Search results for "R1"
showing 10 items of 1016 documents
A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland
2022
Bacillus Calmette-Guérin (BCG) is a vaccine against tuberculosis and contains a live, attenuated strain of Mycobacterium bovis as its essential constituent. Being a live, attenuated strain with potential pathogenicity, BCG can cause different complications, both near the inoculation site and through blood dissemination, especially in patients with immunodeficiency. IFN-γR1 deficiency is an autosomal recessively inherited immunodeficiency characterized by predisposition to infections with intracellular pathogens, in particular mycobacteria.
 We report a rare case of chronic osteomyelitis lasting 30 years due to BCG in a woman with IFN-γR1 deficiency who had previous clinical history of …
Metabolic Adaptation and Protein Complexes in Prokaryotes.
2012
Protein complexes are classified and have been charted in several large-scale screening studies in prokaryotes. These complexes are organized in a factory-like fashion to optimize protein production and metabolism. Central components are conserved between different prokaryotes; major complexes involve carbohydrate, amino acid, fatty acid and nucleotide metabolism. Metabolic adaptation changes protein complexes according to environmental conditions. Protein modification depends on specific modifying enzymes. Proteins such as trigger enzymes display condition-dependent adaptation to different functions by participating in several complexes. Several bacterial pathogens adapt rapidly to intrace…
Gut Microbiota, Microbial Metabolites and Human Physical Performance
2021
Trillions of microbes inhabiting the gut modulate the metabolism of the host. Cross-sectional studies have reported associations between physical performance and the gut microbiota (GM). Physical activity seems to increase GM diversity and the abundance of certain health-beneficial microbes. We reviewed the evidence from longitudinal studies on the connection between physically active lifestyle or long-term exercise interventions and the GM. We made literature searches using databases of Web of Science and PubMed Medline to collect human studies showing or not the associations between the GM and exercise. Many controversies exist in the studies. However, the longitudinal studies show that f…
From ethnobotany to experimental research: the therapeutic properties of Sicilian hellebore
2018
In Sicily, the genus Helleborus (Ranuculaceae) is only represented by H. bocconei subsp. siculus (= H. bocconei subsp. intermedius). In some mountain areas of the Island, the rhizomes of this plant, harvested in a particular month of the year (May) and dried, are used in traditional veterinary practice for treating pneumonia in domestic animals, cattle and horses in particular. The same usage – with rhizomes of other Helleborus species or subspecies – is reported from various other areas of Mediterranean Europe. Phytochemical tests have permitted the isolation and characterization of new biologically active molecules. The extracts of rhizomes and aerial parts of the plant were shown antibac…
Crossing a Multi-Lane Street: Irrelevant Cars Increase Unsafe Behavior
2011
Before crossing a road or an intersection, road users have to determine among the surrounding traffic whether or not they have enough time to safely complete their maneuver. Temporal judgments have been investigated for single cars approaching an intersection, however, close to nothing is known about how street-crossing decisions are being made when several vehicles are simultaneously approaching in two adjacent lanes. We conducted a simulator experiment in which observers indicated whether or not they had enough time to complete safe street crossing. Traffic gaps were presented either with a single or two oncoming cars on different lanes, in such a way that in all cases, only the shortest …
Food Tray Sealing Fault Detection in Multi-Spectral Images Using Data Fusion and Deep Learning Techniques
2021
A correct food tray sealing is required to preserve food properties and safety for consumers. Traditional food packaging inspections are made by human operators to detect seal defects. Recent advances in the field of food inspection have been related to the use of hyperspectral imaging technology and automated vision-based inspection systems. A deep learning-based approach for food tray sealing fault detection using hyperspectral images is described. Several pixel-based image fusion methods are proposed to obtain 2D images from the 3D hyperspectral image datacube, which feeds the deep learning (DL) algorithms. Instead of considering all spectral bands in region of interest around a contamin…
Comparative analysis and antimicrobial action of some essential oils from plants
2021
In this research, essential oils (EOs) were extracted through steaming from aerial parts of three plants: basil (Ocinum basilicum L.), peppermint (Mentha piperita L.) and oregano (Origanum vulgare L.) form Sibiu County, Romania. The GC-MS analysis indicated that eugenol and apiol were the major compounds in the basil EO. Timol, ɣ-terpinene, and p-cymene were the major compounds in the volatile oil extracted from oregano and menthol and methone the main components in the peppermint EO. In the first 48 h of analysis, basil EO inhibition action was the highest against Salmonella anatum (48%), followed by Aspergillus niger (26%), Bacillus cereus (21%) and Saccharomyces cerevisiae (15%); this ac…
Histoire et évolution des appellations d'origine françaises
2019
During the 20th century, wine appellations of origin have largely developed to represent a significant part of the wine production of some countries, especially in Europe. The globalization of the production, trade and consumption of wine is a major fact of the 21st century economy. The question of appellations of origin and more generally geographical indications must be asked: Is it a survival 100 years after the first law on appellations of origin was adopted in France? Historical knowledge makes it possible to understand how law, both national and international, has been marked by major developments in this area. Regulations on the origin of products have undergone significant changes o…
L'histoire du vin comme patrimoine et atout économique
2017
La connaissance historique du vin est aujourd'hui un enjeu scientifique, culturel mais aussi economique. La precocite du commerce international et de la consommation du vin dans de nombreuses regions du monde permet d'avoir une reflexion en longue duree – sur plusieurs siecles – concernant la globalisation. Au 20e siecle l'instauration de normes internationales partagees, notamment grâce a l'activite de l'OIV, donne aujourd'hui encore a reflechir sur un developpement economique international appuye sur des normes partagees. Le traitement numerique et la mise a disposition du Bulletin de l'OIV fondes sur un travail universitaire realise a Dijon est un outil mis a la disposition de tous pour …
Combined Bacteriophage and Antibiotic Treatment Prevents Pseudomonas aeruginosa Infection of Wild Type and cftr- Epithelial Cells
2020
International audience; With the increase of infections due to multidrug resistant bacterial pathogens and the shortage of antimicrobial molecules with novel targets, interest in bacteriophages as a therapeutic option has regained much attraction. Before the launch of future clinical trials, in vitro studies are required to better evaluate the efficacies and potential pitfalls of such therapies. Here we studied in an ex vivo human airway epithelial cell line model the efficacy of phage and ciprofloxacin alone and in combination to treat infection by Pseudomonas aeruginosa. The Calu-3 cell line and the isogenic CFTR knock down cell line (cftr-) infected apically with P. aeruginosa strain PAO…