showing 36 of ~574560 from 574555 documents
Study of BESIII trigger efficiencies with the 2018 J/psi data
2021
Using a dedicated data sample taken in 2018 on the $J/\psi$ peak, we perform a detailed study of the trigger efficiencies of the BESIII detector. The efficiencies are determined from three representative physics processes, namely Bhabha-scattering, dimuon production and generic hadronic events with charged particles. The combined efficiency of all active triggers approaches $100\%$ in most cases with uncertainties small enough as not to affect most physics analyses.
Role of antiangiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction
2021
Abstract Introduction and objectives Angiogenesis helps to reestablish microcirculation after myocardial infarction (MI). In this study, we aimed to further understand the role of the antiangiogenic isoform vascular endothelial growth factor (VEGF)-A165b after MI and to explore its potential as a coadjuvant therapy to coronary reperfusion. Methods Two mice MI models were formed: a) permanent coronary ligation (nonreperfused MI); b) transient 45-minute coronary occlusion followed by reperfusion (reperfused MI); in both models, animals underwent echocardiography before euthanasia at day 21 after MI induction. We determined serum and myocardial VEGF-A165b levels. In both experimental MI models…
Monitoring the Internal and External Loads of Young Team Handball Players during Competition
2021
This study aimed to examine the internal- and external-training-load (ITL and ETL, respectively) during a match of young handball players. Field testing included heart-rate monitoring (memory belt, Suunto) as a marker of ITL and accelerometry (motion-biosensor, Actical Respironcis, Philips) as a marker of ETL. Time motion analysis data were obtained by recording the player’s game activities and later analysed with the Matlab software package. T-test and Pearson-product-moment correlation coefficient were used to examine the differences and the relationship between variables collected in the study. The t-test analysis did not show significant differences between the total distance covered (2…
Root canal shaping of curved canals by Reciproc Blue system and Pro Taper Gold: A micro-computed tomographic study
2021
Background This study aimed to evaluate the centralization and transportation of ProTaper Gold (PTG) rotary system and Reciproc Blue (RB) reciprocating system in curved canals, by using micro-CT. Material and Methods Twenty extracted mandibular molars were previously scanned by using the SkyScan 1174 microtomograph to select the Vertucci IV anatomic type. The specimens were divided into two groups (n=10) according to the mechanized system used to prepare the root canals. The teeth were scanned by micro-CT to calculate the increase volume, percentage of dentin removed, remaining dentin thickness, structure model index (SMI), degree of transportation and centering ability of root canals. The …
Multicompartmental Lipopolyplex as Vehicle for Antigens and Genes Delivery in Vaccine Formulations
2021
Vector design and its characterization is an area of great interest in current vaccine research. In this article, we have formulated and characterized a multicompartmental lipopolyplex, which associates multiple liposomes and polyplexes in the same complex. These particles allow the simultaneous delivery of lipid or water-soluble antigens associated with genes to the same cell, in much higher amounts than conventional lipopolyplexes. The vector characterization and optimization were carried out using liposomes with entrapped carboxyfluorescein and adapted electrophoretic assays. Two types of lipopolyplexes (containing hydrophilic or lipophilic antigens) were employed to evaluate their inter…
Flexible modelling of the risks associated with donor sex and age of blood on survival after red blood cell transfusion
2021
Etat de la question Les etudes realisees jusqu’a present en epidemiologie transfusionnelle affichent des resultats contradictoires sur l’association entre caracteristiques du CGR et la mortalite du patient receveur. La prise en compte des transfusions repetees de concentres de globules rouges (CGR) dans la survie est un domaine methodologiquement complexe, pouvant expliquer le manque de consensus scientifique. L’objectif de notre etude etait d’analyser l’impact du sexe du donneur et de la duree de conservation sur la survie par modele flexibles de type « Weighted Cumulative Exposure » (WCE) et de comparer les resultats au modele de Cox. Materiel et methodes Cette etude de survie a ete reali…
Approximation of functions over manifolds : A Moving Least-Squares approach
2021
