showing 36 of ~574560 from 574555 documents
Análisis de la microestructura del sistema de conducción cardíaco basado en histología y análisis de imagen. Descripción en el humano y otras especie…
2021
El sistema de conducción cardíaca es una estructura ramificada que permite el inicio y la rápida propagación de impulsos eléctricos que desencadenan la despolarización eléctrica del tejido miocárdico. Los nodos cardíacos son la fuente del impulso eléctrico que se transmite al corazón y la función principal del sistema de conducción ventricular es la activación eléctrica rápida de los ventrículos. El objetivo de este trabajo fue estudiar las características histológicas y morfométricas de los diferentes componentes del sistema de conducción cardiaco en humanos, cerdos, caballos y perros, así como sus posibles variaciones. Se utilizó un grupo de diez corazones de humanos, diez de cerdo, diez …
Alkuorientaatio koronan keskellä : alkukeitoksen avulla kemian opintoihin kiinni
2021
Korkeakouluopintojen merkityksellinen aloitus antaa suuntaa niiden yleiselle sujuvuudelle. Yliopistojen alkuorientaatioviikoilla tai -kursseilla on täten suuri merkitys opintoihin integroitumiselle ja myös niiden jatkuvuudelle. Jyväskylän yliopiston kemian laitoksella alkuorientaatio on vuodesta 2007 lähtien järjestetty kahden opintopisteen arvoisena kemian perusopintokokonaisuuteen sisältyvänä Alkukeitos-kurssina. Kurssin tavoitteena on tukea kemian opiskelijoiden opintojen sujuvaa aloitusta ja opintoihin sitoutumista. Syksyllä 2020 Alkukeitos-kurssin järjestäminen aiheutti haasteita vallitsevan koronatilanteen vuoksi. Kurssin korona-ajan toimintamallin toimivuutta arvioitiin palautekeskus…
Computational approach to design of aptamers to the receptor binding domain of SARS-CoV-2
2021
The aim of the research. In this work, in silico selection of DNA-aptamers to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was performed using molecular modeling methods. Material and methods. A new computational approach to aptamer in silico selection is based on a cycle of simulations, including the stages of molecular modeling, molecular docking, molecular dynamic simulations, and quantum chemical calculations. To verify the obtained calculated results flow cytometry, fluorescence polarization, and small-angle X-ray scattering methods were applied. Results. An initial library consisted of 256 16-mer oligonucleotides was modeled. Based on molecular docking results, th…
«Vi deler de jo for å få bedre dager» En kvalitativ studie av barnehagelærerens tanker rundt hvorfor og hvordan man deler i grupper i barnehagen.
2021
Master´s thesis in Kindergarten Knowledge
Análisis jurisprudencial de la legitimación pasiva de las entidades financieras en las reclamaciones realizadas por consumidores derivadas de una com…
2021
Consumers, who acquired real estate through a deed of sale with a mortgage subrogation, have made numerous claims against the financial entities. They request the nullity of the clause that imposes upon them all the expenses cause by the notarial deed. Financial entities have alleged that they do not have the capacity to be sued. Courts decisions have been diverse.
Logística, trabajo y almacenes: el lado oscuro de la digitalización
2021
Institutional Issues About Social Entrepreneurship
2021
This chapter summarizes the main conclusions of this part of the book. In doing so, it explains the value that social ventures add to their contexts. Revisiting each one of the chapters of the macro perspective addressed in the second section of the book, social entrepreneurship is seen as a way to solve social problems. By way of this problem-solving, social ventures present legitimacy issues. However, once the difficulties are overcome, it is important to spread the values and principles that guide social entrepreneurship. The last part of this chapter is dedicated to limitations and future research in acquiring the macro approach.
