Search results for "TetR"

Acid-mediated reaction of bis(pyridine)iodonium(I) tetrafluoroborate with aromatic compounds. A selective and general iodination method

1993

Reaction of aromatic compounds with bis(pyridine)iodonium(I) tetrafluoroborate (IPy2BF4) in the presence of HBF4 or CF3SO3H in CH2Cl2 at room temperature furnishes monoiodo derivatives with excellent regioselectivity and yields. Use of either acid gives comparable results with activated aromatics, whereas CF3SO3H is much more effective in the iodination of deactivated aromatics. © 1993 American Chemical Society.

Fatal measles as AIDS presentation in Italy

2019

Vulvodynia¿It Is Time to Accept a New Understanding from a Neurobiological Perspective

2021

Vulvodynia is one the most common causes of pain during sexual intercourse in premenopausal women. The burden of vulvodynia in a woman’s life can be devastating due to its consequences in the couple’s sexuality and intimacy, in activities of daily living, and psychological well-being. In recent decades, there has been considerable progress in the understanding of vulvar pain. The most significant change has been the differentiation of vulvar pain secondary to pathology or disease from vulvodynia. However, although it is currently proposed that vulvodynia should be considered as a primary chronic pain condition and, therefore, without an obvious identifiable cause, it is still believed that …

Modeling S-carboxymethyl-L-cysteine protonation and activity coefficients in sodium and tetramethylammonium chloride aqueous solutions by SIT and Pit…

2007

Solubility and acid–base properties of S-carboxymethyl-l-cysteine (carbocysteine, ccys) in NaClaq and tetramethylammonium chloride, (CH3)4NClaq ,a tt =2 5 ◦ C and at different ionic strengths were investigated. Solubility was studied at 1.0 ≤ I (mol L −1 ) ≤ 5.0 for NaClaq and 1.0 ≤ I (mol L −1 ) ≤ 3.0 for (CH3)4NClaq, while potentiometric measurements (by ISE-H + , glass electrode) were performed at 0.1 ≤ I (mol L −1 ) ≤ 5.0 for NaClaq and 0.5 ≤ I (mol L −1 ) ≤ 3.0 for (CH3)4NClaq. Solubility data allowed us to determine Setschenow constants and activity coefficients of neutral carbocysteine (H2ccys). Dependence on ionic strength and ionic medium of protonation constants and activity coeff…

Acute Promyelocytic Leukemia during Pregnancy: A Systematic Review of the Literature

2020

The management of pregnant women with acute promyelocytic leukemia (APL) is a challenging situation where limited evidence-based information is available. We performed a systematic literature review to analyze the outcomes reported for both mother and fetus when APL is diagnosed during pregnancy. PubMed, Scopus and Web of Science databases were systematically searched to identify studies reporting cases of APL during pregnancy. Sixty-six articles met the eligibility criteria (53 single case reports). Ninety-two patients were eligible for induction therapy, with most them being treated with all-trans retinoic acid alone (32%) or combined with chemotherapy (43%), while the remaining patients …

A quantum mechanics/molecular mechanics study of the acylation reaction of TEM1 β-lactamase and penicillanate

2000

The acylation step in β-lactamase catalyzed hydrolysis of β-lactams has been explored by means of a quantum mechanics/molecular mechanics approach (AM1/CHARMM). The TEM1 enzyme, a class A β-lactamase, and the penicillanate constitute the system employed in our study. The entire molecular system is divided into a quantum and a classical region: the quantum part is composed by the substrate, the serine Ser70 and the essential moieties of key active site residues, Lys73, Ser130 and Glu166, as well as a water molecule present in the active site region, while the classical part is formed by the remaining residues and structural waters of the enzyme. In particular, the sequence of steps proposed …

Die Herstellung einer molekulareinheitlichen Tri-, Tetra- und Pentamethacrylsäure. V. Mitt. Modelle für Matrizenreaktionen

1968

Vom p-Kresol sowie einer phenolischen Zwei- und einer Dreikernverbindung wurden mit verschiedenen Acylierungsmethoden Methacrylsaureester erhalten; die Zweikernverbindung enthielt danach zwei und die Dreikernverbindung drei Methacrylreste. Loste man diese Methacrylsuureester in groser Verdunnung in siedendem Benzol und lies gleichzeitig einen grosen Uberschus an Radikalen aus α.α′-Azoisobuttersauredinitril einwirken, so wurde beim Methacrylsaure-p-kresylester eine Polymerisation unterdruckt. Bei den mehrfachen Estern der Mehrkernverbindungen wurde die polyrmerisationsahnliche Additionsreaktion auf die einzelnen Molekule begrenzt (intramolckulare Polymerisation); sie ergab neben einer cyclis…

A new electrophilic addition to acetylenes. Synthesis of 1,2-iodofunctionalized olefins

1986

Abstract Acetylenes react with bis(pyridine)iodo(I) tetrafluoroborate ( 1 ) in the presence of a wide variety of nucleophiles (F, Cl, Br, I, SCN, pyridine, OAc, anisole, H) to give 1,2-iodofunctionalized olefins ( 4 ).

Diversity in Itraconazole Cocrystals with Aliphatic Dicarboxylic Acids of Varying Chain Length

2013

The cocrystal formation potential of itraconazole, a potent antifungal drug, with C2–C10 aliphatic dicarboxylic acids has been investigated. Using two experimental screening techniques (solvent-assisted grinding and evaporation-based crystallization), the cocrystals of itraconazole with C2–C7 dicarboxylic acids have been successfully synthesized and characterized by powder X-ray diffraction, solid state nuclear magnetic resonance, Raman spectroscopy, and thermal analysis. The characterized multicomponent compounds include anhydrous cocrystals (malonic, succinic, glutaric, and pimelic acids), a cocrystal hydrate (adipic acid), and cocrystal solvates with acetone and tetrahydrofuran (oxalic a…

Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions.

1997

The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respectively.