0000000000408385
AUTHOR
S. Costa
Optimization of the JUNO liquid scintillator composition using a Daya Bay antineutrino detector
To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and <0.01 mg/L to 4 g/L and 13 mg/L, respectively. The numbers of total detected photoelectrons suggest that, with the optically purified solvent, the bis-MSB concentration does not need to be more than 4 mg/L. To bridge the one order of magnitude in the detect…
Metallothionein genes in sea urchin embryos and their induction by cadmium
Metallothioneins (MTs) are proteins that play a major role in metal homeostasis and as a reservoir. The MT gene/protein systems of sea urchins are an invaluable model for the study of gene expression regulation and MT isoform-specific functionality of these proteins. We isolated five paralogous MT isogenes and we studied their expression in the sea urchin embryo Paracentrotus lividus. The Cadmium-dependent transcriptional activation of the five isogenes was assessed using quantitative Real Time PCR. Two of the five P. lividus MT (MT-7 and MT-8) isogenes appeared to be constitutively expressed and upregulated upon cadmium treatment. Three isogenes (MT-4/MT-6) are not transcribed in control e…
The fast photon detection system of COMPASS RICH-1
Abstract A fast photon detection system has been built for the upgrade of COMPASS RICH-1, the large size gaseous RICH detector in use at the COMPASS Experiment at the CERN SPS since 2001. The photon detectors of the central region have been replaced by a new system based on multi-anode photomultipliers coupled to individual fused silica lens telescopes and a fast readout electronics system, while in the outer region the existing MWPCs with CsI photocathodes have been equipped with a new readout system, based on the APV chip. RICH-1 has been successfully operated in its upgraded version during the 2006 run. We report on the upgrade design and construction, and on the preliminary characteriza…
Design and status of COMPASS FAST-RICH
In the context of the upgrade of COMPASS RICH-1, we are developing a fast photodetection system for RICH counters, based on UV extended Multi-Anode PhotoMultiplier Tubes (MAPMT) and a custom, low dead-time electronic readout system. Photons are concentrated on the MAPMT photocathode by an optical system that preserves the position information. The ratio between the collection and the photosensitive surfaces is ∼7.5 in our design, larger than in previous applications. A new front-end electronics, based on a modified version of the MAD4 discriminator chip, is being realized to digitize the MAPMT signals. We report about the design of the photodetection system and of the associated electronic …
GENE STRUCTURE, DIFFERENTIAL EXPRESSION AND PHYLOGENETIC ANALYSIS OF THE METALLOTHIONEIN GENE FAMILY OF THE SEA URCHIN PARACENTROTUS LIVIDUS
Metallothioneins (MT) are small and cysteine-rich proteins that bind metal ions such as zinc, copper, cadmium, and nickel1. Several functions were proposed for these peptides, ranging from toxic metal protection to physiological metal homeostasis, free radical scavenging, oxidative stress protection, antiapoptotic defense, control of the redox status of the cell and also roles during development. Previously, we reported the identification of five different MT homologues (PlMT4-8) from the Mediterranean sea urchin species P. lividus2. In order to shed some light on MT gene structure and evolution, we cloned seven P. lividus MT genes, comparing them to Echinodermata and Chordata genes3. Moreo…
The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit.
BACKGROUND: Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer outcomes than both laparoscopic completed or planned open surgery. The primary aim of this study was to determine whether laparoscopic conversion was associated with a higher major complication rate than planned open surgery in contemporary, international practice.METHODS: Combined analysis of the European Society of Coloproctology 2017 and 2015 audits. Patients were included if they underwent elective resection of a colonic segment from the caecum to the rectosigmoid jun…
In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries
Contains fulltext : 284232.pdf (Publisher’s version ) (Closed access) The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., "If you do not practice these steps, you can endanger yourself and others") or potential gains (e.g., "If you practice these steps, you can protect yourself and others")? Collecting data in 48 languages from 15,929 participants in 84 countries, we…
Different mRNA localization patterns for metallothioneins (MTs) during embryo development
MTs play pivotal roles in physiological and redox homeostasis. They are also essential during embryo development of P. lividus sea urchin. At least five MT genes are expressed in P. lividus embryo. MT7 and MT8 are constitutively expressed; while, MT4, 5, and 6 are considered as metal-induced homologues. Whole mount in situ hybridization (WMISH) defined the MT mRNAs localization across the embryo territories of the sea urchin. At the gastrula stage, MT7 is localized principally in the endomesoderm, in the vegetal pole. Progressively, it becomes heavily expressed in the endoderm during archenteron specialization in midgut and hindgut and then in stomach and intestine at the pluteus stage. In …
Effectiveness of screening for known mutations in Sicilian patients with "probable" familial hypercholesterolemia.
