Clinical and therapeutic features of acute cholecystitis in diabetic patients

2021

The present study aimed to compare the clinical, paraclinical, intraoperative findings, and postoperative complications in acute cholecystitis in diabetic patients vs. non-diabetic patients. A 2-year retrospective study was performed on the patients who underwent emergency cholecystectomy for acute cholecystitis between 2017 and 2019 at the 4th Department of Surgery, Emergency University Hospital Bucharest. The diabetic subgroup numbered 46 eligible patients and the non-diabetic one 287 patients. Demographics, the severity of the clinical forms, biological variables (including white cell count, urea, creatinine, coagulation and liver function tests) comorbidity status, surgical approach, po…

Multi-mycotoxin contamination of green tea infusion and dietary exposure assessment in Moroccan population

2021

Green tea infusion is one of the most widely drunk beverages worldwide due to its health benefits associated with microelements, essential oils, and polyphenols, etc. Several studies have reported that green tea is subjected to contamination by various toxigenic fungi. Thus, this work aims to investigate the co-occurrence of 15 mycotoxins [four aflatoxins (AFB1, AFB2, AFG1, AFG2), ochratoxin A (OTA), beauvericin (BEA), four enniatins (ENA, ENA1, ENB, ENB1), zearalenone (ZEN), alternariol (AOH), tentoxin (TENT), T-2 and HT-2 toxins] in green tea samples available in Morocco by liquid chromatography tandem mass spectrometry method. Analytical and consumption data were then used to assess the …

Supramolecular Chirogenesis in Bis-Porphyrin: Crystallographic Structure and CD Spectra for a Complex with a Chiral Guanidine Derivative

2021

The complexation of (3aR,7aR)-N-(3,5-bis(trifluoromethyl)phenyl)octahydro-2H-benzo[d]imidazol-2-imine (BTI), as a guest, to ethane-bridged bis(zinc octaethylporphyrin), bis(ZnOEP), as a host, has been studied by means of ultraviolet-visible (UV-Vis) and circular dichroism (CD) absorption spectroscopies, single crystal X-ray diffraction, and computational simulation. The formation of 1:2 host-guest complex was established by X-ray diffraction and UV-Vis titration studies. Two guest BTI molecules are located at the opposite sides of two porphyrin subunits of bis(ZnOEP) host, which is resting in the anti-conformation. The complexation of BTI molecules proceed via coordination of the imine nitr…

Impact of climate, soil properties and grassland cover on soil water repellency

2021

Abstract Numerous soil water repellency (SWR) studies have investigated the possible causes of this temporal phenomenon, yet there remains a lack of knowledge on the order of importance of the main driving forces of SWR in the context of changing environmental conditions under grassland ecosystems. To study the separate and combined effects of soil texture, climate, and grassland cover type on inducing or altering SWR, four sites from different climatic and soil regions were selected: Ciavolo (CI, IT), Csolyospalos (CSP, HU), Pwllpeiran (PW, UK), Sekule (SE, SK). The investigated parameters were the extent (determined by repellency indices RI, RIc and RIm) and persistence (determined by wat…

Phase 2 du programme "Trames noires du Massif central" (IPAMAC). Compte-rendu intermédiaire. Visite du Parc naturel régional Livradois-Forez

2021

Are deep eutectic solvents useful in chromatography? A short review.

2021

A literature update has been done concerning Deep Eutectic Solvents (DES) use in chromatography applications. The literature survey was based on the period from 2010 till 2020 and manuscripts reported in the data bases Web of Science and Scopus. The use of DES as mobile phase and mobile phase additives, stationary phases and solid phase modifiers and the use of DES as reaction solvents for chromatography use, were evaluated. Emphasis was placed on the differentiation of DES and Ionic Liquids (ILs) and the advanced green characteristics of the new solvents as compared with traditional organic solvents and ILs with a look into the drawbacks and future perspectives in the field of separation m…

Les difficultés de la construction d’un registre explicatif de la formation des chaînes de montagnes par des apprenants confrontés à un texte histori…

2021

En sciences de la terre et dans le cadre de la théorie de la tectonique des plaques, les processus orogéniques peuvent être difficiles à concevoir par des lycéens et des enseignants. Dans ce papier, on s’interroge, par le biais d’un questionnaire, sur les difficultés à la construction d’un registre explicatif de la formation des chaînes de montagnes par les apprenants. Nous confrontons aussi, dans un atelier-débat, les explications de l’orogenèse proposées par des enseignants à celles avancées par Avicenne. Les registres explicatifs des apprenants sont multiples et l’usage de l’histoire des sciences leur a permis de travailler dans un registre explicatif mobiliste.

DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels.

2021

Abstract We investigated whether docosahexaenoic acid (DHA), a dietary n-3 fatty acid, modulates calcium (Ca2+) signaling and cell cycle progression in human Jurkat T-cells. Our study demonstrates that DHA inhibited Jurkat T-cell cycle progression by blocking their passage from S phase to G2/M phase. In addition, DHA decreased the plasma membrane expression of TRPC3 and TRPC6 calcium channels during T-cell proliferation. Interestingly, this fatty acid increased plasma membrane expression of TRPC6 after 24 h of mitogenic stimulation by phorbol-13-myristate-12-acetate (PMA) and ionomycin. These variations in the membrane expression of TRPC3 and TRPC6 channels were not directly correlated with…

Impact of Thoracic Endografting on the Hemodynamics of the Native Aorta: Pre- and Postoperative Assessments of Wall Shear Stress and Vorticity Using …

2021

Purpose To quantify the hemodynamic consequences of thoracic endovascular aortic repair (TEVAR) by comparing the preoperative and postoperative wall shear stress (WSS) and vorticity profiles on computational fluid dynamics (CFD) simulations. Materials and Methods The pre- and postoperative computed tomography (CT) scans from 20 consecutive patients (median age 69 years, range 20–87) treated for different thoracic aortic pathologies (11 aneurysms, 5 false aneurysms, 3 penetrating ulcers, and 1 traumatic aortic rupture) were segmented to construct patient-specific CFD models using a meshless code. The simulations were run over the cardiac cycle, and the WSS and vorticity values measured at th…

Performance, balance and posture variations with Occlusal Splint and Taopatch® devices: a retrospettive cross-over study

2021

Background The aim of the study was to evaluate how muscular performances, balance and posture were influenced applying Occlusal Splints and Taopatch® 8 (Tao Technologies Srls, Cittadella, Padua, Italy) devices in athletes. Methods Eighteen athletes, 7 females and 11 males, with an average age of 23.8 years, were included. Two devices were used: 1) a customized soft occlusal splint to be applied to the lower ach; 2) nanotechnological devices based on carbon nanotubules and quantum dots (Taopatch®) positioned on C7 and xiphoid process. Four functional tests were performed: surface electromyography (sEMG), kinesiography, the squat jump and counter movement jump and handgrip test. The tests we…

Psychometric properties of the stress control mindset measure in university students from Australia and the UK

2021

Abstract Introduction Beliefs about the consequences of stress, stress mindsets, are associated with health and performance outcomes under stress. This article reports the development and examination of the psychometric properties of a measure of stress mindset: The Stress Control Mindset Measure (SCMM). The measure is consistent with theory on mindsets about self‐attributes and conceptualizes stress mindset as the extent to which individuals endorse beliefs that stress can be enhancing. Methods The study adopted a correlational cross‐sectional survey design in two student samples. Undergraduate students from an Australian university (Sample 1, N = 218) and a UK university (Sample 2, N = 21…

New Challenges for Sustainable Organizations in Light of Agenda 2030 for Sustainability

2021

Sustainability is one of humanity’s most daunting issues at present. Increasing popula- tion, escalation of anthropogenic activities, industrialization, modern agricultural practices that pollute water, air, and soil around the world, and ever-increasing greenhouse gas emissions mean that sustainability is now in doubt [1]. In response to these critical concerns, the world has come up with several initiatives including Agenda 2030. Agenda 2030 is a commitment to eradicate poverty and achieve sustainable development worldwide, ensuring that no one is left behind by 2030. Its adoption was a landmark achievement, providing a shared vision towards sustainable development for all. Its 17 Sustain…

The broad phenotypic spectrum of PPP2R1A -related neurodevelopmental disorders correlates with the degree of biochemical dysfunction

2021

PURPOSE: Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A) dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA, and more rarely in PPP2R1A. Here, we aimed to better understand the latter by characterizing 30 individuals with de novo and often recurrent variants in this PP2A scaffolding Aα subunit. METHODS: Most cases were identified through routine clinical diagnostics. Variants were biochemically characterized for phosphatase activity and interaction with other PP2A subunits. RESULTS: We describe 30 individuals with 16 different variants in PPP2R1A, 21 of whom had variants not previously reported. The severity of developmental delay …

Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia

2021

BackgroundT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a poor cure rate for relapsed/resistant patients. Due to the lack of T-cell restricted targetable antigens, effective immune-therapeutics are not presently available and the treatment of chemo-refractory T-ALL is still an unmet clinical need. To develop novel immune-therapy for T-ALL, we generated an afucosylated monoclonal antibody (mAb) (ahuUMG1) and two different bispecific T-cell engagers (BTCEs) against UMG1, a unique CD43-epitope highly and selectively expressed by T-ALL cells from pediatric and adult patients.MethodsUMG1 expression was assessed by immunohistochemistry (IHC) on a wide panel of normal t…

