Determination of the LEP centre-of-mass energy from Zγ events

Radiative returns to the Z resonance (Zgamma events) are used to determine the LEP2 centre-of-mass energy from the data collected with the ALEPH detector in 1997. The average centre-of-mass energy is measured to be: E_CM = 182.50 +- 0.19(stat) +- 0.08(syst) GeV in good agreement with the precise determination by the LEP energy working group of 182.652 +- 0.050 GeV. If applied to the measurement of the W mass, its precision translates into a systematic error on M_W which is smaller than the statistical error achieved from the corresponding dataset.

HEp-2 Intensity Classification based on Deep Fine-tuning

Laboratorio a contaminazione controllata per tecniche fisiche applicate ai beni culturali

Search for γγ→ηb in e+e− collisions at LEP 2

A search for the pseudoscalar meson eta_b is performed in two-photon interactions at LEP~2 with an integrated luminosity of 699 pb^-1 collected at e+e- centre-of-mass energies from 181 GeV to 209 GeV. One candidate event is found in the six-charged-particle final state and none in the four-charged-particle final state, in agreement with the total expected background of about one event. Upper limits of Gamma_gammagamma(eta_b) * BR(eta_b -> 4 charged particles) 6 charged particles) < 132 eV are obtained at 95% confidence level, which correspond to 95% confidence level upper limits of 9.0% and 25% on these branching ratios.

Automatic Segmentation of HEp-2 Cells Based on Active Contours Model

In the past years, a great deal of effort was put into research regarding Indirect Immunofluorescence techniques with the aim of development of CAD systems. In this work a method for segmenting HEp-2 cells in IIF images is presented. Such task is one of the most challenging of automated IIF analysis, because the segmentation algorithm has to cope with a large heterogeneity of shapes and textures. In order to address this problem, numerous techniques and their combinations were evaluated, in a process aimed at maximizing the figure of merit. The proposed method, for a greater definition of cellular contours, uses the active contours in the last phase of the process. The initial conditions, c…

Hard X-Ray Response of Pixellated CdZnTe Detectors

In recent years, the development of cadmium zinc telluride (CdZnTe) detectors for x-ray and gamma ray spectrometry has grown rapidly. The good room temperature performance and the high spatial resolution of pixellated CdZnTe detectors make them very attractive in space-borne x-ray astronomy, mainly as focal plane detectors for the new generation of hard x-ray focusing telescopes. In this work, we investigated on the spectroscopic performance of two pixellated CdZnTe detectors coupled with a custom low noise and low power readout application specific integrated circuit (ASIC). The detectors (10x10x1 and 10x10x2 mm3 single crystals) have an anode layout based on an array of 256 pixels with a …

Four-jet final state production in e+e- collisions at centre-of-mass energies of 130 and 136 GeV

The four-jet final state is analyzed to search for hadronic decays of pair-produced heavy particles. The analysis uses the ALEPH data collected at LEP in November 1995 at centre-of-mass energies of 130 and 136 GeV, corresponding to a total integrated luminosity of 5.7 pb(-1). An excess of four-jet events is observed with respect to the standard model predictions. In addition, these events exhibit an enhancement in the sum of the two di-jet masses around 105 GeV/c(2). The properties of these events are studied and compared to the expectations from standard processes and to pair production hypotheses. RI ANTONELLI, ANTONELLA/C-6238-2011; Passalacqua, Luca/F-5127-2011; Murtas, Fabrizio/B-5729-…

An Automatic HEp-2 Specimen Analysis System Based on an Active Contours Model and an SVM Classification

The antinuclear antibody (ANA) test is widely used for screening, diagnosing, and monitoring of autoimmune diseases. The most common methods to determine ANA are indirect immunofluorescence (IIF), performed by human epithelial type 2 (HEp-2) cells, as substrate antigen. The evaluation of ANA consist an analysis of fluorescence intensity and staining patterns. This paper presents a complete and fully automatic system able to characterize IIF images. The fluorescence intensity classification was obtained by performing an image preprocessing phase and implementing a Support Vector Machines (SVM) classifier. The cells identification problem has been addressed by developing a flexible segmentati…

Mammographic images segmentation based on chaotic map clustering algorithm

Background: This work investigates the applicability of a novel clustering approach to the segmentation of mammographic digital images. The chaotic map clustering algorithm is used to group together similar subsets of image pixels resulting in a medically meaningful partition of the mammography. Methods: The image is divided into pixels subsets characterized by a set of conveniently chosen features and each of the corresponding points in the feature space is associated to a map. A mutual coupling strength between the maps depending on the associated distance between feature space points is subsequently introduced. On the system of maps, the simulated evolution through chaotic dynamics leads…

Tecniche fisiche integrate applicate allo studio di rocce sedimentarie

Deep CNN for IIF Images Classification in Autoimmune Diagnostics

The diagnosis and monitoring of autoimmune diseases are very important problem in medicine. The most used test for this purpose is the antinuclear antibody (ANA) test. An indirect immunofluorescence (IIF) test performed by Human Epithelial type 2 (HEp-2) cells as substrate antigen is the most common methods to determine ANA. In this paper we present an automatic HEp-2 specimen system based on a convolutional neural network method able to classify IIF images. The system consists of a module for features extraction based on a pre-trained AlexNet network and a classification phase for the cell-pattern association using six support vector machines and a k-nearest neighbors classifier. The class…

Preliminary results of the project A.I.D.A. (Auto Immunity: Diagnosis Assisted by computer)

In this paper, are presented the preliminary results of the A.I.D.A. (Auto Immunity: Diagnosis Assisted by computer) project which is developed in the frame of the cross-border cooperation Italy-Tunisia. According to the main objectives of this project, a database of interpreted Indirect ImmunoFluorescence (IIF) images on HEp 2 cells is being collected thanks to the contribution of Italian and Tunisian experts involved in routine diagnosis of autoimmune diseases. Through exchanging images and double reporting; a Gold Standard database, containing around 1000 double reported IIF images with different patterns including negative tests, has been settled. This Gold Standard database has been us…

Transverse momentum correlations in hadronic Z decays

Using data obtained with the ALEPH detector at the Z resonance, a measure based on transverse momentum is shown to exhibit a correlation between the two halves of a hadronic event which cannot be explained by energy-momentum conservation, flavour conservation, the imposition of an event axis or imperfect event reconstruction. Two possible interpretations based on existing Monte Carlo models are examined: a) ARIADNE, with the correlation forming early in the parton shower and with the transition from partons to hadrons playing only a minor part; b) JETSET, with the correlation forming at the fragmentation stage. A correlation technique based on a jet cluster analysis is used to make a compar…

Two-dimensional analysis of Bose-Einstein correlations in hadronic Z decays at LEP

Performance of a digital CdTe X-ray spectrometer in low and high counting rate environment

Abstract The high performances of CdTe detectors for X-ray and gamma ray spectroscopy are already well known. Among the traditional semiconductor spectrometers, CdTe detectors show high detection efficiency and good room temperature performance and are well suited for the development of compact detection systems. In this work, we investigated the performance of a CdTe detector coupled with a custom digital pulse processing (DPP) system for X-ray spectroscopy. The DPP method, implemented on a PC platform, performs a pile-up inspection and a pulse height analysis of the preamplifier output pulses, digitized by a 14-bit, 100 MHz ADC. The spectroscopic results point out the excellent performanc…

High Bias Voltage CZT Detectors for High-flux Measurements

In this work, we present the performance of new travelling heater method (THM) grown CZT detectors, recently developed at IMEM-CNR Parma, Italy. Thick planar detectors (3 mm thick) with gold electroless contacts on CZT crystals grown by Redlen Technologies (Victoria BC, Canada) were realized, with a planar cathode covering the detector surface (4.1 x 4.1 mm(2)) and a central anode (2 x 2 mm(2)) surrounded by a guard ring electrode. The detectors, characterized by low leakage currents at room temperature (4.7 nA/cm(2) at 1000 V/cm), allow good room temperature operation even at high bias voltages (> 7000 V/cm). At low rates, the detectors exhibit an energy resolution around 4 % FWIEM at 59.5…

Direct Measurement of Mammographic X-Ray Spectra with a Digital CdTe Detection System

In this work we present a detection system, based on a CdTe detector and an innovative digital pulse processing (DPP) system, for high-rate X-ray spectroscopy in mammography (1–30 keV). The DPP system performs a height and shape analysis of the detector pulses, sampled and digitized by a 14-bit, 100 MHz ADC. We show the results of the characterization of the detection system both at low and high photon counting rates by using monoenergetic X-ray sources and a nonclinical X-ray tube. The detection system exhibits excellent performance up to 830 kcps with an energy resolution of 4.5% FWHM at 22.1 keV. Direct measurements of clinical molybdenum X-ray spectra were carried out by using a pinhole…

