showing 36 of ~574560 from 574555 documents
Simulation of granular organic fertilizer application by centrifugal spreader
2021
There is no specialized equipment designed to spread granular cylindrical organic fertilizer in the soil. There are also no rational recommendations available on how to spread this type of fertilizer. Mineral fertilizer spreaders are most often used for spreading granulated organic fertilizer. However, these fertilizers are significantly different from mineral fertilizers. Due to these differences, organic granular fertilizers often are spread unevenly, and the fertilizer does not reach the required working width. Furthermore, the rate of spreading is not accurate, and the fertilizer is often crushed too much. The objective of this research is to develop a simulation model for granular orga…
Time for AI (Ethics) maturity model is now
2021
Publisher Copyright: Copyright © 2021 for this paper by its authors. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0). There appears to be a common agreement that ethical concerns are of high importance when it comes to systems equipped with some sort of Artificial Intelligence (AI). Demands for ethical AI are declared from all directions. As a response, in recent years, public bodies, governments, and universities have rushed in to provide a set of principles to be considered when AI based systems are designed and used. We have learned, however, that high-level principles do not turn easily into actionable advice for practitioners. Hence, also companie…
Risks Associated with the Use of Garcinia as a Nutritional Complement to Lose Weight
2021
Nowadays, obesity is one of the great nutritional problems facing public health. The prevalence of this pathology has increased in a worrying way over recent years, currently reaching epidemic proportions. In this context, nutritional supplements are presented as a therapeutic alternative to which more and more people are turning to. Nutritional supplements to lose weight based on the Garcinia plant, specifically on Garcinia cambogia, are commonly used. The active principle of this plant to which these properties have been attributed, is hydroxycitric acid (HCA). The aim of the present review is to gather reported data concerning the effectiveness of nutritional supplements based on Garcini…
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma
2021
Simple Summary Osteosarcoma, Ewing’s sarcoma, and H3K27M-mutant diffuse midline glioma are rare but aggressive malignancies occurring mainly in children. Due to their rareness and often fatal course, drug development is challenging. Here, we repurposed the existing drugs dinutuximab and eliglustat and investigated their potential to directly target or indirectly modulate the tumor cell-specific ganglioside GD2. Our data suggest that targeting and/or modulating tumor cell-specific GD2 may offer a new therapeutic strategy for the above mentioned tumor entities. Abstract The ganglioside GD2 is an important target in childhood cancer. Nevertheless, the only therapy targeting GD2 that is approve…
Familial and Parental Predictors of Physical Activity in Late Adolescence: Prospective Analysis over a Two-Year Period
2021
Children’s health behaviors are highly influenced by their parents and family. This study aimed to prospectively evaluate the parental/familial factors associated with physical activity levels (PALs) among older adolescents. The participants were 766 adolescents, who were prospectively observed at baseline (when they were 16 years of age), at first follow-up measurement (FU1
Extracellular vesicles do not mediate the anti-inflammatory actions of mouse-derived adipose tissue mesenchymal stem cells secretome
2021
Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1422-0067/22/3/1375 Este artículo pertenece al número especial "The Role of Mesenchymal Stem Cells on Inflammatory and Fibrotic Diseases". Adipose tissue represents an abundant source of mesenchymal stem cells (MSC) for therapeutic purposes. Previous studies have demonstrated the anti-inflammatory potential of adipose tissue-derived MSC (ASC). Extracellular vesicles (EV) present in the conditioned medium (CM) have been shown to mediate the cytoprotective effects of human ASC secretome. Nevertheless, the role of EV in the anti-inflammatory effects of mouse-derived ASC is not known. The current study has investiga…
Photon bunching of the nonlinear photoluminescence emitted by plasmonics metals
2021
International audience; In this report, we investigate the statistical temporal distribution of nonlinear upconverted photoluminescence emitted by gold and silver nanostructures excited by focused near-infrared laser pulses. We systematically observe a clear signature of photon bunching regardless of the nano-object's geometry, material's crystalline arrangement, and electronic band structure. The similarity of the data obtained across very different plasmonic objects confirms that these types of nonlinear radiation share a common chaotic origin and result from a collection of emitters. The correlation of photons at a picosecond time scale released by nanoscale nonlinear sources of broadban…
Functional and bioactive properties of peptides derived from marine side streams
2021
In fish processing, a great amount of side streams, including skin, bones, heads and viscera, is wasted or downgraded as feed on a daily basis. These side streams are rich sources of bioactive nitrogenous compounds and protein, which can be converted into peptides through enzymatic hydrolysis as well as bacterial fermentation. Peptides are short or long chains of amino acids differing in structure and molecular weight. They can be considered as biologically active as they can contribute to physiological functions in organisms with applications in the food and pharmaceutical industries. In the food industry, such bioactive peptides can be used as preservatives or antioxidants to prevent food…
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metab…
2021
Gut: first published.