Influence of habitual dairy food intake on LDL cholesterol in a population-based cohort

2021

Background: Cholesterol has a pivotal role in human physiology, exerting both structural and functional activity. However, higher blood cholesterol levels, especially low-density lipoprotein cholesterol (LDL-C), are a major cardiovascular risk factor. Therefore, special attention has been given to the effect of dietary factors in influencing LDL-C blood levels. In particular, much research has focused on dairy products, since they are a main component of different dietary patterns worldwide. A large body of evidence did not support the hypothesis that dairy products significantly increase circulating LDL-C, but no definitive data are available. Hence, we aimed to assess the relationships am…

Arqueología del futuro en el barrio El Raval de Barcelona: a propósito de tres inercias del urbanismo tecnocrático y sus efectos indeseables

2021

Este artículo es el resultado de nuestro esfuerzo analítico para comprender cómo se han pensado y practicado intervenciones urbanísticas, extremadamente drásticas, contra el barrio El Raval de Barcelona en períodos formalmente democráticos. Lo que consideramos original de nuestra propuesta analítica es la identificación de una suerte de doxa tecnocrática que habría impregnado el urbanismo –también el barcelonés- desde sus inicios, y que acabará caracterizando el aclamado tanto como discutido “Modelo Barcelona”. La metodología utilizada proviene de la antropología histórica y de la sociología urbana. Nuestro prisma teórico entrecruza perspectivas historiográficas como la biopolítica, socioló…

Przyczynek do biografii kardynała Jana Maurycego Puzyny (1842–1911)

2021

Kardynał Jan Duklan Maurycy Paweł Puzyna należy do tych postaci, zapisanych na kartach historii Polski, których działalność budzi do dziś wątpliwości i kontrowersje. Podejmowane przez niego niepopularne decyzje stały się główną przyczyną tego, że stał się on z czasem symbolem odchodzącego świata idei konserwatywnych, zmarginalizowanych na przełomie XIX i XX stulecia przez rozwój nowoczesnych ruchów politycznych i światopoglądowych. W strukturach Kościoła kardynał Puzyna kojarzony jest do dziś głównie z ostatnią oficjalną próbą bezpośredniej ingerencji władzy świeckiej w proces wyboru papieża, co miało miejsce w trakcie pamiętnego konklawe w 1903 r.
 Zasadniczym celem, który postawił so…

Problematic Social Media Use and Health among Adolescents

2021

1) Background: The use of social media has become an integral part of adolescents’ daily lives. However, the intensive use of social media can develop into a health-threatening addiction, but unfavourable health consequences can occur even with less use. Social media user groups categorized as no-risk, moderate risk (of developing problematic behaviour), and problematic use were examined with reference to their prevalence, their associations with individual determinants and health, and the increased health risk between groups. (2) Methods: The Finnish nationally representative HBSC data (persons aged 11, 13, and 15, n = 3408) and descriptive and binary logistic regression analysis were appl…

The development of school well-being in secondary school: High academic buoyancy and supportive class- and school climate as buffers

2021

Abstract Students experience increasing pressure to perform well and worry about their academic performance before critical school transitions. These challenges may compromise students' school well-being. Drawing on the Model of Personality and Affect for Education (Matthews et al., 2005) as well as on the Conservation of Resources Theory (Hobfoll, 1989), we investigated the buffering role of high academic buoyancy and supportive class- and school climate against decreases in school well-being (i.e., school-related stress, anti-school attitude, and satisfaction with school) among Finnish lower secondary school students (N = 1024) from grades seven to nine. Controlling for gender, fluid inte…

Development of a Reference Database for Beta-Delayed Neutron Emission

2021

Beta-delayed neutron emission is important for nuclear structure and astrophysics as well as for reactor applications. Significant advances in nuclear experimental techniques in the past two decades have led to a wealth of new measurements that remain to be incorporated in the databases. We report on a coordinated effort to compile and evaluate all the available beta-delayed neutron emission data. The different measurement techniques have been assessed and the data have been compared with semi-microscopic and microscopic-macroscopic models. The new microscopic database has been tested against aggregate total delayed neutron yields, time-dependent group parameters in 6-and 8-group re-present…

Intérêt en EHPAD du robot émotionnel Pepper dans les troubles neurocomportementaux de la maladie d’Alzheimer