Background and Aim: More than 750 mutations in the low-density lipoprotein (LDL) receptor gene are currently known to cause familial hypercholesterolemia (FH), but the array of mutations varies considerably in different populations. The definition of essentially all the LDL receptor gene mutations in a population is therefore a prerequisite for the implementation of nation-wide genetic testing for FH. Methods and Results: In this study, a screening strategy based on PCR-enzymatic digestion and PCR-allele specific hybridisation procedures was used to evaluate the frequency distributions of 11 known mutations in a cohort of 214 unrelated subjects meeting the diagnostic criteria of "probable" …
Spin asymmetry A1d and the spin-dependent structure function g1d of the deuteron at low values of x and Q2
Abstract We present a precise measurement of the deuteron longitudinal spin asymmetry A 1 d and of the deuteron spin-dependent structure function g 1 d at Q 2 1 ( GeV / c ) 2 and 4 × 10 −5 x 2.5 × 10 −2 based on the data collected by the COMPASS experiment at CERN during the years 2002 and 2003. The statistical precision is tenfold better than that of the previous measurement in this region. The measured A 1 d and g 1 d are found to be consistent with zero in the whole range of x.
Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery
INTRODUCTION: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.METHODS: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any r…
The Polarised Valence Quark Distribution from semi-inclusive DIS
The semi-inclusive difference asymmetry A^{h^{+}-h^{-}} for hadrons of opposite charge has been measured by the COMPASS experiment at CERN. The data were collected in the years 2002-2004 using a 160 GeV polarised muon beam scattered off a large polarised ^6LiD target and cover the range 0.006 < x < 0.7 and 1 < Q^2 < 100 (GeV/c)^2. In leading order QCD (LO) the asymmetry A_d^{h^{+}-h^{-}} measures the valence quark polarisation and provides an evaluation of the first moment of Delta u_v + Delta d_v which is found to be equal to 0.40 +- 0.07 (stat.) +- 0.05 (syst.) over the measured range of x at Q^2 = 10 (GeV/c)^2. When combined with the first moment of g_1^d previously measured …
An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME)
Introduction: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients undergoing elective total mesorectal excision (TME) for malignancy between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 2579 included patients, 76.2% (1966/257…
Collins and Sivers asymmetries for pions and kaons in muon-deuteron DIS
The measurements of the Collins and Sivers asymmetries of identified hadrons produced in deep-inelastic scattering of 160 GeV/c muons on a transversely polarised 6LiD target at COMPASS are presented. The results for charged pions and charged and neutral kaons correspond to all data available, which were collected from 2002 to 2004. For all final state particles both the Collins and Sivers asymmetries turn out to be small, compatible with zero within the statistical errors, in line with the previously published results for not identified charged hadrons, and with the expected cancellation between the u- and d-quark contributions.
The nucleic acid binding protein PcCNBP is transcriptionally regulated during the immune response in red swamp crayfish Procambarus clarkii
Cellular nucleic acid binding proteins (CNBPs) represent a highly conserved protein family among vertebrates; they harbour seven tandem zinc finger repeats CCHC type and have been described as transcriptional and translational regulators. To date, there is little characterization of CNBP in invertebrates since its structure and function have been analysed solely in Drosophila melanogaster. However, no CNBP has been investigated in other arthropod systems. In an effort to isolate immune-related genes in Procambarus clarkii, a partial mRNA coding a zinc finger containing protein was found to be up-regulated during the response to white spot syndrome virus (WSSV) infection. The red swamp crayf…
The COMPASS experiment at CERN
The COMPASS experiment makes use of the CERN SPS high-intensitymuon and hadron beams for the investigation of the nucleon spin structure and the spectroscopy of hadrons. One or more outgoing particles are detected in coincidence with the incoming muon or hadron. A large polarized target inside a superconducting solenoid is used for the measurements with the muon beam. Outgoing particles are detected by a two-stage, large angle and large momentum range spectrometer. The setup is built using several types of tracking detectors, according to the expected incident rate, required space resolution and the solid angle to be covered. Particle identification is achieved using a RICH counter and both…
The Deuteron Spin-dependent Structure Function g1(d) and its First Moment
We present a measurement of the deuteron spin-dependent structure function g1d based on the data collected by the COMPASS experiment at CERN during the years 2002-2004. The data provide an accurate evaluation for Gamma_1^d, the first moment of g1d(x), and for the matrix element of the singlet axial current, a0. The results of QCD fits in the next to leading order (NLO) on all g1 deep inelastic scattering data are also presented. They provide two solutions with the gluon spin distribution function Delta G positive or negative, which describe the data equally well. In both cases, at Q^2 = 3 (GeV/c)^2 the first moment of Delta G is found to be of the order of 0.2 - 0.3 in absolute value.
