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RESEARCH PRODUCT
Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup.
Elizabeth A M FeijenAnna Font-gonzalezElvira C Van DalenHelena J H Van Der PalReulen Raoul CDavid L WinterClaudia E KuehniRiccardo HauptDaniela AlessiJulianne ByrneEdit BardiZsuzsanna JakabDesiree GrabowStanislaw GarwiczMomcilo JankovicGill A LevittRoderick SkinnerLorna Zadravec ZaletelLars HjorthWim J E TissingFlorent De VathaireMike M HawkinsLeontien C M KremerPancaresurfup Consortiumsubject
PediatricsCritical Care and Emergency MedicineCancer Treatmentlcsh:MedicineADULT SURVIVORSCHILDREN030204 cardiovascular system & hematologyDOXORUBICIN THERAPYPediatricsCohort Studies0302 clinical medicineRisk FactorsNeoplasmsMedicine and Health SciencesSurvivorsYoung adultChildlcsh:Scienceeducation.field_of_studyMultidisciplinaryGUIDELINE HARMONIZATION GROUPCancer Risk Factors3. Good healthEuropeOncologyHelminth Infections030220 oncology & carcinogenesisChild PreschoolCohortHEALTH OUTCOMESRecord linkageCohort studyResearch ArticleNeglected Tropical DiseasesAdultCARDIOTOXICITYmedicine.medical_specialtyAdolescentHeart DiseasesLONG-TERMPopulationCardiology610 Medicine & health03 medical and health sciencesYoung Adult360 Social problems & social servicesDiagnostic MedicineEchinococcosismedicineCancer Detection and DiagnosisParasitic DiseasesHumanseducationAdverse effectCONGESTIVE-HEART-FAILUREbusiness.industryMORTALITYlcsh:RCase-control studyCancerInfantmedicine.diseaseTropical DiseasesPediatric OncologyCase-Control StudiesRISK-FACTORSlcsh:Qbusinessdescription
Background and AimChildhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup.MethodsEight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data on symptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected.ResultsThe PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/hospital or regional based databases, and patient-and general practitioner-based questionnaires.ConclusionThe cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platform for future research studies in childhood cancer patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-09-19 | PLoS ONE |