The Coordination Problem in Regional Integration
2021
A catch-22 situation or coordination failure between the slow creation of well-integrated regional markets and low economic diversification (plus sophistication and specialization) is unfolding in Africa. Ubiquitous trade barriers translate into a paradoxical tariff pattern by which African neighbours are treated worse than remote trade partners. In the face of widespread irregularities and high trade costs, ‘trade facilitation’ has become an important technical approach to easing trade with the support of donor agencies. This chapter examines the systemic potential and limits of trade facilitation programmes. As a general alternative to institution-heavy, imperfect integration along the tr…
An Avenue to Social Equilibrium
2021
The purpose of the second part of the third part of the book is to show how the theory translates into reality. That is why the most important factors studied in the first and second parts of the book are concluded in this chapter. The first part of the chapter is addressed to examine the personal characteristics and motivation of the social entrepreneur, that is, it is focused on the micro approach. The second part is addressed to analyze the institutional context, that is, it comprehends the macro approach. Based on this, the chapter shows the stages followed by social entrepreneurs to shift the context. The legitimation process is the base of this shift.
sj-pdf-1-jou-10.1177_1464884920985407 – Supplemental material for Media’s portrayal of CAM: Exploring 40 years of narratives and meanings in public d…
2021
Supplemental material, sj-pdf-1-jou-10.1177_1464884920985407 for Media’s portrayal of CAM: Exploring 40 years of narratives and meanings in public discourse by Emilia H Lopera-Pareja and Lorena Cano-Orón in Journalism
Do we understand the solid-like elastic properties of confined liquids?
2021
Recently, in polymeric liquids, unexpected solid-like shear elasticity has been discovered, which gave rise to a controversial discussion about its origin (1⇓–3). The observed solid-like shear modulus G depends strongly on the distance L between the plates of the rheometer according to a power law G ∝ L − p with a nonuniversal exponent ranging between p = 2 and p = 3 . Zaccone and Trachenko (4) have published an article in which they claim to explain these findings by a nonaffine contribution to the liquid shear modulus. The latter is represented as Δ G ∝ − ∑ λ = L , T 1 V … [↵][1]1To whom correspondence may be addressed. Email: giancarlo.ruocco{at}roma1.infn.it. [1]: #xref-corresp-1-1
Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and gene…
2021
In myelodysplastic syndromes (MDS), the 20q deletion [del(20q)] may cause deletion of the ASXL1 gene. We studied 153 patients with MDS and del(20q) to assess the incidence, prognostic value and impact on response to azacitidine (AZA) of ASXL1 chromosomal alterations and genetic mutations. Additionally, in vitro assay of the response to AZA in HAP1 (HAP1(WT)) and HAP1 ASXL1 knockout (HAP1(KN)) cells was performed. ASXL1 chromosomal alterations were detected in 44 patients (28 center dot 5%): 34 patients (22%) with a gene deletion (ASXL1(DEL)) and 10 patients (6 center dot 5%) with additional gene copies. ASXL1(DEL) was associated with a lower platelet count. The most frequently mutated genes…
Newborn crawling and rooting in response to maternal breast odor
2021
International audience; A growing literature shows that perception and action are already tightly coupled in the newborn. The current study aimed to examine the nature of the coupling between olfactory stimuli from the mother and the newborn's crawling and rooting (exploratory movements of the head). To examine the coupling, the crawling and rooting behavior of 28 2-day-old newborns were studied while they were supported prone on a mobility device shaped like a mini skateboard, the Crawliskate®, their head positioned directly on top of a pad infused with either their mother's breast odor (Maternal) or the odor of water (Control). Video and 3D kinematic analyses of the number and types of li…
Long-term response of marine benthic fauna to thin-layer capping with powdered activated carbon in the Grenland fjords, Norway
2021
The Grenland fjords in Norway have a long history of contamination by large emissions of dioxins and mercury. As a possible sediment remediation method in situ, thin-layer capping with powdered activated carbon (AC) mixed with clay was applied at two test sites at 30 m and 95 m depth in the Grenland fjords. This study presents long-term effects of the AC treatment on the benthic community structure, i.e. nine years after capping. Capping with AC significantly reduced the number of species, their abundance and biomass at the two test sites, compared to uncapped reference sites. At the more shallow site, the dominant brittle star species Amphiura filiformis disappeared shortly after capping a…
Health-related Quality of Life in Patients with Advanced Prostate Cancer: A Systematic Review
2021
Abstract Context The assessment of “soft” endpoints such as health-related quality of life (HRQOL) is increasingly relevant when evaluating the optimal treatment sequence of novel therapeutic options in patients with advanced prostate cancer (PCa). Objective To systematically review contemporary data regarding HRQOL outcomes in patients with advanced PCa. Evidence acquisition A systematic review of the literature published between January 2011 and March 2019 was performed using the PubMed/Medline Database. In total, 873 articles were screened, and 14 articles including 12 661 patients were selected for synthesis and included in the current analysis according to the Preferred Reporting Items…
Trade Associations: Why Not Cartels?
