Immunogenicity and safety of an inactivated hepatitis A vaccine in anti-HIV positive and negative homosexual men.

1995

The immunogenicity, reactogenicity, and safety of an inactivated hepatitis A vaccine were assessed in anti-HIV positive homosexual men. Fourteen anti-HIV positive (group 1) and 20 anti-HIV negative (group 2) men received vaccine (containing 720 ELISA units of hepatitis A antigen per dose) intramuscularly at 0, 1, and 6 months. Twelve unvaccinated anti-HIV positive men (group 3) were included as controls to evaluate disease progression. Seroconversion (anti-hepatitis V virus (HAV ⩾20 mlU/ml) was higher in group 2 than group 1 at months 2 (100% vs. 73%) and 7 (l00%vs. 77%). Group 2 had higher antibody titres than group 1 at months 1 (201 vs. 92 mlU/ml) and 7 (1, 687 vs. 636 mlU/ml). The decli…

Thermal deformations of inhomogeneous elastic plates

1995

We consider thermal deformations of transversally inhomogenous elastic plates. Thin plate equations are derived as limits of full three-dimensional models both in the linear was well as in the non-linear case with appropriate convergence proofs. In the non-linear case also the corresponding von Karman equations are formulated. Its is obtained that the inhomogeneity leads to the loss of some symmetry properties at the von Karman equations

Characterization and Expression of Multiple Alternatively Spliced Transcripts of the Goodpasture Antigen Gene Region. Goodpasture Antibodies Recogniz…

1995

Collagen IV, the major component of basement membranes, is composed of six distinct alpha chains (alpha 1-alpha 6). Atypically among the collagen IV genes, the exons encoding the carboxyl-terminal region of the human alpha 3(IV) chain undergo alternative splicing. This region has been designated as the Goodpasture antigen because of its reactivity in the kidney and lung with the pathogenic autoantibodies causing Goodpasture syndrome. The data presented in this report demonstrate that, in human kidney, the gene region encompassing the Goodpasture antigen generates at least six alternatively spliced transcripts predicting five distinct proteins that differ in their carboxyl-terminus and retai…

Very long nuclear relaxation times of spin polarized helium 3 in metal coated cells

1995

Abstract We obtained very long relaxation times T 1 of up to 120 h for the nuclear polarization of an optically pumped helium 3 gas. The glass containers were internally coated with metallic films such as bismuth or cesium. These findings will have applications in the field of helium magnetometers and polarized targets.

Long-lasting exocytosis and massive structural reorganisation in the egg periphery during cortical reaction inPlatynereis dumerilii(Annelida, Polycha…

1995

SummaryThe course of the cortical reaction in thePlatynereis dumeriliiegg is described from live observation and from sectioned fixed material and is found to differ in several aspects from the course of cortical reactions in better-known systems. Cortical granules are unusually numerous. They are discharged by exocytosis during a period of about 25 min following fertilisation (18°C). Most of the surplus membrane material brought to the egg surface by exocytosis is set free into the perivitelline space. Swelling of egg jelly precursor secreted by cortical granule exocytosis may be causal for the detachment of the vitelline envelope from the egg cell surface which, however, remains attached …

The variations of technical and allocation coefficients : are they comparable really ?

1995

Two great alternative hypothesis are possible in the analysis input-output : the model may be demand-driven (Leontief) or supply-driven (Ghosh). To test the consistency of these hypotheses on the long term, this paper studies the interest of proportional filters (comparison of column or row coefficients) and the interest of the biproportional filter for the temporalcomparison of input-output matrices. An application is proposed for France between 1980 and 1993. The result is the following : in the long period, there are more sectors supply-driven than demand-driven (i.e. row coefficients are less variable than column coefficients for the majority of the sectors). (FRE) Deux grandes hypothès…

Pumping of single electrons with a traveling wave

1995

Abstract We describe the operation and performance of a one-dimensional chain of small metallic islands whose potentials are modulated in a wave-like manner. The sinusoidal voltages, applied to the gate electrodes, carry individual charges coherently through the array. In practice, the wave-like potential is induced on the gates by a surface acoustic wave (SAW) traveling on a piezoelectric substrate. The resulting transfer of charges should produce a DC current I = ± ef through the chain, where f is the frequency of the wave and the sign ofthe current depends on the value of the common DC bias of the islands as well as on the direction of the wave propagation. We observe, however, a much sm…

Cellular distribution in the rat telencephalon of mRNAs encoding for the alpha 3 and alpha 4 subunits of the nicotinic acetylcholine receptor.

