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RESEARCH PRODUCT
Involvement of leucocyte/endothelial cell interactions in anorexia nervosa.
Antonio Hernández-mijaresVanessa Saiz-alarconVictor M. VictorMilagros RochaLuis RojoLuis Rojo-bofillCelia BañulsSusana Rovira-llopisMaria C. SangüesaCarmen De PabloÁNgeles ÁLvarezsubject
Adultmedicine.medical_specialtyAnorexia NervosaAdolescentClinical BiochemistryPopulationInflammationAnorexiaBiochemistrybehavioral disciplines and activitiesBody Mass IndexProinflammatory cytokineYoung AdultleucocytesInternal medicinemental disordersHuman Umbilical Vein Endothelial CellsmedicineHumansCell adhesioneducationInflammationeducation.field_of_studyCell adhesion moleculebusiness.industrydigestive oral and skin physiologyEndothelial CellsGeneral Medicinecytokineslipid profileCross-Sectional StudiesEndocrinologyAnorexia nervosa (differential diagnoses)anorexiaCase-Control StudiesImmunologyLeukocytes MononuclearAdhesionAdhesion anorexia cytokines leucocytes/endothelium interaction lipid profileCytokinesFemaleEndothelium Vascularmedicine.symptombusinessCell Adhesion MoleculesBody mass indexhormones hormone substitutes and hormone antagonistsendothelium interactiondescription
Background Anorexia nervosa is a common psychiatric disorder in adolescence and is related to cardiovascular complications. Our aim was to study the effect of anorexia nervosa on metabolic parameters, leucocyte–endothelium interactions, adhesion molecules and proinflammatory cytokines. Materials and Methods This multicentre, cross-sectional, case–control study employed a population of 24 anorexic female patients and 36 controls. We evaluated anthropometric and metabolic parameters, interactions between leucocytes polymorphonuclear neutrophils (PMN) and human umbilical vein endothelial cells (HUVEC), proinflammatory cytokines such as tumour necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) and soluble cellular adhesion molecules (CAMs) including E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Results Anorexia nervosa was related to a decrease in weight, body mass index, waist circumference, systolic blood pressure, glucose, insulin and HOMA-IR, and an increase in HDL cholesterol. These effects disappeared after adjusting for BMI. Anorexia nervosa induced a decrease in PMN rolling velocity and an increase in PMN rolling flux and PMN adhesion. Increases in IL-6 and TNF-α and adhesion molecule VCAM-1 were also observed. Conclusions This study supports the hypothesis of an association between anorexia nervosa, inflammation and the induction of leucocyte–endothelium interactions. These findings may explain, in part at least, the increased risk of vascular disease among patients with anorexia nervosa.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |