Search results for "POSITRON EMISSION TOMOGRAPHY"
showing 10 items of 235 documents
Whole-body magnetic resonance imaging and FDG-PET/CT for lymphoma staging: Assessment of patient experience
2017
Purpose: To compare patient experience of whole-body MRI and FDG-PET/CT performed for lymphoma staging. Methods: One-hundred-fifteen patients (59 males, 56 females; 53 Hodgkin, 62 non-Hodgkin; mean age: 43.8 years) with lymphoma underwent whole-body MRI and FDG-PET/CT for staging and filled a questionnaire regarding their experience of the examinations using a 4-point Likert scale (1, very good; 4,very bad). Differences were evaluated using Wilcoxon signed-rank test. Patients were asked to express their preference on both techniques. Preferences were compared on the basis of gender, age, and Ann Arbor stage using the chi-square test. A p-value ≤ .05 was considered significant. Results: Most…
Contributions to the physical and experimental validation of a simultaneous PET/MRI system dedicated to small animal imaging
2020
Simultaneous PET/MRI is a dynamic research field of both medical and preclinical domains. The ability of integrated systems to acquire the highly complementarity MR morphological and PET functional data in a single examination paves the way to innovative applications. The hereby document presents a series of experimentations dealing with the performance evaluation and the experimental in vivo capacities of such a device. Physical measurements were implemented based on international standards or inspired by articles of reference. The evaluated system consists of a compact SiPM-based PET subsystem fully integrated in a 7 T preclinical MRI based on the dry magnet technology. Experimentations s…
Inclusion of Inter Crystal Scatter data in PET
2012
In PET, as the spatial resolution of the measurement system is increased, multiple interactions of a single photon may be separately measured and such events are often removed from the data used in image reconstruction. While for some PET imaging tasks this effect is unimportant, for primate, brain and high-spatial-resolution imaging where sensitivity is important, such Inter Crystal Scattering (ICS) events may constitute a large fraction of the measured data. On-the-fly list-mode image reconstruction is generally required in order to use all the information provided by ICS. Simulated One-Pass List-mode image reconstruction is used in this investigation to study the inclusion of ICS informa…
Timing results using an FPGA-based TDC with large arrays of 144 SiPMs
2015
Silicon photomultipliers (SiPMs) have become an alternative to traditional tubes due to several features. However, their implementation to form large arrays is still a challenge especially due to their relatively high intrinsic noise, depending on the chosen readout. In this contribution, two modules composed of SiPMs with an area of roughly mm mm are used in coincidence. Coincidence resolving time (CRT) results with a field-programmable gate array, in combination with a time to digital converter, are shown as a function of both the sensor bias voltage and the digitizer threshold. The dependence of the CRT on the sensor matrix temperature, the amount of SiPM active area and the crystal type…
Preliminary assessment of the imaging capability of the YAP–(S)PET small animal scanner in neuroscience
2006
The new and fully engineered version of the YAP–(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4 � 4c m 2 of YAlO3:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axially � 4c m + transaxially. In PET mode, the volume resoluti…
Time of flight measurements based on FPGA and SiPMs for PET–MR
2014
Coincidence time measurements with SiPMs have shown to be suitable for PET/MR systems. The present study is based on 3 x 3 mm(2) SiPMs, LSO crystals and a conditioning signal electronic circuit. A Constant Fraction Discriminator (CFD) is used to digitalize the signals and a TDC FPGA-implemented is employed for fine time measurements. TDC capability allows processing the arrival of multiple events simultaneously, measuring times under 100 ps. The complete set-up for time measurements results on a resolution of 892 +/- 41 ps for a pair of detectors. The details of such implementation are exposed and the trade-offs of each configuration are discussed. (C) 2013 Elsevier By, All rights reserved,
Detector blockbased on arrays of 144 SiPMs and monolithic scintillators: A performane study
2015
[EN] We have developed a detector block composed by a monolithic LYSO scintillator coupled to a custom made 12 12 SiPMs array. The design is mainly focused to applications such as Positron Emission Tomography. The readout electronics is based on 3 identical and scalable Application Specific Integrated Circuits (ASIC). We have determined the main performance of the detector block namely spatial, energy, and time resolution but also the system capability to determine the photon depth of interaction, for different crystal surface treatments. Intrinsic detector spatial resolution values as good as 1.7 mm FWHM and energies of 15% for black painted crystals were measured. & 2014 Elsevier B.V. All…
Validation of the Monte Carlo Simulation of a Siemens Biograph mCT PET
2016
Geant4 Application for Tomography Emission (GATE) is a simulation platform based on GEANT4. It is designed to perform numerical simulations in medical imaging and radiotherapy. It is also used to simulate Emission Tomography (Positron Emission Tomography, PET and Single Photon Emission Computed Tomography, SPECT), Computed Tomography (CT) and Radiotherapy experiments. The purpose of this study is to validate a GATE model of the commercial PET/CT Siemens Biograph, the latest acquisition of the Clinical Hospital of Salamanca. The geometry of the system has been implemented in GATE, including the detector ring, the crystal blocks, the PMTs etc. Radionuclides for all measurements shall be \(^{1…
Data for: Synthesis and evaluation of 89Zr-labeled and long-lived GLP-1 receptor agonists for PET imaging
2020
Appendix B. PET imaging 3D rendered images. 1. PET 3D of 4-89Zr 2. PET 3D of 5-89Zr
Low in vivo brain glucose consumption and high oxidative stress in accelerated aging
2009
AbstractThe validity of the free radical theory of aging has been recently questioned. Our aim was to test whether there is oxidative stress in tissues critically involved in accelerated aging (senescence-accelerated mice, SAM) and whether this correlates with lower glucose consumption in vivo and behavioural tests. Positron emission tomography shows that brains of old SAM-prone animals consume less glucose than young ones. Behavioural characteristics, mitochondrial peroxide production, and damage in both the central nervous system and bone marrow stem cells also indicate that SAM-prone animals age faster than SAM-resistant ones. Our results support the role of the free radical theory of ag…