Spectroscopic response of a CdZnTe multiple electrode detector

Abstract The spectroscopic performances of a CdZnTe detector (crystal size: 5×5×0.9 mm 3 ) with five electrodes (cathode, anode and three steering electrodes) were studied. The anode layout, which consists of a circular electrode ( φ =80 μm) surrounded by two ring electrodes (gap=100 μm; radial width Δ r =100 μm) and by one electrode that extends to the edge of the crystal, is mostly sensitive to the electron carriers, overcoming the well known effect of the hole trapping in the measured spectra. We report on the spectroscopic response of the detector at different bias voltages of the electrodes and at various photon energies ( 109 Cd, 241 Am and 57 Co sources). The CdZnTe detector exhibits…

Unsupervised clustering method for pattern recognition in IIF images

Autoimmune diseases are a family of more than 80 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. Diagnosis of autoimmune pathologies is based on research and identification of antinuclear antibodies (ANA) through indirect immunofluorescence (IIF) method and is performed by analyzing patterns and fluorescence intensity. We propose here a method to automatically classify the centromere pattern based on the grouping of centromeres on the cells through a clustering K-means algorithm. The described method was tested on a public database (MIVIA). The results of the test showed an Accuracy…

Development of new CdZnTe detectors for room-temperature high-flux radiation measurements

Recently, CdZnTe (CZT) detectors have been widely proposed and developed for room-temperature X-ray spectroscopy even at high fluxes, and great efforts have been made on both the device and the crystal growth technologies. In this work, the performance of new travelling-heater-method (THM)-grown CZT detectors, recently developed at IMEM-CNR Parma, Italy, is presented. Thick planar detectors (3 mm thick) with gold electroless contacts were realised, with a planar cathode covering the detector surface (4.1 mm × 4.1 mm) and a central anode (2 mm × 2 mm) surrounded by a guard-ring electrode. The detectors, characterized by low leakage currents at room temperature (4.7 nA cm−2 at 1000 V cm−1), a…

Search for $\gamma\gamma$ decays of a Higgs boson produced in association with a fermion pair in $e^+ e^-$ collisions at LEP

A serach for gamma gamma decays of Higgs boson is performed in the data sample collected at LEP with the ALEPH detector between 1991 and 1999. This corresponds to an integrated luminosity of 672 pb-1 centre-of-mass energies ranging from 88 to 202 GeV. The search is based on topologies arising from a Higgs boson produced in association with a fermion pair via the Higgs-strahlung process e+e- -&gt; Hffbar, with ffbar = nunubar, e+e-, mu+mu-, tau+tau- or qqbar... (CERN)

Studies of QCD in ${\rm e^+ e^-}\to $ hadrons at $E_{\rm cm} = 130$ and 136 GeV

Studies of QCD in $\mbox{e}^+\mbox{e}^- \rightarrow$ Hadrons at $E_{cm} = $} 130 and 136 GeV The ALEPH Collaboration An analysis of the properties of hadronic final states produced in electron-positron annihilation at centre-of-mass energies of 130 and 136 GeV is presented. The measurements are based on a data sample of 5.7 $\mbox{pb}^{-1}$ collected in November 1995 with the \Aleph detector at LEP. Inclusive charged particle distributions, jet rates and event-shape distributions are measured and the results are compared with the predictions of QCD-based models. From the measured distributions quantities are determined for which the dependence on the centre-of-mass energy can be predicted b…

Characterization of Al-Schottky CdTe detectors

In the last decades, great efforts are being devoted to the development of CdTe detectors for high resolution X-ray and gamma ray spectroscopy. Recently, new rectifying contacts based on aluminum (Al) are very appealing in the development of CdTe detectors with low leakage currents and anode pixellization. In this work, we report on preliminary results of electrical and spectroscopic investigations on Schottky CdTe diode detectors (4.1 × 4.1 × 0.75 and 4.1 × 4.1 × 2 mm3) with Au/Ti/Al/CdTe/Pt electrode configuration. The detectors are characterized by very low leakage currents even at room temperature (26 pA at 25 °C under a bias voltage of −100 V for the 2 mm thick detector). Polarization …

A multi-process system for HEp-2 cells classification based on SVM

An automatic system for pre-segmented IIF images analysis was developed.A non-standard pipeline for supervised image classification was adopted.The system uses a two-level pyramid to retain some spatial information.From each cell image 216 features are extracted.15 SVM classifiers one-against-one have been implemented. This study addresses the classification problem of the HEp-2 cells using indirect immunofluorescence (IIF) image analysis, which can indicate the presence of autoimmune diseases by finding antibodies in the patient serum. Recently, studies have shown that it is possible to identify the cell patterns using IIF image analysis and machine learning techniques. In this paper we de…

Searches for neutral Higgs bosons in e+e− collisions at centre-of-mass energies from 192 to 202 GeV

Searches for neutral Higgs bosons are performed with the 237 pb-1 of data collected in 1999 by the ALEPH detector at LEP, for centre-of-mass energies between 191.6 and 201.6 GeV. These searches apply to Higgs bosons within the context of the Standard Model and its minimal supersymmetric extension (MSSM) as well as to invisibly decaying Higgs bosons. No evidence of a signal is seen. A lower limit on the mass of the Standard Model Higgs boson of 107.7 GeV/c2 at 95% confidence level is set. In the MSSM, lower limits of 91.2 and 91.6 GeV/c2 are derived for the masses of the neutral Higgs bosons h and A, respectively. For a Higgs boson decaying invisibly and produced with the Standard Model cros…

A flavour-independent Higgs boson search in e+e- collisions at sqrt(s) up to 209GeV

A search for the Higgsstrahlung process e+e- → HZ is carried out, covering decays of the Higgs boson into any quark pair, a gluon pair or a tau pair. The analysis is based on the 630 pb-1 of data collected by the ALEPH detector at LEP at centre-of-mass energies from 189 to 209 GeV. A 95% C.L. lower mass limit of 109.1 GeV/c2 is obtained for a Higgs boson cross section equal to that expected from the Standard Model if the Higgs boson decays exclusively into hadrons and/or taus, irrespective of the relative branching fractions. © 2002 Elsevier Science B.V. All rights reserved.

Deep Convolutional Neural Network for HEp-2 fluorescence intensity classification

Indirect ImmunoFluorescence (IIF) assays are recommended as the gold standard method for detection of antinuclear antibodies (ANAs), which are of considerable importance in the diagnosis of autoimmune diseases. Fluorescence intensity analysis is very often complex, and depending on the capabilities of the operator, the association with incorrect classes is statistically easy. In this paper, we present a Convolutional Neural Network (CNN) system to classify positive/negative fluorescence intensity of HEp-2 IIF images, which is important for autoimmune diseases diagnosis. The method uses the best known pre-trained CNNs to extract features and a support vector machine (SVM) classifier for the …

Inclusive production of neutral vector mesons in hadronic Z decays

Data on the inclusive production of the neutral vector mesons rho(0)(770), omega(782), K*(0)(892), and phi (1020) in hadronic Z decays recorded with the ALEPH detector at LEP are presented and compared to Monte Carlo model predictions. Bose-Einstein effects are found to be important in extracting a reliable value for the p(0) production rate. An average p(0) multiplicity of 1.45 +/- 0.21 per event is obtained. The omega is detected via its three pion decay mode omega --> pi(+)pi(-)pi(0) and has a total rate of 1.07 +/- 0.14 per event. The multiplicity of the K*(0) is 0.83 +/- 0.09, whilst that of the phi is 0.122 +/- 0.009, both measured using their charged decay modes. The measurements pro…

Study of spectral response of a CZT multiple-electrode detectors

Comparison of two portable solid state detectors with an improved collimation and alignment device for mammographic x-ray spectroscopy.

We describe a portable system for mammographic x-ray spectroscopy, based on a 2 X 2 X 1 mm3 cadmium telluride (CdTe) solid state detector, that is greatly improved over a similar system based on a 3 X 3 X 2 mm3 cadmium zinc telluride (CZT) solid state detector evaluated in an earlier work. The CdTe system utilized new pinhole collimators and an alignment device that facilitated measurement of mammographic x-ray spectra. Mammographic x-ray spectra acquired by each system were comparable. Half value layer measurements obtained using an ion chamber agreed closely with those derived from the x-ray spectra measured by either detector. The faster electronics and other features of the CdTe detecto…

A massive lesion detection algorithm in mammography

A new algorithm for massive lesion detection in mammography is presented. The algorithm consists in three main steps : 1) reduction of the dimension of the image to be processed through the identifi cation of regions of interest (rois) as candidates for massive lesions ; 2) characterization of the roi by means of suitable feature extraction ; 3) pattern classifi cation through supervised neural networks. Suspect regions are detected by searching for local maxima of the pixel grey level intensity. A ring of increasing radius, centered on a maximum, is considered until the mean intensity in the ring decreases to a defi ned fraction of the maximum. The rois thus obtained are described by avera…

A Fuzzy Logic C-Means Clustering Algorithm to Enhance Microcalcifications Clusters in Digital Mammograms

The detection of microcalcifications is a hard task, since they are quite small and often poorly contrasted against the background of images. The Computer Aided Detection (CAD) systems could be very useful for breast cancer control. In this paper, we report a method to enhance microcalcifications cluster in digital mammograms. A Fuzzy Logic clustering algorithm with a set of features is used for clustering microcalcifications. The method described was tested on simulated clusters of microcalcifications, so that the location of the cluster within the breast and the exact number of microcalcifications is known.

