Search results for "ODR"

Effective Linear Friction Welding Machine Redesign through Process Analysis

2014

Linear friction welding is a solid-state joining process developed for non-axisymmetric components in which the joining of the specimens is obtained through reciprocating motion and pressure. In the process, the friction forces work due to the high frequency oscillation and the pressure between the specimens is converted in thermal energy. In order to design an effective machine, relevant issues derive from the high frequency and the large inertial forces involved in the process. In this study, the authors describe the redesign of a preexisting prototypal machine for LFW processes. A machine redesign is needed when welding high resistant materials, i.e. steels or titanium alloys, with high …

Representaciones sociales a través del lenguaje en la lexicografía hispanoamericana decimonónica

2014

Este articulo parte de una propuesta de analisis relativamente reciente de la primera lexicografia hispanoamericana despues de la independencia, que consiste en asumir una estrecha relacion entre la elaboracion, difusion y recepcion de los primeros diccionarios del espanol americano –en cuanto produccion cultural de la elite criolla–, y los procesos historicos y socio-politicos de la epoca. Sobre esta base, se postula la existencia de una unidad del discurso lexicografico, a pesar de la diversidad de obras y autores, que es posible entrever y caracterizar. Se analizan, en consecuencia, los mecanismos que en este discurso se ponen en funcionamiento para ofrecer representaciones sociales –en …

Valencia, Rodrigo Osorio, hacia 1589: público, «Autor» y fecha para «El Grao de Valencia», de Lope de Vega

2022

La trayectoria escénica de El Grao de Valencia, de Lope de Vega, nos es desconocida, pero hay buenas razones para suponer que fue el autor de comedias Rodrigo Osorio quien se encargó de llevar la pieza a las tablas ante el público valenciano entre 1588 y 1590, durante el exilio de Lope en Valencia. Para llegar a tales conclusiones -y tras discutir un supuesto estreno en Toledo, que no carece de fundamento- se tendrá en cuenta la posición que ocupa El Grao de Valencia en El peregrino en su patria, la documentación existente en torno a la actividad teatral de Osorio en la ciudad del Turia y la adecuación de su compañía al reparto de la comedia, así como ciertos detalles del texto y el argumen…

Biophysical Characterization of Polysialic Acid—Membrane Nanosystems

2019

Polysialic acid (polySia) is a long, membrane-bound, polyanionic polymer (with the degree of polymerization, DP, up to 400) of negatively charged sialic acid monomers. Biological roles of polySia are based on its ability to modulate repulsive and attractive interactions, and its ability to modulate membrane surface charge density, pH at the membrane surface, and membrane potentials. PolySia is used in anti-bacterial and anti-cancer therapies, and in neural tissue repair. Hydrophobically-modified polySia chains can form nano-structures (micelles or liposomes) with high stability and low toxicity for drug delivery. The analysis, based on the Goldman-Hodgkin-Katz equation, of transmembrane pot…

Re-visitando a Federica Montseny : Una lectura de la Victoria y sus lecturas

2006

This article wants to be a close reading of La Victoria, Federica Montseny’s novel published in 1925, in order to achieve two objectives: on the one hand, to break down the clichés that normally appear in Montseny’s work –her “revolutionary melodrama”- as a perfect example of the eternal “ethic-aesthetic” paradox and, on the other hand, to point out the capability of this kind of study to dynamize the so-called “women’s literature” in the context of the XX Century Spanish literature.

Integrability Conditions: Recent Results in the Theory of Integrable Models

1990

This paper reports various results achieved recently in the theory of integrable models. These are summarised in the Fig.1! At the Chester meeting [1] two of the authors were concerned [1] with the local Riemann-Hilbert problem (double-lined box in the centre of Fig.1), its limit as a non-local Riemann-Hilbert problem used to solve classical integrable models in 2+1 dimensions (two space and one time dimensions) [2,3], and the connection of this Riemann-Hilbert problem with Ueno’s [4] Riemann-Hilbert problem associated with the representation of the algebra gl(∞) in terms of Z⊗Z matrices (Z the integers) and the solution of the K-P equations in 2+1. We were also concerned [1] with the const…

MARTÍN MARTÍNEZ, José; RODRÍGUEZ CUADROS, Evangelina (eds). "Andreu Alfaro. En torno a la escultura. Escritos y entrevistas"

2016

Anticancer Activity, Reduction Mechanism and G-Quadruplex DNA Binding of a Redox-Activated Platinum(IV)–Salphen Complex

2022

Aiming at reducing the unselective cytotoxicity of Pt(II) chemotherapeutics, a great deal of effort has been concentrated into the design of metal-containing drugs with different anticancer mechanisms of action. Inert Pt(IV) prodrugs have been proposed to be a valid alternative as they are activated by reduction directly into the cell releasing active Pt(II) species. On the other hand, a promising strategy for designing metallodrugs is to explore new potential biological targets rather than canonical B-DNA. G-quadruplex nucleic acid, obtained by self-assembly of guanine-rich nucleic acid sequences, has recently been considered an attractive target for anticancer drug design. Therefore, comp…

Calorimetric investigation of the interaction between a macromolecular prodrug of diflunisal and human platelets

1995

The thermal effect due to the interaction between human platelets and α,β poly(N-hydroxy-ethyl)-DL-aspartamide (PHEA) or the PHEA-Diflunisal conjugate was measured by the calorimetric technique at 25°C. The experimental data confirm that PHEA is a biocompatible macromolecule and that its conjugate influences the physiological activity of human platelets.

Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy

2011

In the last twenty years a depth study on potential pharmaceutical applications of synthetic polymers at proteinlike structure as carrier for macromolecular prodrug production has been performed in academia and in industry. In particular α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), α,β-polyaspartylhydrazide (PAHy), poly(glutamic acid) (PGA), poly(aspartic acid) (PAA) and polylysine (PLL) have been extensively studied in this field. In the present review, the use of PHEA, PAHy, PGA as starting materials to prepare macromolecular prodrugs is reported and drug delivery and targeting aspects have been considered.