Search results for "NSC"
showing 10 items of 5810 documents
HYALURONIC ACID DERIVATIVE MICELLES AS OCULAR PLATFORMS TO DRUG RELEASE AND CORNEAL PERMEATION
2016
In traditional ocular formulations, only small amount of the administered drug penetrates the cornea to reach the intraocular tissue. One approach to improve the drug ocular bioavailability was to develop colloidal drug delivery systems. Polymeric micelles seem to be very promising for their capacity to dissolve a variety of hydrophobic drugs by enhancing their water solubility and so their bioavailability. They are able to increase ocular drug permeability due to interact with the complex corneal structure. Considering the advantages to use mucoadhesive polymer to increase drug residence time on the ocular surface, the aim of this work was to prepare hyaluronic acid-based micelles as a pla…
Improving the Effect of Transcranial Alternating Current Stimulation (tACS): A Systematic Review
2021
With the development of electrical stimulation technology, traditional transcranial alternating current stimulation (tACS) technology has been found to have the drawback of not targeting a specific area accurately. Studies have shown that optimizing the number and position of electrodes during electrical stimulation has a very good effect on enhancing brain stimulation accuracy. At present, an increasing number of laboratories have begun to optimize tACS. However, there has been no study summarizing the optimization methods of tACS. Determining whether different optimization methods are effective and the optimization approach could provide information that could guide future tACS research. …
Transkreācija reklāmas materiālos Latvijā
2017
Pirms Industriālās revolūcijas reklāma bija fenomens, kas izplatījās vietējā mērogā, taču mūsdienās reklāmdevēji uzskata, ka ir „jādomā globāli, bet jārīkojas lokāli”. Paralēli sarunām, kas noris starp globālas un lokālas reklāmas piekritējiem, reklāmdevējiem ir jāatrod veidi, kā patērētājiem pārdot produktus, un viens no veidiem ir transkreācija. Transkreācija ir salīdzinoši jauns jēdziens un tam ir veltīta neliela pētnieciskā darbība, turklāt latviešu valodā šis termins vēl nav atzīts (lai gan Latvijas reklāmdevēji lieto terminu „adaptācija”). Tādēļ pētījuma mērķis ir noteikt transkreācijas izplatību un īpašības reklāmas materiālos Latvijā. Pētījuma teorētiskajā daļā tiek pētīta reklāmas …
La transcreazione nei testi delle canzoni : la canzone straniera nelle voci italiane da Riccardo del Turco a Claudio Lolli
2022
There are different ways of translating popular songs or pop music. They can be translated for a volume that collects lyrics only to be read, to understand the meaning of the song’s message. If the song must be translated to be sung, for the performance, and you do not want to change the music, the only way to go is that of adaptation, in the appropriate choice of rhyming words that must adapt to the musical, mask (Low 2008). Our thesis, supported by three original case studies whose results we will study in the transition from a foreign language to Italian, is that this adaptation can coincide with what is now called transcreation.
Criteris per a la transcripció del corpus Parlars. Segona versió
2019
Els criteris de transcripció que presentem s’ajusten als objectius del corpus Parlars (projecte CorDiVal: Elaboració d'un corpus oral dialectal del valencià col·loquial, Ref. GV/2017/094, finançat per la Generalitat Valenciana; https://www.uv.es/corvalc/), és a dir, un corpus orientat a l’estudi de la variació dialectal i diafàsica de la llengua oral. Aquesta segona versió dels criteris és el resultat de diverses proves pilot i pretenen ser un model que facilite al màxim les tasques de tokenització i lematització automàtica.
Criteris per a la transcripció del corpus Parlars
2019
Els criteris de transcripció que presentem s’ajusten als objectius del corpus Parlars (projecte CorDiVal, Ref. GV/2017/094, finançat per la Generalitat Valenciana; https://www.uv.es/corvalc/), és a dir, un corpus oral, col·loquial i dialectal del català del País Valencià. El corpus Parlars tindrà dues transcripcions: una transcripció fonoortogràfica que provarà de reflectir al màxim possible les característiques lingüístiques del discurs i una transcripció ortogràfica estandarditzada que ha de facilitar les tasques d’anotació. Aquest model serà possible perquè optem per una estratègia d’anotació multicapes (stand-off) que combina la superposició de diversos nivells de transcripció i anotaci…
Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma
2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Here, we investigated a correlation between the EV-mediated osteogenic inhibition and MM vesicle content, focusing on miRNAs. By the use of a MicroRNA Card, we identified a pool of miRNAs, highly expressed in EVs, from MM cell line (MM1.S EVs), expression of which was confirmed in EVs from bone marrow (BM) plasma of patients affected by smoldering myeloma (SMM) and MM. Notably,we found that miR-129-5p, whic…
The LuxR Regulators PcoR and RfiA Co-regulate Antimicrobial Peptide and Alginate Production in
2017
Cyclic lipopeptides (CLPs) are considered as some of the most important secondary metabolites in different plant-associated bacteria, thanks to their antimicrobial, cytotoxic, and surfactant properties. In this study, our aim was to investigate the role of the Quorum Sensing (QS) system, PcoI/PcoR, and the LuxR-type transcriptional regulator RfiA in CLP production in the phytopatogenic bacterium, Pseudomonas corrugata based on our previous work where we reported that the pcoR and rfiA mutants were devoid of the CLPs cormycin and corpeptin production. Due to the close genetic link between the QS system and the RfiA (rfiA is co-transcribed with pcoI), it was difficult to ascertain the specifi…
Deep transcriptome profile of early host responses to Huanglongbing in citrus fruit and leaf tissues.
2010
Identification of omic profiles for diagnosis and monitoring of bladder cancer
2019
La presente Tesis titulada Identificación de perfiles ómicos para el diagnóstico y la monitorización del cáncer de vejiga se centra en la identificación de biomarcadores metabolómicos urinarios no invasivos para el diagnóstico y la monitorización del cáncer de vejiga (CaV). Con este fin, se han utilizado dos plataformas analíticas: la Resonancia Magnética Nuclear (Nuclear Magnetic Resonance, 1H NMR) y la Cromatografía Líquida de alta resolución acoplada a la Espectrometría de Masas (Ultraperformance Liquid Chromatography–Mass Spectrometry, UPLC-MS). Además, se han analizado tejidos vesicales mediante la técnica de Resonancia Magnética Nuclear de Alta Resolución con Giro de Ángulo Mágico (Hi…