2021
First published: 30 September 2020 The relevance of special interests lobbying in modern democracies can hardly be questioned. But if large trade associations can overcome the free riding problem and form effective lobbies, why do they not also threaten market competition by forming equally effective cartels? We argue that the key to understanding the difference lies in supply elasticity. The group discipline which works in the case of lobbying can be effective in sustaining a cartel only if increasing output is sufficiently costly ‐ otherwise the incentive to deviate is too great. The theory helps organizing a number of stylized facts within a common framework. This article has been accept…
Fractal dimension of superfluid turbulence : A random-walk toy model
2021
This paper deals with the fractal dimension of a superfluid vortex tangle. It extends a previous model [J. Phys. A: Math. Theor. {\bf 43}, 205501 (2010)] (which was proposed for very low temperature), and it proposes an alternative random walk toy model, which is valid also for finite temperature. This random walk model combines a recent Nemirovskii's proposal, and a simple modelization of a self-similar structure of vortex loops (mimicking the geometry of the loops of several sizes which compose the tangle). The fractal dimension of the vortex tangle is then related to the exponents describing how the vortex energy per unit length changes with the length scales, for which we take recent pr…
How to keep your staff healthy in the educational sector?
2021
The purpose of the paper is to identify risks and challenges for alternative forms of work during online classes for teaching personnel. Musculoskeletal disorders (MSD) affect the body’s bones, muscles, joints, ligaments/tendons, and nerves. Musculoskeletal health risk in the educational sector should be taken into consideration to ensure the safety and healthy employees, especially when online classes require a physical inactivity and a prolonged sitting in front of the computer. MSD management requires an integrated approach integrating wellbeing with a focus on prevention, recognizing physical, social and emotional influences and early intervention. Workplace wellness has been a valuable…
Numerical modeling of blood flow in the internal jugular vein with the use of computational fluid mechanics software.
2021
ObjectivesTo determine the site and nature of altered hemodynamics in pathological internal jugular veins.MethodWith the use of computational fluid mechanics software we simulated blood flow in 3 D models of the internal jugular veins that exhibited different morphologies, including nozzle-like strictures in their upper parts and valves in the lower parts.ResultsIn a majority of models with nozzle-like strictures, especially those positioned asymmetrically, abnormal flow pattern was revealed, with significant flow separation and regions with reversed flow. Abnormal valves had no significant impact on flow in a case of already altered flow evoked by stricture in upper part of the vein.Conclu…
M-TRAP: Safety and performance of metastatic tumor cell trap device in advanced ovarian cancer patients
2021
Objective. Despite radical surgery and chemotherapy, most patients with ovarian cancer die due to disease progression. M-Trap is an implantable medical device designed to capture peritoneal disseminated tumor cells with the aim to focalize the disease. This trial analyzed the safety and performance of the device. Methods. This first-in-human prospective, multi-center, non-blinded, single-arm study enrolled 23 women with high-grade serous advanced ovarian cancer. After primary or interval debulking surgery, 3 M-Trap devices were placed in the peritoneum of the abdominal cavity. 18-months post-implantation or at disease progression, devices were initially removed by laparoscopy. The primary s…
