Search results for "combinatorial"

ChemInform Abstract: Catalytic Aminomercuration of Olefins in a Tandem Aminomercuration-Deoxymercuration; One-Step Synthesis of Secondary N-Arylallyl…

1990

Abstract Allyl alcohols react with primary aromatic amines and stoichiometric amounts of mercury(II) tetrafluoroborate to give mixtures of mono- and diallyl anilines. However, the use of the tandem aminomercuration-deoxymercuration promoted by catalytic mercury(II) tetrafluoroborate allows to perform regiospecifically the monoallylation reaction with very high yields. A mechanism is proposed to account for the observed results.

ChemInform Abstract: Pyrazolo[3,4-d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling Studies.

2009

The pyrazolo[3,4-d]pyrimidine system shows a multitude of interesting pharmacological properties. Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4-d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H-pyrazolo[3,4-d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N-benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters. Compounds 8a, b, 10a-d, and 11a, b revealed a superior inhibitory profile against COX-2, when compared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results.

Synthesis and labeling of a squaric acid containing PSMA-inhibitor coupled to AAZTA5 for versatile labeling with 44Sc, 64Cu, 68Ga and 177Lu

2020

ChemInform Abstract: Thioetherification of Chloroheteroarenes: A Binuclear Catalyst Promotes Wide Scope and High Functional-Group Tolerance.

2015

The nucleophilic substitution of a variety of chloro- and bromohetarenes with arylthiols is optimized to use [PdCl(allyl)]2 in combination with a ferrocenyltetraphosphane as ligand.

Solid-Phase Synthesis of Biologically Important Glycopeptides

2003

New Perspectives in Polymer-Supported Peptide Synthesis

1982

The (2-Phenyl-2-trimethylsilyl)ethyl(PTMSEL) Linker—A Novel Linker for the Solid-Phase Synthesis of Protected Peptides and Glycopeptides Cleavable wi…

2002

Novel bis(tetrahydropyrrolo[3,4-b]carbazoles) linked with aliphatic chains: synthesis and structural aspects

2001

Syntheses of novel bis(tetrahydropyrrolo[3,4-b]carbazoles) by a [4+2]cycloaddition reaction are described. By variation of dienophiles bis(tetrahydropyrrolo[3,4-b]carbazoles) of varying aliphatic spacer length could be obtained in high yields. These conformationally highly flexible molecules represent an interesting class of compounds, believed to have an affinity towards DNA, as potential DNA ligands.

Synthesis of porphyrin-bis(polyazamacrocycle) triads via Suzuki coupling reaction

2014

Suzuki–Miyaura cross-coupling reaction has been used for the synthesis of tricyclic architectures based on trans-A2B2-porphyrins and bisaminal-protected polyazamacrocycles which are linked directly or by a p-phenylene spacer. This modular approach allowed the synthesis of ligands with various substituted porphyrin macrocycles and bisaminal-protected tetraazamacrocycles possessing different cavity sizes. These molecules can be assembled into dimers using a DABCO linker. Deprotection of these compounds afforded porphyrin-bis(polyazamacrocycle) triads.

ChemInform Abstract: A Versatile Palladium/Triphosphane System for Direct Arylation of Heteroarenes with Chloroarenes at Low Catalyst Loading.

2010

The present new catalyst system can be used for the direct arylation of various heteroaromatic compounds at low palladium loadings.