Search results for "Transformation"
showing 10 items of 1634 documents
MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review
2021
Background MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results Fifteen articles were included for analysis, among which in …
Identification and expression of the 11β‐steroid hydroxylase from Cochliobolus lunatus in Corynebacterium glutamicum
2019
Hydroxylation of steroids has acquired special relevance for the pharmaceutical industries. Particularly, the 11β-hydroxylation of steroids is a reaction of biotechnological importance currently carried out at industrial scale by the fungus Cochliobolus lunatus. In this work, we have identified the genes encoding the cytochrome CYP103168 and the reductase CPR64795 of C. lunatus responsible for the 11β-hydroxylase activity in this fungus, which is the key step for the preparative synthesis of cortisol in industry. A recombinant Corynebacterium glutamicum strain harbouring a plasmid expressing both genes forming a synthetic bacterial operon was able to 11β-hydroxylate several steroids as subs…
Preventing technostress through positive technology
2018
Over the past decade, the workplace has experienced significant changes as a result of Information and Communication Technologies (ICTs) and the subsequent digital transformation (Mcafee, 2006; Matt et al., 2015). Such technological, cultural, and organizational changes have redefined business models and competition. As evidenced by the shift from the Enterprise 1.0 to the Enterprise 2.0 business models, ICTs offer companies increased productivity and efficiency (Bilbao-Osorio et al., 2013). At the same time, introduction of ICTs can pose a threat to both a company and its employees through misuse, abuse, and overuse, resulting in technostress (Gaudioso et al., 2017). This emerging risk see…
The Role of External Environment in Upper Echelons Theory
2014
Upper echelons research has largely focused on the antecedents and consequences of top management teams (TMTs) from the team and firm levels of analysis. This paper reviews empirical research on TMTs with a specific emphasis on the role of the external environment. Applying institutional and industrial organization theories, a cross-level conceptual model outlining the direct, mediating, and moderating effects of the external environment on upper echelons is developed. This review distinguishes between industry and institutional levels of analysis and three types of environmental characteristics: stable, dynamic, and transformational. The paper further explains the relationships between ea…
How to be an effective charismatic leader: lessons for leadership development
2006
PurposeTo highlight and explore the concept of charisma and charismatic leadership and to suggest how good leadership is possible.Design/methodology/approachThe article is based on the conceptual consideration.FindingsA way to better charismatic leadership is possible to achieve, but this needs a lot of work and commitment.Practical implicationsThe article suggests some key points to develop better charismatic leadership.Originality/valueThe article will be of value to those business managers who want to develop their skills of leadership
Transformational leadership and depressive symptoms among employees : mediating factors
2014
Purpose– The purpose of this paper is to examine whether the link between transformational leadership and depressive symptoms among employees is mediated by such personal resources as occupational self-efficacy, perceived meaningfulness of the work, and work-related rumination.Design/methodology/approach– The study was conducted using questionnaires among 557 Finnish municipal employees in various occupations. The statistical analysis was based on structural equation modeling. A multiple mediation model enabled us to investigate the specific indirect effects of each mediator. Model comparison was applied to ascertain whether the mediation should be considered as full or partial.Findings– Re…
Transformational leadership, learning, and employability
2011
PurposeNumerous empirical works have found evidence to support a positive relationship between managers' transformational leadership behaviour and employees' individual performance. Studies have also begun to examine the process by which the effects on performance ultimately take place. This research aims to move forward in this direction. The paper aims to analyse the mediating role of a contextual variable (organizational learning capability) and a subordinate characteristic (employability) in the relationship between transformational leadership and individual performance.Design/methodology/approachThe hypothesis was tested through a sample of 795 workers from 75 university departments, u…
The influence of leadership styles on the internationalisation of 'born-global' firms and traditionally global-expanding firms
2018
Leadership and internationalisation are both established areas of scientific research, yet their interplay remains insufficiently examined. The present study focuses on the former and aims to shed more light on the intersection of leadership and internationalisation. By utilising fsQCA, a qualitative comparative analysis, to a set of 437 active international firms, results suggest that under distinct conditions transactional as well as transformational leadership can lead to a high level of internationalisation for both traditional internationalising and so-called 'born-global' firms.
Culture specific and cross-culturally generalizable implicit leadership theories
1999
This study focuses on culturally endorsed implicit theories of leadership (CLTs). Although cross-cultural research emphasizes that different cultural groups likely have different conceptions of what leadership should entail, a controversial position is argued here: namely that attributes associated with charismatic/transformational leadership will be universally endorsed as contributing to outstanding leadership. This hypothesis was tested in 62 cultures as part of the Global Leadership and Organizational Behavior Effectiveness (GLOBE) Research Program. Universally endorsed leader attributes, as well as attributes that are universally seen as impediments to outstanding leadership and cultur…
Las influencias históricas y circunstancias sociales y sociológicas en la creación de estructuras sociales informales de naturaleza criminal: estudio…
2018
Essential elements cementing every community are the factors: ontological, structural, fixed mechanisms of conduct including moral, religious, legal, or traditional tradition, or tradition, which is the carrier of continuity of this community. Lack of social stabilization, which in the old days was caused, among other things, by often changing rulers, the lack of justice that would equally affect all social groups, or the grossly unfair distribution of goods between the various social groups, led to the emergence of informal organizations, These often replaced the official law or administration, in the area inhabited by some community