Search results for "zur"
showing 10 items of 321 documents
Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from n…
1988
Effects of the organic calcium antagonists verapamil and flunarizine on pentylenetetrazol induced paroxysmal depolarizations were tested in organotypic neocortical explants taken from neonatal rats. In these in vitro experiments the papaverin derivative verapamil depressed, and finally abolished, epileptic discharges in all cases. The piperazine derivative flunarizine, however, which is known to suppress epileptic discharges in hippocampal CA3 neurons (Bingmann and Speckmann 1986), showed no significant antiepileptic effects in the explanted neocortical neurons. Thus, the present findings may indicate that the suppressive action of flunarizine on the generation of paroxysmal depolarizations…
Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated
2017
Neuronal growth regulator 1 (NEGR1), a member of the immunoglobulin superfamily cell adhesion molecule subgroup IgLON, has been implicated in neuronal growth and connectivity. In addition, genetic variants in or near the NEGR1 locus have been associated with obesity and more recently with learning difficulties, intellectual disability and psychiatric disorders. However, experimental evidence is lacking to support a possible link between NEGR1, neuronal growth and behavioral abnormalities. Initial expression analysis of NEGR1 mRNA in C57Bl/6 wildtype (WT) mice by in situ hybridization demonstrated marked expression in the entorhinal cortex (EC) and dentate granule cells. In co-cultures of co…
One-Dimensional Convolutional Neural Networks Combined with Channel Selection Strategy for Seizure Prediction Using Long-Term Intracranial EEG
2022
Seizure prediction using intracranial electroencephalogram (iEEG) has attracted an increasing attention during recent years. iEEG signals are commonly recorded in the form of multiple channels. Many previous studies generally used the iEEG signals of all channels to predict seizures, ignoring the consideration of channel selection. In this study, a method of one-dimensional convolutional neural networks (1D-CNN) combined with channel selection strategy was proposed for seizure prediction. First, we used 30-s sliding windows to segment the raw iEEG signals. Then, the 30-s iEEG segments, which were in three channel forms (single channel, channels only from seizure onset or free zone and all c…
One and Two Dimensional Convolutional Neural Networks for Seizure Detection Using EEG Signals
2021
Deep learning for the automated detection of epileptic seizures has received much attention during recent years. In this work, one dimensional convolutional neural network (1D-CNN) and two dimensional convolutional neural network (2D-CNN) are simultaneously used on electroencephalogram (EEG) data for seizure detection. Firstly, using sliding windows without overlap on raw EEG to obtain the definite one-dimension time EEG segments (1D-T), and continuous wavelet transform (CWT) for 1D-T signals to obtain the two-dimension time-frequency representations (2D-TF). Then, 1D-CNN and 2D-CNN model architectures are used on 1D-T and 2D-TF signals for automatic classification, respectively. Finally, t…
La Suprema Corte limita il privilegio processuale in favore del credito fondiario
2019
Lo scritto esamina una recente pronuncia della Corte di Cassazione, che ha ristretto la possibilità per i creditori fondiari di partecipare alla distribuzione del ricavato della espropriazione individuale proseguita ai sensi dell’art. 41, 2° comma, TUB (D.Lgs. 1° settembre 1993, n. 385). L’A., dopo avere ripercorso la disciplina positiva che regola i rapporti tra credito fondiario e fallimento, espone alcune considerazioni critiche sulla decisione. A recent judgment of the Supreme Court narrows the rights of banks, as mortgagee creditors, to seize the assets of the debtor notwithstanding bankruptcy proceedings, according to paragraph 41, subsection 2, of the Italian Consolidated Law on Bank…
Datu integrācija Microsoft Azure mākoņvidē
2021
Bakalaura darba mērķis ir izpētīt pieejamos Azure mākoņvides resursus datu integrācijai, kā arī, salīdzināt izveidotās datu integrācijas diviem scenārijiem - virtuālai datu integrācijai un datu noliktavas datu integrācijai, pēc pieciem laba mākoņrisinājuma dizaina principiem. Mērķa sasniegšanai tika izveidoti divi autora izdomāti scenāriji, abiem datu integrācijas arhitektūras veidiem, kuriem darba autors veidoja datu integrāciju risinājumus izmantojot Azure piedāvātos resursus. Izveidotās datu integrācijas vēlāk tika apskatītas pēc pieciem laba mākoņrisinājuma dizaina principiem. Bakalaura darba beigās autors apkopoja iegūto informāciju gan par Azure piedāvātiem datu integrācijas resursiem…
Examinations of Bilateral Epileptiform Activities in Hippocampal Slices Obtained From Young Mice
2021
Bilateral interconnections through the hippocampal commissure play important roles in synchronizing or spreading hippocampal seizure activities. Intact hippocampi or bilateral hippocampal slices have been isolated from neonatal or immature rats (6–7 or 12–21 days old, respectively) and the mechanisms underlying the bilateral synchrony of hippocampal epileptiform activities have been investigated. However, the feasibility of examining bilateral epileptiform activities of more developed hippocampal circuitryin vitroremains to be explored. For this, we prepared bilateral hippocampal slices from C57 black mice, a strain commonly used in neuroscience and for genetic/molecular modifications. Youn…
Ensayo clínico multicéntrico, aleatorizado y enmascarado con topiramato versus placebo para el tratamiento de recién nacidos con encefalopatía hipóxi…
2021
Antecedentes: La encefalopatía hipóxico-isquémica (EHI) perinatal constituye una de de las principales causas de muerte o discapacidad a largo plazo en recién nacidos a término en el mundo occidental, afectando a aproximadamente 1-4 por cada 1000 nacidos vivos y, en consecuencia, a alrededor de 5000-20000 recién nacidos por año en Europa. La hipotermia terapéutica se ha convertido en el tratamiento estándar de la EHI moderada o grave, siendo una terapia segura y eficaz para mejorar el desarrollo neurológico tras un insulto hipóxico-isquémico perinatal. A pesar de la hipotermia y las mejoras en los cuidados intensivos neonatales, el 45-50% de los recién nacidos con EHI moderada o grave muere…
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excit…
2008
Abstract Corticotropin releasing hormone (CRH) is the central modulator of the mammalian hypothalamic–pituitary–adrenal (HPA) axis. In addition, CRH affects other processes in the brain including learning, memory, and synaptic plasticity. Moreover, CRH has been shown to play a role in nerve cell survival under apoptotic conditions and to serve as an endogenous neuroprotectant in vitro . Employing mice overexpressing murine CRH in the CNS, we observed a differential response of CRH-overexpressing mice (CRH-COE hom -Nes) to acute excitotoxic stress induced by kainate compared with controls (CRH-COE con -Nes). Interestingly, CRH-overexpression reduced the duration of epileptic seizures and pre…
Na beztydzień i od święta - o tradycyjnych zupach w śląskim menu
2018
Przedmiotem niniejszego artykułu jest śląskie menu ze szczególnym uwzględnieniem tradycyjnych zup, czyli polewek. Na podstawie materiałów archiwalnych oraz materiałów pozyskanych w trakcie prowadzonych badań terenowych wśród ludności autochtonicznej dwóch województw: opolskiego i śląskiego (w latach 2007-2017) omówiono w nim wybrane, charakterystyczne zupy spożywane w ciągu tygodnia oraz te obowiązujące w dni świąteczne. Zwrócono w nim także uwagę na przemiany, jakim one podlegały w ciągu wieków. W opracowaniu zaprezentowane zostały następujące zupy. zupy z chleba, tj. wodzionka, germuszka i biermuszka-, dalej zaś żur, siemieniotka/konopiotka, rosół i rosół z młodzików.