Search results for "PREP"
showing 10 items of 1334 documents
The application of phospholipid removal columns and ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry for quantificati…
2016
In this study a robust and sensitive method based on a proposed sample purification procedure, using zirconia-coated Phree™ columns and analysis by ultra-high performance liquid chromatography with triple quadrupole tandem mass spectrometry are presented for the assessment of multi-class antibiotics in farmed fish species. The sample preparation procedure benefited from combined precipitation of proteins and selective removal of phospholipids by Phree™ columns, resulting in a high sensitivity of the method (LOQ 0.3-9mgkg(-1)). The in-house validation results (precision, repeatability, decision limit CCα, detection capability CCβ, etc.) indicate that the elaborated method is fully suitable f…
Evolución de la competencia comunicativa mediante intervención pragmática en retraso del lenguaje: estudio de caso
2021
En el presente trabajo se describe la eficacia de la evaluación e intervención pragmática en un caso de retraso del lenguaje secundario a daño cerebral infantil. La intervención logopédica adoptó un marco teórico de psicolingüística cognitiva funcional y se centró en potenciar las habilidades pragmáticas comunicativas mediante la estimulación de las categorías pragmáticas interactivas en contextos conversacionales naturales. Mediante el PREP-R (Protocolo Rápido de Evaluación Pragmática Revisado) se ha hecho un seguimiento de la orientación comunicativa de los turnos, la predictibilidad, la eficacia comunicativa, la habilidad pragmática (general, específica y gramatical) y los elementos que …
Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine
2020
Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this disorder are also involved in the regulation of PPI. Recently, we have reported that baseline PPI levels in mice can predict their sensitivity to the conditioned reinforcing effects of cocaine in the conditioned place preference (CPP) paradigm. Mice with a low PPI presented a lower sensitivity to the conditioned rewarding effects of cocaine; however, once they acquired conditioned preference with a higher dose of the drug, a more persistent associa…
Preclinical models for colonic absorption, application to controlled release formulation development.
2018
Oral controlled release (CR) formulations have many benefits and have become a valuable resource for the local and systemic administration of drugs. The most important characteristic of these pharmaceutical products is that drug absorption occurs mainly in the colon. Therefore, this review analyses the physiological and physicochemical features that may affect an orally administered CR product, as well as the different strategies to develop a CR dosage form and the methods used to evaluate the formulation efficacy. The models available to study the intestinal permeability and their applicability to colonic permeability determinations are also discussed.
Comparison of the efficacy of chemomechanical caries removal (Carisolv') with that of conventional excavation in reducing the cariogenic flora
2004
Summary. Objectives. The usage of minimally invasive procedures and attention to patient comfort are of great importance, especially for dental treatment in small children. This has led to the development of chemomechanical methods for caries removal. The aim of this study was to compare the efficacy of chemomechanical caries removal with that of conventional excavation in reducing the count of the cariogenic flora. Design and setting. Subjects for this study were chosen from children admitted to dental clinic for restorative procedures under general anaesthesia. Samples and methods. Twenty-one children (mean age 43·5 ± 12·0 months) with early childhood caries were included in this stu…
The exact bounds for the degree of commutativity of a p-group of maximal class, I
2002
Abstract The first major study of p-groups of maximal class was made by Blackburn in 1958. He showed that an important invariant of these groups is the ‘degree of commutativity.’ Recently (1995) Fernandez-Alcober proved a best possible inequality for the degree of commutativity in terms of the order of the group. Recent computations for primes up to 43 show that sharper results can be obtained when an additional invariant is considered. A series of conjectures about this for all primes have been recorded in [A. Vera-Lopez et al., preprint]. In this paper, we prove two of these conjectures.
Virtual element method for computational homogenization of composite and heterogeneous materials
2020
Abstract In this study, a two-dimensional multi-region framework, based on the use of the Virtual Element Method (VEM), is developed for computational materials homogenization and applied to different classes of widely employed heterogeneous materials. The VEM has recently emerged as a powerful generalisation of the Finite Element Method capable of dealing with very general polygonal mesh elements, including non-convex or highly distorted elements. Such features are appealing for the treatment of problems whose analysis domains present complex or statistical morphological features, which would generally require careful and time-consuming mesh/data preparation and regularization. In this wor…
Control de la comprensión durante la lectura de textos de ciencias en inglés. ¿Están preparados los estudiantes universitarios españoles para integra…
2011
Se presenta un estudio empírico realizado con estudiantes universitarios. Se estudió el control de la comprensión durante la lectura de textos de ciencias en inglés. Los resultados muestran dificultades importantes en el procesamiento de las macroideas respecto de las microideas y esas dificultades disminuyen muy lentamente a medida que crece el nivel de dominio del inglés. Dado que el procesamiento de macroideas es necesario para el aprendizaje profundo de los contenidos de ciencias, estos estudiantes tendrían graves dificultades en seguir un Grado universitario impartido en inglés, de acuerdo con los cánones del Espacio Europeo de Educación Superior. El inglés parece requerir una revisión…
Continuing Education in the Health Sciences in Spain
2008
<div class="ftSection"><span class="ftInlineSubsectionTitle">Background:</span><p>Employers have long been concerned about the professional qualifications of their employees. Decision makers in the health sciences are no exception, particularly now that they are seriously considering the improvement and full accreditation of continuing education as part of the planned European convergence.</p></div><div class="ftSection"><span class="ftInlineSubsectionTitle">Method:</span><p>Medical and nursing professionals were questioned about their views on continuing education, suitable content of possible programs, and implementation, in comp…
Recommendation of RILEM TC237-SIB on cohesion test of recycled asphalt
2018
This recommendation describes how to evaluate the presence of potentially active bitumen in recycled asphalt (RA) materials through the cohesion test. The experimental protocol is designed according to the research performed by the RILEM Technical Committee 237-SIB ‘‘Testing and characterization of sustainable innovative bituminous materials and systems’’ with the purpose, to develop a new, simple and fast method for the characterization of RA while limiting the need for conventional rheological tests. The guidelines in this recommendation focus on the testing procedure including specimen preparation, data analysis and provide information on the preparation of a tests report.