showing 36 of ~574560 from 574555 documents
EU-wide cross-sectional observational study of lipid-modifying therapy use in secondary and primary care: the DA VINCI study
2021
Abstract Aims To provide contemporary data on the implementation of European guideline recommendations for lipid-lowering therapies (LLTs) across different settings and populations and how this impacts low-density lipoprotein cholesterol (LDL-C) goal achievement. Methods and results An 18 country, cross-sectional, observational study of patients prescribed LLT for primary or secondary prevention in primary or secondary care across Europe. Between June 2017 and November 2018, data were collected at a single visit, including LLT in the preceding 12 months and most recent LDL-C. Primary outcome was the achievement of risk-based 2016 European Society of Cardiology (ESC)/European Atherosclerosis…
Predicting the current and future global distribution of the invasive freshwater hydrozoan Craspedacusta sowerbii
2021
AbstractThe freshwater jellyfish Craspedacusta sowerbii is one of the most widespread invasive species, but its global distribution remains uncertain due to ephemeral appearances and general lack of information in various aquatic environments. The aim of this study was to map current and future distributions (2050 and 2100) using Species Distribution Models allowing to visualize the habitat suitability and make projections of its changes under potential climate change scenarios. Except in Oceania where the range decreased, an expansion of C. sowerbii was projected during the next century under modeled future scenarios being most intensive during the first half of the century. The present st…
Exposure of heat-not-burn tobacco effect on the quality of air and expiratory plume
2021
Abstract The increasing interest to avoid the consumption of regular tobacco has lead in the development of several types of devices to decrease the effects of this practice on active and bystanders. In this work, the impact of the use of new heat-not-burn (HnB) devices has been evaluated and compared with that of regular cigarettes and electronic cigarettes (e-cigs). Portable monitoring devices were employed for CO, CO2, particulate matter (PM) and volatile organic compounds (VOCs) to evaluate the quality of indoor air and expiratory plume of both, active and passive, users during these practices. It can be noticed that the levels of VOCs in active HnB smokers expiratory air are five times…
Georgien zwischen Eigenstaatlichkeit und russischer Okkupation. Die Wurzeln des Konflikts vom 18. Jh. bis 1924
2021
Psychological Network Analysis of General Self-Efficacy in High vs. Low Resilient Functioning Healthy Adults
2021
Resilience to stress has gained increasing interest by researchers from the field of mental health and illness and some recent studies have investigated resilience from a network perspective. General self-efficacy constitutes an important resilience factor. High levels of self-efficacy have shown to promote resilience by serving as a stress buffer. However, little is known about the role of network connectivity of self-efficacy in the context of stress resilience. The present study aims at filling this gap by using psychological network analysis to study self-efficacy and resilience. Based on individual resilient functioning scores, we divided a sample of 875 mentally healthy adults into a …
Zarząd "kadłubowy" w spółce z ograniczoną odpowiedzialnością
2021
Niniejszy artykuł przedstawia zagadnienie zarządu „kadłubowego” w spółce z ograniczoną odpowiedzialnością. Omawiana instytucja prawa handlowego nie została unormowana przez Kodeks spółek handlowych, lecz została wypracowana przez doktrynę. Autor w niniejszym artykule przedstawia typowe aspekty funkcjonowania zarządu – reprezentacja spółki oraz prowadzenie spraw spółki przez zarząd „kadłubowy”. Analizując różne stanowiska wypracowane zarówno przez doktrynę, jak i orzecznictwo sądowe, Autor stara się pokazać, że ważniejszą kwestią od istnienia samego organu dla prawidłowego funkcjonowania spółki niezbędna jest odpowiednia liczebność organu w celu dokonania ważnych czynności prawnych w sferze …
Iterative Optimal Design of Special Moment Resisting Devices for Steel Frames
2021
Abstract The present paper proposes an iterative procedure devoted to reaching the optimal design of an innovative, recently proposed, moment resisting device. This special device, called Limited Resistance Plastic Device (LRPD), can be utilized, as an example, to equip a steel frame when it is required that the frame must be designed to substitute a masonry panel, i.e., it must be characterized by a structural behaviour as close as possible to the one of the replaced masonry wall. This purpose can be reached by designing the relevant frame imposing appropriate constraints on the elastic stiffness and on the limit resistance. The result can be obtained just by ensuring that the elastic stif…