1995

Pharmacological and electrophysiological studies provide evidence for the involvement of different nicotinic acetylcholine receptor isoforms in rat neocortical and hippocampal signal transduction. Yet, rather little is known on the cellular localization of these isoforms. With the availability of isoform specific nucleic acid probes and sensitive non-isotopic detection systems, nicotinic receptors can be studied on the mRNA level in individual neurons. In this way, we have paradigmatically studied the distribution of the alpha 3 and alpha 4 isoform mRNAs of the nicotinic receptor in the rat telencephalon. In the cerebral cortex, alpha 3 transcripts were mainly located in pyramidal neurons o…

Complexes of tryptophan dipeptides with the R2Sn(IV)2+ ion (R=Me, Ph): Spectroscopic studies, solution properties and structural implications

1995

Tryptophan dipeptides such as L-tryptophyl-L-alanine (H 2 TrpAla), L-tryptophyl-L-tyrosine (H 2 TrpTyr), L-tryptophyl-L-tryptophan (H 2 TrpTrp), along with L-histidyl-L-tyrosine (H 2 HisTyr), were reacted with R 2 SnO (R=Me, Ph) yielding the corresponding complexes. The complexes have been characterized by IR and 119 Sn Mossbauer spectroscopy in the solid state and by 1 H and 13 C NMR in CD 3 OD solutions. Monomeric species were detected, with the tin atom arranged in a pentacoordinated trigonal-bipyramidal structure. The dipeptides are coordinated via the terminal amino group, deprotonated peptide nitrogen and terminal carboxylate group. No side-chain appears to be involved in bonding. Det…

Noise Levels in an Urban Hospital and Workers' Subjective Responses

1995

Internal noise levels were measured in a 232-point grid that encompassed the main building of a major University Hospital in Valencia, Spain. Most noise equivalent sound levels that were obtained exceeded 55 dBA, and in some instances these sound levels were very high. Hospital workers' subjective responses to noise were evaluated with a self-answered questionnaire. A total of 295 workers volunteered to participate. Their answers revealed that the most important noise sources were located primarily inside the hospital. Noise levels were perceived to be sufficiently high to interfere with their work, and noise levels were also thought to affect patients' comfort and recovery. Most subjects t…

Determination of Boron in Fertilizers by Inductively Coupled Plasma-Atomic Emission Spectrometry: Studies of Some Spectral Interferences at Different…

1995

Abstract The most sensitive analytical wavelengths of boron cannot be used in the determination of boron in fertilizers by inductively coupled plasma-atomic emission spectrometry because of spectral interference by potassium, phosphorus, and iron. For the 4 wavelengths of boron investigated, it was noticed that, at the same wavelength, the pattern of spectral interference changes according to fertilizer composition. The spectral interference patterns at the 4 analytical boron wavelengths were studied by adding matrix elements typically found in fertilizers to real fertilizer samples. When levels of added matrix elements correlate less than 0.2 to each other, the effect of added matrix eleme…

Zeolithe als Adsorbentien für die Trennung, Reinigung und Konzentrierung von organischen Wertprodukten in der präparativen Säulen-Flüssig-Chromatogra…

1995

Detection of IgM antibodies specific for measles virus by capture and indirect enzyme immunoassays.

1995

Summary During a measles outbreak, 112 serum specimens from 88 hospitalized patients were received in our laboratory for investigation of a morbilliform rash. These specimens (88 acute- and 24 convalescent-phase) were tested for the presence of measles-specific IgM antibodies by a capture EIA (enzyme immunoassay) using peroxidase-conjugated measles virus antigens and by an indirect EIA. Commercially available indirect EIA kits for measles-specific IgM antibodies were also used and compared with our homemade EIAs. Specificity studies included a collection of serum specimens containing rheumatoid factor, antinuclear antibodies or IgM antibodies specific to other viruses, and sera from blood d…

Use of a new aneurysm clip with an inverted-spring mechanism to facilitate visual control during clip application. Technical note.

