Search results for "supply"
showing 10 items of 1190 documents
Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet
2020
The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the …
Obesity and Cardiometabolic Risk Factors : from Childhood to Adulthood
2021
Obesity has become a major epidemic in the 21st century. It increases the risk of dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk factors and components of the metabolic syndrome. Although overt cardiovascular (CV) diseases such as stroke or myocardial infarction are the domain of adulthood, it is evident that the CV continuum begins very early in life. Recognition of risk factors and early stages of CV damage, at a time when these processes are still reversible, and the development of prevention strategies are major pillars in reducing CV morbidity and mortality in the general population. In this review, we will discuss the role of well-known but also …
Clinical microbeam radiation therapy with a compact source: specifications of the line-focus X-ray tube
2020
Highlights • Line-focus X-ray tubes are suitable for clinical microbeam radiation therapy (MRT). • A modular high-voltage supply safely enables high electron beam powers. • An electron accelerator was designed to generate an eccentric focal spot. • We simulated a peak-to-valley dose ratio above 20 for single-field MRT. • Microbeam arc therapy spares healthy brain tissue compared to single-field MRT.
Immigration, factor endowments and the productive structure of Spanish regions, 1996-2005.
2012
The participation of immigrants in the Spanish labour market has increased from less than 3% in 1996 to more than 13% in 2005. The factor proportion model of production was used to examine the impact of such a large labour supply shock on the industrial structure of Spanish regions. The results confirm that, first, labour endowment differences across regions help to explain the regional patterns of industry specialization. Second, immigrants and natives act as complementary factors in most industries. Third, the importance of immigration is relatively small compared with production technique changes and idiosyncratic industry changes in explaining the overall changes in industrial structure. …
Bayesian forecasting of demand time-series data with zero values
2013
This paper describes the development of a Bayesian procedure to analyse and forecast positive demand time-series data with a proportion of zero values and a high level of variability for the non-zero data. The resulting forecasts play decisive roles in organisational planning, budgeting, and performance monitoring. Exponential smoothing methods are widely used as forecasting techniques in industry and business. However, they can be unsuitable for the analysis of non-negative demand time-series data with the aforementioned features. In this paper, an unconstrained latent demand underlying the observed demand is introduced into the linear heteroscedastic model associated with the Holt-Winters…
Combined effects of compost and Medicago sativa in recovery a PCB contaminated soil
2020
The effectiveness of adding compost and the plant Medicago sativa in improving the quality of a soil historically contaminated by polychlorinated biphenyls (PCBs) was tested in greenhouse microcosms. Plant pots, containing soil samples from an area contaminated by PCBs, were treated with the compost and the plant, separately or together. Moreover, un-treated and un-planted microcosms were used as controls. At fixed times (1, 133 and 224 days), PCBs were analysed and the structure (cell abundance, phylogenetic characterization) and functioning (cell viability, dehydrogenase activity) of the natural microbial community were also measured. The results showed the effectiveness of the compost an…
Approaching sales forecasting using recurrent neural networks and transformers
2022
Accurate and fast demand forecast is one of the hot topics in supply chain for enabling the precise execution of the corresponding downstream processes (inbound and outbound planning, inventory placement, network planning, etc). We develop three alternatives to tackle the problem of forecasting the customer sales at day/store/item level using deep learning techniques and the Corporaci\'on Favorita data set, published as part of a Kaggle competition. Our empirical results show how good performance can be achieved by using a simple sequence to sequence architecture with minimal data preprocessing effort. Additionally, we describe a training trick for making the model more time independent and…
Defining and measuring the network flexibility of humanitarian supply chains: insights from the 2015 Nepal earthquake
2019
International audience; The efficient and effective response to disasters critically depends on humanitarian supply chains (HSCs). HSCs need to be flexible to adapt to uncertainties in needs, infrastructure conditions, and behavior of other organizations. The concept of ‘network flexibility’ is, however, not clearly defined. The lack of an unanimous definition has led to a lack of consistent understanding and comparisons. This paper makes a threefold contribution: first, it defines the concept of network flexibility for HSC in the context of sudden onset disasters. Second, it proposes a framework to measure network flexibility in HSCs. Third, we apply our framework to the 2015 Nepal earthqu…
How markets slowly digest changes in supply and demand
2008
In this article we revisit the classic problem of tatonnement in price formation from a microstructure point of view, reviewing a recent body of theoretical and empirical work explaining how fluctuations in supply and demand are slowly incorporated into prices. Because revealed market liquidity is extremely low, large orders to buy or sell can only be traded incrementally, over periods of time as long as months. As a result order flow is a highly persistent long-memory process. Maintaining compatibility with market efficiency has profound consequences on price formation, on the dynamics of liquidity, and on the nature of impact. We review a body of theory that makes detailed quantitative pr…
On the Fallacy of Forward Linkages: A Note in the Light of Recent Results
2009
Following on from de Mesnard’s (2009) radical criticism of the Ghosh supply-driven model, this paper draws the dramatic consequences for the widespread use of forward linkages in input-output analysis applied to regional science: the practice must be abandoned. The arguments are based on three points: (i) it is impossible simultaneously to choose the Leontief model for the backward effects and the Ghosh model for the forward effects; (ii) it is impossible simultaneously to consider a production function of complementary inputs (Leontief) and a production function of perfectly substitutable inputs (Ghosh); and most importantly (iii) price effects and output effects remain inextricably mixed …