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RESEARCH PRODUCT

Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients

Ingrid MüllerPhilip BerginShanthi HerathMarkus MunderPascale KropfTom ClokeGraham P. TaylorManuel Modolell

subject

AdultCD4-Positive T-LymphocytesMaleNeutrophilsHiv seropositivePopulationlcsh:MedicineHIV InfectionsDiseaseCD13 AntigensBiologyPeripheral blood mononuclear cellFlow cytometryYoung Adult03 medical and health sciences0302 clinical medicinemedicineHumansYoung adultlcsh:ScienceeducationSpecific Gravity030304 developmental biology0303 health scienceseducation.field_of_studyMultidisciplinaryArginasemedicine.diagnostic_testlcsh:RMiddle AgedViral LoadVirologyPhenotypeCD4 Lymphocyte Count3. Good healthPhenotypeImmunologyHIV-1lcsh:QFemaleViral loadBiomarkersResearch Article030215 immunology

description

We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.

yearjournalcountryeditionlanguage
2013-09-09PLoS ONE
https://doi.org/10.1371/journal.pone.0072034