Flexi(nse)curity in adult webcamming: Romanian women’s experiences selling digital sex services under platform capitalism
2021
The global sex industry has undergone a tremendous transformation, and many different forms of commercial sex have emerged with the growth of digital media. The advent of ‘platform work’ in diverse...
Identification of Gip as a novel phage-encoded gyrase inhibitor protein featuring a broad activity profile
2021
AbstractBacteriophages represent a powerful source for the identification of novel antimicrobial proteins. In this study, a screening of small cytoplasmic proteins encoded by the CGP3 prophage of Corynebacterium glutamicum, resulted in the identification of the novel gyrase-inhibiting protein Cg1978 (Gip), which shows a direct interaction with the gyrase subunit A (GyrA). In vitro supercoiling assays further suggest a stabilization of the cleavage complex by Gip. Overproduction of Gip in C. glutamicum resulted in a severe growth defect as well as an induction of the SOS response. The cells adapted to gip overexpression by increasing expression levels of gyrAB and by reducing topA expression…
Teletrabajo docente durante el confinamiento por COVID19 en Argentina. Condiciones materiales y perspectivas sobre la carga de trabajo, la responsabi…
2021
En Argentina las medidas para enfrentar la pandemia del COVID 19 incluyeron la suspensión de las clases presenciales en todos los niveles educativos y la implementación de una política de continuidad educativa. El objetivo de este artículo es analizar, por un lado, cuáles han sido las condiciones materiales y temporales del teletrabajo docente al inicio del confinamiento. Por el otro, examina las percepciones docentes respecto del grado de participación en la toma de decisiones respecto de su tarea remota mediada por TIC; la carga mental que el teletrabajo forzado implicó; y su responsabilidad frente al sostenimiento de las trayectorias educativas de sus estudiantes. Nuestro abordaje se nut…
La educación en tiempos virales: el caso de Portugal
2021
Este artículo presenta una contribución para comprender los efectos de la pandemia de COVID-19 en la educación (básica y secundaria). Se centra en el proceso de confinamiento y la consiguiente transición hacia un modelo de enseñanza a distancia vivido en Portugal entre marzo y junio de 2020. Para ello, se empieza por buscar un marco teórico adecuado que permita comprender un fenómeno novedoso, imprevisible y que cuenta con un trasfondo biológico, pero que ha accionado un conjunto complejo de dinámicas políticas, económicas, sociales y culturales. A continuación, se discuten algunos informes internacionales relevantes. En la segunda parte, tras algunas notas metodológicas, se analizan los pr…
Data from: Choosy beetles: how host trees and southern boreal forest naturalness may determine dead wood beetle communities
2021
See methods section of paper for detailed information on dataset and sources; briefly, these .csv files includes numbers of each beetle species captured at all sites used in the project, as well as information about each site and about each species. Data from: Choosy beetles: how host trees and southern boreal forest naturalness may determine dead wood beetle communities Ryan C. Burner, Tone Birkemoe, Jörg G. Stephan, Lukas Drag, Jörg Muller, Otso Ovakainen, Mária Potterf, Olav Skarpaas, Tord Snall, Anne Sverdrup-Thygeson Forest Ecology and Management, 2021 From abstract of paper: Wood-living beetles make up a large proportion of forest biodiversity, and contribute to important ecosystem se…
Individual alpha peak frequency, an important biomarker for live Z-Score training neurofeedback in adolescents with learning disabilities
2021