Custodie eucaristiche in Sicilia tra Tardo Gotico e Rinascimento
2021
Review of Eucharistic cases, aka monstrances, of architectural typology produced in Sicily between the 15th and 17th centuries. Analysis of the compositional and stylistic characteristics. Framing in the broader historical, artistic and cultural context of reference
Social Innovation Toward a Meaningful Everyday Life for Nursing Home Residents: An Ethnographic Study
2021
Background: The literature shows that innovation, which includes culture change, may be important to create a meaningful everyday life for nursing home residents. However, there is a gap in how social innovation practices may contribute to this. The theoretical discourse for the study is person-centered care.Aim: The main aim was to explore phenomena within social innovation that can contribute to improving nursing home residents’ everyday lives.Design and Method: This study uses an ethnographic design with observations and interviews in two nursing homes in Southern Norway.Findings: The main theme was that social innovation within working practices in nursing homes includes phenomena that …
The Southeast Asian Lady {Boy}
2021
Singapore, una città-stato dal carattere decisamente cosmopolita, proietta nel mondo un'immagine urbana di frizzante modernità, ricchezza e benessere. All'ombra di potenti landmark architettonici e ai margini di una società opulenta, si nascondono però le condizioni di povertà ed esclusione in cui vive una buona metà della popolazione. Il vero ritratto di Singapore è quindi inciso da una profonda frattura, acuita dalla multietnicità della popolazione. Ed è nell'ambito di questi profondi contrasti, come talvolta può accadere nelle situazioni più estreme, che avvengono straordinari miracoli. Ed ecco che il miracolo è stato compiuto dalla cucina! Nonostante la città sia una delle più care al m…
Non‐invasive diagnostic techniques in pigmentary skin disorders and skin cancer
2021
Background Diagnosis of pigmentary skin disorders, pre-cancerous and cancerous skin diseases is traditionally relied on visual assessment. The most widely applied invasive diagnostic technique is the skin biopsy. There have been significant technological advances in non-invasive diagnostic methods for skin disorders. Objective The objective of this article is to discuss different non-invasive diagnostic modalities, used in the diagnosis of pigmentary skin disorders and cutaneous cancers. Methods Comprehensive literature search was performed to screen articles related to non-invasive diagnostic techniques in pigmentary skin disorders and cutaneous cancers. Articles published in journals inde…
Error messages in relational database management systems: A comparison of effectiveness, usefulness, and user confidence
2021
Abstract The database and the database management system (DBMS) are two of the main components of any information system. Structured Query Language (SQL) is the most popular query language for retrieving data from the database, as well as for many other data management tasks. During system development and maintenance, software developers use a considerable amount of time to interpret compiler error messages. The quality of these error messages has been demonstrated to affect software development effectiveness, and correctly formulating queries and fixing them when needed is an important task for many software developers. In this study, we set out to investigate how participants ( N = 152 ) …
Folding and insertion of transmembrane helices at the ER
2021
In eukaryotic cells, the endoplasmic reticulum (ER) is the entry point for newly synthesized proteins that are subsequently distributed to organelles of the endomembrane system. Some of these proteins are completely translocated into the lumen of the ER while others integrate stretches of amino acids into the greasy 30 Å wide interior of the ER membrane bilayer. It is generally accepted that to exist in this non-aqueous environment the majority of membrane integrated amino acids are primarily non-polar/hydrophobic and adopt an α-helical conformation. These stretches are typically around 20 amino acids long and are known as transmembrane (TM) helices. In this review, we will consider how tra…
A Study of the Coevolution of Digital Organisms with an Evolutionary Cellular Automaton
2021
This article belongs to the Section Evolutionary Biology.
The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?