Measurement of W-pair production in $e^+ e^-$ collisions at 189 GeV

The production of W-pairs is analysed in a data sample collected by ALEPH at a mean centre-of-mass energy of 188.6 GeV, corresponding to an integrated luminosity of 174.2 pb^-1. Cross sections are given for different topologies of W decays into leptons or hadrons. Combining all final states and assuming Standard Model branching fractions, the total W-pair cross section is measured to be 15.71 +- 0.34 (stat) +- 0.18 (syst) pb. Using also the W-pair data samples collected by ALEPH at lower centre-of-mass energies, the decay branching fraction of the W boson into hadrons is measured to be BR (W &gt; hadrons) = 66.97 +- 0.65 (stat) +- 0.32 (syst) %, allowing a determination of the CKM matrix el…

Measurements of the charged particle multiplicity distribution in restricted rapidity intervals

Charged particle multiplicity distributions have been measured with the ALFPH detector in restricted rapidity intervals \Y\ less than or equal to 0.5, 1.0, 1.5, 2.0 along the thrust axis and also without restriction on rapidity. The distribution for the full range can be parametrized by a log-normal distribution. For smaller windows one finds a more complicated structure, which is understood to arise from perturbative effects. The negative-binomial distribution fails to describe the data both with and without the restriction on rapidity. The JETSET model is found to describe all aspects of the data while the width predicted by HERWIG is in significant disagreement.

Digital filtering and analysis for a semiconductor X-ray detector data acquisition

Abstract Pile-up distortion is a major drawback in X-ray spectroscopy at high count rate. Pulse width narrowing with shaping techniques can lead to the reduction of the pile-up distortion, but a low shaping time reduces the noise filtration and leads to a poor energy resolution. Thus, only a best compromise solution between the pile-up and the noise requirements is achievable. The hardware manipulation needed to adjust the parameters of the traditional electronic shaping amplifiers makes it uneasy to tests various settings in different conditions. Digital techniques can help to overcome such difficulties. A digital signal processing and analysis system for X-ray spectroscopy is described in…

A completely automated CAD system for mass detection in a large mammographic database

Mass localization plays a crucial role in computer-aided detection (CAD) systems for the classification of suspicious regions in mammograms. In this article we present a completely automated classification system for the detection of masses in digitized mammographic images. The tool system we discuss consists in three processing levels: (a) Image segmentation for the localization of regions of interest (ROIs). This step relies on an iterative dynamical threshold algorithm able to select iso-intensity closed contours around gray level maxima of the mammogram. (b) ROI characterization by means of textural features computed from the gray tone spatial dependence matrix (GTSDM), containing secon…

A test to evaluate the impact of the CAD tools in mammographic diagnosis

In this work we present the results of a study about the impact of CAD tools on Sensitivity and Specificity in mammographic diagnosis. The approach is aimed to evaluate the statistical significance through the comparison of these figures of merit obtained in different situations. For this purpose two different CAD tools, the CALMA station (INFN project) and the SecondLook™ station (by CADx) have been used as a support for radiologists.

Prepocessing methods for nodule detection in lung CT

Measurement of the hadronic photon structure function at LEP 1 for 〈Q2〉 values between 9.9 and 284 GeV2

Inclusive γ*γ interactions to hadronic final states where one scattered electron or positron is detected in the electromagnetic calorimeters have been studied in the LEP 1 data taken by ALEPH from 1991 to 1995. The event sample has been used to measure the hadronic structure function of the photon F2γ in three bins with of 9.9, 20.7 and 284 GeV2.

Preprocessing methods for nodule detection in lung CT

Abstract The use of automatic systems in the analysis of medical images has proven to be very useful to radiologists, especially in the framework of screening programs, in which radiologists make their first diagnosis on the basis of images only, most of those corresponding to healthy patients, and have to distinguish pathological findings from non-pathological ones at an early stage. In particular, we are developing preprocessing methods to be applied for pulmonary nodule Computer Aided Detection in low-dose lung Multi Slice CT (computed tomography) images.

Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project.

International audience; Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF) method, and performed by analyzing patterns and fluorescence intensity. This paper introduces the AIDA Project (autoimmunity: diagnosis assisted by computer) developed in the framework of an Italy-Tunisia cross-border cooperation and its preliminary results. A database of interpreted IIF images is being collected through the exchange of images and double reporting and a Gold Standard database, containing around 1000 double reported images, has been settled. The Gold Standard database is used for optimization of …

Study of D0– mixing and D0 doubly Cabibbo-suppressed decays

Abstract Using a sample of four million hadronic Z events collected in ALEPH from 1991 to 1995, the decays D ∗+ → D 0 π s + , with D0 decaying to K−π+ or to K+π−, are studied. The relative branching ratio B(D0→K+π−)/B(D0→K−π+) is measured to be 1.84±0.59( stat. ) ±0.34( syst. ) %. The two possible contributions to the D0→K+π− decay, doubly Cabibbo-suppressed decays and D0– D 0 mixing, are disentangled by measuring the proper-time distribution of the reconstructed D0's. Assuming no interference between the two processes, the upper limit obtained on the mixing rate is 0.92% at 95% CL . The possible effect of interference between the two amplitudes is also assessed.

Electrical properties of Au/CdZnTe/Au detectors grown by the boron oxide encapsulated Vertical Bridgman technique

Abstract In this work we report on the results of electrical characterization of new CdZnTe detectors grown by the Boron oxide encapsulated Vertical Bridgman technique (B-VB), currently produced at IMEM-CNR (Parma, Italy). The detectors, with gold electroless contacts, have different thicknesses (1 and 2.5 mm) and the same electrode layout, characterized by a central anode surrounded by a guard-ring electrode. Investigations on the charge transport mechanisms and the electrical contact properties, through the modeling of the measured current–voltage ( I – V ) curves, were performed. Generally, the detectors are characterized by low leakage currents at high bias voltages even at room tempera…

A REST-based framework to support non-invasive and early coeliac disease diagnosis

The health sector has traditionally been one of the early adopters of databases, from the most simple Electronic Health Record (formerly Computer-Based Patient Record) systems in use in general practice, hospitals and intensive care units to big data, multidata based systems used to support diagnosis and care decisions. In this paper we present a framework to support non-invasive and early diagnosis of coeliac disease. The proposed framework makes use of well-known technologies and techniques, both hardware and software, put together in a novel way. The main goals of our framework are: (1) providing users with a reliable and fast repository of a large amount of data; (2) to make such reposi…

Noise reduction for magnetic resonance imaging by wavelet. An application to the study of the capilary water absorption in sedimentary rocks

Fermion pair production in e+e- collisions at 189-209 GeV and constraints on physics beyond the Standard Model

Cross sections, angular distributions and forward-backward asymmetries are presented, of two-fermion events produced in e+e- collisions at centre-of-mass energies from 189 to 209 GeV at LEP, measured with the ALEPH detector. Results for e+e-, mu+mu-, tau+tau-, qq, bb and cc production are in agreement with the Standard Model predictions. Constraints are set on scenarios of new physics such as four-fermion contact interactions, leptoquarks, Z' bosons, TeV-scale quantum gravity and R-parity violating squarks and sneutrinos.

Single vector boson production in e(+)e(-) collisions at centre-of-mass energies from 183 to 209 GeV

The cross sections for single vector boson production in the Wenu and Zee channels are measured from the data collected by AA the ALEPH detector at LEP for centre-of-mass energies between 183 and 209 GeV. These data correspond to a total integrated luminosity of 683 pb(-1). Single-W production is studied in both hadronic and leptonic decay channels. Hadronic and dimuon decays are used for single-Z production. The measured cross sections agree with the Standard Model predictions.

