showing 36 of ~574560 from 574555 documents
Efficacy of CAR-T immunotherapy in MET overexpressing tumors not eligible for anti-MET targeted therapy
2022
Abstract Background Aberrant activation of the MET receptor in cancer is sustained by genetic alterations or, more frequently, by transcriptional upregulations. A fraction of MET-amplified or mutated tumors are sensible to MET targeting agents, but their responsiveness is typically short-lasting, as secondary resistance eventually occurs. Since in the absence of genetic alterations MET is usually not a tumor driver, MET overexpressing tumors are not/poorly responsive to MET targeted therapies. Consequently, the vast majority of tumors exhibiting MET activation still represent an unmet medical need. Methods Here we propose an immunotherapy strategy based on T lymphocytes expressing a Chimeri…
Motivational Challenges of Engineers Participating in an Online Upskilling Program
2022
The present powerful surge of available online learning platforms will provide employees with enhanced opportunities to rapidly develop their skills, regardless of time and place. Despite the potential, there are challenges for participants on online learning platforms to finalise the courses they engage in. The reasons for the high number of students dropping out before completion of the course are motivational, social, and technological. Studies show that large skill gaps exist among industry employees worldwide. It is often caused by the implementation of new technologies, digitalization, as well as increasing requirements on sustainability and resilience. E-learning provides a major opp…
Individual and country-level factors associated with self-reported and accelerometer-based physical activity in old age: a cross-national analysis of…
2022
AbstractThis study aimed to investigate associations between individual-level (personality traits, quality of life) and country-level (gross domestic product per capita, number of policies and action plans for physical activity) factors with self-reported and accelerometer-based physical activity and cross-level interactions among European countries. Based on the Survey of Health, Ageing and Retirement in Europe (SHARE) from 2019–2020, self-reported physical activity (N = 46,617 from 27 countries) and accelerometer-based average acceleration and intensity gradient (N = 855 from 10 countries) were analyzed. Mixed-model regressions with two levels (individuals nested within countries) were us…
Textbook myths about early atomic models
2022
Most physics textbooks at college and university level introduce quantum physics in a historical context. However, the textbook version of this history does not match the actual history. In this article, the first in a series of articles looking at the textbook description of the quantum history, we follow an exceptional student through her endeavors to understand the early atomic models that led up to the work of Niels Bohr. We experience her disappointment when she discovers that the description of the famous atomic model by Thomson, is a mere caricature with almost no trace of Thomson's work and that the supposedly important radiative instability of Rutherford's atoms, is not there at al…
Correlation Between Long-Term Acetylsalicylic Acid Use and Prostate Cancer Screening with PSA. Should We Reduce the PSA Cut-off for Patients in Chron…
2022
Guglielmo Mantica,1 Francesco Chierigo,1,2 Farzana Cassim,3 Francesca Ambrosini,1,2 Stefano Tappero,1,2 Rafaela Malinaric,1,2 Stefano Parodi,1,2 Andrea Benelli,4 Federico Dotta,4 Marco Ennas,4 Martina Beverini,1,2 Chiara Vaccaro,5 Salvatore Smelzo,6 Giovanni Guano,1,2 Federico Mariano,1,2 Calogero Paola,1,2 Giorgia Granelli,1,2 Virginia Varca,5 Carlo Introini,4 Salvatore Dioguardi,7 Alchiede Simonato,7 Andrea Gregori,8 Franco Gaboardi,6 Carlo Terrone,1,2 André Van der Merwe3 1IRCCS Ospedale Policlinico San Martino, U.O. Urologia, Genova, Italy; 2Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genova, Italy; 3Department of Urology, Tygerberg Academic …
Active Biomonitoring of Heavy Metal Concentrations in Aquatic Environment Using Mosses and Algae
2022
In this paper, we present an analysis of the pollution of surface water and air by the heavy metals: Mn, Fe, Ni, Cu, Zn, Cd and Pb in the area of the smelter in Ozimek (Opolskie Voivodeship, Poland). The marine algae Palmaria palmata was exposed in the Mała Panew River, and three species of forest mosses: Pleurozium schreberi, Sphagnum fallax and Dicranum polysetum were also applied. Active biomonitoring was also carried out using P. schreberi mosses to assess air pollution, since the area and the river are influenced by the smelter’s activities. Analytes were determined by atomic absorption spectrometry. Student’s T-test and Mann–Whitney U test were used to assess th…
Idiopathic Retroperitoneal Fibrosis: What Is the Optimal Clinical Approach for Long-Term Preservation of Renal Function?