We present an algorithm for approximating a function defined over a $d$-dimensional manifold utilizing only noisy function values at locations sampled from the manifold with noise. To produce the approximation we do not require any knowledge regarding the manifold other than its dimension $d$. We use the Manifold Moving Least-Squares approach of (Sober and Levin 2016) to reconstruct the atlas of charts and the approximation is built on-top of those charts. The resulting approximant is shown to be a function defined over a neighborhood of a manifold, approximating the originally sampled manifold. In other words, given a new point, located near the manifold, the approximation can be evaluated…
Revealing colonial power relations in early childhood policy making: An autoethnographic story on selective evidence
2021
The COVID-19 pandemic exposes uncertainty, instability and glaring inequality that requires urgent global policy decisions. Historically, bureaucrats regard uncertainty as the enemy and look for tested solutions (Stevens, 2011). In contrast, Fielding & Moss (2010) acknowledge an uncertain future and encourage shifting policy making towards the search for possibilities instead of replicating singular solutions. Escobar (2020) advocates for pluriversal politics, with many possibilities created through collective decision-making by autonomous interlinked networks. In this paper, I combine autoethnography with policy analysis drawing on my own experience in South African early childhood pol…
Breastfeeding and COVID-19 vaccination: position statement of the Italian scientific societies
2021
AbstractThe availability of a COVID-19 vaccine has raised the issue of its compatibility with breastfeeding. Consequently, the Italian Society of Neonatology (SIN), the Italian Society of Pediatrics (SIP), the Italian Society of Perinatal Medicine (SIMP), the Italian Society of Obstetrics and Gynecology (SIGO), the Italian Association of Hospital Obstetricians-Gynecologists (AOGOI) and the Italian Society of Infectious and Tropical Diseases (SIMIT) have made an ad hoc consensus statement. Currently, knowledge regarding the administration of COVID-19 vaccine to the breastfeeding mother is limited. Nevertheless, as health benefits of breastfeeding are well demonstrated and since biological pl…
Influence of different photoinitiators on the resistance of union in bovine dentin: Experimental and microscopic study
2021
Background To evaluate in vitro the influence of photoinitiators on the microtensile strength of adhesive systems and composite resins in bovine dentin. Material and Methods Forty dentin obtained from bovine teeth were randomly distributed in four groups (n = 10) according to the different adhesive systems and composite resins used: G1 - AAPS + VAPS (Ambar APS + Vittra APS); G2- AAPS + O (Ambar APS + Opallis); G3 - A + VAPS (Ambar + Vittra APS) and G4 - A + O (Ambar + Opallis). After restoration with the composite, the samples were sectioned to obtain toothpicks that were subjected to the microtensile and nanofiltration test (1.0 mm/min). Results The Kruskal-Wallis test did not show signifi…
A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients
2021
Objectives To examine whether specific T-cell-responses to SARS-CoV-2 peptides can be detected in COVID-19 using a whole-blood experimental setting, which may be further explored as potential diagnostic tool. Methods We evaluated IFN-γ levels after stimulating whole-blood with spike and remainder-antigens peptides megapools (MP) derived from SARS-CoV-2 sequences; IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17A, eotaxin, basic FGF, G-CSF, GM-CSF, IFN-γ, IP-10, MCP-1, MIP-1α, MIP-1β, PDGF, RANTES, TNF-α, VEGF were also evaluated. Results IFN-γ-response to spike and remainder-antigens MPs was significantly increased in 35 COVID-19-patients compare…
C3 Drives Inflammatory Skin Carcinogenesis Independently of C5
2021
Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (cSCC) is the most common form of cancer and can occur as a consequence of DNA damage to the epithelium by UVR or chemical carcinogens. There is growing evidence that the complement system is involved in cancer immune surveillance; however, its role in cSCC remains unclear. Here, we show that complement genes are expressed in tissue from patients with cSCC, and C3 activation fragments are present in cSCC biopsies, indicating complement activation. Using a range of complement-deficient mice in a two-stage mouse model of chemically-induced cSCC, where a subclinical dose of 7,12-dimethylbenz[a]anthracene causes oncogenic mutatio…
Experiments on tritium generation and yield from lithium ceramics during neutron irradiation
2021
Abstract The vacuum extraction method with a mass spectrometry registration of tritium is presented in paper. It can provide a full-range analysis of gas phase composition in the chamber with samples under neutron irradiation. Lithium ceramics Li2TiO3 in the form of pebbles with lithium enrichment on 6Li isotope of 96% was examined. The paper shows the results of reactor experiments on study the extraction of tritium-containing molecules from lithium ceramics Li2TiO3 at various temperatures and reactor power levels at the WWR-K research reactor (Almaty, Kazakhstan). The time dependences of tritium yield from the ampoule with ceramics during reactor irradiation were obtained. Near-surface co…
Crystallographic and (spectro)electrochemical characterizations of cobalt(II) 10-phenyl-5,15-di-p-tolylporphyrin
2021
International audience; The synthesis, cyclic and rotating disk electrode voltammograms, UV-visible absorption and Xray diffraction analyses of cobalt(II) 10-phenyl-5,15-dip -tolylporphyrin (1-Co) are described. 1-Co was crystallized by slow diffusion of n-hexane into a concentrated CH2Cl2 solution. X-ray diffraction analyses reveals porphyrin aromatic cycle stacking in the crystal, C-H•••π interactions of the CH2Cl2 solvent with the π-system of one tolyl group and Co(II)•••π (porphyrin ring) interactions. The abstraction of 1.0 F/mol during the electrolysis at the first oxidation potential was followed by spectroelectrochemistry. It leads to the Co(II) → Co(III) transformation rather than …
Psychometrics of the Spanish Version of the Screen for Adult Anxiety Related Disorders (SCAARED)
2021
Objectives: To translate and validate the Screen for Adult Anxiety Related Disorders (SCAARED) questionnaire into Spanish.Method: The original SCAARED was translated into Spanish and administered to a non-clinical sample of 131 university students (92.4% women, mean age 22 years) in Valencia, Spain. To assess the concurrent validity of the SCAARED, the Depression, Anxiety and Stress Scale−21(DASS) and the Beck's Anxiety Inventory (BAI) were also administered. Test-retest reliability was evaluated 2 weeks after the first administration.Results: The internal consistency of SCAARED was high (α = 0.91) and the stability of the measurement was also high (test-retest 0.81). The results of the Exp…
Information quality life cycle in secondary use of EHR data
2021
Abstract The paper argues that existing research on information quality (IQ) mainly focuses on the primary use of electronic health record (EHR) data, whereas IQ in secondary use of EHR data needs further deliberation. The current view of IQ in a healthcare context is static. It assumes that once the EHR system generates the information product, individual users may act on the information based on their subjective perception of its quality. However, this view ignores the complexities of secondary use of EHR data, in which users are actively involved in (re)generating and communicating the information product. Thus, IQ does not remain static but keeps on transforming through active engagemen…
Gender differences in bicycle sharing system usage in the city of Valencia
2021
Abstract Bicycle sharing systems (BSS) in cities are an environmentally friendly alternative to fossil-fuel-based transport. Among the different factors that influence its use, the scientific literature points out that there are gender differences in the frequency of trips made. The present study analysed the movements of men and women who use the BSS in the city of Valencia during weekdays. Our database contained a total of 5,300,328 trips by users over a period of 4 years. Ridership networks were constructed through user's trips (arcs) between the bicycle exchange stations (nodes). Different parameters of centrality and density of the generated networks were calculated, and the Voronoi sp…
Les difficultés de la construction d’un registre explicatif de la formation des chaînes de montagnes par des apprenants confrontés à un texte histori…
2021
En sciences de la terre et dans le cadre de la théorie de la tectonique des plaques, les processus orogéniques peuvent être difficiles à concevoir par des lycéens et des enseignants. Dans ce papier, on s’interroge, par le biais d’un questionnaire, sur les difficultés à la construction d’un registre explicatif de la formation des chaînes de montagnes par les apprenants. Nous confrontons aussi, dans un atelier-débat, les explications de l’orogenèse proposées par des enseignants à celles avancées par Avicenne. Les registres explicatifs des apprenants sont multiples et l’usage de l’histoire des sciences leur a permis de travailler dans un registre explicatif mobiliste.