High-rate x-ray spectroscopy in mammography with a CdTe detector: A digital pulse processing approach

Purpose:Direct measurement of mammographic x-ray spectra under clinical conditions is a difficult task due to the high fluence rate of the x-ray beams as well as the limits in the development of high resolution detection systems in a high counting rate environment. In this work we present a detection system, based on a CdTe detector and an innovative digital pulse processing (DPP) system, for high-rate x-ray spectroscopy in mammography. Methods: The DPP system performs a digital pile-up inspection and a digital pulse height analysis of the detector signals, digitized through a 14-bit, 100 MHz digitizer, for x-ray spectroscopy even at high photon counting rates. We investigated on the respon…

High-rate x-ray spectroscopy in mammography with a CdTe detector: A digital pulse processing approach

Purpose:Direct measurement of mammographic x-ray spectra under clinical conditions is a difficult task due to the high fluence rate of the x-ray beams as well as the limits in the development of high resolution detection systems in a high counting rate environment. In this work we present a detection system, based on a CdTe detector and an innovative digital pulse processing (DPP) system, for high-rate x-ray spectroscopy in mammography. Methods: The DPP system performs a digital pile-up inspection and a digital pulse height analysis of the detector signals, digitized through a 14-bit, 100 MHz digitizer, for x-ray spectroscopy even at high photon counting rates. We investigated on the respon…

Fast Fourier Transform Filtering for Bilateral Mammography Comparison

Bilateral Asymmetry is one of the breast abnormalities that may indicate a cancer in early stage. The computer methods for the bilateral subtraction developed up to now show the problem of large false positives number because the alignment defects. On the other hand the computer methods using FFT approach suffer of a low S/N ratio to distinguish massive lesions from background. In this paper a method (FFT-RF-BMC) is presented to enhanche the bilateral asymmetry using a FFT to detect massive lesions through a Recursive Filtering.

Improved search for $B_{s}^{0} - \overline{B}_{s}^{0}$ oscillations

An improved search for Bs oscillations is performed in the ALEPH data sample collected during the first phase of LEP, and reprocessed in 1998. Three analyses based on complementary event selections are presented. First, decays of Bs mesons into hadronic flavour eigenstates are fully reconstructed. This selection yields a small sample of candidates with excellent decay length and momentum resolution and high average Bs purity. Semileptonic decays with a reconstructed Ds- meson provide a second sample with larger statistics, high average Bs purity, but a poorer momentum and decay length resolution due to the partial decay reconstruction. Finally, semileptonic b-hadron decays are inclusively s…

Search for charged Higgs bosons in $e^+ e^-$ collisions at energies up to $\sqrt{s}$ = 189 GeV

The data collected at centre-of-mass energies of 188.6 GeV by ALEPH at LEP, corresponding to an integrated luminosity of 176.2 pb-1, are analysed in a search for pair-produced charged Higgs bosons H+/-. Three analyses are employed to select the taunutaunu, taunucs and cscs final states. No evidence for a signal is found. Upper limits are set on the production cross section as a function of the branching fraction BR(H+ to tau nu) and of the mass M(H+), assuming that the sum of the branching ratios is equal to one. In the framework of a two-Higgs-doublet model, charged Higgs bosons with masses below 65.4 GeV/c2 are excluded at 95% confidence level independently of the decay mode.

CT imaging applied to capillary water absorption in sicilian sedimentary rocks used in cultural heritages

First measurement of the quark-to-photon fragmentation function

Earlier measurements at LEP of isolated hard photons in hadronic Z decays, attributed to radiation from primary quark pairs, have been extended in the ALEPH experiment to include hard photon production inside hadron jets. Events are selected where all particles combine democratically to form hadron jets, one of which contains a photon with a fractional energy z greater than or equal to 0.7. After statistical subtraction of non-prompt photons, the quark-to-photon fragmentation function, D(z), is extracted directly from the measured 2-jet rate. By taking into account the perturbative contributions to D(z) obtained from an O(alpha alpha(s)) QCD calculation, the unknown non-perturbative compone…

Production of orbitally excited charm mesons in semileptonic B decays

A sample of 3.6 million hadronic Z decays recorded between 1991 and 1995 with the ALEPH detector at LEP is used to investigate semileptonic decays of B mesons into final states involving orbitally excited charm mesons. Topological vertex criteria are used to search for decays involving narrow D** states as well as wide D** resonances and non-resonant D(*)pi final states. The sum of the branching ratios for these processes is measured to be Br((B) over bar --> D pi l(-)(v) over bar) + Br((B) over bar --> D*pi l(-)(v) over bar) = (2.26 +/-t 0.29(stat) +/- 0.33(syst))%, which accounts for a significant fraction of the deficit between inclusive measurements and the sum of exclusive semileptonic…

Diagnostic Mammographic X-ray spectra analysis with CZT and CdTe solid state detector

Datazione mediante la tecnica della TL: Il teatro greco-romano di Taormina

Detection and classification of microcalcifications clusters in digitized mammograms

In the present paper we discuss a new approach for the detection of microcalcification clusters, based on neural networks and developed as part of the MAGIC-5 project, an INFN-funded program which aims at the development and implementation of CAD algorithms in a GRID-based distributed environment. The proposed approach has as its roots the desire to maximize the rejection of background during the analytical pre-processing stage, in order to train and test the neural network with as clean as possible a sample and therefore maximize its performance. The algorithm is composed of three modules: the image pre-processing, the feature extraction component and the Backpropagation Neural Network mod…

Environmental risk assesment around archaeological sites in Sicily

Energy resolution and throughput of a new real time digital pulse processing system for x-ray and gamma ray semiconductor detectors

New generation spectroscopy systems have advanced towards digital pulse processing (DPP) approaches. DPP systems, based on direct digitizing and processing of detector signals, have recently been favoured over analog pulse processing electronics, ensuring higher flexibility, stability, lower dead time, higher throughput and better spectroscopic performance. In this work, we present the performance of a new real time DPP system for X-ray and gamma ray semiconductor detectors. The system is based on a commercial digitizer equipped with a custom DPP firmware, developed by our group, for on-line pulse shape and height analysis. X-ray and gamma ray spectra measurements with cadmium telluride (Cd…

Search for a scalar top almost degenerate with the lightest neutralino e(+)e(-) collisions at root s up to 202 GeV

Data collected at centre-of-mass energies from 189 GeV to 202 GeV by the ALEPH detector at LEP corresponding to an integrated luminosity of 411 pb(-1), are analysed in a search for the scalar top in the decay channels (t) over tilde --> c/u chi for small mass differences between the stop and the lightest neutralino. No evidence for deviations from the Standard Model expectation is found and a lower limit of 59 GeV/c(2) is set for the stop mass, independent of the stop to neutralino mass difference and of the stop lifetime. (C) 2000 Elsevier Science B.V. All rights reserved.

FLUXEN portable equipment for direct X-ray spectra measurements

Abstract The proper use of imaging equipment in radiological units is based on an appropriate knowledge of the physical characteristics of the X-ray beam used. The FLUXEN PROJECT is working on a portable apparatus which, together with dedicated software, is able to perform an exact spectral reconstruction of the radiation produced in diagnostic X-ray tubes. The apparatus characterizes the energy spectrum of radiological tubes and also provides a measurement of the emitted flux. The acquisition system is based on a commercial CZT detector (3×3×2 mm 3 ), produced by AMPTEK, cooled by a Peltier cell, with a high efficiency in the diagnostic X-ray energy range and modified in the shaping electr…

Charge carrier transport mechanisms in CdZnTe detectors grown by the vertical Bridgman technique

In this work, we report on the results of electrical characterization of CdZnTe (CZT) detectors, with gold electroless contacts, grown by the boron oxide encapsulated vertical Bridgman technique (B-VB), currently produced at IMEM-CNR (Parma, Italy). The detectors, with different thicknesses (1 and 2.5 mm), have the same electrode layout: the anode is a central electrode (2 x 2 mm(2)) surrounded by a guard ring electrode. The cathode is a planar electrode covering the detector surface (4.1 x 4.1 mm(2)). Current-voltage (I-V) characteristics were measured at different temperatures in order to study the charge transport and the electrical properties. These detectors were compared with the trav…

Measurement of the cross section for open b-quark production in two-photon interactions at LEP

DATAZIONE MEDIANTE LA TECNICA DELLA TERMOLUMINESCENZA

Energy Recovery of Multiple Charge Sharing Events in Room Temperature Semiconductor Pixel Detectors

Multiple coincidence events from charge-sharing and fluorescent cross-talk are typical drawbacks in room-temperature semiconductor pixel detectors. The mitigation of these distortions in the measured energy spectra, using charge-sharing discrimination (CSD) and charge-sharing addition (CSA) techniques, is always a trade-off between counting efficiency and energy resolution. The energy recovery of multiple coincidence events is still challenging due to the presence of charge losses after CSA. In this work, we will present original techniques able to correct charge losses after CSA even when multiple pixels are involved. Sub-millimeter cadmium–zinc–telluride (CdZnTe or CZT) pixel detectors we…

Improved measurement of theB 0 andB + meson lifetimes

The lifetimes of the B 0 and B + mesons have been measured with the Aleph detector at LEP, using approximately 3 million hadronic Z decays collected in the period 1991 1994. In the first of three methods, semileptonic decays of B 0 and B + mesons were partially reconstructed by identifying events containing a lepton with an associated D*- orbar D^0 meson. The second method used fully reconstructed B 0 and B + mesons. The third method, used to measure the B 0 lifetime, employed a partial reconstruction technique to identify B 0→ D*- π + X decays. The combined results are begin{gathered} tau _0 = 1.55 ± 0.06 ± 0.03 ps, \ tau _ + = 1.58 ± 0.09 ± 0.03 ps, \ tfrac{{tau _ + }}{{tau _0 }} = 1.03 ±…