1995

✓ When operating on deep-seated cerebral aneurysms, the surgeon's visual control of clip application may be impaired by the clip holder unless adjacent structures are retracted. To improve visual control and reduce the necessity for retraction, the senior author (A.P.) developed a new concept: an aneurysm clip with an inverted-spring mechanism. The clip has two jaws that point away from the clip blades. The jaws of the clip holder articulate with the inner side of the clip jaws. By distending the jaws of the clip holder the blades of the clip are opened and vice versa. Thus the visual field increases while the clip application is proceeding. This instrumentation is useful, especially in cas…

Hydroxylation of collagen type I: evidence that both lysyl and prolyl residues are overhydroxylated in osteogenesis imperfecta

1995

The composition of the collagens secreted into the media of fibroblast cultures of 39 patients with osteogenesis imperfecta (OI) was the same in controls and OI cultures. An abnormal migration pattern of collagens upon SDS-PAGE was evident in one third of the cultures investigated. Lysyl and prolyl hydroxylation of HPLC-purified alpha 1(I) chains was elevated in about 60% of cultures. The degree of hydroxylation was highest in the lethal forms. The extent of lysyl and prolyl hydroxylation showed a strong correlation (r = 0.74, P < 0.001). While high levels of hydroxylation are frequently observed in OI patients, a direct correlation between lysyl or prolyl hydroxylation and fracture rate or…

Effect of different treatments in calcium-free medium on basal tone and contractile responses of guinea pig tracheae.

1995

Acetylcholine (ACh; 0.1 mmol/l) and KCl (80 mmol/l) induce a biphasic contractile response in isolated guinea pig tracheae maintained at 37 degrees C either in the presence or absence of extracellular Ca2+. Exposure of the tissue to Ca(2+)-free solution evokes a significant decrease in basal tone and the sources of Ca2+ appear to be decreased by prolonged agonist stimulation, and even more by successive agonist stimulation. After an incubation period of 20 min in Ca(2+)-containing solution, the response is restored. Mg(2+)-depletion in Ca(2+)-free medium increased the contractile response to ACh, but not to KCl, and delayed the tonic component of the next contraction elicited in Ca(2+)-cont…

Modes of complexation of non-substituted and substituted tetraazamacrocycles with Group 6 metal carbonyls. X-ray structure of [(permethylcyclam)Mo(CO…

1995

Abstract Reactions of complexation of tetraazamacrocycles L with Group 6 metal carbonyls [M(CO)6](M = Cr, Mo, or W) lead to [LM(CO)4], [LM(CO)3] or [LM(CO)2] entities, depending both on the size of the macrocycle and on the metal M. The structure of one representative complex [(permethylcyclam)Mo(CO)4] has been determined by X-ray diffraction (permethylcyclam: 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane).

Macromolecules in ordered media. II. A fluorescence study of the polymer-liposome association

1995

The interactions of poly (4-vinyl pyridine) with dimyristoylphosphatidic acid-based liposomes were studied in heterogeneous solution systems. The polymer was dispersed in aqueous buffer solutions of small unilamellar vesicles and after a suitable period of incubation to raise the equilibrium, the experiments has been conducted as a function of polymer concentration and temperature. According to the measurements of the steady-state fluorescence spectra, changes in the intensities as well as shifts in the emission peak wavelength, has served as raw data to accounting for the polymer-vesicle interactions. Quantitative evaluation of the interaction has been done using a simple associating model…

Optical saturation, diffusion and convection effects in thermal lens spectrometry

1995

Abstract In thermal lens spectrometry (TLS) the intense pump radiation can lead the chromophore to partial optical saturation conditions in which the ground state is depleted and the population of an intermediate excited state increases. A model in which the excitation process competes with both the decay processes and diffusion and convection of the species in the excited and ground states is developed. The model is used to explain the variations of the TLS/spectrophotometry sensitivity ratios found for a series of phthalein and azo dyes in aqueous media.

Is there a role for recombinant tumor necrosis factor alpha in the intravesical treatment of superficial bladder tumors?--a phase II study

1995

Clinical use of recombinant tumor necrosis factor-alpha is strongly limited by its severe toxicity, mainly cardiovascular, when systemically administered. Recent studies suggest that topical (intrapleural, intraperitoneal, intratumoral) administration is free of significant toxicity. Human recombinant tumor necrosis factor-alpha was administered intravesically, at a dose of 500 mg dissolved in 30 ml of phosphate buffer (pH7.6-7.8) plus 0.25% human albumin, weekly for two months to 18 patients with papillary transitional cell carcinoma of the bladder. Of the 15 evaluable patients, four (26%) achieved a complete response. Systemic and local tolerability were excellent. Int J Urol 1995;2:100-1…