2021
Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of micronutrients in chronic liver disease is currently receiving particular attention since abnormalities in vitamin levels are often detected. At present, treatment programs are focused on correcting vitamin deficiencies, which are frequently correlated to higher rates of comorbidities with poor outcomes. The literature reviewed here indicates that liver diseases are often related to vitamin disorders, due to both liver impairment and abnormal intake. M…
Historical Landscape Ecology of the Favorita Park in Palermo (Sicily)
2021
Historical Landscape Ecology of the Favorita Park in Palermo
Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynor…
2021
Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown. In this study, we first described the anxious and depression-prone inbred mouse strain, DBA/2J, as an animal model to assess the antidepressant-like effects of ketamine and HNK in vivo. To decode the molecular mechanisms mediating HNK's rapid antidepressant effects, a longitudinal cerebrospinal fluid (CSF) proteome profiling of its acute and sustained effects was conducted using an unbiased, hypothesis-free mass spectrometry-based proteomics app…
false
2021
Abstract The present article summarizes the results of a study of optical Cherenkov radiation (ChR) spectral properties both theoretically and experimentally. This type of radiation has a continuous spectral distribution which allows to use it in different fields of physics as for charged particle identification or generation of intense THz radiation. By exploiting the frequency dependency of the target permittivity it is possible to observe quasi–monochromatic radiation. A theoretical model based on a surface current approach is presented which allows to predict angular and spectral properties of ChR. In order to test the model predictions, an experiment was carried out using 855 MeV elect…
Time-of-flight photoelectron momentum microscopy with 80–500 MHz photon sources: electron-optical pulse picker or bandpass pre-filter
2021
Journal of synchrotron radiation 28(6), 1891 - 1908 (2021). doi:10.1107/S1600577521010511
UV light induced processes in pure and doped AlN ceramics
2021
The present research has been sponsored by the Latvian Council of Science , Grant No. lzp-2018/1-0361 “Research of luminescence mechanisms and dosimeter properties in prospective nitrides and oxides using TL and OSL methods “; Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union's Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 73950 , project CAMART 2
„Wir wussten, dass es schwierig wird, doch damit haben wir nicht gerechnet!“ Erfahrungen beim Studieneinschluss von Krebspatient*innen mit Migrations…
2021
Zusammenfassung Hintergrund Der Prozess des Studieneinschlusses von Teilnehmenden ist ein wichtiger Bestandteil und oftmals aufwendiger Arbeitsschritt in wissenschaftlichen Forschungsprojekten. Aufgrund unterschiedlicher finanzieller, organisatorischer und ethischer Rahmenbedingungen stellt die fristgerechte Gewinnung von Teilnehmenden haufig eine Herausforderung dar. In diesem Beitrag berichten wir uber unsere Erfahrungen hinsichtlich des Studieneinschlusses, die wir im Projekt „Psychoonkologische Versorgung von Krebspatienten mit Migrationshintergrund – eine Mixed-Methods-Studie“ (POM) gemacht haben. Methode Die Gewinnung von Teilnehmenden erfolgte uber ambulante hamato-onkologische Schwe…
Degree of conversion and microhardness of resin cements photoactivated through glass ceramic
2021
Background To assess whether glass-ceramic shade, thickness and translucency affect degree of conversion (DC) and Knoop microhardness (KHN) of resin cements photoactivated using light-emitting diode (LED) or quartz-tungsten-halogen (QTH) units. Material and Methods Glass-ceramic blocks were cut (2, 3 and 4mm) and sintered. For DC FT Raman spectroscopy (n=3), film specimens of cements (RelyX ARC, U200, Veneer, C&B) were obtained. For KHN test (n=3), cements were inserted in cylindrical matrix and covered by polyester strip. Specimens were photoactivated (30s) using LED or QTH according to each group: direct photoactivation (DP), interposing ceramic specimens or no photoactivation (NP). Data …
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs.
