Search results for "quinoline"

ChemInform Abstract: α-Cyanation of Aromatic Tertiary Amines Using Ferricyanide as a Non-Toxic Cyanide Source.

2016

Aromatic tertiary amines, mostly isoquinoline derivatives and analogous N-heterocycles, are treated with the non-toxic agent (II) under conditions A) or B) to produce the desired N-aminonitrile compounds as amino acid precursors and as building blocks of complex nitrogen heterocycles.

ChemInform Abstract: Differential Reactivity of Fluorinated Homopropargylic Amino Esters vs Gold(I) Salts. The Role of the Nitrogen Protecting Group.

2015

The gold(I)-catalyzed hydroarylation/isomerization reaction of N-protected homopropargyl amino esters (III) gives quinoline derivatives of type (IV).

A Highly Enantioselective Access to Tetrahydroisoquinoline and β-Carboline Alkaloids with Simple Noyori-Type Catalysts in Aqueous Media

2009

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 5. Mitt. Imidazo[4,5-h]isochinoline

1975

Es werden zwei Wege zur Darstellung des neuen Heterotricyclus Imidazo[4,5-h]isochinolin (7a) sowie zwei seiner partiell hydrierten Derivate 6, 7, 8, 9-Tetrahydro-imidazo[4,5-h]isochinolin (7b) und 4,5,5a,6,7,8,9,9a-Octahydro-imidazo-[4,5-h]isochinolin (7c) beschrieben. Imidazo[4,5-h]isoquinolines Two ways for the preparation of the new heterotricycle imidazo[4,5-h]isoquinoline (7a) and two of its partially reduced derivatives, 6,7,8,9-tetrahydro-imidazo[4,5-h]isoquinoline (7b) and 4,5,5a,6,7,8,9,9a-octahydro-imidazo[4,5-h]isoquinoline (7c), are described.

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 12 Mitt.: Imidazo[4,5-g]chinoline

1975

Es werden zwei Wege zur Darstellung des Heterotrizyklus Imidazo[4,5-g]chinolin (8b) sowie zwei seiner partiell reduzierten Derivate 5,6,7,8-Tetrahydro-imidazo[4,5-g]chinolin (8c) und 4,4a,5,6,7,8,8a,9-Octahydro-imidazo[4,5-g]chinolin (8d) beschrieben. Imidazo[4,5-g]quinolines. Two ways for the preparation of the heterotricycle imidazo[4,5-g]quinoline (8b) and two of its partially reduced derivatives, 5,6,7,8-tetrahydro-imidazo[4,5-g]quinoline (8c) and 4,4a,5,6,7,8,8a,9-octahydro-imidazo[4,5-g]quinoline (8d), are described.

ChemInform Abstract: Heterocyclic Photorearrangements. Photoinduced Rearrangement of 3-Styryl-1,2,4-oxadiazoles.

1990

The photochemical behaviour of 3-styryl-5-phenyl-(5-methyl)-1,2,4-oxadiazoles in methanol at 254 nm has been investigated. A photoinduced rearrangement to the quinoline system has been pointed out and explained as proceeding through an initial photolysis of the ring ON bond, followed by a six membered ring closure reaction involving the styryl moiety.

Anion Receptors Based on a Quinoline Backbone

2007

2-Amido-8-urea substituted quinoline derivatives are potent receptors for the binding of halide or benzoate anions in chloroform. The selectivity and affinity of the receptors for fluoride can be tuned by variation of the substituents at the receptor side chains. Computational considerations show that the cleft of the receptors provides space for effective binding of F–, but not bigger anions.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

ChemInform Abstract: Gold-Catalyzed Intramolecular Hydroamination of o-Alkynylbenzyl Carbamates: A Route to Chiral Fluorinated Isoindoline and Isoqui…

2013

Title compounds are prepared in enantiomerically pure form by the diastereoselective addition of fluorinated nucleophiles to N-(tert-butanesulfinyl)imines (I) followed by a sequence of Sonogashira cross-coupling/gold(I)-catalyzed cycloisomerization of the corresponding carbamate.

Molecular modeling of intercalation complexes of antitumor active 9-aminoacridine and a [d, e]-anellated isoquinoline derivative with base paired deo…

1996

Intercalators are molecules capable of sliding between DNA base pairs without breaking up the hydrogen bonds between the DNA bases. On the basis of molecular mechanics calculations structural, models of B-DNA tetranucleotide intercalation complexes of some cytostatic active 9-aminoacridines and of a [d, e]-anellated isoquinoline derivative are presented. The drug complexes are stabilized by energetically favouredvan der Waals interactions and by selective hydrogen bonds between the side chains of the drugs and the DNA bases. Semiempirical quantum chemistry calculations revealed that the chromophoric system of the intercalators is able to form π,π-charge-transfer interactions with the purine…

Synthesis and Conformational Analysis of Tetrahydroisoquinoline-Fused 1,3,2-Oxazaphospholidines and 1,2,3-Oxathiazol­idines

2008

The cyclizations of tetrahydroisoquinoline 1,2-amino alcohols with phenylphosphonic dichloride, bis(2-chloroethyl)phosphoramidic dichloride, thionyl chloride and sulfuryl chloride were utilized to synthesize 1,5,6,10b-tetrahydro-1,3,2-oxazaphospholo[4,3-a]isoquinolines (2, 3), 1,5,10,10a-tetrahydro-1,3,2-oxazaphospholo[3,4-b]isoquinolines (8, 9), 1,5,6,10b-tetrahydro-1,2,3-oxathiazolo[4,3-a]isoquinolines (4–6) anda 1,5,10,10a-tetrahydro-1,2,3-oxathiazolo[3,4-b]isoquinoline (11), which are the first representatives of these ring systems. NMR spectroscopic analysis revealed the existence of conformational equilibria that are fast on the NMR timescale. Theoretical DFT calculations pointed to t…