structures determined by X-ray diffraction. In each structure the conformation of phenyl ring with respect to the indole group of the umifenovir moiety is different. The water solubility and melting points of the studied umifenovir salts have been determined.
ChemInform Abstract: Enantioselective Friedel-Crafts Alkylation of Indoles with (E)-1-Aryl-4-benzyloxybut-2-en-1-ones Catalyzed by an (R)-3,3′-Br2BIN…
2013
A highly enantioselective Friedel–Crafts reaction of unprotected indoles with (E)-1-aryl-4-benzyloxybut-2-en-1-ones catalyzed by a new chiral [Hf{(R)-3,3′-Br2-BINOL}(OtBu)2]2 complex has been developed to functionalize the C-3 position of the indole nucleus with a side chain bearing a 1,4-difunctionalized moiety and a benzylic stereogenic center. The reaction proceeds in good to excellent yields and excellent enantioselectivities (up to 97 % ee). The usefulness of this approach was illustrated with the synthesis of a tryptophol derivative.
Enantioselective Friedel-Crafts Alkylation of Indoles with (E)-1-Aryl-4-benzyloxybut-2-en-1-ones Catalyzed by an (R)-3,3′-Br2BINOLate-Hafnium(IV) Com…
2013
A highly enantioselective Friedel–Crafts reaction of unprotected indoles with (E)-1-aryl-4-benzyloxybut-2-en-1-ones catalyzed by a new chiral [Hf{(R)-3,3′-Br2-BINOL}(OtBu)2]2 complex has been developed to functionalize the C-3 position of the indole nucleus with a side chain bearing a 1,4-difunctionalized moiety and a benzylic stereogenic center. The reaction proceeds in good to excellent yields and excellent enantioselectivities (up to 97 % ee). The usefulness of this approach was illustrated with the synthesis of a tryptophol derivative.
ChemInform Abstract: Palladium-Catalyzed Domino C-H/N-H Functionalization: An Efficient Approach to Nitrogen-Bridged Heteroacenes.
2015
Palladium-catalyzed domino CH/NH functionalization for the synthesis of novel nitrogen-bridged thienoacenes and 10H-benzo[4,5]thieno[3,2-b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial CH functionalization of the benzo[b]thiophene moiety, followed by Buchwald–Hartwig coupling. This transformation is also useful for the synthesis of highly π-extended compounds.
3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity
2015
A new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and the indole unit bound to position 2 of the thiazole ring was substituted by a 7-azaindole moiety, was efficiently synthesized. Two of the new nortopsentin analogues showed good antiproliferative effect against the totality of the NCI full panel of human tumor cell lines (~60) having GI50 values ranging from low micromolar to nanomolar level. The mechanism of the antiproliferative effect of these derivatives, investigated on human hepatoma HepG2 cells, was pro-apoptotic, being associated with externalization of plasma membrane phosphatidylserine and mitochondrial dysfunctio…
SYNTHESIS, LASER-RAMAN, INFRARED AND PROTON MAGNETIC RESONANCE SPECTRA OF (CH3)3PtX2- 3 IONS (X = Cl−, Br−) AND (CH3)3Ptiv ISOCYANIDE COMPLEXES
1976
Abstract The novel ionic complexes [(C6H5)4As]2 [(CH3)3PtX3](X = Cl− and Br−) and [(CH3)3Pt(bipy)L]+[B(C6H5)4]− (bipy = 2,2′-bipyridine, L = aliphatic and aromatic isocyanide) have been prepared. The structure of the complex ions has been inferred from Laser-Raman and infrared spectra in the solid state and 1H NMR in solution. These data are consistent with a facial configuration of the organometallic moiety. Trends in vibrational frequencies ν(Pt-C) and ν(Pt-X) indicate a “trans” influence sequence for the ligands, which in the case of (CH3)3PtX2- 3 is related with that found for (CH3)2AuX− 2 ions.
Complexes of organometallic compounds
1971
Abstract A number of novel compounds of dimethyllead(IV) and diphenyllead(IV) moieties with ligands having a rigid geometry when coordinating, have been prepared and characterized. The goal of the work was the building of model molecules for five-coordinated R 2 Pb IV , with known configuration of the CPbC skeleton. From spectroscopic data it is inferred that the complexes under investigation have a distorted bipyramidal trigonal structure, with the CPbC moiety allocated in the trigonal plane.
Structures and Magnetic Properties of Bis(μ‐phenoxido), Bis(μ‐phenoxido)‐μ‐carboxylato and Bis(μ‐phenoxido)bis(μ‐carboxylato) Fe III Ni II Compounds …
2015
This report describes the syntheses, characterization, crystal structures and magnetic properties of five dinuclear FeIIINiII compounds derived from two Robson-type tetraiminodiphenol macrocyclic ligands H2L1 and H2L2, which are the [2+2] condensation products of 4-ethyl-2,6-diformylphenol and 1,3-diaminopropane (for H2L1) or 2,2-dimethyl-1,3-diaminopropane (for H2L2). The compositions of the compounds are [FeIII(N3)2L1NiII(H2O)2](ClO4) (1), [FeIII(benzoato)L1NiII(H2O)(μ1,3-benzoato)](ClO4) (2), [FeIII(benzoato)L2NiII(H2O)(μ1,3-benzoato)](ClO4) (3), [FeIIIL2NiII(μ1,3-acetato)2](ClO4)·H2O (4) and [FeIIIL2NiII(μ1,3-propionato)2](ClO4)·H2O (5). The bridging moieties between the two metal ions …
Heterometallic 3d−4f Polyoxometalate Derived from the Weakley-Type Dimeric Structure
2009
Polyanion [{Ce(H(2)O)(2)}(2)Mn(2)(B-alpha-GeW(9)O(34))(2)](8-) (1) constitutes the first example of a heterometallic 3d-4f cluster related to the Weakley-type dimeric structure, and it contains an unprecedented Ce(III)(2)Mn(III)(2)O(20) rhomblike moiety displaying dominant Ce(III)-Mn(III) ferromagnetic interactions.