2022
<b><i>Background:</i></b> The aim of this study was to investigate the long-term effects of ureteral stenting and the exact timing of stent removal in favor of surgery in patients with idiopathic retroperitoneal fibrosis (IRF). <b><i>Summary:</i></b> Medline research terms of “idiopathic retroperitoneal fibrosis” AND “ medical therapy” OR “ureteral stenting” OR “surgical treatment” were done. Systematic reviews and observational and clinical studies were analyzed to obtain indication regarding the objective of the study for a narrative review. Ninety-two papers were analyzed. The treatment of IRF includes the monitoring of retroperitoneal fibr…
The Management of Invasive Non-Native Trees in the Mediterranean Protected Areas: Sicily as a Case Study
2022
Invasive non-native trees (INNTs) are increasingly recognized to have negative effects on biodiversity and ecosystem services in protected areas. The management of INNTs is one of the major challenges to preserving native species and ecosystems, to which more and more efforts and resources are bound to be destined in the coming decades. Indeed, the combined effects of climate change and increasing disturbance factors (e.g. wildfires) are likely to aid the spread of many INNTs in the Mediterranean protected areas, as well as favouring their competitive relationships with native species. However, the effective implementation of control measures is far from being fully achieved. I assessed how…
Tolerance, Adaptation, and Cell Response Elicited by Micromonospora sp. Facing Tellurite Toxicity: A Biological and Physical-Chemical Characterization
2022
The intense use of tellurium (Te) in industrial applications, along with the improper disposal of Te-derivatives, is causing their accumulation in the environment, where oxyanion tellurite (TeO32−) is the most soluble, bioavailable, and toxic Te-species. On the other hand, tellurium is a rare metalloid element whose natural supply will end shortly with possible economic and technological effects. Thus, Te-containing waste represents the source from which Te should be recycled and recovered. Among the explored strategies, the microbial TeO32− biotransformation into less toxic Te-species is the most appropriate concerning the circular economy. Actinomycetes are ideal candidates in…
Evaluation of Effects of Various Irrigating Solutions on Chemical Structure of Root Canal Dentin Using FTIR, SEM, and EDS: An In Vitro Study
2022
Background: Sequential chemical application for irrigating a root canal during chemomechanical debridement can affect the dentin microstructure. Understanding the effects of various irrigants on chemical properties of dentin can elucidate their effects on physical properties and thereby explain the higher incidence of structural failure in endodontically treated teeth. This in vitro research aimed to compare and evaluate the effects of three different irrigating solutions on the chemical structure of root canal dentin in extracted human teeth. Methods: Forty-eight extracted single-rooted mandibular premolar teeth were sectioned at the cemento–enamel junction by a diamond disc and were…
Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis.