2021

International audience; Can geriatric technologies really be effective among elderly people with Alzheimer's dementia and living in institutions? Our controlled, randomized, single-blind, comparative study attempted to answer this question. The study was conducted in two nursing homes among 31 subjects with an average age of 79.4 ± 6.9, and an average MMSE score of 12.2 ± 3.6. The results show that the Pepper robot, compared to a soft toy, is capable not only of entertaining, but above all of inducing qualitative and quantitative clinical effects. During the 20-minute sessions, a decrease in apathy was observed with Pepper (6.7 ± 6.5 min vs. 18.4 ± 3.8 min, P < 0.001), a decrease in ambulat…

A dynamic panel study on digitalization and firm's agility: What drives agility in advanced economies 2009–2018

2021

Abstract Firm agility today is not a factor of competitiveness or success but a survival instrument on the market. Disruptive innovations and technological advancement, together with digitalization, change the role of firm agility. We show that the link between the national/industry level of digitalization and firm agility is statistically robust and essential. We study the link on data from 2009 to 2018 in fifteen EU advanced economies using dynamic panel data modeling. The digitalization impact level differs across firms by ownership type (family to non-family firms). Agility in family firms is strongly influenced by the national/industry level of digitization and investments in intangibl…

Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases

2021

Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continuously growing. Curcumin has been proposed for the treatment of several of these pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to the ability of this molecule to reduce inflammation and aggregation of involved proteins. Nevertheless, the poor metabolic stability and bioavailability of curcumin reduce the possibilities of its practical use. For these reasons, many curcumin derivatives were synthetized in order to overcome some limitations. In this review will be highlighted recent results on modification of curcumin scaffold in the search of new effective therap…

Prevention of venous thromboembolic events occurring in myeloma patients treated with second-generation novel agents

2021

Thrombosis and neoplasms are strictly linked, and the diagnosis of a malignancy is a relevant risk factor for venous thromboembolism (VTE). In particular, between gammopathies, the VTE risk is known to be increased in both monoclonal gammopathy of uncertain significance and in multiple myeloma, with a 3- and 9-fold increase respectively, when compared to the general population. The risk appears to be further increased in patients treated with immunomodulating drugs, such as thalidomide, especially when in combination with dexamethasone or conventional cytotoxic chemotherapies, and lenalidomide. In 2008 the International Myeloma Working Group put out thrombosis prophylaxis recommendations fo…

Water retention characteristics of substrates containing biochar and compost as peat and perlite replacements for ornamental plant production

2021

In Italy peat and perlite are commonly used as growth substrates in ornamental plant nurseries. Requests for ecologically sustainable growth substrates have recently focused research on the study of new media. In this context, biochar and compost, by-products of other production chains, may play a relevant role. Four growth substrates were prepared by mixing (v/v) different porous matrices including a 2-mm sieved sandy loam soil namely: 50% peat and 50% perlite (PPr), 50% compost and 50% biochar (CB), 25% peat, 25% perlite, 25% compost and 25% biochar (PPrCB) and 25% peat, 25% compost and 50% mineral soil (PCM). Water retention curves of porous matrices and growth substrates were determined…

Harnessing TH9 cells in cancer immunotherapy

2021

CD4 T cell effector subsets not only profoundly affect cancer progression, but recent evidence also underscores their critical contribution to the anticancer efficacy of immune checkpoint inhibitors. In 2012, the two seminal studies suggested the superior antimelanoma activity of TH9 cells over other T cell subsets upon adoptive T cell transfer. While these findings provided great impetus to investigate further the unique functions of TH9 cells and explore their relevance in cancer immunotherapy, the following questions still remain outstanding: are TH9 cell anticancer functions restricted to melanoma? What are the factors favouring TH9 cell effector functions? What is the contribution of T…

Gender differences in technical-tactical behaviour of La Liga Spanish football teams

2021

[Abstract] The aim of this study was to identify differences in technical-tactical behaviour between the men and women first division football teams of the Spanish league, to this end 68 matches corresponding to 2016/17 season were analysed. A comparative analysis of the medians was carried out using the Mann-Whitney U-tests were conducted as post hoc tests. The size effect of this test was calculated and, finally, we performed a grouping of the variables through the clustering bootstrapping technique in both groups. We have detected statistically significant differences (p <0.01) regarding all accurate passes, in favour of men, as well as a greater number of yellow cards. In female footbal…

Insights into the effect of the spacer on the properties of imidazolium based AIE luminogens