Reconfigurations in sustainability transitions : a systematic and critical review
2021
Two streams of literature have become especially prominent in understanding social change toward sustainability within the past decades: the research on socio-technical transitions and applications of social practice theory. The aim of this article is to contribute to efforts to create dialogue between these two approaches. We do this by focusing on the concept of reconfiguration, which has become a much-used, but poorly defined notion in the discussion on sustainability transitions. To understand what is defined as reconfiguration in systems and practices, and how the understanding of reconfiguration in regimes could benefit from insights about reconfiguration in practices, we conducted a …
Partnerzy bez partnerstwa? Realizacja zasady partnerstwa w procesie wdrażania regionalnych programów operacyjnych w Polsce w perspektywie finansowej …
2021
W niniejszym artykule podjęto próbę określenia stopnia realizacji zasady partnerstwa w procesie wdrażania regionalnych programów operacyjnych (RPO) w Polsce w obecnej perspektywie finansowej (2014–2020). Przyjęto założenie, że instytucjonalnym sposobem realizacji zasady partnerstwa jest powołanie i funkcjonowanie komitetów monitorujących (KM). Analizą porównawczą objęto praktyczne aspekty działania komitetów w ramach RPO w trzech województwach: lubuskim, świętokrzyskim i kujawsko-pomorskim. Do celów porównawczych wykorzystano następujące parametry instytucjonalno-organizacyjne: liczba posiedzeń komitetów w perspektywie finansowej 2014–2020, liczba przeprowadzonych procedur głosowania obiego…
Nierejestrowane wyludnienie i sytuacja na lokalnym rynku pracy na tle procesów rozwojowych powiatu nyskiego
2021
The research, that the results of which are included in the book, is devoted to three closely related issues. The first is the assessment of the processes of demographic changes, including depopulation, also the one not recorded by official statistics. The second is the identification of interdependencies between spatial and development conditions and demographic processes, their directions and structure in the rural, small, subregional, regional and metropolitan development centers system. The third issue is the diagnosis of the situation on the labor market in rural areas and its relationship with the mobility of the population and − more broadly − with development processes. The publicat…
Eric Griffiths: Jedynie jako krytyk
2021
The Role of Small-Angle X-Ray Scattering and Molecular Simulations in 3D Structure Elucidation of a DNA Aptamer Against Lung Cancer
2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here we present a general optimization procedure for finding most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated aptamer LC-18t was developed. A three-dimensional shape of LC-18t was reported based on small-angle X-ray scattering (SAXS) experiments and m…
Second-forbidden nonunique β− decays of 59,60Fe:possible candidates for gA sensitive electron spectral-shape measurements
2021
In this work, we present a theoretical study of the electron spectral shapes for the second-forbidden nonunique β−-decay transitions 59Fe(3/2−)→59Co(7/2−) and 60Fe(0+)→60Co(2+) in the framework of the nuclear shell model. We have computed the involved wave functions by carrying out a complete 0ℏω calculation in the full fp model space using the KB3G and GXPF1A effective interactions. When compared with the available data, these interactions predict the low-energy spectra and electromagnetic properties of the involved nuclei quite successfully. This success paves the way for the computations of the β-decay properties, and comparison with the available data. We have computed the electron spec…