Learning disabilities (LDs) have an estimated prevalence between 5% and 9% in the pediatric population and are associated with difficulties in reading, arithmetic, and writing. Previous electroencephalography (EEG) research has reported a lag in alpha-band development in specific LD phenotypes, which seems to offer a possible explanation for differences in EEG maturation. In this study, 40 adolescents aged 10–15 years with LDs underwent 10 sessions of Live Z-Score Training Neurofeedback (LZT-NF) Training to improve their cognition and behavior. Based on the individual alpha peak frequency (i-APF) values from the spectrogram, a group with normal i-APF (ni-APF) and a group with low i-APF (li-…
Inactivation of Pepper Mild Mottle Virus in Water by Cold Atmospheric Plasma
2021
Water scarcity is one of the greatest threats for human survival and quality of life, and this is increasingly contributing to the risk of human, animal and plant infections due to waterborne viruses. Viruses are transmitted through polluted water, where they can survive and cause infections even at low concentrations. Plant viruses from the genus Tobamovirus are highly mechanically transmissible, and cause considerable damage to important crops, such as tomato. The release of infective tobamoviruses into environmental waters has been reported, with the consequent risk for arid regions, where these waters are used for irrigation. Virus inactivation in water is thus very important and cold a…
Le poète comme cortège de voix : écrire et réciter la poésie dans l'oeuvre de Jacques Roubaud
2021
International audience; Anthologiste, traducteur, revuiste, Jacques Roubaud compte parmi ces poètes contemporains qui n'ont cessé de donner à entendre d'autres voix que la leur. Son oeuvre renoue avec la définition étymologique de la polyphonie comme pluralité de voix à cela près que le poète roubaldien se définit comme une mémoire de poésie qui cite et récite sans doute plus qu'elle ne chante. De la poésie médiévale japonaise aux chants indiens d'Amérique du Nord en passant par la poésie des troubadours, le sonnet de Marot à Malherbe et la poésie française de 1914 à 1932, Roubaud rejoue l'expérience enfantine de la récitation. Il fait ainsi de sa propre voix poétique un cortège voix famili…
Educación y brecha digital en tiempos del COVID-19. Perfiles y problemáticas experimentadas por el alumnado juvenil para continuar sus estudios duran…
2021
En este artículo analizamos los principales perfiles y problemáticas experimentadas por el alumnado de secundaria (obligatoria y postobligatoria) y de estudios universitarios para afrontar el curso académico durante el confinamiento debido a la pandemia del COVID-19. A partir de un análisis cuantitativo bivariado y multivariable, basado en la reciente investigación De puertas adentro y pantallas afuera. Jóvenes en confinamiento (Sanmartín et al., 2020), mostramos cómo los grupos sociales más vulnerables han tenido más dificultades para continuar con la educación online. Además, elaboramos una tipología de dificultades experimentadas por el alumnado (Q1-sin problemas importantes, Q2-problema…
The Relationship Between Salivary Redox, Diet, and Food Flavor Perception.
2021
The mouth is the gateway for entrance of food and microorganisms into the organism. The oral cavity is bathed by saliva, which is thus the first fluid that food and microorganisms will face after their entrance. As a result, saliva plays different functions, including lubrication, predigestion, protection, detoxification, and even transport of taste compounds to chemoreceptors located in the taste buds. To ensure its function of protection, saliva contains reactive harmful compounds such as reactive oxygen species that are controlled and neutralized by the antioxidant activity of saliva. Several antioxidant molecules control the production of molecules such as reactive oxygen compounds, neu…
Comportement alimentaire, facteurs psychosociaux et Indice de Masse Corporelle
2021
International audience
Reconstruction of the Parker spiral with the Reverse in situ data and MHD APproach - RIMAP
2021