METODO AUTOMATICO PER LA RIVELAZIONE PRECOCE DI ZONE TUMORALI IN IMMAGINI BIOMEDICHE

A fourier-based algorithm for micro-calcification enhancement in mammographic images

Breast cancer is the most widespread cancer in women in the world; it manifests mostly in two forms: microcalcifications and massive lesions. These two forms differ in density, size, shape and number. Consequently, there are two different kinds of mammographic CAD algorithms: those for microcalcifications detection, and those for massive lesions detection. The microcalcifications detection is a hard task, since they are quite small and often poorly contrasted against the background, especially in images affected by digitization noise. In a CAD system the ROI Hunter plays an important role, because missed microcalcifications at this level are definitely lost. For this reason, highlighting me…

Mammogram Segmentation by Contour Searching and Mass Lesions Classification with Neural Network

The mammography is the most effective procedure for an early diagnosis of the breast cancer. In this paper, an algorithm for detecting masses in mammographic images will be presented. The database consists of 3762 digital images acquired in several hospitals belonging to the MAGIC-5 collaboration (Medical Applications on a Grid Infrastructure Connection). A reduction of the whole image's area under investigation is achieved through a segmentation process, by means of a ROI Hunter algorithm, without loss of meaningful information. In the following classification step, feature extraction plays a fundamental role: some features give geometrical information, other ones provide shape parameters.…

Production of excited beauty states in Z decays

A data sample of about 3.0 million hadronicZ decays collected by the ALEPH experiment at LEP in the years 1991 through 1994 is used to make an inclusive selection of B hadron events. In this event sample 4227±140±252B* mesons in the decayB*→Bγ and 1944±108±161B** u,d mesons decaying into a B meson and a charged pion are reconstructed. Here and in the followingB** u,d denotes the eightL=1(bū) and (bd) states and their charge conjugate. For the well establishedB* meson the following quantities are obtained:ΔM=M B*−MB=(45.30±0.35±0.87) MeV/c2 andN B*/(N B+N B*)=(77.1±2.6±7.0)%. The angular distribution of the photons in theB* rest frame is used to measure the relative contribution of longitudi…

GPCALMA: A Grid-based tool for mammographic screening

The next generation of High Energy Physics (HEP) experiments requires a GRID approach to a distributed computing system and the associated data management: the key concept is the Virtual Organisation (VO), a group of distributed users with a common goal and the will to share their resources. A similar approach is being applied to a group of Hospitals which joined the GPCALMA project (Grid Platform for Computer Assisted Library for MAmmography), which will allow common screening programs for early diagnosis of breast and, in the future, lung cancer. HEP techniques come into play in writing the application code, which makes use of neural networks for the image analysis and proved to be useful…

GPCALMA, a mammographic CAD in a GRID connection

Purpose of this work is the development of an automatic system which could be useful for radiologists in the investigation of breast cancer. A breast neoplasia is often marked by the presence of microcalcifications and massive lesions in the mammogram: hence the need for tools able to recognize such lesions at an early stage. GPCALMA (Grid Platform Computer Assisted Library for MAmmography), a collaboration among italian physicists and radiologists, has built a large distributed database of digitized mammographic images (at this moment about 5500 images corresponding to 1650 patients). This collaboration has developed a CAD (Computer Aided Detection) system which, installed in an integrated…

Spectroscopic response and charge transport properties of CdZnTe detectors grown by the vertical Bridgman technique

In this work, we present the results of spectroscopic investigations on CdZnTe (CZT) detectors grown by the boron oxide encapsulated vertical Bridgman technique (1MEM-CNR, Parma, Italy). The detectors, with different thicknesses (1 and 2.5 mm), are characterized by the same electrode layout (gold electroless contacts): the anode is a central electrode (2 x 2 mm(2)) surrounded by a guard-ring electrode, while the cathode is a planar electrode covering the detector surface (4.1 x 4.1 mm(2)). The results of electrical investigations point out the low leakage currents of these detectors even at high bias voltages: 38 nA/cm(2) (T = 25 degrees C) at 10000 V/cm. The time stability and the spectros…

Determination of sin^2(theta(eff)(w)) using jet charge measurements in hadronic Z decays

The electroweak mixing angle is determined with high precision from measurements of the mean difference between forward and backward hemisphere charges in hadronic decays of the Z. A data sample of 2.5 million hadronic Z decays recorded over the period 1990 to 1994 in the ALEPH detector at LEP is used. The mean charge separation between event hemispheres containing the original quark and antiquark is measured for b (b) over bar and c (c) over bar events in subsamples selected by their long lifetimes or using fast D*'s. The corresponding average charge separation for light quarks is measured in an inclusive sample from the anticorrelation between charges of opposite hemispheres and agrees wi…

METHOD FOR PROCESSING BIOMEDICAL IMAGES

The present invention relates to a method for highlight and to diagnose regions of interest in biomedical radiographic images, useful in the context of a CAD tool processing operating as recond reader during the normal clinical and screening routine, so to reducing the costs of management of the "double reading" procedure.

Un sistema digitale innovativo per la caratterizzazione energia-flusso di fasci X diagnostici

La conoscenza della distribuzione energetica e del rateo di fluenza dei fasci X è essenziale nei controlli di qualità in medicina diagnostica, sia in termini dosimetrici che della qualità delle immagini. Gli spettri energetici possono essere utilizzati per stime accurate delle tensioni dei tubi (kVp), per la correzione di distorsioni dovute al beam-hardening e per la corretta implementazione delle nuove tecniche dual-energy [1]. In mammografia, gli spettri energetici possono essere usati per stimare l’esposizione, il kerma in aria e la distribuzione energetica della dose assorbita nei tessuti, superando gli inconvenienti dovuti alla dipendenza energetica della risposta dei dosimetri (a stat…

Datazione mediante la tecnica della Termoluminescenza

Deuteron and anti-deuteron production in e+ e- collisions at the Z resonance

Deuteron and anti-deuteron production in Z decays has been observed in the ALEPH experiment at LEP. The production rate of anti-deuterons is measured to be per hadronic Z decay in the anti-deuteron momentum range from 0.62 to 1.03 GeV/c. The coalescence parameter , which characterizes the likelihood of anti-deuteron production, is measured to be in Z decays. These measurements indicate that the production of anti-deuterons is suppressed in collisions compared to that in pp and photoproduction collisions

A method to reduce the FP/imm number through CC and MLO views comparison in mammographic images

In this paper we propose a method to reduce the FP/imm number through CC and MLO mammographic views comparison of the same patient. The proposed solution uses the symmetry properties of the breast to compute a geometric transformation that permits to represent the two images in comparable coordinates systems. Through this method, potential pathological ROIs of one of the projections are correlated with the ROIs in the second view. To show the effectiveness of the result we apply the method on a dataset composed of 112 couples of pathological images. Experiments shows that method enables a reduction by up to 700/0 of the FP/imm number detected after the classification step

Caratterizzazione di rivelatori CdZnTe a pixel

Dissimilarity Application for Medical Imaging Classification

In the traditional way of learning from examples of objects the classifiers are built in a feature space. However, alternative ways can be found by constructing decision rules on dissimilarity (distance) representations. In such a recognition process a new object is described by its distances to (a subset of) die training samples. The use of the dissimilarities is especially of interest when features are difficult to obtain or when they have a little discriminative power. Purpose of this work is the development of an automatic classification system which could be useful for radiologists in the investigation of breast cancer. The software has been designed in the framework of the MAGIC-5 col…

Search for pentaquarks states in Z decays

Exotic hadrons made of five quarks (pentaquarks) are searched for in hadronic Z decays collected by the ALEPH detector at LEP. No significant signal is observed. At 95% C.L. upper limits are set on the production rates N of such particles and their charge-conjugate state per Z decay: N Θ(1535)+·BR(Θ(1535)+→pK S0)<6.2×10-4, N Ε(1862)-·BR(Ε(1862)-→Ε -π-)<4.5×10-4, N Ε(1862)0·BR(Ε(1862)0→Ε -π+)<8.9×10-4, N Θc(3100)0·BR(Θc(3100) 0→D*-p)<6.3×10-4, N Θc(3100)0·BR(Θc(3100) 0→D-p)<31×10-4. © 2004 Elsevier B.V. All rights reserved.

