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RESEARCH PRODUCT

Assessment of lung microstructure with magnetic resonance imaging of hyperpolarized Helium-3

Anette HerwelingK. K. GastMichael WindirschClaus P. HeusselAndreas E. MorbachHans-ulrich KauczorWolfgang SchreiberTrine StavngaardJörg SchmiedeskampLise Vejby Søgaard

subject

Pulmonary and Respiratory MedicineTime FactorsSwinePhysiologyHyperpolarized Helium 3HeliumDiffusion AnisotropyNuclear magnetic resonanceIsotopesImage Processing Computer-AssistedmedicineAnimalsHumansEffective diffusion coefficientTissue DistributionDiffusion (business)LungLungmedicine.diagnostic_testChemistryGeneral NeuroscienceMagnetic resonance imagingMiddle AgedMicrostructureHeart ArrestDiffusion Magnetic Resonance Imagingmedicine.anatomical_structureBreath TestsCase-Control StudiesAnisotropyDiffusion MRI

description

Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this study was the assessment of potential sources of systematic errors of the ADC measurement. The influence of macroscopic motion was determined by measurements at two different delays after initiating the breath-hold, and before and after cardiac arrest. An intercentre comparison was performed in two age- and lung function-matched groups of lung-healthy volunteers at two research sites. Moreover, measurements of diffusion anisotropy were performed. We found no dependency of the ADC as a function of the delay after stop of inspiration. The influence of cardiac motion was less than 10%. In the intercentre comparison study, an excellent agreement between the two sites was found. First measurements of the diffusion tensor of intrapulmonary Helium-3 are shown.

yearjournalcountryeditionlanguage
2005-08-01Respiratory Physiology & Neurobiology
https://doi.org/10.1016/j.resp.2005.05.002