The reconstruction of plasma parameters in the interplanetary medium is very important to understand the interplanetary propagation of solar eruptions and for Space Weather application purposes. Because only a few spacecraft are measuring in situ these parameters, reconstructions are currently performed by running complex numerical Magneto-hydrodynamic (MHD) simulations starting from remote sensing observations of the Sun. Current models apply full 3D MHD simulations of the corona or extrapolations of photospheric magnetic fields combined with semi-empirical relationships to derive the plasma parameters on a sphere centered on the Sun (inner boundary). The plasma is then propagated in the i…
Hormonal responsiveness in the Trier Social Stress Test and the dexamethasone‐corticotropin releasing hormone test in healthy individuals
2021
A number of different laboratory procedures investigate the hormonal response in a standardized pharmacological challenge test (dexamethasone-corticotropin releasing hormone; DEX-CRH) or in a psychosocial stress induction on the hypothalamic-pituitary-adrenocortical axis by the Trier Social Stress Test (TSST). However, the magnitude of the response related to the different stressors and the interaction of the responsiveness between the two tests is still unclear. Fifty-two participants underwent both the DEX-CRH test and the TSST on two separate days. The cortisol and the plasma adrenocorticotropic hormone (ACTH) release were assessed before and after the stress tests. For a specification o…
false
2021
Background: Immunomodulatory properties of bisphosphonates (BP) are suggested to contribute to the development of medication-associated osteonecrosis of the jaw (MRONJ). Furthermore, bisphosphonate-derived immune modulation might contribute to the anti-metastatic effect observed in breast cancer patients. Macrophages are potential candidates for the mediation of immunomodulatory effects of bisphosphonates. The study aimed to investigate the influence of bisphosphonates alone and in combination with surgical trauma on systemic macrophage polarization (M1 vs. M2) using an in vivo rat model. Methods: A total of 120 animals were divided into four groups. Groups 2 and 4 were treated with 8 × 40 …
Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol…
2021
Background: Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence.Methods: Sixty-eight hospitalized early-abstinence AD male patients and 68 age- and education-matched healthy controls (HCs) underwent resting-functional magnetic resonance imaging (r-f…
New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
2021
Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been paid to prevention, where diet plays a preponderant role. Recently, potential antioxidants such as resveratrol have received much attention as potential tools against various ocular diseases. In this review, we focus on the mechanisms of resveratrol against ocular diseases, in particular age-related macular degeneration, glaucoma, cataract, diabetic retinopathy, and vitreoretinopathy. We analyze, in…
A contribution to the characterization of Ruppia drepanensis (Ruppiaceae), a key species of threatened Mediterranean wetlands
2021
To elucidate the taxonomic status of Ruppia drepanensis Tineo ex Guss. (Alismatales, Ruppiaceae), we performed morphological analysis and DNA barcoding of historical materials (including the lectotype) and fresh samples (including those from a recently discovered population near the locus classicus in Sicily, Italy). We conclude that R. drepanensis is a separate species, closely related to R. spiralis L. ex Dumort., that occurs in temporary inland waters from the western to central sectors of the Mediterranean region. We also highlight the importance of vouchers and the need to link molecular investigations to field, ecological, and morphological investigations.
Spanish Dentists’ Awareness, Knowledge, and Practice Regarding COVID-19: A Multiple Regression Analysis
2021
The authors thank the Spanish Society of Epidemiology and Oral Public Health (SESPO) for expert supervision of the questionnaire; the Spanish General Council of Dentists (GCD) and the Spanish societies of dental hygienists for their rapid dissemination of the survey to their members.
Erratum for Yahav et al., "New β-Lactam-β-Lactamase Inhibitor Combinations".
