The Role of Palliative Radiotherapy in the Treatment of Spinal Bone Metastases from Head and Neck Tumors-A Multicenter Analysis of a Rare Event.

6533b86dfe1ef96bd12c952a

RESEARCH PRODUCT

The Role of Palliative Radiotherapy in the Treatment of Spinal Bone Metastases from Head and Neck Tumors-A Multicenter Analysis of a Rare Event.

Tanja Sprave Nils H. Nicolay Arnulf Mayer Ingmar Schlampp Tilman Bostel Daniel Wollschläger Anca-ligia Grosu Sati Akbaba Tilmann Rackwitz Harald Rief Tristan Klodt Robert Förster Alexander Rühle Laura Oebel Heinz Schmidberger Jürgen Debus

subject

Larynx Cancer Research medicine.medical_specialty medicine.medical_treatment lcsh:RC254-282 Gastroenterology Article Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine SINS radiotherapy Performance status business.industry Proportional hazards model Pharynx Head and neck cancer Bone metastasis spinal bone metastases lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Radiation therapy instability medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis head and neck cancer business 030217 neurology & neurosurgery

description

This retrospective multi-center analysis aimed to assess the clinical response and stabilizing effects of palliative radiotherapy (RT) for spinal bone metastases (SBM) in head and neck cancer (HNC), and to establish potential predictive factors for stability and overall survival (OS). Patients included in this analysis were treated at the University Hospitals of Mainz, Freiburg, and Heidelberg between 2001 and 2019. Clinical information was taken from the medical records. The stability of affected vertebral bodies was assessed according to the validated spine instability neoplastic score (SINS) based on CT-imaging before RT, as well as 3 and 6 months after RT. OS was quantified as the time between the start of palliative RT and death from any cause or last follow-up. Potential predictive factors for stability and OS were analyzed using generalized estimating equations and Cox regression for time-varying covariates to take into account multiple observations per patient. The mean follow-up time of 66 included patients after the first palliative RT was 8.1 months (range 0.3&ndash

year	journal	country	edition	language
2020-07-18	Cancers

10.3390/cancers12071950 https://pubmed.ncbi.nlm.nih.gov/32708389