Search results for "induction"
showing 10 items of 769 documents
Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos.
2012
Objective To evaluate correlations between metabolic activity and implantation potential of transferred embryos in a study based on oxygen (O 2 ) consumption (OC) measurements, because O 2 uptake is directly related to the capacity of an embryo to produce energy via adenosine triphosphate. Design Retrospective cohort study. Setting Infertility institute. Patient(s) Five hundred seventy-five injected oocytes in 56 first oocyte donation cycles with embryo transfer on day 3. Intervention(s) None. Main Outcome Measure(s) We analyzed embryo destination viability and implantation depending on the embryo OC rate obtained from 47,741 measurements (up to 85 measurements per embryo, 2–3 measurements …
PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data
2014
The aim of this study is to investigate the effects of the metformin administration in patients with previous reproductive failures. Inclusion criteria: 13 patients with chronic anovulation and PCOS, age < 38 years old, sterility not less than 2 years, C.C. resistance, conception failure in previous cycles with only r-FSH and negativity to the multiple miscarriages tests, absence of others infertility factors. Metformin administration started 2 months before the ovulation induction. Alternatively a spontaneous menstruation it was induced by progestin. Ovulation was performed with r-FSH and patients were invited to have sexual intercourse during the 48h after the HCG trigger. Luteal support …
Clinical management of endometrial receptivity.
2014
The endometrial window of implantation (WOI), the cycle days during which normal embryo implantation can occur, has generally been assumed to begin on cycle day 19 or 20 of an idealized 28 days cycle and last for 4 to 5 days. Noyes et al took the first steps in defining the WOI by establishing a set of morphological criteria to evaluate endometrial development and receptivity, but recent studies have invalidated their use in the routine evaluation of infertility. Based on greater than 10 years of extensive research, our group has developed a molecular diagnostic tool (the endometrial receptivity array [ERA] test) based on the specific transcriptomic signature that identifies the receptive e…
Ovulation induction and epigenetic anomalies
2013
In this systematic review of ovulation induction and epigenetic control, studies mainly done in the mouse model highlight how hormone treatments may be prejudicial to the epigenetic reprogramming of gametes as well as early embryos. Moreover, the hormone protocols used in assisted reproduction may also modify the physiologic environment of the uterus, a potential link to endometrial epigenetic disturbances. At present, the few available data in humans are insufficient to allow us to independently determine the impact of a woman's age and infertility problems and treatment protocols and hormone doses on such processes as genomic imprinting.
Ovarian stimulation for ovulation induction and in vitro fertilization in patients with systemic lupus erythematosus and antiphospholipid syndrome.
2008
Objective To review the current evidence regarding the relationship between systemic lupus erythematosus (SLE) and antiphospholipid syndrome and female infertility, as well as the risks associated with ovarian stimulation for ovulation induction and IVF. To establish, based on this information, guidelines for safe and successful assisted reproductive technology (ART). Design A MEDLINE computer search was performed to identify relevant articles. Result(s) Systemic lupus erythematosus and antiphospholipid syndrome are not related to infertility, except for cases of amenorrhea accompanying severe flares, renal insufficiency-related hypofertility, and ovarian failure secondary to cyclophosphami…
Input-output feedback linearizing control of linear induction motor taking into consideration the end-effects. Part I: Theoretical analysis
2015
Abstract This first part of a paper, divided into two parts, deals with the theoretical formulation of the input–output feedback linearization (FL) control technique as to be applied to linear induction motors (LIMs). Linear induction motors, differently from rotating induction motors (RIMs), present other strong non-linearities caused by the so-called dynamic end effects, leading to a space-vector model with time-varying inductance and resistance terms and an additional braking force term. This paper, starting from a dynamic model of the LIM taking into consideration its dynamic end effects, previously developed by the same authors, defines a feedback linearization (FL) technique suited fo…
Input-Output Feedback Linearizing Control of Linear Induction Motor Taking into Consideration the End-Effects. Part II: Simulation and Experimental R…
2015
This is the second part of a paper, divided in two parts, dealing with the application of the input–output feedback linearization (FL) control technique to linear induction motors (LIMs). The first part has treated the theoretical formulation of the input–output feedback linearization control technique as to be applied to linear induction motors. This second part describes the set of tests, both in numerical simulations and experiments, performed to assess the validity of the control technique. In particular, it addresses the issues of the sensitivity of the FL control versus the LIM electrical parameters’ variations and the improvements achievable by considering the LIM dynamic end effects…
Parameter identification of linear induction motor model in extended range of operation by means of input-output data
2012
This paper proposes a technique for the off-line estimation of the electrical parameters of the equivalent circuit of linear induction machines (LIM), taking into consideration the end effects, and focuses on the application of an algorithm based on the minimization of a suitable cost function involving the differences of measured and computed by simulation inductor current components. This method exploits an entire start-up transient of the LIM to estimate all the 4 electrical parameters of the machine (Rs, L s, σ Ls, Tr). It proposes also a set of tests to be made to estimate the variation of the magnetic parameters of the LIM versus the magnetizing current as well as the magnetizing curv…
Effects of four carbamate compounds on antioxidant parameters
2009
Abstract The effect of four carbamates, aldicarb and its metabolites (aldicarb sulfone and aldicarb sulfoxide) and propoxur on glutathione content and the activity of the enzymes involved in the sulfur-redox cycle in the mammalian cellular model CHO-K1 cells after 24-h exposure were determined. Carbamate exposure resulted in a depletion of intracellular reduced glutathione (GSH) content, no change was observed in oxidized glutathione (GSSG) and a decrease in GSH/GSSG ratio was detected. After carbamates exposition a GSH/GSSG decreases in ranged from 12.44% to 21.35% of control was observed. Depletion of GSH levels was accompanied by the induction of glutathione reductase (GR) after 24 h exp…
A phase-II study of low-dose cyclophosphamide and recombinant human interleukin-2 in metastatic renal cell carcinoma and malignant melanoma.
1989
Recent preclinical and clinical studies that have demonstrated antitumor activity of high-dose recombinant interleukin-2 (rIL-2), and animal models that demonstrated a synergistic effect of low-dose cyclophosphamide, led us to study rIL-2 (Cetus Corp., Emeryville, Calif) in a phase II clinical trial in combination with low-dose cyclophosphamide in 32 patients, 18 with malignant melanoma and 14 with renal cell carcinoma. rIL-2 was given once daily at 3 x 10(6) U/m2, as a 30-min infusion for 14 days in cycle I and for 2 x 5 days in cycles II and III respectively; if tolerated, the dose was increased to a maximum of 6 x 10(6) U m-2 day-1; the cycles, separated by 1 week treatment-free interval…