Social Workers’ Reflections on Forced Migration and Cultural Diversity : Towards Anti-Oppressive Expertise in Child and Family Social Work
2021
Social work in Finland, like in many other countries, has faced various challenges after the large scale of forced migration in 2015. Although working with migrants is not a new area in social work, the exceptionally large amount of asylum seekers in the Finnish society caused a need for improved social work expertise. Our article deals with Finnish social work practitioners’ reflections on multicultural, multilingual and transnational issues with a client group, which is in a vulnerable situation after forced or other forms of migration. The practitioners participating in our study have either attended a specializing education of child, youth and family social work or taken part in peer gr…
Tallenes tale om leiligheter i Søgne : En empirisk analyse av leilighetsmarkedet i Søgne mellom 2000-2020
2021
Master's thesis in Business administration (BE501) Denne oppgaven er en kvantitativ analyse på leilighetsmarkedet i Søgne hvor hensikten er å synliggjøre hva som driver prisene og gjøre en vurdering på hvordan markedet vil forløpe seg i fremtiden. Estimatene er gjort på basis av data på leilighetssalg i perioden 2000-2020 og vurderer ulike attributter påvirker salgsprisen. Den siste tiden har Søgne og Greipstad Sparebank registrertattilbudssiden av leilighetsmarkedet har økt spesielt i området Tangvall. Dette har fått banken til å stille spørsmål om mulig konsekvenser fra dette på prisutviklingen for slike objekter og andre ringvirkninger for boligmarkedet i Søgne. Hovedårsaken til at de er…
Miljø og medborgerskap i Arne Svingens barnebok En himmel full av skyer
2021
I læreplanen for norskfaget integrerer fagfornyelsen bærekraftig utvikling samt demokrati og medborgerskap som tverrfaglige temaer. Denne artikkelen argumenterer for å kombinere arbeidet med begge temaene. Med bakgrunn i miljø- og klimaproblematikken har det blitt utviklet forskjellige modeller av medborgerskap som også omfatter miljørelaterte aspekter. Artikkelen tar utgangspunkt i de tre mest innflytelsesrike av disse modellene: Derek Bells miljømedborgerskap, Andrew Dobsons økologiske medborgerskap og John Barrys bærekraftmedborgerskap. Disse modellenes ulike definisjoner av medborgernes miljørelaterte rettigheter og plikter brukes som teoretisk bakgrunn i en analyse av Arne Svingens bar…
Baltā fosfora alfa un beta fāzu Ramana spektroskopiskie pētījumi
2021
Baltais fosfors ir molekulārs kristāls, kas sastāv no tetraedra formas P4 molekulām, kuru savstarpējais izkārtojums kristāliskajā režģī mainās, pārejot starp trim pazīstamajām fāzēm: α; β; γ. Materiāls ir pazīstams jau sen, taču kā molekulārs kristāls tas ir pētīts salīdzinoši maz, it īpaši ar svārstību spektroskopijas metodēm, kas, piemēram, spētu apstiprināt vai noliegt no rentgenstaru difrakcijas iegūto kristālisko struktūru pareizību. Šajā darbā eksperimentāli iegūti baltā fosfora α un β fāzu Ramana izkliedes spektri pie dažādām temperatūrām apgabalā no -125°C līdz -20°C. Darbā apskatīts hipotētisks baltā fosfora α fāzes kristāliskās struktūras modelis ar augstu simetriju, kam izveidots…
Vispārējās koordinācijas noteikšana un nozīme pusaudžu vecuma skolēniem
2021
Koordinācija ir viena no piecām fiziskajām spējām, kurai ir vairāki izpausmes veidi. Koordinācijas attīstīšanai ir labvēlīga ietekme uz kognitīvo spēju attīstību kā arī tā ir fizisko spēju attīstības pamatā. To var attīstīt apgūstot jaunas daudzveidīgas kustības kā arī pēc iespējas dažādojot kustību pieredzi. Klātienes un attālināto mācību laikā atbilstošs veids kā koordināciju noteikt ir “flamingo” tests, tā veikšanai ir nepieciešami nelieli resursi un veikšana nav sarežģīta. Veicot testu 68 piektās klases skolēniem un iegūtos rezultātus salīdzinot ar normatīvu izveides pētījumu, novērots, ka rezultātu tendences ir ļoti līdzīgas.