Corresponding doses of mometasone furoate (MF) in once-daily inhaled fixed-dose combination (FDC) of indacaterol/mometasone furoate (IND/MF) and inda…
2021
The broad phenotypic spectrum of PPP2R1A -related neurodevelopmental disorders correlates with the degree of biochemical dysfunction
2021
PURPOSE: Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A) dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA, and more rarely in PPP2R1A. Here, we aimed to better understand the latter by characterizing 30 individuals with de novo and often recurrent variants in this PP2A scaffolding Aα subunit. METHODS: Most cases were identified through routine clinical diagnostics. Variants were biochemically characterized for phosphatase activity and interaction with other PP2A subunits. RESULTS: We describe 30 individuals with 16 different variants in PPP2R1A, 21 of whom had variants not previously reported. The severity of developmental delay …
Changes in Energy Status of Saccharomyces cerevisiae Cells During Dehydration and Rehydration
2021
Anhydrobiosis is the state of life when cells are exposed to waterless conditions and gradually cease their metabolism. In this study, we determined the sequence of events in Saccharomyces cerevisiae energy metabolism during processes of dehydration and rehydration. The intensities of respiration and acidification of the medium, the amounts of phenyldicarbaundecaborane (PCB−) bound to yeast membranes, and the capabilities of cells to accumulate K+ were assayed using an electrochemical monitoring system, and the intracellular content of ATP was measured using a bioluminescence assay. Mesophilic, semi-resistant to desiccation S. cerevisiae strain 14 and thermotolerant, very resistant to desic…
Near-normal aerobic capacity in long-term survivors after lung transplantation
2021
The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testin…
Evaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomes
2021
This study was focused on the estimation of the targeted modification of 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties of 1,4-DHP (C12, C14 and C16)
Response to “letter to editor effect of a brief progressive resistance training program in hospital porters on pain, work ability and physical functi…
2021
Effects of external imbalances on GDP recovery patterns
2021
Abstract A decade after the beginning of the Great Recession, flow external imbalances, measured by the current account (CA) have narrowed markedly. However, stock or net foreign assets (NFA) imbalances have kept increasing and have created challenges for future macroeconomic and financial stability. To date, early warning systems (scoreboards) have focused more on flow than on stock variables. To approach this problem, in this paper we analyze expansions using two complementary sets of indicators proposed by Harding and Pagan (2002) and Gadea et al. (2017) for the period 1950–2016. After controlling for a large set of explanatory variables, we find that the effect of CA imbalances is limit…
The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An Overview
2021
The relationship between gut microbiota and neurodegenerative diseases is becoming clearer. Among said diseases amyotrophic lateral sclerosis (ALS) stands out due to its severity and, as with other chronic pathologies that cause neurodegeneration, gut microbiota could play a fundamental role in its pathogenesis. Therefore, polyphenols could be a therapeutic alternative due to their anti-inflammatory action and probiotic effect. Thus, the objective of our narrative review was to identify those bacteria that could have connection with the mentioned disease (ALS) and to analyze the benefits produced by administering polyphenols. Therefore, an extensive search was carried out selecting the most…
Les processus d’auto-sélection : le cas de la Garantie jeunes
2021
Colloque organisé en ligne; International audience; Cette communication s’intéresse à l’auto-sélection des bénéficiaires du dispositif Garantie jeunes. L’originalité de notre recherche tient à la notion de compétences sociales puisque l’on suppose que le jeune va mobiliser un certain nombre d’entre elles à l’entrée du dispositif puis tout au long de celui-ci. En effet, nos résultats démontrent que la façon dont le dispositif est appréhendé par les bénéficiaires dépend en partie de ces compétences mais aussi du parcours antérieur, à la fois scolaire et professionnel.
