Search results for "SIMULATION"
showing 10 items of 5095 documents
Predicting Lung Deposition of Extrafine Inhaled Corticosteroid-Containing Fixed Combinations in Patients with Chronic Obstructive Pulmonary Disease U…
2021
Background: Functional respiratory imaging (FRI) is a computational fluid dynamics-based technique using three-dimensional models of human lungs and formulation profiles to simulate aerosol deposition. Methods: FRI was used to evaluate lung deposition of extrafine beclomethasone dipropionate (BDP)/formoterol fumarate (FF)/glycopyrronium bromide (GB) and extrafine BDP/FF delivered through pressurized metered dose inhalers and to compare results with reference gamma scintigraphy data. FRI combined high-resolution computed tomography scans of 20 patients with moderate-to-severe chronic obstructive pulmonary disease (mean forced expiratory volume in 1 second 42% predicted) with in silico comput…
Assessment of the fundamental flexural guided wave in cortical bone by an ultrasonic axial-transmission array transducer
2013
Abstract The fundamental flexural guided wave (FFGW), as modeled, for example, by the A0 Lamb mode, is a clinically useful indicator of cortical bone thickness. In the work described in this article, we tested so-called multiridge-based analysis, based on the crazy climber algorithm and short-time Fourier transform, for assessment of the FFGW component recorded by a clinical array transducer featuring a limited number of elements. Methods included numerical finite-element simulations and experiments in bone phantoms and human radius specimens ( n = 41). The proposed approach enabled extraction of the FFGW component and determination of its group velocity. This group velocity was in good ag…
Patient-specific simulation of the intrastromal ring segment implantation in corneas with keratoconus
2015
Purpose The purpose of this study was the simulation of the implantation of intrastromal corneal-ring segments for patients with keratoconus. The aim of the study was the prediction of the corneal curvature recovery after this intervention. Methods Seven patients with keratoconus diagnosed and treated by implantation of intrastromal corneal-ring segments were enrolled in the study. The 3D geometry of the cornea of each patient was obtained from its specific topography and a hyperelastic model was assumed to characterize its mechanical behavior. To simulate the intervention, the intrastromal corneal-ring segments were modeled and placed at the same location at which they were placed in the s…
El diàleg paradigmàtic en Educació Social: la simulació com una manera d'ensenyar i aprendre en les aules universitàries
2012
El text presenta una pràctica de simulació a l'aula, realitzada -en els últims anys- amb estudiants que han cursat l'assignatura de 'Pedagogia Social' a la Diplomatura d'Educació Social i en la Llicenciatura de Pedagogia (ara Graus), a la Facultat de Ciències de l'Educació de la Universitat de Santiago de Compostel la. Amb un enfocament didàctic innovador, en què els alumnes adquireixen un protagonisme directe en els processos d'ensenyament-aprenentatge que es proposen, els seus plantejaments metodològics es projecten en un 'diàleg paradigmàtic' que pren com a referència els tres models de racionalitat teòrica (teories) als que sol remetre la Pedagogia-Educació Social: tecnològic, interpret…
Assessment of University Students’ Critical Thinking: Next Generation Performance Assessment
2019
Following employers’ criticisms and recent societal developments, policymakers and educators have called for students to develop a range of generic skills such as critical thinking (“twenty-first c...
Performative Architecture: New Semantic for New Shapes?
2008
Two innovations have more deeply changed the building process: the operational continuity of the design and construction phases and the software allowing not only the representation but also the autonomous creation of complex shapes never before thought, just because they could not be represented. This last innovation introduce to a "Performative Architecture" that addresses to emerge a new kind of architecture. Building performances (structural, environmental, energetic) are guiding design principles, adopting new building performance-based priorities for the design of cities, buildings and landscape. This emerging architecture places broadly defined performance above form making; It utili…
Intravascular pillars and pruning in the extraembryonic vessels of chick embryos.
2010
To investigate the local mechanical forces associated with intravascular pillars and vessel pruning, we studied the conducting vessels in the extraembryonic circulation of the chick embryo. During the development days 13-17, intravascular pillars and blood flow parameters were identified using fluorescent vascular tracers and digital time-series video reconstructions. The geometry of selected vessels was confirmed by corrosion casting and scanning electron microscopy. Computational simulations of pruning vessels suggested that serial pillars form along pre-existing velocity streamlines; blood pressure demonstrated no obvious spatial relationship with the intravascular pillars. Modeling a Re…
Semiflexible macromolecules in quasi-one-dimensional confinement: Discrete versus continuous bond angles
2015
The conformations of semiflexible polymers in two dimensions confined in a strip of width D are studied by computer simulations, investigating two different models for the mechanism by which chain stiffness is realized. One model (studied by molecular dynamics) is a bead-spring model in the continuum, where stiffness is controlled by a bond angle potential allowing for arbitrary bond angles. The other model (studied by Monte Carlo) is a self-avoiding walk chain on the square lattice, where only discrete bond angles (0° and ±90°) are possible, and the bond angle potential then controls the density of kinks along the chain contour. The first model is a crude description of DNA-like biopolymer…
Understanding the Multiple Length Scales Describing the Structure of Bottle-brush Polymers by Monte Carlo Simulation Methods
2011
Bottle-brush polymers contain a long flexible macromolecule as a backbone to which flexible side chains are grafted. Through the choice of the grafting density and the length of the side chains the local stiffness of this cylindrical molecular brush can be controlled, but a quantitative understanding of these phenomena is lacking. Monte Carlo simulation results are presented and discussed which address this issue, extractingmesoscopic length scales (such as the cross-sectional radius, persistence length, and contour length of these objects). Large-scale simulations of the bond fluctuation model are combined with simulations of the simple selfavoiding walk (SAW) model with flexibility contro…
The perception loop in CiceRobot, a museum guide robot
2009
The paper discusses a model of robot perception based on a comparison loop process between the actual and the expected robot input sensory data generated by a 3D robot/environment simulator. The perception loop process is operating in CiceRobot, a functional robot architecture implemented on an autonomous robot RWI B21 offering guided tours at the Archaeological Museum of Agrigento, Italy.