Search results for "medicinal"

showing 10 items of 2966 documents

Crystal structure and magnetic properties of (tris­{4-[1-(2-meth­oxy­eth­yl)imidazol-2-yl]-3-aza­but-3-enyl}amine)­iron(II) bis­(hexa­fluorido­phosph…

2019

The title compound, [Fe(C27H41N10O3)](PF6)2, is an example of an iron(II) spin-crossover compound. In this compound, C⋯F and CH⋯F/O contacts, present between the cations and anions, extend the structure into a three-dimensional supra­molecular network.

crystal structureCrystal structure010402 general chemistry01 natural sciencesMedicinal chemistryIonResearch Communicationslcsh:Chemistrychemistry.chemical_compoundspin crossoverSpin crossoverImidazoleGeneral Materials Scienceta116010405 organic chemistryChemistryspin transitionGeneral ChemistrykompleksiyhdisteetCondensed Matter PhysicsHEXAkidetiedeMagnetic susceptibility3. Good health0104 chemical sciencesBond lengthlcsh:QD1-999Amine gas treatingActa Crystallographica Section E: Crystallographic Communications
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Crystal structure of 2-{[1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yloxy]carbonyl}benzoic acid

2014

In the title compound, C15H15N3O6, the dihedral angle between the planes of the benzene and imidazole rings is 34.93 (10)°. An intramolecular C—H...O hydrogen bond is observed. In the crystal, O—H...N hydrogen bonds link the molecules into chains parallel to thecaxis.

crystal structureCrystal structurepharmaceuticalsDihedral angleBioinformaticsMedicinal chemistrynitro­imidazolesCrystalchemistry.chemical_compoundImidazoleGeneral Materials SciencePhysics::Chemical PhysicsO—H⋯N hydrogen bondsBenzeneBenzoic acidQuantitative Biology::BiomoleculesnitroimidazolesCrystallographyHydrogen bondGeneral ChemistryCondensed Matter PhysicsData ReportsO—H...N hydrogen bondschemistryQD901-999NitroActa Crystallographica Section E Structure Reports Online
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Crystal structure of tricarbon­yl(N-di­phenyl­phosphanyl-N,N′-diisopropyl-P-phenyl­phospho­nous di­amide-κ2 P,P′)cobalt(I) tetra­carbonyl­cobaltate(−…

2014

The title compound {Co(CO)3[Ph2PN(i-Pr)P(Ph)N(H)i-Pr]}[Co(CO)4] is an ionic species consisting of a Co(CO)3[Ph2PN(i-Pr)P(Ph)N(H)i-Pr] cation and a [Co(CO)4] anion.

crystal structureCrystallographyChemistryHydrogen bondmetallacycleTricarbonchemistry.chemical_elementGeneral ChemistryCrystal structureMetallacycleCondensed Matter PhysicsTolueneMedicinal chemistrycobaltResearch Communicationsphosphine ligandchemistry.chemical_compoundQD901-999AmideGeneral Materials ScienceCobaltCoordination geometryActa Crystallographica Section E: Structure Reports Online
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Chlorido(2,2′-{[2-(1-methyl-1H-imidazol-2-yl-κN 3)imidazolidine-1,3-diyl-κN]bis(methylene)}bis(1-methyl-1H-imidazole-κN 3))copper(II) perchlorate

2019

In the crystal structure of the title complex, [CuCl(C17H24N8)]ClO4, the copper(II) metal exhibits an N4Cl pentacoordinate environment in a distorted square-pyramidal geometry. Coordination to the metal centre occurs through the three 1-methylimidazole N atoms from the pendant groups, one amine N atom from the imidazolidine moiety and one chlorido anion. Intermolecular interactions take place at two of the 1-methyl-imidazole rings in the form of parallel-displaced π–π stacking interactions forming chains parallel to the a axis. Three O atoms of the perchlorate anion are rotationally disordered between two orientations with occupancies of 0.5.

crystal structureCrystallographyCopper(II) perchlorate010405 organic chemistrychemistry.chemical_elementGeneral ChemistryCrystal structure010402 general chemistryCondensed Matter Physics01 natural sciencesMedicinal chemistryCopper0104 chemical sciencesPerchloratechemistry.chemical_compoundchemistryQD901-999ImidazolidineImidazoleMoietyGeneral Materials Scienceimidazolidine ligandEne reactioncopper complexActa Crystallographica Section E Crystallographic Communications
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Crystal structure of (E)-4-[N-(7-methyl-2-phenyl-imidazo[1,2-a]pyridin-3-yl)carboximido-yl]phenol.

2015

The molecule of the title compound, C21H17N3O, is built up from fused five- and six-membered rings connected to a methyl group, a phenyl ring and an (iminomethyl)phenol group. The fused ring system is almost planar (r.m.s. deviation = 0.031 Å) and forms dihedral angles of 64.97 (7) and 18.52 (6)° with the phenyl ring and the (iminomethyl)phenol group, respectively. In the crystal, centrosymmetric molecules are linked by pairs of C—H...π interactions into dimeric units, which are further connected by O–H...N hydrogen bonds to form layers parallel to (101).

crystal structureCrystallographyHydrogen bondimidazo[12a]pyridine derivativeGeneral ChemistryCrystal structureDihedral angleCondensed Matter PhysicsRing (chemistry)Bioinformaticshydrogen bondingC—H⋯π inter­actionsMedicinal chemistryData ReportsCrystalchemistry.chemical_compoundC—H...π interactionschemistryQD901-999Group (periodic table)PhenolGeneral Materials ScienceMethyl groupActa crystallographica. Section E, Crystallographic communications
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Crystal structure of 5-(4-tert-butoxyphenyl)-3-(4-n-octyloxyphenyl)-4,5-dihydroisoxazole