2021
Mitochondria contain a specific translation machinery for the synthesis of mitochondria-encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs) are also generated from the mitochondrial DNA and, similar to their cytoplasmic counterparts, are post-transcriptionally modified. Here, we find that the RNA methyltransferase METTL8 is a mitochondrial protein that facilitates 3-methyl-cytidine (m3C) methylation at position C32 of the mt-tRNASer(UCN) and mt-tRNAThr. METTL8 knockout cells show a reduction in respiratory chain activity, whereas overexpression increases activity. In pancreatic cancer, METTL8 levels are high, which correlates with lower patient survival and an enhanced resp…
Associations of Sex Hormones and Hormonal Status With Arterial Stiffness in a Female Sample From Reproductive Years to Menopause
2021
ObjectiveLoss of sex hormones has been suggested to underlie menopause-associated increment in cardiovascular risk. We investigated associations of sex hormones with arterial stiffness in 19–58-years-old women. We also studied associations of specific hormonal stages, including natural menstrual cycle, cycle with combined oral contraceptives (COC) and menopausal status with or without hormone therapy (HT), with arterial stiffness.MethodsThis study includes repeated measurements of 65 healthy women representing reproductive (n=16 natural, n=10 COC-users) and menopause (n=5 perimenopausal, n=26 postmenopausal, n=8 HT-users) stages. Arterial stiffness outcomes were aortic pulse wave velocity (…
An Insight into the Role of Postmortem Immunohistochemistry in the Comprehension of the Inflammatory Pathophysiology of COVID-19 Disease and Vaccine-…
2021
On 11 March 2020, the World Health Organization (WHO) declared a pandemic due to the spread of COVID-19 from Wuhan, China, causing high mortality rates all over the world. The related disease, which mainly affects the lungs, is responsible for the onset of Diffuse Alveolar Damage (DAD) and a hypercoagulability state, frequently leading to Severe Acute Respiratory Syndrome (SARS) and multiorgan failure, particularly in old and severe-critically ill patients. In order to find effective therapeutic strategies, many efforts have been made aiming to shed light on the pathophysiology of COVID-19 disease. Moreover, following the late advent of vaccination campaigns, the need for the comprehension …
Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia
2021
Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for cognitive impairment and dementia is advanced age followed by other determinants such as genetic, socioeconomic, and environmental factors, including nutrition and physical activity. In the next decades, a rise in dementia cases is expected due largely to the aging of the world population. There are no hitherto effective pharmaceutical therapies to treat age-associated cognitive impairment and dementia, which underscores the crucial role of prevention. A relationship among diet, physical activity, and other lifestyle factors with cognitive function has been intensive…
Unraveling metabolic flexibility of rhodococci in PCB transformation
2021
International audience; Even though the genetic attributes suggest presence of multiple degradation pathways, most of rhodococci are known to transform PCBs only via regular biphenyl (bph) pathway. Using GC-MS analysis, we monitored products formed during transformation of 2,4,4′-trichlorobiphenyl (PCB-28), 2,2′,5,5′-tetrachlorobiphenyl (PCB-52) and 2,4,3′-trichlorobiphenyl (PCB-25) by previously characterized PCB-degrading rhodococci Z6, T6, R2, and Z57, with the aim to explore their metabolic pleiotropy in PCB transformations. A striking number of different transformation products (TPs) carrying a phenyl ring as a substituent, both those generated as a part of the bph pathway and an array…
A two steps Lagrangian–Eulerian numerical model for the simulation of explosive welding of three dissimilar materials joints
2021
Abstract Explosion welding (EXW) is a solid-state joining process used to produce lap joints out of metal plates of dissimilar materials. During the process, a controlled explosive detonation results in a pressure wave pushing one of the plates to be welded, called flyer, against the other with high velocity. The high pressure and temperature generated, because of the impact energy decaying into heat, create the conditions for solid bonding phenomenon to take place. Due to the complexity of experimental tests, numerical simulation is considered a fundamental design tool for the process. Different approaches are found in literature to simulate the process. In this paper, a dual step Lagrangi…
The 21st Century Reforms (Re)Shaping the Education Policy of Inclusive and Special Education in Finland
2021