2022
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease, characterized by the progressive degeneration of the upper and lower motor neurons in the cortex and spinal cord. Although the pathogenesis of ALS remains unclear, evidence concerning the role of the clonotypic immune system is growing. Adaptive immunity cells often appear changed in number, or in terms of their activation profiles, both peripherally and centrally; however, their role in ALS appears conflictive. Data from human and animal model studies, which are currently reported in the literature, show that each subset of lymphocytes and their mediators may mediate a protective or toxic mechanism in ALS, affecting both…
Autologous conditioned serum for chronic pain in patients with osteoarthritis: A feasibility observational study
2022
Background Autologous conditioned serum is a product of blood origin, with fragmented evidence of therapeutic properties in osteoarthritis chronic pain. This pilot observational prospective study aimed to evaluate the feasibility of a treatment with conditional autologous serum (ACS) in patients with severe chronic pain and grade I-III osteoarthritis and to describe its cytokine content. Methods We prospectively collected data on consecutive patients affected by osteoarthritis grade I to III and treated with four weekly injections of ACS at our outpatient pain service. The primary outcome was pain intensity, measured with the visual analogic scale (VAS). Additional outcomes were symptoms ev…
LA POLITICA ORDINARIA E DI COESIONE NELLE REGIONI ITALIANE: UNA VALUTAZIONE SETTORIALE SUL FUNZIONAMENTO DEL PRINCIPIO DI ADDIZIONALITA'
2022
This paper analyses the degree of additionality of the Cohesion Policy to ordinary domestic spending in the Italian NUTS-2 regions during the last two programming periods (2007-2013 and 2014-2020). The European Commission has established that the Structural Funds must not be used to replace the disbursement of the Member States to the regions. However, the treatment could distort the allocative choices of the national policy maker. The main element of novelty is the ex-post panel evaluation of cohesion funds’ additionality to the Ordinary Policy through a sectoral breakdown of spending, controlling for the potential endogeneity of the cohesion variable. The sectoral approach allows us to as…
Study of the Effect of Two Phases in Li4SiO4–Li2SiO3 Ceramics on the Strength and Thermophysical Parameters
2022
This research was funded by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan (No. BR11765580). The research of the team from Latvia (A.M., V.P. and A.I.P.) has been carried out within the framework of the EUROfusion Consortium, funded by the European Union via the Euratom Research and Training Programme (Grant Agreement No. 101052200—EUROfusion). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the European Commission can be held responsible for them. The research was partly (A.M., V.P. and A.I.P.) performed in …
Individual and population-scale carbon and nitrogen isotopic values of Procambarus clarkii in invaded freshwater ecosystems
2022
Este artículo contiene 16 páginas, 1 figura, 1 tablas.
A snapshot of the transition from monogenetic volcanoes to composite volcanoes: Case study on the Wulanhada Volcanic Field (northern China)
2022
The transition processes from monogenetic volcanoes to composite volcanoes are poorly understood. The Late Pleistocene to Holocene intraplate monogenetic Wulanhada Volcanic Field (WVF) in northern China provides a snapshot of such a transition. Here we present petrographic observations, mineral chemistry, bulk rock major and trace element data, thermobarometry, and a partial melting model for the WVF to evaluate the lithology and partial melting degree of the mantle source, the crystallization conditions, and pre-eruptive magmatic processes occurring within the magma plumbing system. The far-field effect of India–Eurasia collision resulted in a relatively high degree (10 %–20 %) of partial …
Da Croce a Vico, vita come opera
2022
This paper is dedicated to the investigation of a particular discursive genre, that of philosophical autobiography. Although the dialogue between philosophers is not only about the doctrine they propose, but also about the genres through which they decide to communicate that doctrine, the philosophical autobiography is usually regarded as having no doctrinal value. In this genre the enunciative scene is made explicit, so that the ‘I’ who thinks coincides with the ‘I’ who writes and, in some cases, also with the ‘I’ who lives. We will investigate the enunciation procedures and, above all, the relations between enunciation and enunciatee.
Exclusive J/ψ and ϒ production in high-energy pp and p-Pb collisions
2022
We present a formalism for determining the cross section for exclusive heavy vector meson production (J/ψ,ϒ) as a function of rapidity, in both high-energy proton-proton and proton-heavy ion collisions, at next-to-leading order in QCD. We compare and contrast the production in pp and p-Pb collisions and show how data for these processes can give information on the low-x gluon distribution of the proton and heavy ions at a range of different scales.
