6533b7defe1ef96bd1275b16
RESEARCH PRODUCT
A case of severe repeated immunological reactions to intermittent rifampicin treatment
T. R. WeihrauchD. HöfflerP. FiegelB. KrönigA. Arndt-hanserJ. Jahneckesubject
Pharmacologymedicine.medical_specialtyNauseabusiness.industryImmature cellsPharmacology toxicologyGeneral MedicineJaundiceSurgeryAnesthesiaShiveringmedicineBack painEtiologyPharmacology (medical)medicine.symptombusinessRifampicinmedicine.drugdescription
A case is reported in which a 36-year-old patient twice suffered a rapidly-developing severe reaction to intermittent rifampicin therapy. The symptoms were upper abdominal and back pain, nausea and shivering. Acute renal failure, thrombocytopenia, jaundice and haemolytic anaemia also developed. Aetiologically this was due to an immunopathological effect. This case was unusual in that all the previously observed reactions to rifampicin of an immunological aetiology occurred together, resulting in a marked leucocytosis with the presence of immature cells. It appears that the immediate administration of high-dose corticosteroids can favourably influence this condition. We consider that despite its greater risks daily treatment with rifampicin is to be preferred to discontinuous therapy because of its better tuberculostatic effect.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1972-10-01 | European Journal of Clinical Pharmacology |