Reservoir characteristics of Mainz pouch studied in animal model

1993

In a canine model of the Mainz pouch, intracavitary pressure and compliance were measured during instillation of isosmotic and hyperosmotic (900 mmol/kg water) solutions of saline. Wall properties of small- and large-bowel segments of the pouch were assessed individually by sonomicrometry. Intraluminal pressures increased more steeply during filling with hyperosmotic solution, resulting in reduced distensibility of small- and large-bowel segments. Additionally, instillation of the hyperosmotic solution resulted in increased amplitudes and frequency of intracavitary pressure waves. The results indicate that this was the result of a combination of intensified bowel contractions and an increas…

Optociliary veins and central retinal vein occlusion.

1993

In a follow up of 94 patients with central retinal vein occlusion (CRVO) whose onset had taken place less than 1 year earlier, optociliary veins (OCVs) were found in 7.4% at first examination. Among the 79 eyes in which the fundus of the eye was very visible after a follow up of more than 1 year OCVs were found in 30.4%, showing a late development of OCVs in many cases of CRVO. No difference was found in the occurrence of OCVs between non-ischaemic and ischaemic forms of CRVO. The visual acuity of the eyes with CRVO that developed OCVs was not significantly different from the visual acuity of the eyes without OCVs. Thus, the presence of OCVs in CRVO does not seem to be associated with bette…

Divergent Evolution of an "Orphon" Historic Gene Cluster in Chironomus

1993

The histone genes of the midge Chironomus thummi thummi are organized in tandemly repeated gene groups, each containing the four core histone genes plus an H1 gene. These repetitive gene groups are found at five different loci, linked on one chromosomal arm. In addition to the clustered gene groups an isolated histone gene group exists which is found spatially separated on a different chromosome ("orphon" gene group). These orphon genes have been cloned and analysed in detail. Nucleotide sequence and in situ hybridization data suggest that the orphon gene group was established early during chironomid speciation, possibly by a transposition-like mechanism. This allowed the genes to be moved …

Clean-up and confirmation procedures for gas chromatographic determination of pesticide residues in contaminated waters. Part I

1993

The effects of sulphuric acid, potassium hydroxide and chromic acid on eleven organochlorine and ten organophosphorus pesticides were investigated. The treatments destroy some pesticides totally or partially, leave others unaltered and have a clean-up effect. These reactions can be used to confirm the presence of an identified pesticide. The clean-up extracts in the environmental samples facilitate the identification of the organochlorine and organophosphorus pesticides and their quantitative analysis. The results obtained for contaminated surface waters show the usefulness of these methods for multi-residue capillary gas chromatography without the need for other additional separative chrom…

Lumbar spine mobility in Marfan syndrome

1993

Low back pain symptoms and lumbar spine mobility were assessed by questionnaires and by clinical and radiological measurements in 32 patients with Marfan syndrome. Frequently occurring low back pain was reported by 19% of the patients, but the disability was slight in all of them. Flexion and extension mobility of the lumbar spine (L1-S1) assessed from radiographs was 59.9 degrees and 13.2 degrees, respectively. Mean lumbar angular mobility between flexion and extension radiographs was 7.4 degrees at L1-2, 13.2 degrees at L2-3, 16.0 degrees at L3-4, 19.3 degrees at L4-5 and 18.3 degrees at L5-S1. No correlation was found between the manual assessment of lumbar segmental instability and radi…

1H 2D-NMR characterization of Ni(II)-substituted azurin fromPseudomonas aeruginosa

1993

1 H two-dimemional NMR experiments on nickel(II)-substituted azurin have been succesfully applied. Despite the short relaxation time of the hyperfine-shifted resonances, the combined use of NOESY and COSY spectra allowed the alignment of 15 resonances belonging to the metal-coordinated residues Gly-45, His-46, His-117 and Met-121. Even in the case of the two broad and furthest downfield resonances, the NOESY spectra were successful in assigning these signals to the β-CH 2 protons of Cys-112. The protons of the non-coordinated residues Met-13, Phe-15 and Trp-48 were also assigned via NOESY, COSY and TOCSY experiments

Effects of alkylxanthines on contractility of diaphragm fibres isolated from normal and sensitized guinea-pigs.