Inclusive production of neutral pions in hadronic Z decays

A measurement of the inclusive production of pi(0) mesons in hadronic Z decays is presented and compared to Monte Carlo model predictions. The analysis is based on approximately 2 million hadronic events recorded with the ALEPH detector at LEP at a centre-of-mass energy of root s = 91.2 GeV. Neutral pions are reconstructed using photons measured in the electromagnetic calorimeter and photons from conversion pairs. The inclusive pi(0) momentum spectrum is measured in the range 0.025 < x(p) = p/p(beam) < 1. In this range the number of pi(0) per hadronic Z is found to be 4.80 +/- 0.07(stat) +/- 0.31(sys). The differential inclusive pi(0) cross section is also measured as a function of transver…

Computer assisted diagnosis (CAD) in mammography. Comparison of diagnostic accuracy of a new algorithm (Cyclopus(R), Medicad) with two commercial systems

The study compares the diagnostic accuracy (correct identification of cancer) of a new computer-assisted diagnosis (CAD) system (Cyclopus) with two other commercial systems (R2 and CADx). Cyclopus was tested on a set of 120 mammograms on which the two compared commercial systems had been previously tested. The set consisted of mammograms reported as negative, preceding 31 interval cancers reviewed as screening error or minimal sign, and of 89 verified negative controls randomly selected from the same screening database. Cyclopus sensitivity was 74.1% (R2=54.8%; CADx=41.9%) and was higher for interval cancers reviewed as screening error (90.9%; R2=54.5%; CADx=81.8%) compared with those revie…

Search for sleptons in e(+)e(-) collisions at centre-of-mass energies up to 184 GeV

The data collected by the ALEPH experiment at LEP at centre-of-mass energies around 183 GeV are analysed to search for sleptons, the partners of leptons in supersymmetric theories. The previously published search for acoplanar leptons and missing energy has been updated. New searches have been developed to cover a wider range of slepton signals. These include single electrons, acoplanar leptons accompanied by two photons plus missing energy as well as particles with lifetime. No evidence for the production of any such particles is found. Slepton mass limits are reported within gravity mediated and gauge mediated SUSY breaking scenarios. (C) 1998 Elsevier Science B.V. All rights reserved.

Digital pulse processing techniques for X-ray and gamma ray semiconductor detectors

Digital pulse processing (DPP) systems, based on direct digitizing and processing of detector signals, have recently been favoured over analog electronics, ensuring higher flexibility, stability and lower dead time. We present our research activities on the development of X-ray and gamma ray spectrometers based on semiconductor detectors and DPP systems. We developed off-line and real-time DPP systems able to perform precise height and shape analysis of detector pulses. X-ray and gamma ray spectra measurements with cadmium telluride (CdTe) and germanium (Ge) detectors highlight the excellent performance of the systems both at low and high rate environments (up to 800 kcps).

Measurement of triple gauge-boson couplings at 172 GeV

The triple gauge-boson couplings, αWΦ, αW and αBΦ, have been measured using 34 semileptonically and 54 hadronically decaying W+W- candidate events. The events were selected in the data recorded during 1996 with the ALEPH detector at 172 GeV, corresponding to an integrated luminosity of 10.65 pb-1. The triple gauge-boson couplings have been measured using optimal observables constructed from kinematic information of W+W- events. The results are in agreement with the Standard Model expectation.

Fermi-Dirac correlations in Lambda pairs in hadronic Z decays

Two-particle correlations of Lambda Lambda and pairs have been studied in multihadronic Z decays recorded with the ALEPH detector at LEP in the years from 1992 to 1995. The correlations were measured as a function of the four-momentum difference Q of the pair. A depletion of events is observed in the region Q 2 GeV the fraction of pairs with spin one is consistent with the value of 0.75 expected for a statistical spin mixture, whilst for Q pairs, where no Fermi-Dirac correlations are expected, the spin one fraction is measured to be consistent with 0.75 over the entire analysed Q range. (C) 2000 Elsevier Science B.V. All rights reserved.

Metodo di Template Matching per l'Analisi di Immagini

La presente invenzione si riferisce ad un metodo di Template Matching per l’analisi di immagini da ImmunoFluorescenza Indiretta (IFI) per la rivelazione e classificazione automatica di pattern autoanticorpali. L’invenzione qui presentata generalizza il metodo del Template Matching operando innovativamente il mapping del contenuto visuale dell’immagine con particolari funzioni discrete qui denominate “mappatori”; inoltre, utilizzando le informazioni provenienti dalla sovrapposizione dei vari mappatori con un metodo di confronto funzionale, realizza una funzione di correlazione originale. La metodologia descritta nel seguito presenta una flessibilità tale da renderla applicabile a qualsiasi p…

Tau hadronic branching ratios

From 64492 selected tau-pair events, produced at the Zeta(o) resonance, the measurement of the tau decays into hadrons from a global analysis using 1991, 1992 and 1993 ALEPH data is presented. Special emphasis is given to the reconstruction of photons and pi(o)'s, and the removal of fake photons. A detailed study of the systematics entering the pi(o) reconstruction is also given. A complete and consistent set of tau hadronic branching ratios is presented for 18 exclusive modes. Most measurements are more precise than the present world average. The new level of precision reached allows a stringent test of tau - mu universality in hadronic decays, g(tau)/g(mu) = 1.0013 +/- 0.0095, and the fir…

Un sistema portatile per la caratterizzazione di apparati mammografici.

Performance of Fine-Tuning Convolutional Neural Networks for HEp-2 Image Classification

The search for anti-nucleus antibodies (ANA) represents a fundamental step in the diagnosis of autoimmune diseases. The test considered the gold standard for ANA research is indirect immunofluorescence (IIF). The best substrate for ANA detection is provided by Human Epithelial type 2 (HEp-2) cells. The first phase of HEp-2 type image analysis involves the classification of fluorescence intensity in the positive/negative classes. However, the analysis of IIF images is difficult to perform and particularly dependent on the experience of the immunologist. For this reason, the interest of the scientific community in finding relevant technological solutions to the problem has been high. Deep lea…

Automated approach for indirect immunofluorescence images classification based on unsupervised clustering method

Autoimmune diseases (ADs) are a collection of many complex disorders of unknown aetiology resulting in immune responses to self-antigens and are thought to result from interactions between genetic and environmental factors. ADs collectively are amongst the most prevalent diseases in the U.S., affecting at least 7% of the population. The diagnosis of ADs is very complex, the standard screening methods provides seeking and recognizing of Antinuclear Antibodies (ANA) by Indirect ImmunoFluorescence (IIF) based on HEp-2 cells. In this paper an automatic system able to identify and classify the Centromere pattern is presented. The method is based on the grouping of centromeres present on the cell…

The "Livio Scarsi" X-Ray Facility at University of Palermo for Device Testing

In this work, we report on the characteristics of the Livio Scarsi X-ray facility at University of Palermo. The facility is able to produce low energy X rays, within the energy range of 0.1-60 keV, with fluence rates ranging from 105-108 photons/mm2 s. The laboratory is equipped with an innovative digital detection system, based on semiconductor detectors (Si and CdTe detectors), able to provide accurate and precise estimation of the fluence rate, the energy and the exposure of X rays, even at high counting rate conditions. Instrumentation for electrical characterization (DC-AC) of semiconductor devices, for both off-line and on-line (i.e. during the irradiation) measurements, is also avail…

Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project-Global Strategy Protocol.

Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate t…

Diagnostic Mammographics X-Ray Spectra Analisys with CZT and CdTe Solide State Detectors

X-ray response of CdZnTe detectors grown by the vertical Bridgman technique: Energy, temperature and high flux effects

Abstract Nowadays, CdZnTe (CZT) is one of the key materials for the development of room temperature X-ray and gamma ray detectors and great efforts have been made on both the device and the crystal growth technologies. In this work, we present the results of spectroscopic investigations on new boron oxide encapsulated vertical Bridgman (B-VB) grown CZT detectors, recently developed at IMEM-CNR Parma, Italy. Several detectors, with the same electrode layout (gold electroless contacts) and different thicknesses (1 and 2.5 mm), were realized: the cathode is a planar electrode covering the detector surface (4.1×4.1 mm2), while the anode is a central electrode (2×2 mm2) surrounded by a guard-rin…

Search for γγ decays of a Higgs boson in e+e- collisions at √s up to 209 GeV

A search for events with a photon pair arising from the decay of a Higgs boson produced in association with a fermion pair, is performed in 893 pb-1 of data recorded by the ALEPH detector at LEP at centre-of-mass energies up to 209 GeV. No excess of such events is found over the expected background, An upper limit is derived on the product of the e+e- → HZ cross section and the H → γγ branching fraction as a function of the Higgs boson mass. A fermiophobic Higgs boson produced with the Standard Model cross section is excluded at 95% confidence level for all masses below 105.4 GeV/c2. © 2002 Elsevier Science B.V. All rights reserved.