2021

Abstract With the aim to obtain organic salts with potential applications in high performance molecular electronics, we combined properties of π-conjugated spacers, like 1,4-diethynylbenzene and 1,6-diethynylpyrene, with the ones of both imidazole and imidazolium units. Physico-chemical properties of obtained fluorescent organic salts were investigated performing thermo-gravimetric analysis (TGA), differential scanning calorimetry (DSC) and cyclic voltammetry measurements (CV). Photophysical behavior of the salts was analyzed in conventional solvents and ionic liquids, by UV–vis and fluorescence investigation. Solution phase aggregation study revealed that these salts self-assemble in conve…

Development of a fast characterization setup for radionuclide generators demonstrated by a 227Ac-based generator

2021

Abstract The development of a setup for a fast online characterization of radionuclide generators is reported. A generator utilizing the mother nuclide 227Ac sorbed on a cation exchange resin is continuously eluted by using a peristaltic pump. To allow continuous and pulse-free elution of a large volume over extended time periods a 3D-printed interface designed to remove pressure-oscillations induced by the pump was placed between pump and generator column to ensure undisturbed generator elution. The eluate of the generator is passed through a 3D printed flow cell placed inside a borehole Na(Tl)-scintillation detector for high counting efficiency. Alternatively, a HPGe detector suitable for…

Théorie et pratique du jouet dans la première moitié du XXe siècle

2021

International audience

Small pelagic fish in the new millennium: A bottom-up view of global research effort

2021

The present review is an outcome of discussions at the ICES-PICES Symposium on Drivers of Dynamics of Small Pelagic Fish convened in Victoria, B.C., Canada in spring 2017.-- This review is a first contribution of a new international Working Group on Small Pelagic Fish started jointly by ICES (WGSPF) and PICES (WG43) to continue world-wide collaboration to advance knowledge on the drivers of populations of SPF.

Prevalence and Potential Risk Factors of Helicobacter pylori Infection among Asymptomatic Individuals in Kazakhstan

2021

Background: Helicobacter pylori (H. pylori) infection is associated with several risk factors such as demographic, socioeconomic status and personal habits, which vary in different populations. This is the most up-to-date data on H. pylori prevalence and potential risk factors for H. pylori infection among asymptomatic middle-aged individuals in Kazakhstan. Methods: Apparently healthy individuals aged 40 to 64, who took part in the health control in the outpatient clinic, were invited to participate in the study; answered a questionnaire, donated a blood sample. The antibodies to H. pylori were analysed by latex agglutination method. The baseline characteristics of study subjects with or wi…

Diagnosis and management of silent coronary ischemia in patients undergoing carotid endarterectomy.

2021

Abstract Background Coronary artery disease is the primary cause of death in patients with carotid artery disease and silent ischemia is a marker for adverse coronary events. A new noninvasive cardiac diagnostic test, coronary computed tomography-derived fractional flow reserve (FFRCT) can reliably identify ischemia-producing coronary stenosis in patients with coronary artery disease and help to select patients for coronary revascularization. The purpose of this study is to determine the prevalence of silent coronary ischemia in patients undergoing carotid endarterectomy (CEA) and to evaluate the usefulness of FFRCT in selecting patients for coronary revascularization to decrease cardiac ev…

Mortality Risk Assessment at the Admission in Patient With Proximal Femur Fractures: Electrolytes and Renal Function

2021

In patients over 65y.o. who were surgically treated for a hip fracture, electrolytes have not been specifically studied as predictors of mortality. The main purpose of this study was to assess whether electrolytes and chronic kidney disease (CKD) stages, evaluated at admission, could represent a pre-operative prognostic factor in this population. Moreover, the role of epidemiological and clinical parameters was analyzed with and without a surgical timing stratification. This retrospective study included 746 patients. For each patient, their age, gender, fracture classification, Hb value, comorbidities, ASA class, chronic kidney disease, creatinine levels, electrolytes and surgical timing w…

Use of platelet concentrate gel in second-intention wound healing: a case report.

2021

Abstract Background Wound healing is a complex and dynamic process. Healing of acute and chronic wounds can be impaired by patient factors (that is, comorbidities) and/or wound factors (that is, infection). Regenerative medicine products, such as autologous/homologous platelet-rich plasma gel, may speed up the healing process. Autologous/homologous platelet-rich plasma is an advanced wound therapy used for hard-to-heal acute and chronic wounds. The cytokines and growth factors contained in platelet-rich plasma play a crucial role in the healing process. Case presentation A 61-year-old Caucasian male patient, suffering from mental retardation following meningitis, with a transplanted kidney …

Laparoscopy for Abdominal Testes: Nationwide Analysis of German Routine Data

2021

Introduction: Laparoscopy has been used for the evaluation of impalpable testes for more than 30 years. However, its use for intra-abdominal testes has never been evaluated in a population-based ap...