Spectral and structural insights of copper reduction pathways in the system of CuX2-R2S (X=Cl, Br; R=allyl, n-propyl)
2021
Abstract We have explored the behaviour of Cu(II)/Cu(I) redox couple in the system CuX2-R2S, X = Cl, Br; R = allyl, n-propyl, under anhydrous and anaerobic conditions, thus simulating the reduction half cycle in the copper catalyzed oxidation of thioethers. In doing so, the Cl−Br substitution was critical for tuning the reduction potentials, while the replacement of propyl group by allyl group supported the trapping of oxidation by-product, halogen molecules. It was therefore possible to use the spectrophotometric titration, thereby providing information on the distribution of complex species in acetonitrile solution. The study showed that the trinuclear mixed−valence copper (I-II-II) aggre…
The role of emotion dysregulation in adolescents’ problematic smartphone use: A study on adolescent/parents triads
2021
Abstract The pervasive use of mobile phones among adolescents has led researchers to evaluate the role of parental characteristics in connection with their children's problematic smartphone use (PSU). The present study involved mother/father/adolescent triads and aimed to test a model examining the role of both parents' and adolescents' emotion dysregulation (ED) in predicting children's PSU. Two hundred and fifty-two adolescent (57.5% females; M age = 13.54, SD = 0.73)/mother (M age = 43.92, SD = 4.46)/father (M age = 47.60, SD = 5.10) triads provided measures of PSU and ED. Results from path model showed that, after controlling for adolescents' age and gender as well as for parents' age a…
Centralised or decentralised banking supervision? Evidence from European banks
2021
Abstract This paper analyses the impact of the Banking Union on European bank credit risk. Specifically, we investigate the effect that the establishment of the Single Supervisory Mechanism has had on the credit risk of the banks it supervises in comparison to financial institutions that are still supervised by National Supervisory Authorities. We analyse a sample of 746 European banks over the period 2011–2018, by means of a difference-in-differences methodology. We provide empirical evidence that Single Supervisory Mechanism supervised banks reduced credit risk exposure compared to banks supervised by National Supervisory Authorities, suggesting that the Banking Union has successfully red…
Narratives and Counter-Narratives about Radicalization: Experiences of Moderation of an Online Communication Campaign
2021
This paper presents the results of a cyber-ethnographic study. The research analyzes the dynamics that make, calm and increase the radicalization narratives. This study is part of the Oltre project (ISF - DG Migration and Home Affairs, EU) which directly involved 42 Italian and second generation youths in the dissemination and moderation of an online communication campaign in order to prevent radicalized behaviors. This paper illustrates how the young “moderators” interacted each other, highlighting how counter-narratives can represent useful tools for deconstructing "complex" issues such as radicalization. Furthermore, the paper shows (using social network analysis) how on the social media…
La consegna educativa
2021
Una rilettura critica del saggio “La consegna”, di Antonio Bellingreri. La riflessione, di pedagogia fondamentale e filosofia dell’educazione, è volta ad indagare i tratti costitutivi, ovvero l’essenza, della persona umana, a partire da un’analisi dell’epoca contemporanea, restituitaci dalla letteratura come tardo-moderna. Di una gioventù privata di significativi modelli di comportamento e sistemi valoriali, diffidente del passato non meno che del futuro, intende farsi carico l’educazione, privilegiato strumento per re-immettere in circolo valori e significati smarriti. Divenendo consegna, la relazione educativa risponde al bisogno posto al fondo della persona umana (il bisogno di riconosci…
The usefulness of NEWS2 at day 7 of hospitalization in predicting COVID-19 evolution and as an early endpoint in therapeutic trials
2021
Highlights • There is a need for reliable tools to predict the evolution of hospitalized patients suffering from COVID-19 • The likelihood of unfavourable evolution for patients hospitalized for COVID-19 with a National • Early Warning Score 2 (NEWS2) below 7 at Day 7 of hospitalization is nearly non-existent • Such a score could thus be used to allow earlier discharge of the patients and as a judgement criterion in therapeutic trials
ReMindCare, an app for daily clinical practice in patients with first episode psychosis: A pragmatic real-world study protocol.
2021
[EN] Aim Despite the potential benefits of e-health interventions for patients with psychosis, the integration of these applications into the clinical workflow and analysis of their long-term effects still face significant challenges. To address these issues, we developed the ReMindCare app. This app aims to improve the treatment quality for patients with psychosis. We chose to study the app in real world and pragmatic manner to ensure results will be generalizable. Methods This is a naturalistic empirical study of patients in a first episode of psychosis programme. The app was purpose-designed based on two previous studies, and it offers the following assessments: (a) three daily questions…
Toeplitz band matrices with small random perturbations
2021
We study the spectra of $N\times N$ Toeplitz band matrices perturbed by small complex Gaussian random matrices, in the regime $N\gg 1$. We prove a probabilistic Weyl law, which provides an precise asymptotic formula for the number of eigenvalues in certain domains, which may depend on $N$, with probability sub-exponentially (in $N$) close to $1$. We show that most eigenvalues of the perturbed Toeplitz matrix are at a distance of at most $\mathcal{O}(N^{-1+\varepsilon})$, for all $\varepsilon >0$, to the curve in the complex plane given by the symbol of the unperturbed Toeplitz matrix.