Search results for "Stone"

Fruit Trees and Bushes as a Biodiversity Element in the “Górażdże” Quarry Reclaimed Areas

2019

The assumption of biological land reclamation in the forest direction is to introduce trees and shrubs on the reclaimed area so as to bring it as close as possible to the natural state based on the species characteristic for forest communities. While assessing the concept of biodiversity resulting from the naturalistic approach to the forest as a timeless good, it is necessary to take into account the diversity of plantings used and their multifunctionality. One of the functions is to designate crops for utility purposes, by creating a natural undergrowth, birdhouses, forest fringe plantings and enclaves of edible fruit plants. As part of the research, implementing the biodiversity of midfo…

Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages

2019

Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E-2 (PGE(2)). However, it has been described that dermal fibroblasts behave like mesenchymal stem cells reducing lymphocyte recruitment and dendritic cell activation through PGE(2) release. As the role of fibroblasts in psoriasis remains poorly characterized, in the present study we have evaluated the possible influence of PGE(2) derived from dermal fibroblasts as modulator of the immune response in psoriatic skin. Our results indicate that under inflammatory conditions, psoriatic fibroblasts showed defective induction of COX-2, which …

Architecture, materials and languages. From marble to stone and viceversa (Sicily 15th-16th centuries)

2018

Tra la seconda metà del Quattrocento e i primi decenni del Cinquecento l’architettura in Sicilia offre un caso di coesistenza di due “mondi” legati a tecniche e linguaggi riconducibili ad ambiti culturali differenti: tardogotico e rinascimento secondo le etichette della storiografia tradizionale. Questo contributo propone un approccio non convenzionale che parte da una riflessione su materiali e prerogative professionali dei gruppi portatori delle due differenti culture di progetto, come campo di osservazione per i mutevoli rapporti di forza tra le stesse. Se in un primo momento la pietra è il campo del tardogotico e il marmo bianco quello del classicismo e le due realtà convivono, successi…

Marbles of Sicily (Italy)

2008

STUDIO MINERALOGICO-PETROGRAFICO E PROBLEMI CONSERVATIVI

2011

Il capitolo illustra le risultanze dello studio delle problematiche conservative e della caratterizzazione mineralogico petrografica dei materiali lapidei del teatro ellenistico di Morgantina (Enna). Tale attività è stata finalizzata alla definizione dell'intervento conservativo del teatro. The chapter illustrates the results of the study of conservation issues and petrographic mineralogical characterization of the stone materials of the Hellenistic theater of Morgantina (Enna). This activity was aimed at defining the conservative intervention of the theatre.

Costruire lo spazio. Il cantiere gotico, dal disegno all'esecuzione.

2016

In ogni momento storico il cantiere edile ha rappresentato una sfida, il locus concreto della realizzazione di ambiziosi progetti, innovative sperimentazioni ed evolutive idee, che hanno permesso di imprimere una svolta decisiva al progresso tecnologico. Complessa e variegata appare la condizione del cantiere siciliano, spesso influenzato da innumerevoli apporti derivanti da altre aree culturali del bacino del Mediterraneo, vero e proprio crogiuolo di saperi a confronto, materiali e tecniche eterogenei, progettisti e maestranze itineranti. Se da un canto la costruzione gotica annoverava limitate conoscenze e metodi elementari in materia resistenza dei materiali, composizione delle forze, me…

The Mystery of Tombstone

2012

Italian Abstract: Nella chiesa annessa al complesso monastico basiliano, sito nel quartiere Immacolata di Barcellona Pozzo di Gotto (Messina), e custodita una lapide sepolcrale raffigurante un uomo adulto scolpito a bassorilievo, con una lunga spada posta davanti al corpo e un cane con la testa mozzata ai piedi. Fonti settecentesche tramandano che la lapide era un tempo collocata nella chiesa di Santa Maria di Gala e riportano, seguendo la tradizione locale, che essa raffigurava Simone il Normanno, figlio di Adelasia e Ruggero I, sepolto a Gala. In realta, nella lapide sepolcrale e raffigurata una persona adulta e non un giovane, com’era Simone, morto a dodici anni il 28 settembre del 1105.…

Missionaries, Agents of Empire and Medical Educators: Scottish Doctors in Late Nineteenth-Century Southern and East-Central Africa

2014

Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets.

2021

Quinoline is one of the most important and versatile nitrogen heterocycles embodied in several biologically active molecules. Within the numerous quinolines developed as antiproliferative agents, this review is focused on compounds interfering with DNA structure or with proteins/enzymes involved in the regulation of double helix functional processes. In this light, a special focus is given to the quinoline compounds, acting with classical/well-known mechanisms of action (DNA intercalators or Topoisomerase inhibitors). In particular, the quinoline drugs amsacrine and camptothecin (CPT) have been studied as key lead compounds for the development of new agents with improved PK and tolerability…

Cytotoxic effects of Jay Amin hydroxamic acid (JAHA), a ferrocene-based class I histone deacetylase inhibitor, on triple-negative MDA-MB231 breast ca…

2012

The histone deacetylase inhibitors (HDACis) are a class of chemically heterogeneous anticancer agents of which suberoylanilide hydroxamic acid (SAHA) is a prototypical member. SAHA derivatives may be obtained by three-dimensional manipulation of SAHA aryl cap, such as the incorporation of a ferrocene unit like that present in Jay Amin hydroxamic acid (JAHA) and homo-JAHA [ Spencer , et al. ( 2011 ) ACS Med. Chem. Lett. 2 , 358 - 362 ]. These metal-based SAHA analogues have been tested for their cytotoxic activity toward triple-negative MDA-MB231 breast cancer cells. The results obtained indicate that of the two compounds tested, only JAHA was prominently active on breast cancer cells with a…