Irene Mellis - dabaszinātņu pētniece, publiciste un sekretāre
2022
Latvijas Universitātes studenti, ar kuriem lepojamies, ir veicinājuši zinātnes, latviešu kultūras un dzīvesziņas uzturēšanu savās mītnes zemēs. Irene Mellis (dzim. Putniņa) (1916-2017) ir viena no Latvijas Universitātes (LU) Matemātikas un dabaszinātņu fakultātes absolventēm, kura sekmīgi aizstāvot maģistra darbu “Rembates dolomītsmilšakmens kvantitatīvais minerāloģiskais sastāvs : mēģinājums novērtēt ģeometriskās analīzes noderību iežu uzbūves raksturojumam“, studijas beidza 1944. gadā, bet sava mūža lielāko daļu kopā ar ģimeni pavadīja Zviedrijā. I. Mellis diplomdarbu ar “ ļoti sekmīgi” novērtējuši fakultātes mācību spēki B. Popovs, V. Zāns un N. Delle un tas ir pieejams LU Bibliotēkas kr…
A new selenosteid placoderm from the Late Devonian of the eastern Anti-Atlas (Morocco) with preserved body outline and its ecomorphology
2022
Placoderms are an extinct group of early jawed vertebrates that play a key role in understanding the evolution of the gnathostome body plan, including the origin of novelties such as jaws, teeth, and pelvic fins. As placoderms have a poorly ossified axial skeleton, preservation of the mainly cartilaginous axial and fin elements is extremely rare, contrary to the heavily mineralized bones of the skull and thoracic armor. Therefore, the gross anatomy of the animals and body shape is only known from a few taxa, and reconstructions of the swimming function and ecology are speculative. Here, we describe articulated specimens preserving skull roofs, shoulder girdles, most fins, and body outlines …
Examining the relationships between teacher self-efficacy, professional learning community, and experiential learning in Japan
2022
This study investigated the relationships between professional learning communities (PLCs), teacher self-efficacy, and experiential learning. A conceptual model that connects PLC components, including shared vision, interactive reflection, and collegiality, to teacher self-efficacy was proposed, as mediated by experiential learning. The data comprised 3,604 teachers from 204 primary schools and 787 teachers from 90 lower secondary schools in Japan. First, a multigroup confirmatory factor analysis confirmed that the same constructs of PLC, teacher self-efficacy, and experiential learning were measured at different school levels. Second, multigroup structural equation modelling revealed that …
The new boundaries of digitization: from bim to parametric modelling
2022
The theme of digitization and documentation, which inevitably affects the fields of surveying and designing architecture and urban areas, is constantly innovated by the new digital technologies and new multimedia communication systems that allow us to acquire, analyze and disseminate the value of our historical heritage. Research in this field pushes us to overcome the limits imposed by tested technologies in order to extend the field of application in the surveying and representation of the increasingly complex challenges imposed by the needs of conservation and maintenance. This volume, which follows on from the three previous conferences of the “Digital & Documentation” cycle that to…
Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension: A systematic review
2022
Arterial hypertension (AH) among adults is known to be associated with worse cognitive outcomes. Similarly, children and adolescents with AH could be expected to underperform during neuropsychological evaluations when compared with healthy peers. Our aims were to review the existing literature on cognitive functioning among children and adolescents with primary AH and to identify what additional evidence may be needed to substantiate the impact of hypertension on poor cognitive outcomes in this population. We conducted a systematic review of articles in PubMed and Web of Science published before 17 January 2022, reporting on cognitive testing among children and adolescents with primary AH. …
SPILLOVER SPAZIALI ED EFFETTI DI SPIAZZAMENTO DELLA POLITICA DI COESIONE: UN’ANALISI SUI PROGETTI NELLE PROVINCE ITALIANE
2022
Una delle possibili cause di inefficacia di una politica pubblica è la totale ricaduta dei suoi effetti fuori delle aree territoriali di intervento. Il presente lavoro tratta questo tema analizzando il legame tra spillover spaziali ed effetti di spiazzamento nell'attuazione della Politica di Coesione europea. Valutiamo l’impatto degli interventi sulla crescita del PIL pro-capite, con una strategia econometrica che incorpora gli effetti spaziali. L'analisi è condotta sulle province italiane (NUTS-III) durante gli ultimi due periodi di programmazione (2007-2013 e 2014-2020), considerando anche la Politica di Coesione nazionale. Utilizziamo la versione panel del modello Spatial Durbin, con l'a…
Low NETosis Induced in Anaplasma phagocytophilum-Infected Cells.