1993

Abstract This study investigates the effects of alkylxanthines on twitch tension generated by electrical stimulation (supramaximal pulses, 0·2 ms duration, 1 Hz) of diaphragm muscle fibres isolated from normal and actively-sensitized guinea-pigs. Caffeine, theophylline and theobromine increased, in a concentration-dependent manner (50–500 μm), twitch tension in normal and sensitized diaphragm. Caffeine (500 μm) enhanced contractility to a greater extent than theophylline or theobromine. Twitch potentiation by caffeine (500 μm) was significantly greater in sensitized diaphragm. Verapamil (0·1–100 μm) did not alter twitch contractions in the absence or presence of alkylxanthines in normal or …

Influence of the contrast sensitivity function on the reaction time

1993

The reaction time (RT) vs spatial frequency (SF) curve is determined, using gratings from 1 to 40 c/deg, at seven different contrast levels between 0.95 and 0.02. The form of the RT/SF function: (a) replicated the inverse of the contrast sensitivity function (CSF) at near threshold contrast levels; (b) behaved differently at higher contrasts, exhibiting two branches at contrast close to 1. The interpretation is that there are two factors determining this function: (1) the transition from the operation of fast transient channels at low SF to the operation of slow sustained channels at high SF, the transition taking place within a narrow SF band close to 6 or 8 c/deg (depending on the subject…

Biomechanische Überlegungen über Stoßkräfte und Fußstabilität beim Laufen

1993

The interaction between "man-shoe and surface" is presented as a model to discuss the complexity of human locomotion. Only if the physiological system "man" interacts positively with the physical requirements of shoe and surface quality running will become effective and economical. Especially during the early ground contact phase the hardness of the shoe construction determines the height of the vertical impact load. These adaptations have consequences in the emg amplitudes during the stretch activation phase of the contact. Comparing various jogging shoes with altered construction properties it can be shown that the "hardness" of the shoe material is well adapted by the variation in the em…

Deeply bound pionic atoms with resonant Compton scattering

1993

Abstract We study the contribution to ordinary Compton nuclear scattering of the resonant channel γ + A → (A′ π − ) → γ + A with the π − bound in the nucleus. We show that the interference of this resonant channel with background amplitudes produces significant peaks in the elastic backward differential cross section as a function of the incoming photon energy for light and medium-size nuclei. We also find that for light nuclei the signals in forward Compton scattering or in the total photonuclear cross section are big enough to be observed, provided there is a good resolution in the photon beam. The reaction is particularly suited to find deeply bound pionic states in medium-size nuclei, o…

Riccati-Padé quantization and oscillatorsV(r)=grα

1993

We develop an alternative construction of bound states based on matching the Riccati threshold and asymptotic expansions via their two-point Pad\'e interpolation. As a form of quantization it gives highly accurate eigenvalues and eigenfunctions.

δ objects as a gauge for stress sensitivity of strain rate in mylonites

1993

Abstract Our understanding of the flow properties of deforming rocks in the Earth's lithosphere is mainly based on theoretical work and on the extrapolation of high-strain-rate experimental data to the low strain rates of rock deformation in nature. The geometry of structures in naturally deformed rocks can be an additional source of information on the rheology of the lithosphere. Flow experiments show that the geometry of a mantle of recrystallised material around a rigid object can be used to distinguish between a linear or power-law relation of differential stress and strain rate in strongly deformed rocks such as mylonites. This means that it is possible to use geometrical patterns in d…

Photodisintegration of the deuteron in the Δ-resonance region

1993

Abstract Photodisintegration of the deuteron in the Δ-resonance region is calculated treating the final state interaction within a N N−NΔ coupled channel approach including explicit pion degrees of freedom. For the electromagnetic interaction the nucleonic one-body current, meson exchange currents and the direct Δ-excitation are taken into account. The γN Δ-coupling is fixed in accordance with the M 1+ ( 3 2 ) multipole amplitude for pion photoproduction on the nucleon. The resulting total cross section underestimates the experimental data for photon energies below 340 MeV, whereas a good agreement is achieved by uaing a modified γN Δ-coupling effectively including the nonresonant Born term…

Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenet…

1993

Abstract Rats were treated for 5 weeks with three subconvulsant doses of picrotoxin (PTX) and pentylenetetrazol (PTZ) per week to induce a persistent reduction of the GABA A receptor function which results in chemical kindling. Fifteen days after termination of this treatment schedule, the effect of desipramine (DMI) and alpraxolam (ALP) on immobility time in the forced swim test (FST) was evaluated. Chronic PTX and PTZ did not alter the immobility time. Acute PTX and PTZ reduced the immobility of rats chronically treated with vehicle but not of those exposed chronically to PTX and PTZ. Chronic PTX did not influence the anti-immobility effect of DMI, but blocked that of ALP. Chronic PTZ mar…

Accurate Period Determination of an Eclipsing Binary X-Ray Source in M33

1993

We have analyzed the time variability of one of the X-ray sources in M33 observed by both the ROSAT and Einstein Observatory telescopes. The light curve of M33 X-7 exhibits a variability pattern of high and low states, suggesting an eclipsing binary X-ray source. The data suggest a binary period P=1.78572 days (very close to that of Her X-1) and an eclipse duration of ∼0.4 days. The low phase lasts about one-fourth of the period as in Cen X-3

Identification and cell lineage of individual neural precursors in the Drosophila CNS.

1993

The Drosophila CNS is complex enough to serve as a model for many of the molecular, cellular and developmental functions of the vertebrate CNS, yet simple enough for single-cell analysis. Recent advances have provided molecular markers that allow most Drosophila CNS precursors to be uniquely identified, as well as methods for determining the complete cell lineage of each precursor. A detailed understanding of wild-type neurogenesis, combined with existing molecular genetic techniques, should provide insight into the fundamental mechanisms that generate neuronal and glial diversity.

Biological activity of flucycloxuron, a novel benzoylphenylurea derivative, onTenebrio molitor: comparison with diflubenzuron and triflumuron

1993

Flucycloxuron, a novel benzoylphenylurea (BPU) derivative, exhibited insecticidal activity when injected into newly ecdysed pupae ofTenebrio molitor. Mortality occurs because of defective adult ecdysis. Treatment caused a reduction in both cuticle thickness and incorporation of14C-labelled precursor into chitin, although it had no significant effect on the protein synthesis. The potencies of other BPU compounds as inhibitors of chitin biosynthesis have been examined and results showed that diflubenzuron was less effective than either flucycloxuron or triflumuron.

Atmospheric correction and determination of sea surface temperature in midlatitudes from NOAA-AVHRR data

1993

Abstract In this paper we derive and validate a split-window algorithm for retrieving the sea surface temperature (SST) in midlatitude atmospheric conditions. First we have analyzed thephysical fundamentals of the split-window approach. Then an algorithm has been theoretically derived by means of statistical regression over satellite measurement simulations, and it has been tuned for real NOAA-AVHRR measurements using in situ and coincident satellite data. The accuracy achieved for SST is 0.5 K, which is the limit accuracy that can be obtained from AVHRR measurements over midlatitudes. On the other side, we have proposed a strategy for applying the split-window algorithm without significant…

Affine varieties and lie algebras of vector fields

1993

In this article, we associate to affine algebraic or local analytic varieties their tangent algebra. This is the Lie algebra of all vector fields on the ambient space which are tangent to the variety. Properties of the relation between varieties and tangent algebras are studied. Being the tangent algebra of some variety is shown to be equivalent to a purely Lie algebra theoretic property of subalgebras of the Lie algebra of all vector fields on the ambient space. This allows to prove that the isomorphism type of the variety is determinde by its tangent algebra.

