Search results for "self"
showing 10 items of 4501 documents
A new hydrogen bonding motif involved in self-recognition in the solid state by functionalised macrocycles
2011
Self-recognition within the crystal lattices of three functionalised macrocycles results in the formation of arrays of remarkably similar hermaphroditic pairs of macrocycles. In the case of two of the macrocycles containing acylhydrazine substituents, a hitherto unknown recognition pattern is found in the interaction of the hydrazine moiety with crown-ether oxygen atoms.
Self-assembly of M4L4tetrahedral cages incorporating pendant PS and PSe functionalised ligands
2019
Herein, the synthesis of metal–organic tetrahedral cages featuring flexible thio- and selenophosphate-based ligands is described. The cages were prepared by sub-component self-assembly of AP(OC6H4NH2-4)3 (A = S, Se) or SP(SC6H4NH2-4)3, 2-pyridinecarboxaldehyde, and either Fe[BF4]2 or Co[BF4]2. Preliminary host–guest studies into the ability of the pendant PS and PSe groups to interact with suitable substrates will be discussed.
Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells
2017
Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation
2020
Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP-polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking…
Self‐Assembly and Characterisation of Grid‐Type Iron( II ), Cobalt( II ) and Zinc( II ) Complexes
2003
The reaction of the ligands 5 and 6, containing two tridentate binding units, with iron(II), cobalt(II) and zinc(II) leads to the self-assembly of supramolecular architectures of [2 × 2] grid type containing four ions in octahedral coordination sites. The grid-type structures have been assigned on the basis of the spectroscopic data in solution, and confirmed in the solid state in the case of complexes 6b and 6c by X-ray crystallography. The latter study revealed that each metal ion is situated in a distorted octahedral coordination environment comprising two N,N,O ligand donor sets. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Controlling the Host-Guest Interaction Mode through a Redox Stimulus
2017
International audience; A proof-of-concept related to the redox-control of the binding/releasing process in a host-guest system is achieved by designing a neutral and robust Pt-based redox-active metallacage involving two extended-tetrathiafulvalene (exTTF) ligands. When neutral, the cage is able to bind a planar polyaromatic guest (coronene). Remarkably, the chemical or electrochemical oxidation of the host-guest complex leads to the reversible expulsion of the guest outside the cavity, which is assigned to a drastic change of the host-guest interaction mode, illustrating the key role of counteranions along the exchange process. The reversible process is supported by various experimental d…
The Chemo- and Stereoselective Formation of Pallado- and Platinocryptophanes
2019
International audience
Testing a theoretical resistance law for overland flow on a stony hillslope
2020
Overland flow, sediments, and nutrients transported in runoff are important processes involved in soil erosion and water pollution. Modelling transport of sediments and chemicals requires accurate estimates of hydraulic resistance, which is one of the key variables characterizing runoff water depth and velocity. In this paper, a new theoretical power–velocity profile, originally deduced neglecting the impact effect of rainfall, was initially modified for taking into account the effect of rainfall intensity. Then a theoretical flow resistance law was obtained by integration of the new flow velocity distribution. This flow resistance law was tested using field measurements by Nearing for the …
Stage–Discharge Relationship for an Upstream Inclined Grid with Transversal Bars
2016
AbstractCheck dams with grids upgrading upstream are often used in mountain rivers, where intense sediment transport and steep slopes occur. In some cases, sloping grids are used in the construction of debris flow breakers. In this paper, the outflow process of an upstream-inclined grid with transversal bars is studied by using the dimensional analysis and the incomplete self-similarity theory. Next, the theoretical analysis shows that a power equation can be used for establishing the stage-discharge equation. The coefficient of the power equation depends on both the slope angle and the void ratio, whereas the exponent depends only on the slope angle. Finally, this deduced stage–discharge r…
Modelling of stylolite geometries and stress scaling
2012
International audience; In this contribution we present numerical simulations of stylolite growth to decipher the effects of initial rock heterogeneity and stress on their morphology. We show that stylolite growth in a rock with a uniform grain size produces different patterns than stylolite growth in a rock with a bimodal grain size distribution. Strong pinning of large heterogeneities produce stylolite structures that are dominated by pronounced teeth, whereas a uniform grain size leads to spikes and a roughness that shows variable wavelengths. We compare the simulated stylolites with natural examples and show that the model can reproduce the real structures. In addition we show that stro…