Measurement ofD s + meson production inZ decays and of theB s 0 lifetime

D + mesons produced inZ 0→bb events were separated from theZ 0→cc component using a lifetime tag. Using a sample of 1.5 million hadronicZ decays collected with theAleph detector theB 0 andD s + yields have been measured: $$\begin{gathered} \hfill B(b \to \bar B_s^0 )B(\bar B_s^0 \to D_s^ + ) = 0.088 \pm 0.020(stat.) \\ \hfill \pm 0.020(stat.) \\ \hfill B(c \to D_s^ + ) = 0.088 \pm 0.020(stat.)_{ - 0.016}^{ + 0.019} (syst.) \\ \end{gathered} $$ TheB 0 lifetime was measured in aB 0 enriched sample reconstructing the decay length from the vertex of theD + with a hadron from theB 0 decay. The result obtained is: $$\tau _{B_s } = 1.61_{ - 0.29}^{ + 0.30} (stat.)_{ - 0.016}^{ + 0.018} (syst.)$$ p…

Searches for the neutral Higgs bosons of the MSSM in e+e− collisions at centre-of-mass energies of 181–184 GeV

The data collected by ALEPH at LEP at centre-of-mass energies ranging from 181 to 184 GeV, corresponding to an integrated luminosity of 57 pb(-1), are analysed to search for pair-produced neutral Higgs bosons h and A, in the b (b) over bar b (b) over bar and tau(+)tau(-)b (b) over bar final states. Two events are found in the data with 2.5 expected from standard model processes. When combined with the lower energy data collected by ALEPH and with earlier reported searches for associated hZ production, these analyses are interpreted in the context of the minimal supersymmetric extension of the standard model (MSSM). For standard choices of MSSM parameter sets, this combination results in 95%…

Special Issue on Signal Processing and Machine Learning for Biomedical Data

This Special Issue is focused on advanced techniques in signal processing, analysis, modelling, and classification, applied to a variety of medical diagnostic problems. Biomedical data play a fundamental role in many fields of research and clinical practice. Very often the complexity of these data and their large volume makes it necessary to develop advanced analysis techniques and systems. Furthermore, the introduction of new techniques and methodologies for diagnostic purposes, especially in the field of medical imaging, requires new signal processing and machine learning methods. The recent progress in machine learning techniques, and in particular deep learning, revolutionized various f…

METODO DI ELABORAZIONE DI IMMAGINI BIOMEDICHE

Measurement of the

A new method is presented for the measurement of the mean $\tau$ lepton lifetime using events in which $\tau$'s are pair-produced and both $\tau$'s decay to hadrons and $\nu_\tau$. Based on the correlation between the two $\tau$'s produced at a symmetric $e^+ e^-$ collider, the 3DIP method relies on the three-dimensional information from a double-sided vertex detector and on kinematic constraints for the precise measurement of the $\tau$ decay angles. Using the data collected from 1992 to 1994 with the ALEPH detector at LEP, a $\tau$ lifetime of $288.0 \pm 3.1 \pm 1.3 $\fs is obtained from the sample in which both $\tau$'s decay to one charged track, and $292.8 \pm 5.6 \pm 3.0 $\fs from the…

Two-particle correlations in pp, (p)over-bar(p)over-bar and (KSKS0)-K-0 pairs from hadronic Z decays

Two-particle correlations in pp, and pairs have been studied in hadronic Z decays recorded at LEP with the ALEPH detector. The correlations were measured as a function of the four-momentum difference Q of the pair. For pp, pairs a depletion of events is observed in the region , and for pairs an enhancement of events is observed in the region . These features are consistent with expectations from Fermi–Dirac and Bose–Einstein statistics, respectively.

Integrated techniques to evaluate the features of sedimentary rocks of archaeological areas of sicily.

Sicily includes a great variety of lithologies, giving a high complexity to the geologic landscape. Their prevalent lithology is sedimentary. It is well known that rocks of sedimentary origin, compared with metamorphic and volcanic deposits, can be relatively soft and hence fairly easy to model. Nevertheless, this workability advantage is a drawback for Cultural Heritage applications. In fact, these materials show a high porosity, with pore-size distributions that lead to deterioration through absorption of water. In this paper, several sedimentary rocks used in historical Cultural Heritage items of Sicily, from "Magna Graecia" to nowadays, are classified for mineralogical features, chemica…

Measurement of the W mass by direct reconstruction in e+e- collisions at 172 GeV

The mass of the W boson is obtained from reconstructed invariant mass distributions in W-pair events. The sample of W pairs is selected from 10.65 pb(-1) collected with the ALEPH detector at a mean centre-of-mass energy of 172.09 GeV. The invariant mass distribution of simulated events are fitted to the experimental; distributions and the following W masses are obtained: WW --> , m(W) = 81.30 +/- 0.47(stat.) +/- 0.11(syst.)GeV/c(2), WW --> l nu (l=e,mu), m(W) = 80.54 +/- 0.47(stat.) +/- 0.11(syst.)GeV/c(2), WW --> tau nu, m(W) = 79.56 +/- 1.08(stat.) +/- 0.23(syst.) GeV/c(2). The statistical errors are the expected errors for Monte Carlo samples of the same integrated luminosity as the data…

MAGIC-5: an Italian mammographic database of digitised images for research

The implementation of a database of digitised mammograms is discussed. The digitised images were collected beginning in 1999 by a community of physicists in collaboration with radiologists in several Italian hospitals as a first step in developing and implementing a computer-aided detection (CAD) system. All 3,369 mammograms were collected from 967 patients and classified according to lesion type and morphology, breast tissue and pathology type. A dedicated graphical user interface was developed to visualise and process mammograms to support the medical diagnosis directly on a high-resolution screen. The database has been the starting point for developing other medical imaging applications,…

Window-Based Energy Selecting X-ray Imaging and Charge Sharing in Cadmium Zinc Telluride Linear Array Detectors for Contaminant Detection

The spectroscopic and imaging performance of energy-resolved photon counting detectors, based on new sub-millimetre boron oxide encapsulated vertical Bridgman cadmium zinc telluride linear arrays, are presented in this work. The activities are in the framework of the AVATAR X project, planning the development of X-ray scanners for contaminant detection in food industry. The detectors, characterized by high spatial (250 µm) and energy (&lt;3 keV) resolution, allow spectral X-ray imaging with interesting image quality improvements. The effects of charge sharing and energy-resolved techniques on contrast-to-noise ratio (CNR) enhancements are investigated. The benefits of a new energy-resolved …

TAC applicata allo studio di rocce sedimentarie utilizzate nei Beni Culturali

A Microcalcification Detection System in Mammograms based on ANN Clustering

Breast cancer is one of the leading causes to women mortality in the world. Clustered microcalcifications (MCs) in mammograms can be an important early sign of breast cancer, the detection is important to prevent and treat the disease. In this work, we present a novel method for the detection of MCs in mammograms which consists of regions of Interest (ROIs) segmentation, based on a spatial filter that allows the detection of small and large microcalcifications, clustering and classification of MCs by Artificial Neural Network. The system has been tested on a public dataset of digital images and compared with previous approaches. The results demonstrate that the proposed approach could achie…

A Wavelet approach to extract main features from indirect immunofluorescence images

A number of previous studies have shown that IIF image analysis requires complex and sometimes heterogeneous and diversified methods. Robust solutions can be proposed but they need to orchestrate several methods from low-level analysis up to more complex neural networks or SVM for data classification. The contribution intends to highlight the versatility of Wavelet Transform (WT) and their use in various levels of analysis for the classification of IIF images in order to develop a system capable of performing: image enhancement, ROI segmentation and object classification. Therefore, WT was adopted in the de-noise section, segmentation and classification. This analysis allows frequencies cha…

X-ray spectroscopy and dosimetry with a portable CdTe device.

Abstract X-ray spectra and dosimetry information are very important for quality assurance (QA) and quality control (QC) in medical diagnostic X-ray systems. An accurate knowledge of the diagnostic X-ray spectra would improve the patient dose optimization, without compromising image information. In this work, we performed direct diagnostic X-ray spectra measurements with a portable device, based on a CdTe solid-state detector. The portable device is able to directly measure X-ray spectra at high photon fluence rates, as typical of clinical radiography. We investigated on the spectral performances of the system in the mammographic energy range (up to ∼40 keV). Good system response to monoener…

Bose-Einstein correlations in W-pair decays with an event-mixing technique

Bose-Einstein correlations in W-pair decays are studied using data collected by the ALEPH detector at LEP at e+e- centre-of-mass energies from 183 to 209 GeV. The analysis is based on the comparison of WW→qq̄qq̄ events to "mixed" events constructed with the hadronic part of WW→qq̄ℓν events. The data are in agreement with the hypothesis that Bose-Einstein correlations are present only for pions from the same W decay. The JETSET model with Bose-Einstein correlations between pions from different W bosons is disfavoured.

