Search results for "hole"

Genome Sequence of Lactobacillus plantarum 19L3, a Strain Proposed as a Starter Culture for Slovenská Bryndza Ovine Cheese

2014

ABSTRACT The genome sequence of Lactobacillus plantarum isolated from ovine cheese is presented here. This bacterium is proposed as a starter strain, named 19L3, for Slovenská bryndza cheese, a traditional Slovak cheese fulfilling European Food Safety Authority (EFSA) requirements.

Genome Sequence of Klebsiella pneumoniae KpQ3, a DHA-1 β-Lactamase-Producing Nosocomial Isolate.

2012

ABSTRACT Klebsiella pneumoniae KpQ3 is a multidrug-resistant isolate obtained from a blood culture of a patient in a burn unit in the Hospital Universitario La Paz (Madrid, Spain) in 2008. The genome contains multiple antibiotic resistance genes, including a plasmid-mediated DHA-1 cephalosporinase gene.

NovelAmycolatopsis balhimycinabiochemical abilities unveiled by proteomics

2014

Amycolatopsis balhimycina DSM5908 is an actinomycete producer of balhimycin, an analogue of vancomycin, the antibiotic of ‘last resort’ against multidrug-resistant Gram-positive pathogens. Most knowledge on glycopeptide biosynthetic pathways comes from studies on A. balhimycina as this strain, among glycopeptide producers, is genetically more amenable. The recent availability of its genome sequence allowed to perform differential proteomic analyses elucidating key metabolic pathways leading to antibiotic production in different growth conditions. To implement proteomic data on A. balhimycina derived from 2-DE approaches and to identify novel components, a combined approach based on protein …

Deciphering the role of insertion sequences in the evolution of bacterial epidemic pathogens with panISa software

2020

Next-generation sequencing (NGS) is now widely used in microbiology to explore genome evolution and the structure of pathogen outbreaks. Bioinformatics pipelines readily detect single-nucleotide polymorphisms or short indels. However, bacterial genomes also evolve through the action of small transposable elements called insertion sequences (ISs), which are difficult to detect due to their short length and multiple repetitions throughout the genome. We designed panISa software for the ab initio detection of IS insertions in the genomes of prokaryotes. PanISa has been released as open source software (GPL3) available from https://github.com/bvalot/panISa. In this study, we assessed the utilit…

Hyaluronan alkyl derivatives-based electrospun membranes for potential guided bone regeneration: Fabrication, characterization and in vitro osteoindu…

2020

Item does not contain fulltext The aim of the work was to determine the effects of the chemical functionalization of hyaluronic acid (HA) with pendant aliphatic tails at different lengths and free amino groups in terms of chemical reactivity, degradation rate, drug-eluting features, and surface properties when processed as electrospun membranes (EM) evaluating the osteoinductive potential for a possible application as guided bone regeneration (GBR). To this end, a series of HA derivatives with different aliphatic tails (DD-Cx mol% ≈ 12.0 mol%) and decreasing derivatization of free amino groups (DD(EDA) mol% from 70.0 to 30.0 mol%) were first synthesized, namely Hn. Then dexamethasone-loaded…

Efficient growth of sub-micrometric MOF crystals inside the channels of AAO membranes

2013

International audience; A dynamic step-by-step methodology has been implemented to grow the HKUST-1 porous coordination polymer inside commercial anodic aluminium oxide membranes. Efficient crystal growth is achieved from the membrane inner walls and over the whole membrane thickness when copper acetate colloidal suspensions and benzene tricarboxylic acid solutions are forced to flow through the membrane. Sorption properties of the HKUST-1 embedded in membranes show selectivity for CO2 over CO, CH4, O2 and N2 similar to the bulk material.

Results of industrial breadmaking trials of durum wheat wholegrain flour enriched with citrus fruits fibre

2016

Analyse de la digitalisation du canal de distribution : une approche triadique dans l’étude du risque de désintermédiation des grossistes traditionne…

2020

Intermediaries are little studied in Management Science. The research proposes to put forward a particular type of intermediary that is the wholesaler. Faced with the digitization of all sectors, it is interesting to question the capacity of wholesalers to generate added value in the distribution channel. Based on the triadic methodology and the field of study, it turns out that digital can modify one of the inter-organizational relational processes. In the absence of a strong demand for downstream distribution channels, wholesalers are struggling to put in place a digital strategy that makes sense. On the other hand, this delay allows the industrialist to take the lead on information flows…

The Influence of the Digitalisation of the Distribution Channel in the Process of Bypassing Wholesalers: The Case of a Distribution Triad

2022

• ObjectivesThe wholesaler, a traditional player in distribution, has been going through a new phase in its evolution over the last twenty years. Driven by the digitalisation of activities, upstream and downstream players are trying to bypass it and new players such as commercial platforms are appearing. In order to understand this phenomenon, this research analyses how the wholesaler manages to keep a part of the flows between the actors of the distribution channel.• MethodA qualitative analysis by individual interviews within the building materials sector highlights the appropriation of informational flows by manufacturers leading to the phenomenon of partial disintermediation which affec…

Resistance of traditional wholesalers: a dichotomy of flows within the distribution channel

2020

The wholesaler has often been threatened with the risk of disintermediation both upstream and downstream of the distribution channel. Wholesalers, in their role as intermediaries, remain established in many sectors. The Internet has also generated a current of re-intermediation via digital platforms. The article starts from the premise that wholesalers are always essential players in the distribution channel and increase their value proposition through services and digital. As part of a qualitative study in the French market for the sale of building materials, an interesting phenomenon emerged. It is the partial disintermediation of wholesalers for the benefit of industrialists. This partia…