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RESEARCH PRODUCT
Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study
José M. CastellanoF. Valls-rocaAntonio Fernández-giménezJuan F. AscasoJuan F. AscasoMaria Tellez-plazaRedon JosepDomingo Orozco-beltránJorge Navarro-pérezRamon Durazo-arvizuSalvador Pita-fernándezJose Luis TrilloGinés SanzRichard S. CooperVicente Bertomeu-gonzalezAna María Perez-navarroRafael CarmenaRafael CarmenaVicente Francisco Gil-guillénVicente Bertomeu-martínezAlberto CorderoRuth UsoJose M. Martin-morenoManuel Pascual De La TorreConcepción Carratalá-munueraVicente Pallarés-carrataláCarlos Sanchis-domenechsubject
Malelcsh:MedicineCoronary Disease030204 cardiovascular system & hematology0302 clinical medicineRisk Factors030212 general & internal medicinelcsh:ScienceStrokeeducation.field_of_studyMultidisciplinarymedicine.diagnostic_testMortality rateAbsolute risk reductionMiddle AgedLipidsHospitalizationStrokeDENSITY-LIPOPROTEIN CHOLESTEROLCardiovascular DiseasesHypertensionObesitatSERUM-LIPIDSFemalelipids (amino acids peptides and proteins)HEALTHAdultmedicine.medical_specialtyELECTRICITY GENERATING AUTHORITYRANDOMIZED CONTROLLED-TRIALSPopulationPREDICTION MODELEVENTS03 medical and health sciencesInternal medicineDiabetes mellitusmedicineMortalitatDiabetes MellitusHumansCORONARY-HEART-DISEASEOLDER-PEOPLEeducationTriglyceridesSistema cardiovascularAgedHDL CHOLESTEROLbusiness.industrylcsh:RCholesterol HDLCholesterol LDLmedicine.diseaseAttributable risklcsh:QLipid profilebusinessDyslipidemiadescription
Introduction The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with allcause mortality and hospitalization due to cardiovascular events in a high-risk population. Methods This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008-2012). Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. Lipid biomarkers were evaluated. Primary endpoints were all-cause mortality and hospital admission due to coronary heart disease or stroke. We estimated adjusted rate ratios (aRR), absolute risk differences and population attributable risk associated with adverse lipid profiles. Results 51,462 subjects were included with a mean age of 62.6 years (47.6% men). During an average follow-up of 3.2 years, 919 deaths, 1666 hospitalizations for coronary heart disease and 1510 hospitalizations for stroke were recorded. The parameters that showed an increased rate for total mortality, coronary heart disease and stroke hospitalization were, respectively, low HDL-Cholesterol: aRR 1.25, 1.29 and 1.23; high Total/HDL-Cholesterol: aRR 1.22, 1.38 and 1.25; and high Triglycerides/HDL-Cholesterol: aRR 1.21, 1.30, 1.09. The parameters that showed highest population attributable risk (%) were, respectively, low HDL-Cholesterol: 7.70, 11.42, 8.40; high Total/HDL-Cholesterol: 6.55, 12.47, 8.73; and high Triglycerides/HDL-Cholesterol: 8.94, 15.09, 6.92. Conclusions In a population with cardiovascular risk factors, HDL-cholesterol, Total/HDL-cholesterol and triglycerides/HDL-cholesterol ratios were associated with a higher population attributable risk for cardiovascular disease compared to other common biomarkers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-10-18 |