2021
The limited armamentarium against drug-resistant Gram-negative bacilli has led to the development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this review, we summarize their spectrum of in vitro activities, mechanisms of resistance, and pharmacokinetic-pharmacodynamic (PK-PD) characteristics. A summary of available clinical data is provided per drug. Four approved BLBLIs are discussed in detail. All are options for treating multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa. Ceftazidime-avibactam is a potential drug for treating Enterobacterales producing extended-spectrum β-lactamase (ESBL), Klebsiella pneumoniae carbapenemase (KPC), AmpC, a…
Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences
2021
The specific recognition of AT-rich DNA sequences opens up the door to promising diagnostic and/or therapeutic strategies against gene-related diseases. Here, we demonstrate that amphiphilic PtII complexes of the type [Pt(dmba)(N∧N)]NO3 (dmba = N,N-dimethylbenzylamine-κN, κC; N∧N = dpq (3), dppz (4), and dppn (5)) recognize AT-rich oligonucleotides over other types of DNA, RNA, and model proteins. The crystal structure of 4 shows the presence of significant π-stacking interactions and a distorted coordination sphere of the d8 PtII atom. Complex 5, containing the largest π-conjugated ligand, forms supramolecular assemblies at high concentrations under aqueous environment. However, its aggreg…
false
2021
Background: University students encounter various stressors such as exam preparation, workload and economic concerns. Having to deal with a multitude of stressors can lead to mental health problems and have a negative impact on academic outcomes in students attending university. This paper describes the development and usability evaluation of an open and easily accessible online portal (me@JGU) designed to help students build skills they need to cope with common stressors and manage their own mental health. Methods: We developed a website that addresses the most common stressors among university students and offers strategies for dealing with difficult situations. Initial evaluation results…
Practical Volcano-Independent Recognition of Seismic Events: VULCAN.ears Project
2021
Recognizing the mechanisms underlying seismic activity and tracking temporal and spatial patterns of earthquakes represent primary inputs to monitor active volcanoes and forecast eruptions. To quantify this seismicity, catalogs are established to summarize the history of the observed types and number of volcano-seismic events. In volcano observatories the detection and posterior classification or labeling of the events is manually performed by technicians, often suffering a lack of unified criteria and eventually resulting in poorly reliable labeled databases. State-of-the-art automatic Volcano-Seismic Recognition (VSR) systems allow real-time monitoring and consistent catalogs. VSR systems…
Short-Term Effects of Air Pollution on Cardiovascular Hospitalizations in the Pisan Longitudinal Study
2021
Air pollution effects on cardiovascular hospitalizations in small urban/suburban areas have been scantly investigated. Such effects were assessed among the participants in the analytical epidemiological survey carried out in Pisa and Cascina, Tuscany, Italy (2009–2011). Cardiovascular hospitalizations from 1585 subjects were followed up (2011–2015). Daily mean pollutant concentrations were estimated through random forests at 1 km (particulate matter: PM10, 2011–2015
La educación en tiempos de pandemia : una situación excepcional y cambiante
2021
Clinical validation of 13-gene DNA methylation analysis in oral brushing samples for detection of oral carcinoma: an Italian multicenter study
2021
Background The aim of this Italian multicenter study was to evaluate the diagnostic performance of a minimally invasive method for the detection of oral squamous cell carcinoma (OSCC) based on 13-gene DNA methylation analysis in oral brushing samples. Methods Oral brushing specimens were collected in 11 oral medicine centers across Italy. Twenty brushing specimens were collected by each center, 10 from patients with OSCC, and 10 from healthy volunteers. DNA methylation analysis was performed in blindness, and each sample was determined as positive or negative based on a predefined cutoff value. Results DNA amplification failed in 4 of 220 (1.8%) samples. Of the specimens derived from patien…
Francia : ¿instrumentalización de la COVID-19 contra la igualdad escolar?
2021
La pandemia de COVID-19 ha puesto a prueba los sistemas educativos. Este artículo trata del caso francés, en el que tuvo lugar un confinamiento de dos meses, seguido de una reanudación muy parcial y selectiva del curso antes del verano, que no llegó a funcionar de nuevo realmente hasta septiembre, en condiciones sin precedentes. Muestra que lejos de ser un paréntesis excepcional, la crisis sanitaria fue utilizada por el gobierno para tratar de imponer cambios estructurales. Estas conclusiones se derivan de un análisis de las lógicas que estaban previamente en marcha en los proyectos de reforma de la enseñanza francesa, lo que permite distinguir entre las respuestas puntuales a una situación…
DAZAP2 acts as specifier of the p53 response to DNA damage.
2021
Abstract The DNA damage-responsive tumor suppressors p53 and HIPK2 are well established regulators of cell fate decision-making and regulate the cellular sensitivity to DNA-damaging drugs. Here, we identify Deleted in Azoospermia-associated protein 2 (DAZAP2), a small adaptor protein, as a novel regulator of HIPK2 and specifier of the DNA damage-induced p53 response. Knock-down or genetic deletion of DAZAP2 strongly potentiates cancer cell chemosensitivity both in cells and in vivo using a mouse tumour xenograft model. In unstressed cells, DAZAP2 stimulates HIPK2 polyubiquitination and degradation through interplay with the ubiquitin ligase SIAH1. Upon DNA damage, HIPK2 site-specifically ph…