Search results for "amine"

Narkoprobleemide kajastamine Eesti ajakirjanduses (1993-2009)

2013

P-76D-PENICILLAMINE, AN ACETALDEHYDE SEQUESTERING AGENT, REDUCES ETHANOL PREFERENCE IN ALCOHOL-NAÏVE RATS

2015

In previous investigations, we demonstrated that D-penicillamine (DP), a sulfhydryl aminoacid which has been studied as sequestration agent of acetaldehyde (ACD), is able to prevent the alcohol deprivation effect (ADE) but not voluntary ethanol consumption. Both results were obtained in long-term ethanol-experienced Wistar rats. Based on a previous …

P-56LOCAL BLOCKADE OF THE MU OPIOID RECEPTOR REVEALS THE DUAL MOTOR EFFECT OF ETHANOL IN pVTA

2015

Previous electrophysiological and behavioral data have revealed the existence of ethanol opposite effects (excitatory and inhibitory) on the posterior ventral tegmental area (pVTA) dopamine (DA) neurons activity. These activating and depressing effects of ethanol could be the result of two concurrent and opposing mechanisms, one increasing and the other reducing GABA release …

Micellar electrokinetic chromatography of polyamines and monoacetylpolyamines

2001

A selective procedure for qualitative and quantitative analysis of ten polyamines by micellar electrokinetic chromatography (MEKC) was developed. Benzoylated polyamines and acetylpolyamines in micellar phase of SDS (10 mM) were separated at 25 degrees C by 20 mM borate buffer pH 8.5, containing 8% ethanol, with an applied voltage of 25 kV (5 microA) and then detected at 198 nm. The experimental factors and operational parameters were optimized by performing analysis at different surfactant concentrations, pH, voltage and temperature with and without ethanol. The repeatibility of migration times and peak heights is a peculiarity of the method here described.

SY26-2ACETALDEHYDE ENDOCANNABINOIDS AND DOPAMINE: IS THIS –JUST- “A MENAGE A TROIS”?

2015

As ethanol, its first metabolite, acetaldehyde (ACD), enhances dopamine neurotransmission and exerts rewarding and motivational effects in animal models tailored for studying addictive-like behaviours. The endocannabinoid system fine-tuning dopamine cell activity, affects distinct drug-related behaviours and specific drug-induced effects. In light of this, it becomes urgent to investigate the implications of …

Palladium on pumice: new catalysts for the stereoselective semihydrogenation of alkynes to (Z)-alkenes

2001

Abstract High selectivities (93–99%) and excellent stereoselectivities (>99%) in the semihydrogenation of CC triple bonds were achieved using palladium on pumice with a metal loading of 0.5, 1.5 or 3.0% wt as catalyst. The reactions were carried out in ethanol or tetrahydrofuran with only 2.5% of ethylenediamine allowing a self-terminating semihydrogenation independently on the CC triple bond.

P-78D-PENICILLAMINE PREVENTS THE ALCOHOL DEPRIVATION EFFECT IN THE OPERANT SELF-AMINISTRATION PARADIGM

2015

Although pharmacological treatments for relapse prevention have experienced some progress, their general effectiveness can be considered low and the problem could not be considered solved. In recent years, our group has explored the use of acetaldehyde (ACD) sequestering agents as a new and very promising strategy. These agents, such as …

ChemInform Abstract: Palladium on Pumice: New Catalysts for the Stereoselective Semihydrogenation of Alkynes to (Z)-Alkenes.

2010

Abstract High selectivities (93–99%) and excellent stereoselectivities (>99%) in the semihydrogenation of CC triple bonds were achieved using palladium on pumice with a metal loading of 0.5, 1.5 or 3.0% wt as catalyst. The reactions were carried out in ethanol or tetrahydrofuran with only 2.5% of ethylenediamine allowing a self-terminating semihydrogenation independently on the CC triple bond.

Acetaldehyde effects in the brain

2015

The effects of alcohol have been widely studied during the past century as alcohol abuse is a major health problem in Western society. In the last years, a growing body of evidence indicates that acetaldehyde, the first oxidation product of ethanol, is one of the mediators of peripheral and central effects of ethanol. Indeed, acetaldehyde has been recently taken into account as the mediator of the rewarding properties of alcohol. The role of acetaldehyde in ethanol-related properties has been proved by enzymatic manipulation studies in which the inactivation of acetaldehyde potentially synthesized in the brain produces the same results as blocking the formation of acetaldehyde by inhibiting…

Diastereo- and enantioselective synthesis of orthogonally protected 2,4-diaminocyclopentanecarboxylates: a flip from beta-amino- to beta,gamma-diamin…

2007

Conformationally restricted, orthogonally protected 2,4-diaminocarboxylates with a cyclopentane skeleton were efficiently synthesized from beta-lactam 6, the syntheses involving strategies of diastereoselective epoxidation of the beta-lactam and the corresponding monoprotected amino esters with opposite selectivities followed by regioselective opening of the oxirane ring with sodium azide. The enantiomers were also prepared. This new class of compounds can be regarded not only as conformationally constrained beta,gamma-diamino acid derivatives but also as potential functionalized carbocyclic nucleoside precursors.