Search results for "peripheral"

High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells

2020

Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC) proliferation and is one of the most common hematological malignancies. The potential effect of cannabinoids on the immune system and hematological malignancies has been poorly characterized. Cannabidiol (CBD) may be used to treat various diseases. CBD is known to exert immunomodulatory effects through the activation of cannabinoid receptor 2 (CB2), which is expressed in high levels in the hematopoietic system. Cytokine-induced killer (CIK) cells are a heterogeneous population of polyclonal T lymphocytes obtained via ex vivo sequential incubation of peripheral blood mononuclear cells (PBMCs) with interferon-&gam…

T lymphocyte control of autoreactivity: analysis with human T cell clones and limiting dilution culture

1986

To investigate cellular mechanisms controlling activated autoreactive T lymphocytes, a limiting dilution system was established employing cloned autoreactive major his-tocompatibility complex class II specific lymphocytes (a2/7) as stimulator cells for autologous peripheral blood mononuclear cells. At low responder/stimulator ratios, cytotoxic effector cells were generated capable of lysing clone a2/7. Importantly, within the population of cells mediating autocytotoxic effector function, differential specificities were found to exist. The generation of such autocytotoxic T lymphocytes appears to be inhibited by an additional population of cells circulating at lower frequency suggesting that…

Neurosurgical resident training in Czech Republic

2018

Introduction: Resident training is essential to be able and offer high-quality medical care. Neurosurgical training in its traditional form is currently challenged by law-enforced working hour restrictions and general re-structuring within Europe. We aimed to evaluate the current situation of resident training in the Czech Republic. Methods: An electronic survey was sent to European neurosurgical trainees between 06/2014 and 03/2015. The responses of Czech trainees were compared to those of trainees from other European countries. Logistic regression analysis was used to assess the effect size of the relationship between a trainee being from Czech Republic and the outcomes (e.g. satisfaction…

In vivo ozone exposure does not increase DNA single-strand breaks in human peripheral lymphocytes

2013

In this randomized parallel study, we examined whether an acute ozone (O3) exposure leads to increased DNA strand breaks in human lymphocytes. The groups were exposed to 0.21 ppm O3 or filtered air for two hours. 30min and 4.5 h after exposure, DNA damage was determined in isolated lymphocytes using the Fast Micromethod. There was no detectable effect after O3 exposure. We conclude that an acute O3 exposure at the tested concentration does not lead to persistent DNA damage.

Clinical neurophysiology and imaging of nerve injuries: preoperative diagnostic work-up and postoperative monitoring

2015

Peripheral nerve injuries are a heterogeneous group of lesions that may occurs secondary to various causes. Several different classifications have been used to describe the pathophysiological mechanisms leading to the clinical deficit, from simple and reversible compression-induced demyelination, to complete transection of nerve axons. Neurophysiological data localize, quantify, and qualify (demyelination vs . axonal loss) the clinical and subclinical deficits. High-resolution ultrasound can demonstrate the morphological extent of nerve damage, fascicular echotexture (epineurium vs . perineurium, focal alteration of the cross-section of the nerve, any neuromas, etc. ), and the surrounding t…

Effect of Electrical Stimulation on Denervated Muscle

1986

The possibilities of noninvasive treatment in peripheral nerve injuries are limited. Although it is well known that the severance of a nerve results in paralysis of the dependent tissue, the methods of treating a denervated muscle are still controversial. The most obvious result of denervation is muscle atrophy and paralysis. In 1841 Reid forced the denervated muscle to contract by electrical stimulation to replace the loss of activity and observed that this treatment retarded atrophy. Since then, there has been continuing interest in preventing muscle atrophy with electrotherapy. Peripheral nerve injuries in the two world wars were, for instance, extensively treated with electrical stimula…

TCT-403 Peripheral Endothelial Function and Sympathetic Influence on Dermal Microcirculation Correlate with Long-Term Blood Pressure Response in Rena…

2014

Oral microcirculation observed in vivo by videocapillaroscopy: a review

2009

Capillaroscopy is a non-invasive diagnostic technique that is fundamental in viewing peripheral circulation and in studying microangiopathies. The morphological study of microcirculat ion is of fundamental importance, mainly because the microvascular bed is directly involved in the etiopathogenesis of autoimmune disorders and acute and chronic inflammatory pathological conditions. The value of capillaroscopic investigation as a diagnostic means in cases of peripheral microcirculation disorders has been confirmed by numerous studies. Other studies used capillaroscopic investigations to evaluate microcirculation damage not as a complication of disease (diabetes), but as its initial stage, and…

A comparative study of the sealing ability of two root canal obturation techniques

1995

A comparison was made of the ability of two root canal obturating techniques to prevent dye microleakage: gutta-percha lateral condensation and mechanically plasticized gutta-percha (JS Quick-fill). Twenty central incisors were prepared and obturated by each technique. After rendering the teeth transparent, linear dye penetration was found to be 0.48 and 0.52 mm, respectively. The difference between the two techniques was not significant. As for the distribution of the sealing cement (AH26) in the teeth obturated with JS Quickfill, the cement was located in the most peripheral zone of the obturation alongside the dentinal walls, whereas the gutta-percha was found in the central part of the …

Desmoplastic melanoma may mimic a cutaneous peripheral nerve sheath tumor: Report of 3 challenging cases

2017

Desmoplastic melanoma (DM) and cutaneous malignant peripheral nerve sheath tumors (MPNST) reveal histological and immunohistochemical similarities, including S100 positivity and negative staining for conventional melanocytic markers. We present 3 cases of cutaneous S100-positive spindle cell tumors in elderly patients, in which first findings led to initial misdiagnoses as cutaneous MPNST and benign peripheral sheath nerve tumor (neurofibroma). The identification of adjacent atypical melanocytic hyperplasia in the overlying skin along with tumor cell proliferation, also in the superficial dermis, the neurotropic component and the absence of any relationship between the tumor and a major ner…