An Ovalbumin Peptide-Specific Cytotoxic T Cell Clone with Antigen Self-Presentation Capacity Uses Two Distinct Mechanisms to Kill Target Cells

1993

Abstract Cloned 10BK.1 T cells with specificity for the ovalbumin peptide OVA257-264 are representative of a novel cell type within the CD8 + subset of T cells. In the presence and in the absence of added antigen presenting cells these T cells react toward antigen (Ag) by proliferation and lymphokine production. These data suggest self-presentation of the Ag by 10BK.1 cells. Here we present evidence that 10BK.1 cells exhibit cytotoxic activity that involves two different cytotoxic effector mechanisms. (i) One mechanism is fast killing activity, apparent within 4 hr. Constitutive mouse T cell-specific proteinase-1 (MTSP-1) activity, constitutive expression of MTSP-1 RNA, increased by Ag chal…

Raaj Sah y Joseph E. Stiglitz, Peasants versus City-dwellers. Taxation and the Burden of Economic Development, Oxford, Clarendon Press, 1992, 223 pp.…

1993

Retention of Molybdenum(VI) by Three Finnish Mineral Soils

1993

Retention of molybdate by three Finnish mineral soils from 10−4 and 10−5 M sodium molybdate solutions at room temperature was investigated at pH 2.3–7.5. In the adsorption experiments 0.02 M KCl wa...

Backtracing particle rays through magnetic spectrometers: avoiding systematic errors in the reconstruction of target coordinates

1993

Abstract The procedures used to model [J. Friedrich, Nucl. Instr. and Meth. A 293 (1990) 575] or to determine [N. Voegler et al., Nucl. Instr. and Meth. A 249 (1986) 337, H. Blok et al., ibid., vol. A 262 (1987) 291, and E.A.J.M. Offermann et al., ibid., vol. A 262 (1987) 298] the mapping properties of a magnetic spectrometer are based on a minimization of the variance of target coordinates . We show that backtracing with matrix elements, determined in this way, may contain systematic errors. As alternative, we propose to minimize the variance of the detector coordinates . This procedure avoids these systematic errors.

Adiabatic cooling of antiprotons in a Penning trap

1993

An antiproton cloud cooled at 4.2 K in a Penning trap can be further cooled by adiabatic reduction of the trap magnetic and electric fields. It will be shown that the temperature can be reduced by two orders of magnitude. This cooling method may be useful to obtain ultra-low energy antiprotons for the measurement of their gravitational properties and the production of ultra-low energy antihydrogen atoms.

Desmin pathology in neuromuscular diseases

1993

Desmin is an intermediate filament protein that in striated muscle is normally located at Z-bands, beneath the sarcolemma, and prominently at neuromuscular junctions. It is abundant during myogenesis and in regenerating fibers, but decreases in amount with maturation; in regenerating and denervated muscle fibers it is co-expressed with vimentin. Aggregates of desmin occur as nonspecific cytoplasmic bodies or cytoplasmic spheroid complexes, similar to the aggregates of keratin filaments in Mallory bodies or the neurofilament aggregates in Lewy bodies. In all three instances, alpha-B crystallin may be associated with desmin. There are now increasing numbers of neuromuscular disorders in which…

On the order of the herringbone transition of N2 on graphite: a Monte Carlo study

1993

Using the anisotropic planar-rotor model we investigate the herringbone phase transition of N2 in the (√3 × √3)R30° commensurate phase on graphite by large scale Monte Carlo simulations. The effective correlation length ξ is measured near the transition temperature T0. The data, extrapolated to T0, yield a large but finite ξ at T0 demonstrating that the herringb ordering is a weak first order transition.

Histamine inhibits spontaneous activity of the uterus of the progesterone-treated rat

1993

Achromatic Fresnel diffraction patterns

1993

Abstract A novel method for obtaining a single, but arbitrary, achromatic Fresnel diffraction pattern of any pupil with broadband parallel illumination is presented. The optical device simply consists of an achromatic objective and an on-axis zone plate. A criterion for selecting the system parameters in order to minimize the residual chromatic aberrations is given. The recording of the selected diffraction field is obtained with low chromatic aberrations even for white-light illumination. An experimental verification is shown to illustrate this approach.

Effects of captopril on myocardial protection during cardioplegia

1993

Abstract The study aimed at checking effects exerted by captopril (C) on human myocardial ACE system as well as the role played by tissue ACE inhibition in reducing reperfusion damage. A human experimental model was used during cardioplegia due to aorto-coronary-by-pass (CABG). Fifty-four patients with coronary artery disease affecting 3 vessels having suffered from acute myocardial infarction anterior (AMI-ant), homogeneous as far as ejection fraction (35–55%), number of grafts (3), clamping time, age and sex, were randomised in a double blind experiment, and were given captopril or placebo (P). A total of 4 mg/l Captopril was mixed into the cardioplegic solution with blood according to th…

Financial accounting and reporting in Finland

1993

(1993). Financial accounting and reporting in Finland. European Accounting Review: Vol. 2, No. 3, pp. 592-602.

