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RESEARCH PRODUCT
The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice
Michael MolitorFelix SommerGiulia PontarolloSaravanan SubramaniamYvonne JansenHristo TodorovKerstin JurkMagdolna NagyYvonne DöringYvonne DöringChristian WeberMarijke J.e. KuijpersStefanie AscherSven JäckelPhilip WenzelJohan W. M. HeemskerkCornelia KarwotUlrich WalterKlytaimnistra KiouptsiChristoph ReinhardtSusanne GerberEivor WilmsCarlos NeideckCarlos NeideckFranziska BayerHenning FormesAlexandra GrillEmiel P. C. Van Der VorstPhilip RosenstielBettina Kollarsubject
Male0209 industrial biotechnologyVery low-density lipoproteinChemokine CXCL102 engineering and technology030204 cardiovascular system & hematologyarterial thrombosisApplied Microbiology and BiotechnologyACTIVATIONMicechemistry.chemical_compound020901 industrial engineering & automation0302 clinical medicinegermfree0202 electrical engineering electronic engineering information engineeringMedicinevascular inflammationPlateletChemokine CCL7lcsh:QH301-705.5platelet0303 health sciencesatherosclerosis mouse modelsfood and beveragesThrombosisPlaque AtheroscleroticQR1-502late atherosclerosis3. Good healthHolobiontlow-density lipoprotein receptorgerm-freeplateletscardiovascular systemFemalelipids (amino acids peptides and proteins)GLYCOPROTEIN-VIBlood streamResearch ArticleRECRUITMENTmedicine.medical_specialtyNutritional compositionCOAGULATION610 Medicine & healthBiologyMETABOLISMBiochemistry Genetics and Molecular Biology (miscellaneous)MicrobiologyMicrobiologyHost-Microbe BiologyProinflammatory cytokinePLATELET HYPERREACTIVITY03 medical and health sciencesINFLAMMATIONVirologyInternal medicineatherothrombosisGeneticsmicrobiotaAnimalsInterleukin 9Platelet activationcardiovascular diseasesThrombusMolecular Biology030304 developmental biologygut microbiotabusiness.industryCholesterolcarotid artery020208 electrical & electronic engineeringcholesterolnutritional and metabolic diseasesCell Biologymedicine.diseaseMicroreviewCHLAMYDIA-PNEUMONIAEMice Mutant StrainsGastrointestinal MicrobiomeEndocrinologyReceptors LDLlcsh:Biology (General)chemistryArterial thrombusLDL receptorParasitologyatherosclerosisbusinessEx vivoLipoproteindescription
Our results demonstrate a functional role for the commensal microbiota in atherothrombosis. In a ferric chloride injury model of the carotid artery, GF C57BL/6J mice had increased occlusion times compared to colonized controls. Interestingly, in late atherosclerosis, HFD-fed GF Ldlr−/− mice had reduced plaque rupture-induced thrombus growth in the carotid artery and diminished ex vivo thrombus formation under arterial flow conditions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 | mBio |