The CALMA system: an artificial neural network method for detecting masses and microcalcifications in digitized mammograms

The CALMA (Computer Assisted Library for MAmmography) project is a five years plan developed in a physics research frame in collaboration between INFN (Istituto Nazionale di Fisica Nucleare) and many Italian hospitals. At present a large database of digitized mammographic images (more than 6000) was collected and a software based on neural network algorithms for the search of suspicious breast lesions was developed. Two tools are available: a microcalcification clusters hunter, based on supervised and unsupervised feedforward neural network, and a massive lesions searcher, based on a hibrid approach. Both the algorithms analyzed preprocessed digitized images by high frequency filters. Clini…

Improved measurement of the triple gauge-boson couplings gamma WW and ZWW in e(+)e(-) collisions

Triple gauge-boson couplings ?WW and ZWW involving single-photon, single-W and W-pair production are determined using data samples collected at LEP with the ALEPH detector at centre-of-mass energies between 183 and 209 GeV. The integrated luminosity used is 700 pb-1 for the single-photon measurement and 683 pb-1 for the W channels. Restricting the measurement to C- and P-conserving terms and applying local SU(2) L×U(1)Y gauge invariance, the measured values of the parameters g1 Z, ?? and ?? are: g1 Z=1.001±0. 027(stat)±0.013(syst), ??=0.971±0.055(stat) ±0.030(syst), ??=-0.012±0.027(stat) ±0.011(syst) for single-parameter fits, where the two other parameters are fixed to their Standard Model…

Comparison of two portable solid state detectors with an improved collimation and alignment device for mammographic x-ray spectroscopy

We describe a portable system for mammographic x-ray spectroscopy, based on a 2 X 2 X 1 mm3 cadmium telluride (CdTe) solid state detector, that is greatly improved over a similar system based on a 3 X 3 X 2 mm3 cadmium zinc telluride (CZT) solid state detector evaluated in an earlier work. The CdTe system utilized new pinhole collimators and an alignment device that facilitated measurement of mammographic x-ray spectra. Mammographic x-ray spectra acquired by each system were comparable. Half value layer measurements obtained using an ion chamber agreed closely with those derived from the x-ray spectra measured by either detector. The faster electronics and other features of the CdTe detecto…

Computer-aided diagnosis in digital mammography: comparison of two commercial systems

Aim: Within this work, a comparative analysis of two commercial computer-aided detection or diagnosis (CAD) systems, CyclopusCAD® mammo (v. 6.0) produced by CyclopusCAD Ltd (Palermo, Italy) and SecondLook® (v. 6.1C) produced by iCAD Inc. (OH, USA) is performed by evaluating the results of both systems application on an unique set of mammographic digital images routinely acquired in a hospital structure. Materials & methods: The two CAD systems have been separately applied on a sample set of 126 mammographic digital cases, having been independently diagnosed by two senior radiologists. According to the human diagnosis, the cases in the sample reference set are divided into 61 negatives and 6…

INTEGRATED TECHNIQUE TO EVALUATE THE FEATURES OF SEDIMENTARY ROCKS OF ARCHAELOGICAL AREAS OF SICILY

Noise reduction in magnetic resonance images by Wavelet transforms: an application to the study of capillary water absorption in sedimentary rocks

Magnetic resonance imaging (MRI) is a powerful technique to study capillary water absorption kinetics in sedimentary rocks. However, the noise in the images can limit the correct identification and the quantitative measurement of the average height reached by the wetting front inside the porous material where imbibition occurs. Therefore, denoising methods can be applied to improve the image quality for a more accurate analysis, without the disadvantages of longer acquisition times. This study attempts to improve the signal-to-noise ratio of the images acquired by MRI on a sedimentary rock (Pietra di Lecce) using a waveletbased thresholding technique. The idea is to average some slightly di…

Search for charginos nearly mass degenerate with the lightest neutralino in e+e− collisions at centre-of-mass energies up to 209 GeV

A search for charginos nearly mass degenerate with the lightest neutralino is performed with the data collected by the ALEPH detector at LEP, at centre-of-mass energies between 189 and 209 GeV, corresponding to an integrated luminosity of 628 pb-1. The analysis is based on the detection of isolated and energetic initial state radiation photons, produced in association with chargino pairs whose decay products have little visible energy. The number of candidate events observed is in agreement with that expected from Standard Model background sources. These results are combined with those of other direct searches for charginos, and a lower limit of 88 GeV/c2 at 95 % confidence level is derived…

Incomplete Charge Collection at Inter-Pixel Gap in Low- and High-Flux Cadmium Zinc Telluride Pixel Detectors.

The success of cadmium zinc telluride (CZT) detectors in room-temperature spectroscopic X-ray imaging is now widely accepted. The most common CZT detectors are characterized by enhanced-charge transport properties of electrons, with mobility-lifetime products &mu;e&tau;e &gt; 10&minus;2 cm2/V and &mu;h&tau;h &gt; 10&minus;5 cm2/V. These materials, typically termed low-flux LF-CZT, are successfully used for thick electron-sensing detectors and in low-flux conditions. Recently, new CZT materials with hole mobility-lifetime product enhancements (&mu;h&tau;h &gt; 10&minus;4 cm2/V and &mu;e&tau;e &gt; 10&minus;3 cm2/V) have been fabricated for high-flux measurements (high-flux HF-CZT detectors).…

Measurement of the e+e- → ZZ production cross section at centre-of-mass energies of 183 and 189 GeV

The ee -> ZZ cross section at sqrt(s)=182.7 and 188.6 GeV has been measured using the ALEPH detector. The analysis covers all of the visible ZZ final states and yields cross section measurements of sigma_ZZ(182.7 GeV) = 0.11 +- (0.16,0.11) (stat.) +- 0.04 (syst.) pb and sigma_ZZ(188.6 GeV) = 0.67 +- 0.13 (stat.) +- 0.04 (syst.) pb consistent with the Standard Model expectations.

Fuzzy technique for microcalcifications clustering in digital mammograms

Abstract Background Mammography has established itself as the most efficient technique for the identification of the pathological breast lesions. Among the various types of lesions, microcalcifications are the most difficult to identify since they are quite small (0.1-1.0 mm) and often poorly contrasted against an images background. Within this context, the Computer Aided Detection (CAD) systems could turn out to be very useful in breast cancer control. Methods In this paper we present a potentially powerful microcalcifications cluster enhancement method applicable to digital mammograms. The segmentation phase employs a form filter, obtained from LoG filter, to overcome the dependence from …

Exclusive production of pion and kaon meson pairs in two photon collisions at LEP

Exclusive production of pi and K meson pairs in two photon collisions is measured with ALEPH data collected between 1992 and 2000. Cross-sections are presented as a function of cos theta* and invariant mass, for \ cos theta* \ < 0.6 and invariant masses between 2.0 and 6.0 GeV/c(2) (2.25 and 4.0 GeV/c(2)) for pions (kaons). The shape of the distributions are found to be well described by QCD predictions but the data have a significantly higher normalization. (C) 2003 Published by Elsevier B.V.

Comparative Study of Human and Automated Screening for Antinuclear Antibodies by Immunofluorescence on HEp-2 Cells

Background : Several automated systems had been developed in order to reduce inter-observer variability in indirect immunofluorescence (IIF) interpretation. We aimed to evaluate the performance of a processing system in antinuclear antibodies (ANA) screening on HEp-2 cells. Patients and Methods : This study included 64 ANA-positive sera and 107 ANA-negative sera that underwent IIF on two commercial kits of HEp-2 cells (BioSystems® and Euroimmun®). IIF results were compared with a novel automated interpretation system, the “ Cyclopus CADImmuno®” (CAD). Results : All ANA-positive sera images were recognized as positive by CAD (sensitivity = 100%), while 17 (15.9%) of the ANA-negative sera ima…

Inclusive semileptonic branching ratios of b hadrons produced in Z decays

A measurement of the inclusive semileptonic branching ratios of b hadrons produced in Z decay is presented, using four million hadronic events collected by the ALEPH detector from 1991 to 1995. Electrons and muons are selected opposite to b-tagged hemispheres. Two different methods are explored to distinguish the contributions from direct $\bl$ and cascade $\bcl$ decays to the total lepton yield. One is based on the lepton transverse momentum spectrum, the other makes use of the correlation between the charge of the lepton and charge estimators built from tracks in the opposite hemisphere of the event. The latter method reduces the dependence on the modelling of semileptonic b decays. The r…

Observation of an excess in the search for the Standard Model Higgs boson at ALEPH

A search has been performed for the Standard Model Higgs boson in the data sample collected with the ALEPH detector at LEP, at centre-of-mass energies up to 209GeV. An excess of 3sigma beyond the background expectation is found, consistent with the production of the Higgs boson with a mass near 114GeV/c2. Much of this excess is seen in the four-jet analyses, where three high purity events are selected.

Automatic detection of lung nodules in CT datasets based on stable 3D mass–spring models

We propose a computer-aided detection (CAD) system which can detect small-sized (from 3 mm) pulmonary nodules in spiral CT scans. A pulmonary nodule is a small lesion in the lungs, round-shaped (parenchymal nodule) or worm-shaped (juxtapleural nodule). Both kinds of lesions have a radio-density greater than lung parenchyma, thus appearing white on the images. Lung nodules might indicate a lung cancer and their early stage detection arguably improves the patient survival rate. CT is considered to be the most accurate imaging modality for nodule detection. However, the large amount of data per examination makes the full analysis difficult, leading to omission of nodules by the radiologist. We…

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