2019

The molecule of the title compound, C27H37NO3, was prepared by [3 + 2] 1,3-dipolar cycloaddition of 4-n-octylphenylnitrile oxide and 4-tert-butoxystyrene, the latter compound being a very useful intermediate to the synthesis of liquid-crystalline materials. In the molecule, the benzene rings of the n-octyloxyphenyl and tert-butoxyphenyl groups form dihedral angles of 2.83 (7) and 85.49 (3)°, respectively, with the mean plane of the isoxazoline ring. In the crystal, molecules are linked by weak C—H...O hydrogen interactions into chains running parallel to the b axis.

crystal structureCrystallographyOxideGeneral ChemistryCrystal structureisoxazolinesDihedral angleCondensed Matter PhysicsRing (chemistry)Medicinal chemistrysingle crystalsCrystalchemistry.chemical_compoundliquid crystalschemistryLiquid crystalQD901-999General Materials ScienceIsoxazoleBenzene[3 + 2] cycloadditionActa Crystallographica Section E: Crystallographic Communications
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Diethyl [(2,5-diiodo-4-methylphenyl)methyl]phosphonate

2021

The title compound, C12H17I2O3P, was prepared in three steps from p-xylene. Heterodimers between nearly identical molecules are connected via three hydrogen bonds from benzylic and ester methylene groups to phosphonate. The dimers form chains along the a-axis direction, stabilized by C—H...O bridges.

crystal structureCrystallographyiodine010405 organic chemistryHydrogen bondtwo-component twinCrystal structure010402 general chemistry01 natural sciencesMedicinal chemistryPhosphonate0104 chemical scienceschemistry.chemical_compoundchemistryQD901-999phosphonateIUCrData
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Crystal structure of diaqua[5,10,15,20-tetrakis(4-methoxyphenyl)porphyrinato-κ4N]iron(III) diaqua(18-crown-6)potassium bis(trifluoromethanesulfonate)…

2015

In the title compound, [FeIII(C48H36N4O2)(H2O)2][K(C12H24O6)(H2O)2](SO3CF3)2·2C12H24O6, the FeIIIatom is situated on an inversion centre and is octahedrally coordinated by four pyrrole N atoms of the deprotenated 5,10,15,20-tetrakis(4-methoxyphenyl)porphyrinate ligand and two water molecules. The average equatorial Fe—N(pyrrole) bond length [2.043 (6) Å] is consistent with a high-spin (S= 5/2) iron(III) metalloporphyrin derivative. The K+cation, which also lies on an inversion centre, is chelated by the six O atoms of one 18-crown-6 molecule and is additionally coordinated by two water molecules in a distorted hexagonal–bipyramidal geometry. In the crystal, the cations, anions and one non-c…

crystal structureCrystallographytrifluoromethanesulfonateHydrogen bondStereochemistryLigand18-Crown-6Methane sulfonateGeneral ChemistryCrystal structureCondensed Matter PhysicsMedicinal chemistryPorphyrinData ReportsBond lengthiron(III) complex saltchemistry.chemical_compoundchemistryQD901-999General Materials Sciencetri­fluoro­methane­sulfonateporphyrinPyrroleActa Crystallographica Section E Crystallographic Communications
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Crystal structure and Hirshfeld surface analysis of 3-octyl-4-oxo-2,6-bis(3,4,5-trimethoxyphenyl)piperidinium chloride

2018

The title compound was synthesized by a one-pot Mannich condensation reaction. In the crystal, centrosymmetric dimers are linked into layers parallel to (011) by N—H⋯Cl and C—H⋯Cl hydrogen bonds. A Hirshfeld surface analysis indicates that O—H (20.5%) inter­actions make the largest contribution to the crystal packing.

crystal structureCyclohexane conformationCrystal structure010403 inorganic & nuclear chemistryRing (chemistry)01 natural sciencesMedicinal chemistryChlorideResearch CommunicationsCrystalchemistry.chemical_compoundMannich reactionmedicineHirshfeld surface analysisGeneral Materials ScienceBenzeneMannich reactionCrystallography010405 organic chemistryHydrogen bondChemistryGeneral ChemistryCondensed Matter Physics0104 chemical sciencesQD901-999piperidine-4-onemedicine.drugActa Crystallographica Section E Crystallographic Communications
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Crystal structure of the bis(cyclohexylammonium) succinate succinic acid salt adduct

2015

The title salt adduct comprises two cyclo­hexyl­ammonium cations, one succinate anion and one mol­ecule of succinic acid, linked together through inter­molecular hydrogen-bonding inter­actions giving a two-dimensional layer-like self-assembly lying parallel to (010).

crystal structureDenticityStereochemistryCyclohexane conformationSalt (chemistry)cyclo­hexyl­ammonium cationCrystal structureMedicinal chemistryResearch CommunicationsAdductchemistry.chemical_compoundsuccinic acidGeneral Materials Sciencecyclohexylammonium cationchemistry.chemical_classificationCrystallographymolecular adductHydrogen bondChemistryGeneral ChemistryCondensed Matter PhysicssuccinateAmmonium SuccinateSuccinic acidQD901-999hydrogen bondsorganic saltmol­ecular adductActa Crystallographica Section E: Crystallographic Communications
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