Search results for "neuron"

Hypertrophic adaptations of lower limb muscles in response to three different resistance training regimens

2020

Introduction: The research tested the effects of training in three different load zones. The hypothesis is that this type of training can provide more complete hypertrophic gains compared to workouts performed in a specific, single load area. Materials and methods: 37 participants were divided into 4 groups (SE; S; E; C). The first group trained simultaneously with high loads and low repetitions and with low loads and high repetitions; the second group trained in the high load condition, the third with low loads and high repetitions brought to the point of fatigue and the last control group had not practiced any type of training. The participants performed the training program 3 times a wee…

Triiodothyronine-Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium

1987

Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. A…

Neuronavigation-guided biopsy for differential diagnosis of pseudotumoral demyelinating brain lesions

2014

Abstract Marburg's disease (MD) is an extremely rare and aggressive form of multiple sclerosis (MS). In some cases, MD presents with tumefactive demyelinating lesions with a “tumor-like” appearance in MRI images, for which it may be difficult to achieve a form of differential diagnosis between definitive tumors or abscesses. Here we report a case of MD histopathologically confirmed after neuronavigationguided biopsy. Postoperative course was uneventful and following discharge, the patient attended outpatient follow-up appointments and received i.v. cyclophopsphamide, achieving progressive clinical remission. A nine-month follow-up brain MRI scan with gadolinium showed no signs of progressin…

So quel che senti. Neuroni specchio, arte ed empatia

2009

Il tema di questo libro è "l'empatia estetica", un costrutto teorico che ha avuto uno sviluppo rigoglioso tra Ottocento e Novecento, e che oggi, grazie ai neuroni specchio ("le cellule del cervello più famose di tutte"), è ritornato di grande attualità. Così per il fascino del prefisso "neuro", l'empatia si è imposta come un fatto scientifico incontrovertibile. Ma lo è? La gioia e la tristezza sono passioni invisibili? La Leggerezza e la pesantezza sono qualità del soggetto o dell'oggetto? Passioni e qualità espressive le percepiamo o le empatizziamo. I neuroni specchio sono il correlato neuronale dell'empatia? Quel che senti si incarna nel mio cervello o nel tuo corpo?

The STATe of the Neuron Leads to Synaptic Stripping

2018

In a recent issue of Cell, Di Liberto et al. (2018) elucidate the mechanisms involved in synaptic stripping during viral infection. Infected neurons orchestrate their own synaptic loss downstream of IFNγ signaling, ultimately attracting phagocytic monocytes into the CNS through CCL2 production.

Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease.

2000

The scrapie prion protein, PrP(Sc), as well as its peptide fragment, PrP106-126, are toxic on neuronal cells, resulting in cell death by an apoptotic, rather than necrotic mechanism. The apoptotic process of neuronal cells induced by prion protein supports diagnosis and offers potential targets for therapeutic intervention of the prion diseases. Among the cerebrospinal fluid (CSF) proteins, which may serve as markers of neuronal cell death associated with prion diseases, the 14-3-3 protein(s) turned out to be the most promising one. A new sensitive assay allows the detection of even small changes in the normally low levels of these proteins. In vitro, the toxic effects displayed by PrP(Sc) …

From Small Peptides to Large Proteins against Alzheimer'sDisease.

2022

Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (p-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes invol…

Hippocampal theta activity is selectively associated with contingency detection but not discrimination in rabbit discrimination-reversal eyeblink con…

2009

The relative power of the hippocampal theta-band ( approximately 6 Hz) activity (theta ratio) is thought to reflect a distinct neural state and has been shown to affect learning rate in classical eyeblink conditioning in rabbits. We sought to determine if the theta ratio is mostly related to the detection of the contingency between the stimuli used in conditioning or also to the learning of more complex inhibitory associations when a highly demanding delay discrimination-reversal eyeblink conditioning paradigm is used. A high hippocampal theta ratio was not only associated with a fast increase in conditioned responding in general but also correlated with slow emergence of discriminative res…

Generation and function of the soluble interleukin-6 receptor

1999

Differences in the temperature dependencies of uptake of botulinum and tetanus toxins in Aplysia neurons

1992

The respective neuroselective actions of botulinum type A (BoNT) and tetanus (TeTx) neurotoxins on cholinergic and non-cholinergic synapses of Aplysia are mainly due to differences in their extracellular neuronal targetting. Further information was gained on this neuroselectivity by examining the temperature dependencies of binding, internalization and intracellular action of both toxins. After reduction of temperature from 22 degrees C to 10 degrees C, the binding of neither BoNT nor TeTx was significantly altered whereas the neuronal uptake of BoNT, but not of TeTx, was prevented. Although TeTx internalization could be detected at the low temperature, its intracellular activity was greatl…