Studies on mechanism and physico-chemical parameters at the origin of the cement setting. I. The fundamental processes involved during the cement set…

1995

Abstract The mechanical evolution and the structure of the cement paste have been analysed in relation with the chemical evolution of the system. The setting process can be described as following two fundamental steps: the coagulation of cement grains during the first minutes following the mixing, and the rigidification of the coagulated structure which arises simultaneously with the acceleration of the hydrates formation During the coagulation step, the structure formed is proved to be mechanically reversible. The rigidification of the coagulated structure is provided by the hydrates formation in the contact zone. The increase of the paste cohesion at this stage is proportional to the quan…

PCDEs, PCBs, PCDDs AND PCDFs in black guillemots and white-tailed sea eagles from the Baltic Sea

1995

Abstract Concentrations and patterns of several chloro compounds including polychlorinated dibenzo p-dioxins (PCDD), dibenzofurans (PCDF), biphenyls (PCB) and diphenyl ethers (PCDE) were determined in black guillemots ( Cepphus grylle L.) and white-tailed sea-eagles ( Hallaeetus albicilla L.) from the Baltic Sea environment. Three breast muscles of eagles were analyzed and had different concentrations and patterns of the studied compounds, whereas the three guillemot eggs were found to have more similar levels and patterns. The concentrations of individual PCDE congeners varied from

Calidad de vida en el asma: validación del cuestionario AQLQ para su utilización en población española

1995

The study of morbidity in asthma requires consideration not only of standard physiopathologic and function parameters, but also of the impact the disease has on the patient's life-style as he or she perceives it and evaluates it. The quantification of this factor, known as health-related quality of life (HRQL), is achieved by administering questionnaires specially designed for the purpose. We analyzed the reliability, content validity and construct validity (convergence and divergence) of one instrument, the Asthma Quality of Life Questionnaire (AQLQ) designed by Marks and colleagues. This questionnaire covers 4 dimensions (breathlessness, mood, social limitation and worrying) and gives a t…

Facile synthesis of 5-benzamido-4-diazopyrazole derivatives, a class of biologically active agents and key intermediates

1995

Abstract By reacting l-R1-3-R2-5-(R3-substituted)benzamidopyrazoles with a great ex-cess of nitrous acid in acetic acid media, the related 4-diazoderivatives in 65–80% yields were obtained.

Gibbs-ensemble path-integral Monte Carlo simulations of a mixed quantum-classical fluid

1995

We study a model fluid with classical translational degrees of freedom and internal quantum states in two spatial dimensions. The path-integral Monte Carlo and the Gibbs-ensemble Monte Carlo techniques are combined to investigate the liquid-gas coexistence region in this mixed quantum-classical system. A comparison with the phase diagram obtained in the canonical ensemble is also presented.

On the anionic polymerization of dialkylaminoisoprenes, 3. A nuclear magnetic resonance study of the structure of oligo[5-(N,N-diisopropylamino)isopr…

1995

The structure of oligo[(5-N,N-diisopropylamino)isoprenyllithium] (number-average degree of polymerization Pn = 1-2) prepared by reaction of alkyllithium with 5-(N,N-diisopropylamino)-isoprene1 in nonpolar (benzene) and polar (tetrahydrofuran) solvents has been studied by 1H and 13C NMR spectroscopy. In tetrahydrofuran, as expected, the negative charge at the terminal chain unit is more delocalized than in benzene and, consequently, the carbon-lithium bond has a more ionic character. In both solvents the living chain end shows a cisoid-4, 1-structure. No cistrans isomerization could be detected. This independence of the carbanion structure of the solvent polarity is explained by the complexa…

Role of Associated Cortical Lesions in Motor Partial Seizures and Lenticulostriate Infarcts

1995

In a population-based study, we evaluated seizures occurring in the first 15 days after strokes among 1,640 consecutive patients who had ischemic (814 infarcts with atheroma and 126 with cardiogenic embolism, 273 lacunar infarcts, 259 transient ischemic attacks) or hemorrhagic stroke (129 supratentorial hematomas and 24 subarachnoïd hemorrhage) on computed tomography (CT) scan. Ninety patients had an epileptic seizure in the first 15 days after stroke onset. Thirteen of the 90 had a lenticulostriate infarct, diagnosed on CT scan, without an apparent ipsilateral cortical ischemic lesion. No lenticulostriate hematoma was observed with seizures. To determine the possible existence of an ipsila…