Latvijas nacionālo partizānu kustība Latvijas PSR historiogrāfijas atspogļojumā
2021
Bakalaura darba “Latvijas nacionālo partizānu kustība Latvijas PSR historiogrāfijas atspoguļojumā” mērķis ir noskaidrot bruņotās pretošanās kustības interpretāciju Latvijas PSR literatūrā. Pētījuma gaitā tika noskaidrots, ka bruņotās pretošanās kustības attēlojums padomju laika literatūrā lielākoties ir fragmentārs un stipri ideoloģizēts. Tekstos vērojami tīši noklusējumi un faktu neatbilstība reālajiem vēstures notikumiem. Tuvojoties atmodas periodam, iedzīvotāju izglītošanas nolūkā tika mēģināts apzināt notikumus, kuri risinājās pēckara Latvijas PSR teritorijā. Neskatoties uz publikāciju skaita palielināšanos, kurā skarta nacionālās pretošanās kustības tematika, autori joprojām pauda nost…
Vidzemes reģiona galveno bibliotēku publicitāte oficiālajās tīmekļa vietnēs un sociālo tīklu vietnē Facebook
2021
Bakalaura darbs “Vidzemes reģiona galveno bibliotēku publicitāte oficiālajās tīmekļa vietnēs un sociālo tīklu vietnē Facebook”, izstrādāts ar mērķi - veicot datu analīzi un intervējot bibliotekārus, salīdzināt informāciju, kādu par saviem pakalpojumiem sniedz bibliotēkas savās tīmekļa vietnēs un profilos sociālo tīklu vietnē Facebook. Darba teorētiskā bāze balstīta uz Manuela Kastela Tīkla sabiedrības teoriju un Informācijas jeb zināšanu plaisas teoriju. Tāpat teorētiskajā daļā tika skaidroti termini – “sociālo tīklu vietne” un “tīmekļa vietne.” Darba empīriskajā daļā, izmantojot kvalitatīvo kontentanalīzi un attālinātās intervijas, analizēta un salīdzināta informācija, kādu publicē bibliot…
Kvantu algoritmi simbolu virkņu uzdevumiem
2021
Darbā tiek apskatīti trīs simbolu virkņu uzdevumi. Pirmais no tiem ir nosaukts ”vārda meklēšana tekstā”: dotajam tekstam 𝑠 garuma 𝑛 un vārdam 𝑡 garumā 𝑚, pateikt, vai vārds atro das tekstā. Klasiski šo var atrisināt laikā 𝑂(𝑛 + 𝑚) ar KnutaMorisaPrata algoritmu, kvantiski ̃ √𝑛 + √𝑚) = 𝑂( ̃ √𝑛) laika algoritms. Kaut gan zināms, ka vispārīgajā gadījumā ne eksistē 𝑂( √ pieciešami Ω( 𝑛) vaicājumi virknes simboliem, nav skaidrs, vai šī apakšējā robeža izpildās pie √ jebkuras m vērtības. Šajā darbā mēs pierādām, ka arī tad nepieciešami Ω( 𝑛) vaicājumi. Otrais uzdevums ir nosaukts ”visbiežāk sastopamas virknes meklēšana”: dotiem 𝑛 virknēm garumā 𝑘 √ ̃ pateikt, kāda virknē sastop…
Virtuālā mācību platforma Minecraft Education Edition skolēnu programmēšanas prasmju attīstībā datorikas stundās
2021
Maģistra darbā “Virtuālā mācību platforma Minecraft Education Edition skolēnu programmēšanas prasmju attīstībā datorikas stundās” tiek pētīts, vai interaktīvajās spēlēs balstītās mācību platformas lietojums datorikas stundās pēc pētnieču izstrādātās nodarbību metodoloģijas var sekmēt skolēnu programmēšanas prasmju attīstību. Maģistra darba pētījuma dizains ir darbības pētījums. Pētnieces noskaidro, vai mēģinājumu un kļūdu metode, vingrinoties virtuālajā mācību platformā Microsoft Minecraft Education Edition 5. klašu datorikas fakultatīvajās programmēšanas nodarbībās, ir piemērots didaktiskais paņēmiens. Savukārt, ar izziņas spēju testu tiek novērtēts, vai programmēšanas prasmes fakultatīvo …
Saistības starp sportistu personības iezīmēm, izdegšanu un alkohola lietošanas motiviem
2021
Šī bakalaura darba ietvaros tika aplūkota zinātniskā literatūra un veikts korelatīvs pētījums ar mērķi noskaidrot, vai pastāv saistības starp sportistu personības iezīmēm, sportistu izdegšanas faktoriem un viņu alkohola lietošanas motīviem. Tika atklātas vairākas saistības. Visciešākās saistības bija starp grūtību pārvarēšanas alkohola lietošanas motīvu un izdegšanas faktoriem, kā arī negatīvās saistības starp izdegšanu un tādām personības iezīmēm kā ekstraversija un apzinīgums. Neirotisms bija pozitīvi saistīts ar izdegšanu. Turpmākos pētījumos būtu vērts noskaidrot, kuri no mainīgajiem lielumiem labāk izskaidro alkohola lietošanas motīvus un izdegšanas faktorus, kā arī vai pastāv personīb…