A new measurement of the Collins and Sivers asymmetries on a transversely polarised deuteron target
New high precision measurements of the Collins and Sivers asymmetries of charged hadrons produced in deep-inelastic scattering of muons on a transversely polarised 6LiD target are presented. The data were taken in 2003 and 2004 with the COMPASS spectrometer using the muon beam of the CERN SPS at 160 GeV/c. Both the Collins and Sivers asymmetries turn out to be compatible with zero, within the present statistical errors, which are more than a factor of 2 smaller than those of the published COMPASS results from the 2002 data. The final results from the 2002, 2003 and 2004 runs are compared with naive expectations and with existing model calculations.
Fast photon detection for COMPASS RICH-1
A fast photon detection system has been built and assembled for the upgrade of COMPASS RICH-1. The system is based on multianode photomultipliers coupled to fused silica lenses to collect the light from a larger surface and to guide it to the photocathode, preserving the position information. The emphasis is on the fast response and high rate capability of the detectors and the associated electronics. The photon detection system is now ready and it will be employed in the 2006 COMPASS data taking. We report about the system design and construction.
Measurement of the Spin Structure of the Deuteron in the DIS Region
We present a new measurement of the longitudinal spin asymmetry A_1^d and the spin-dependent structure function g_1^d of the deuteron in the range 1 GeV^2 < Q^2 < 100 GeV^2 and 0.004< x <0.7. The data were obtained by the COMPASS experiment at CERN using a 160 GeV polarised muon beam and a large polarised 6-LiD target. The results are in agreement with those from previous experiments and improve considerably the statistical accuracy in the region 0.004 < x < 0.03.
Validation of high voltage power supplies for the 1-inch photomultipliers of AugerPrime, the Pierre Auger Observatory upgrade
In the framework of the upgrade of the Pierre Auger Observatory, a new high voltage module is being employed for the power supply of the 1-inch photomultiplier added to each water-Cherenkov detector of the surface array with the aim of increasing the dynamic range of the measurements. This module is located in a dedicated box near the electronics and comprises a low consumption DC-DC converter hosted inside an aluminum box. All the modules have undergone specific tests to verify their reliability in the extreme environmental conditions of the Argentinian pampa. In this paper, we describe the validation procedure and the facility developed to this aim. The successful results of the tests on …
Post UV irradiation annealing of E’ centers in silica controlled by H2 diffusion
Abstract We investigate the isothermal annealing of E′ centers generated by UV photons (266 nm) of a pulsed Nd:YAG laser in two natural silica types differing for their OH content. Electron spin resonance and absorption spectra recorded at room temperature at different delays from the laser exposure evidenced a partial reduction of E′ centers, more pronounced in the wet silica. These post irradiation kinetics complete within 10 5 s, regardless the silica type, and they are consistent with a diffusion limited reaction between the E′ centers and the molecular hydrogen H 2 . Analysis of our data is done by theoretical fits using the Waite's equation and compared with the H 2 diffusion paramete…
Genome wide survey of the Toll-like receptor family in the Mediterranean sea urchin
Toll-like receptors (TLRs) represent a conserved family of proteins widely expressed in eukaryotes. They play crucial roles in the innate immune system recognizing different pathogen-associated molecular patterns. In mammals the TLR family comprises 10-13 members, while a huge number of TLR-like genes were recovered in S.purpuratus[1-3]. The Paracentrotus lividus genome project recently generated a new highquality assembly of the genome that represents a valuable resource also for clarifying the evolutionary origin of immune system. In order to identify TLR genes in P.lividus, a genome wide survey was carried out and BLAT searches retrieved 119 TLR genes (PlivTLRs). Ab initio gene predictio…
Gluon polarization in the nucleon from quasi-real photoproduction of high-pT hadron pairs
Abstract We present a determination of the gluon polarization Δ G / G in the nucleon, based on the helicity asymmetry of quasi-real photoproduction events, Q 2 1 ( GeV / c ) 2 , with a pair of large transverse-momentum hadrons in the final state. The data were obtained by the COMPASS experiment at CERN using a 160 GeV polarized muon beam scattered on a polarized 6 LiD target. The helicity asymmetry for the selected events is 〈 A ∥ / D 〉 = 0.002 ± 0.019 ( stat ) ± 0.003 ( syst ) . From this value, we obtain in a leading-order QCD analysis Δ G / G = 0.024 ± 0.089 ( stat ) ± 0.057 ( syst ) at x g = 0.095 and μ 2 ≃ 3 ( GeV / c ) 2 .
A highly integrated low-cost readout system for the COMPASS RICH-1 detector
Particle identification at high multiplicities is a key feature of the COMPASS experiment at CERN's SPS. Hadrons up to 50 GeV/c are identified by a RICH detector with a large horizontal and vertical acceptance of plusmn250 mrad and plusmn180 mrad, respectively. The central region of the photon detector is equipped with multi-anode photomultiplier tubes, the remaining 75% of the total active area are covered by MWPCs with Csl photocathodes. In order to improve the performance of the detector at very high beam intensities, more than 62000 channels of a new analog readout system of the MWPCs, based on the APV25 chip, were developed and installed in 2006. The new system features good single pho…