2022
Anaplasma phagocytophilum are obligatory intracellular bacteria that preferentially replicate inside leukocytes by utilizing biological compounds and processes of these primary host defensive cells. In this study, bioinformatics analysis was conducted to further characterize A. phagocytophilum– host interactions using the neutrophil-like model of human Caucasian promyelocytic leukemia HL60 cells. We detected a hierarchy of molecules involved in A. phagocytophilum-HL60 interactions with overrepresentation in infected human cells of proteins involved in the reactive oxygen species (ROS) pathway and cell surface monocyte markers. As A. phagocytophilum phagocytosis by neutrophils is inhibited, …
Environmental sustainability in restaurants. A systematic review and future research agenda on restaurant adoption of green practices
2022
The adverse impact that restaurants have on the environment has received widespread attention in the last decade from both practice and academia. The current study aims to find, catalog, and synthesize the research body addressing green issues in the restaurant industry. We utilize the systematic literature review method to identify and analyze 68 research articles addressing environmental unsustainability problems in the restaurant industry. The research profile identifies the time trends of publication, key journals, countries studied, methods used, and restaurant types discussed in these studies. The results indicate that green restaurant research has grown exponentially recently and is …
Chemical analysis of the Asian tropopause aerosol layer (ATAL) with emphasis on secondary aerosol particles using aircraft-based in situ aerosol mass…
2022
Abstract. Aircraft-borne in situ measurements of the chemical aerosol composition were conducted in the Asian tropopause aerosol layer (ATAL) over the Indian subcontinent in the summer of 2017, covering particle sizes below ∼3 µm. We have implemented a recently developed aerosol mass spectrometer, which adopts the laser desorption technique as well as the thermal desorption method for quantitative bulk information (i.e., a modified Aerodyne AMS), aboard the high-altitude research aircraft M-55 Geophysica. The instrument was deployed in July and August 2017 during the StratoClim EU campaign (Stratospheric and upper tropospheric processes for better Climate predictions) over Nepal, India, Ban…
El análisis cuantitativo de trayectorias laborales. Un estado del arte
2022
La metodología cuantitativa aplicada al estudio de las trayectorias laborales ha experimentado un rápido auge que se ha extendido más allá del tradicional análisis de secuencias. El presente artículo es un estado del arte del desarrollo de nuevas técnicas estadísticas que pueden aplicarse o ya se aplican al estudio de trayectorias laborales. Además, incluimos sugerencias de software estadístico para la aplicación de cada una de las técnicas descritas. A lo largo de todo el texto, podrá observarse que la descripción de cada técnica se ha realizado desde un punto de vista conceptual, con el objetivo de llegar a un público amplio, que no necesite poseer una fuerte formación estadística. Es med…
The focus and timing of gaze matters : Investigating collaborative knowledge construction in a simulation-based environment by combined video and eye…
2022
Although eye tracking has been successfully used in science education research, exploiting its potential in collaborative knowledge construction has remained sporadic. This article presents a novel approach for studying collaborative knowledge construction in a simulation-based environment by combining both the spatial and temporal dimensions of eye-tracking data with video data. For this purpose, we have investigated two undergraduate physics student pairs solving an electrostatics problem in a simulation-based environment via Zoom. The analysis of the video data of the students’ conversations focused on the different collaborative knowledge construction levels (new idea, explication, eval…
Initial pH Conditions Shape the Microbial Community Structure of Sewage Sludge in Batch Fermentations for the Improvement of Volatile Fatty Acid Prod…
2022
Conversion of wastewater treatment plants into biorefineries is a sustainable alternative for obtaining valuable compounds, thus reducing pollutants and costs and protecting the environment and human health. Under specific operating conditions, microbial fermentative products of sewage sludge are volatile fatty acids (VFA) that can be precursors of polyhydroxyalkanoate thermoplastic polyesters. The role of various operating parameters in VFA production has yet to be elucidated. This study aimed to correlate the levels of VFA yields with prokaryotic microbiota structures of sewage sludge in two sets of batch fermentations with an initial pH of 8 and 10. The sewage sludge used to inoculate th…
