6533b828fe1ef96bd1288e9f
RESEARCH PRODUCT
A morphometric study on sural nerves in metachromatic leucodystrophy.
A. BardosiSabine RopteReinhard L. FriedeHans H. Goebelsubject
AdultAdolescentPopulationSural nerveNerve Fibers Myelinated03 medical and health sciences0302 clinical medicineSural NerveMedicineJuvenileHumansAxoneducationMyelin Sheath030304 developmental biologyMetachromatic leucodystrophy0303 health scienceseducation.field_of_studybusiness.industryInfantAnatomyLeukodystrophy Metachromaticmedicine.diseaseAxonsMetachromatic leukodystrophyMicroscopy Electronmedicine.anatomical_structurePeripheral neuropathySpinal NervesMyelin sheathNeurology (clinical)business030217 neurology & neurosurgerySoftwaredescription
This study reexamines peripheral neuropathy in infantile, juvenile and adult metachromatic leuco-dystrophy. A computer-assisted method was used which gives more detailed information on abnormal fibre structure from scatter diagrams of the g ratio (axon diameter/fibre diameter). The data show marked and statistically significant reductions in sheath thickness, particularly for the thick myelinated fibres, and most severe in the juvenile and adult forms. This is interpreted as evidence of remodelling of virtually the entire fibre population, without a clear-cut selectivity for either thin or thick fibres.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-06-01 | Brain : a journal of neurology |