Caseicin, a bacteriocin from Lactobacillus casei.

1993

The intracellular bacteriocin caseicin 80 was purified from cell extracts of Lactobacillus casei strain B80. It is a thermolabile protein with an apparent molar mass of 42 kDa. As no plasmids were observed in the bacteriocinogenic strain it is assumed that caseicin is encoded by the bacterial chromosome. Using 14C-labelled precursors it was found that biosynthesis of DNA and proteins was influenced by caseicin but this inhibition is probably not the primary effect. The incorporation of fructose but not of glucose into cellular material was inhibited by caseicin.

Extremely cold antiprotons for antihydrogen production

1993

The possibility to produce, trap and study antihydrogen atoms rests upon the recent availability of extremely cold antiprotons in a Penning trap. Over the last five years, our TRAP Collaboration has slowed, cooled and stored antiprotons at energies 1010 lower than was previously possible. The storage time exceeds 3.4 months despite the extremely low energy, which corresponds to 4.2 K in temperature units. The first example of measurements which become possible with extremely cold antiprotons is a comparison of the antiproton inertial masses which shows they are the same to a fractional accuracy of 4×10−8. (This is 1000 times more accurate than previous comparisons and large additional incre…

Optimisation of fast protein separations on non-porous silica-based strong anion exchangers

1993

The adsorbed coating technology using various vinylpyrrolidone-vinylimidazole copolymer compositions was carried out on 1.7 μm non-porous monodisperse silica. It was shown that the retention properties and the loading capacity for bovine serum albumin (BSA) increases with the amount of vinylimidazole in the copolymer composition. The retention behavior of various proteins as a function of the salt composition in the eluent has been applied to find the optimal conditions for the synthesis of the anion-exchange stationary phase. The suitability of these supports for the fast separation of biological molecules is demonstrated. The best resolution and the highest speed in protein analysis was o…

Monte Carlo simulation of dimensional crossover in the XY model.

1993

We report Monte Carlo simulations of Villain's periodic Gaussian XY model on ${\mathit{L}}^{2}$\ifmmode\times\else\texttimes\fi{}N lattices of film geometry (L\ensuremath{\gg}N) with up to N=16 layers, employing the single-cluster update algorithm combined with improved estimators for measurements. The boundary conditions are periodic within each layer and free at the bottom and top layer. Based on data for the specific heat, the spin-spin correlation function, and the susceptibility in the high-temperature phase we study the crossover from three- to two-dimensional behavior as criticality is approached. For the transition temperatures, determined from Kosterlitz-Thouless fits to the correl…

Structure and dynamics of yukawa systems

1993

Abstract Results of molecular dynamics simulations modelling two component charge stabilized colloidal particles interacting via a Yukawa potential are presented. After cooling, the systems freeze into either substitutionally disordered imperfect crystals or into glasslike states. This freezing is characterized by the divergence of a suitable correlation time due to loss of ergodicity. Describing the structure by bond correlation functions, local orientational ordering is observed in the glassy states which is not present in the liquid. In the liquid the diffusion constant obeys an Arrhenius law. As can be deduced from the van Hove functions, in the crystal the particles only oscillate arou…

Further Developments and Tests of a Progressive Algorithm for Multiple Criteria Decision Making

1993

P. Korhonen, H. Moskowitz, and J. Wallenius (1986) developed a progressive algorithm and the supporting theory for modeling and solving multiple criteria decision problems with discrete alternatives. A special feature of the algorithm is that it relaxes the usual assumption of a fixed set of available decision alternatives and complete knowledge of a decision maker's (DM's) preference structure or value function. The algorithm is based on progressively sampling the decision space, obtaining preference information from the DM, determining the likelihood of finding possibly/surely better alternatives, and based on this information, continuing the search or terminating it by making the final …