Chemical analysis of the Asian tropopause aerosol layer (ATAL) with emphasis on secondary aerosol particles using aircraft-based in situ aerosol mass…
2022
Aircraft-borne in situ measurements of the chemical aerosol composition were conducted in the Asian tropopause aerosol layer (ATAL) over the Indian subcontinent in the summer of 2017, covering particle sizes below ∼3 µm. We have implemented a recently developed aerosol mass spectrometer, which adopts the laser desorption technique as well as the thermal desorption method for quantitative bulk information (i.e., a modified Aerodyne AMS), aboard the high-altitude research aircraft M-55 Geophysica. The instrument was deployed in July and August 2017 during the StratoClim EU campaign (Stratospheric and upper tropospheric processes for better Climate predictions) over Nepal, India, Bangladesh, a…
L’apparato effimero allestito nella cattedrale di Palermo per le cerimonie funebri di Carlo III di Borbone (1789): storia e rappresentazione digitale
2022
The paper focus on the ephemeral apparatus realized by the architect Salvatore Attinelli on the occasion of the funeral of Charles III of Bourbon, to be set up inside the cathedral of Palermo, in those years affected by a total internal modernization based on the project commissioned in 1767 to Ferdinando Fuga. This apparatus, in an article published by the academic Giuseppina Leone in 2001, was considered an alternative project to the proposal of Ferdinando Fuga, considered expensive and with a language not responding to the rules of good and modern architecture. The purpose of this paper is to reinforce the hypothesis of an apparatus having design purposes, and to verify its feasibility t…
Cambios recientes en la cuenca media del Túria : reverdecimiento del paisaje
2022
Durante la segunda mitad del siglo xx, los paisajes mediterráneos peninsulares han experimentado importantes modificaciones en los usos del suelo, producto del desarrollo socioeconómico (industrialización, urbanización, intensificación del regadío y la ganadería, y abandono de cultivos). Este artículo describe, cartografía y cuantifica las principales transformaciones ocurridas en la cuenca media del Túria, ejemplo de montaña media mediterránea y un espacio de transición entre las tierras altas y el llano litoral afectado por las dinámicas de expansión del área metropolitana de Valencia. Se han utilizado técnicas de fotointerpretación y el análisis de series del índice de vegetación NDVI ob…
E-cycling and health benefits: A systematic literature review with meta-analyses
2022
The objective of the present study is to review and meta-analyze the effect of E-cycling on health outcomes. We included longitudinal experimental and cohort studies investigating the effect of E-cycling on health outcomes. The studies were identified from the seven electronic databases: Web of Science, Scopus, Medline, Embase, PsycINFO, Cinahl and SportDiscus and risk of bias was assessed with the revised Cochrane Collaboration Risk of Bias Tool (RoB2). We performed meta-analysis with random effects models on outcomes presented in more than one study. Our study includes one randomized controlled trial, five quasi experimental trials and two longitudinal cohort studies. The trials included …
Go Cashless! Mobile Payment Apps Acceptance in Developing Countries: The Jordanian Context Perspective
2022
Despite the expanding global usage of mobile phones in money transactions, the adoption of mobile payment systems in Jordan remains slow. This study employed the technology acceptance model (TAM) to identify the factors with a potential impact on mobile payment systems acceptance. The impact of perceived privacy (PP) and the mediating function of perceived certainty (PC) on the behavioral intention (BI) of mobile payment systems among Jordanian ministries were examined. Data obtained from 270 respondents were analyzed using partial least-squares structural equation modeling (PLS-SEM). The empirical findings show a positive link between perceived usefulness (PU) and PC on the BI of mobile pa…
Machine Learning for Predicting Chemical Potentials of Multifunctional Organic Compounds in Atmospherically Relevant Solutions
2022
We have trained the Extreme Minimum Learning Machine (EMLM) machine learning model to predict chemical potentials of individual conformers of multifunctional organic compounds containing carbon, hydrogen, and oxygen. The model is able to predict chemical potentials of molecules that are in the size range of the training data with a root-mean-square error (RMSE) of 0.5 kcal/mol. There is also a linear correlation between calculated and predicted chemical potentials of molecules that are larger than those included in the training set. Finding the lowest chemical potential conformers is useful in condensed phase thermodynamic property calculations, in order to reduce the number of computationa…