Dimesogenic liquid crystalline oligosiloxanes

1995

Abstract In this paper, the syntheses, phase properties and ferroelectric properties of new liquid crystalline oligosiloxane dimesogens are described. Smectic phases are dominant in this class of materials. Spontaneous polarizations are in the range of 10 to approximately 100 nCcm−2. The materials show interesting properties for display applications. Although offering higher mechanical stability than low molar mass materials, their switching is significantly faster (switching times in the range of some 10−5s) than is the case for similar side group polymers (typically some 10−3s). Therefore these new oligosiloxane derivatives may be ideal for building flexible displays. In addition, mixture…

Synthesis of 9-oxyfunctionalized eudesmanes from artemisin

1995

Abstract Artemisin ( 1 ) was transformed into two natural sesquiterpenoids 2 and 3 in a sequence which involves functionality transfer from C 8 to C 9 and further elaboration of the A ring and the lactone moiety.

Organometallic complexes with biological molecules, IV. Di- and tri-organotin(IV) amoxicillin derivatives: Solid-state and solution-phase spectroscop…

1995

Novel di- and tri-organotin(IV) derivatives of amoxicillin (amoxicillin - =Amox - =6-[D(-)-β-amino-p-hydroxyphenylacetamido] penicillinate) have been prepared. The isolated compounds showed stoichiometries of the type R 2 SnClAmox.2H 2 O, R 3 SnClAmoxNa.2H 2 O and R 2 SnAmox 2 .2H 2 O (R=Me, Bu, Ph). The infrared spectra suggest that Amox − , in both R 2 SnClAmox.2H 2 O and R 2 SnAmox 2 .2H 2 O, behaves as a monoanionic bidentate ligand, coordinating the tin(IV) atom through the ester-type carboxylate, as well as through the lactamic carbonyl. In R 3 SnClAmoxNa.2H 2 O, Amox - coordinates the organotin(IV) moieties through the lactamic carbonyl. In all of the compounds, water molecules are n…

General mathematical concept of compensation in sports science with quantitative analysis in the case of sprinting performance

1995

In many of the known sports disciplines, especially in athletics, the criterion which determines the positions of the competitors is a simple physical value, mostly a time or a distance, and the athlete with the minimum or maximum, respectively, takes the first place. Moreover, sports science explains this criterion by a set of the so-called basic abilities. Compensation means the balance of the inferiority of such a basic ability by the superiority of another one. In the following paper, a general abstract concept to analyse compensation in a quantitative way is presented first. It can be applied to any discipline with a measurable criterion, if, in addition, the performance can be describ…

Gas-filled recoil separator for studies of heavy elements

1995

Abstract A gas-filled recoil separator for the study of heavy elements has been constructed. The separator is of type QDQQ with the first, vertically focusing, quadrupole providing improved matching to the acceptance of the dipole magnet. The separator has been designed also for use in vacuum mode in which case a mass resolving power of ≈ 100 is estimated. The deflection angle is 25° and the radius of curvature is 1850 mm. Maximum beam rigidity is 2.2 T m. In the first experiments, new isotopes in the region Z = 85–90 have been synthesized.

Structures, properties and miscibility behaviour of liquid crystalline polycatenar tetrone derivatives

1995

Abstract The tetrones represent an interesting new mesogenic building block. The results of this study show that they can be incorporated into a variety of mesophases. A smectic phase was observed in the polycatenar compound with four terminal chains as expected. The phase exhibits a tilted structure (Sc phase) to prevent void formation. The compound with six pendant chains forms a columnar phase. In spite of their structural similarity, the tetrones studied tended not to be completely miscible. However, complete miscibility with a semi-discoid phenylhydrazone was observed. When this hydrazone, which forms a columnar ‘Dho phase’, was mixed with tetrone which forms a columnar ‘Dhd phase’ a c…

Rectifiability and analytic capacity in the complex plane

1995

Analytic capacity and removable sets In this chapter we shall discuss a classical problem in complex analysis and its relations to the rectifiability of sets in the complex plane C . The problem is the following: which compact sets E ⊃ C are removable for bounded analytic functions in the following sense? (19.1) If U is an open set in C containing E and f : U\E → C is a bounded analytic function, then f has an analytic extension to U . This problem has been studied for almost a century, but a geometric characterization of such removable sets is still lacking. We shall prove some partial results and discuss some other results and conjectures. For many different function classes a complete so…

Hausdorff measures and dimension

1995

Covering and differentiation

1995