In recent decades, an essential global aim of the reforms of special education has been the promotion of inclusive education. This article discusses the implementation of reforms with a focus on tiered support systems in the context of Finnish comprehensive school education. Based on earlier literature, legislation, and administrative documents, we provide a background for Finnish education policy and special education reforms. The focus of this article is on the description of parallel reforms targeting the re-structuring of the systems around support for students and funding of education in the 2010s. We discuss the processes leading to these reforms and the reforms themselves. In additio…
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey
2021
Abstract REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) is a global strategy and regulation policy of the EU that aims to improve the protection of human health and the environment through the better and earlier identification of the intrinsic properties of chemical substances. It entered into force on 1st June 2007 (EC 1907/2006). REACH and EU policies plead for the use of robust high-throughput "omic" techniques for the in vitro investigation of the toxicity of chemicals that can provide an estimation of their hazards as well as information regarding the underlying mechanisms of toxicity. In agreement with the 3R’s principles, cultured cells are nowadays wide…
The carbon footprint of a knowledge organization and emission scenarios for a post-COVID-19 world
2021
Publisher Copyright: © 2021 The looming climate crisis requires an immediate response, in which organizations, as major contributors, should play a central role. However, these organizations need appropriate tools to measure and mitigate their climate impacts. One commonly applied method is carbon footprint analysis. Carbon footprint analyses have been conducted for various types of organizations, but knowledge organizations, such as universities and research institutes, have received far less attention, because their carbon footprint is often less visible and can be easily underestimated. This study is based on the carbon footprint analysis of one multinational knowledge organization. This…
Ultra-short ion-exchange columns for fast charge variants analysis of therapeutic proteins
2021
Abstract The purpose of this work was to study the potential of recently developed ultra-short column hardware for ion exchange chromatography (IEX). Various prototype and commercial columns having lengths of 5, 10, 15, 20 and 50 mm and packed with non-porous 3 µm particles were systematically compared. Both pH and salt gradient modes of elution were evaluated. Similarly, what has been previously reported for reversed phase liquid chromatography (RPLC) mode, an “on-off” retention mechanism was observed in IEX for therapeutic proteins and their fragments (25–150 kDa range). Because of the non-porous nature of the IEX packing material, the column porosity was relatively low (e = 0.42) and the…
Trauma et symbolisation chez Edvard Munch. Art et psychanalyse
2021
Resume Cet article examine l’evolution du concept de trauma dans une perspective psychanalytique et l’elaboration psychique des consequences du traumatisme a travers la peinture, en prenant pour exemple la vie et l’œuvre du Norvegien Edvard Munch. Chez cet artiste, les experiences traumatiques de l’enfance trouvent leur place dans son art et dans sa vision du monde. L’art permet d’« elaborer psychiquement » les effets de ces experiences douloureuses de l’enfance. Les representations des traumatismes de l’enfance a travers la peinture sont une occasion de donner une « figurabilite », une representation signifiante a l’experience traumatique. Ainsi, l’art visuel, en tant qu’œuvre de symbolisa…
Molecular Approaches Fighting Nonsense
2021
Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...]
Regional Brain Volume, Brain Reserve and MMSE Performance in Healthy Aging From the NEUROAGE Cohort: Contributions of Sex, Education, and Depression …
2021
Objective: The aim of this study was twofold. First, to investigate the relationship between age, gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) volumes, brain reserve (BR), and specific regions of interest (ROIs) with global cognitive function in healthy older adults participating in a longitudinal study on aging in the island country of Cyprus. Second, to assess the contribution of important demographic and psychosocial factors on brain volume. Specifically, the effects of sex and years of education and the association between depression symptoms on brain volume were also explored in this Mediterranean cohort.Methods: Eighty-seven healthy older adults (males = 37, fema…
Predicting entrepreneurial intentions of sports sciences students: A cross-cultural approach
2021
Abstract The importance of entrepreneurship in the sports sector has risen recently. However, few studies analyze the determinants of entrepreneurial intentions with sport sciences students using a cross-cultural approach. This study aims to determine the entrepreneurial potential of sports sciences students and analyze the influence of national culture on sports sciences students' entrepreneurial intentions determinants. The sample is composed of 356 university students from Spain and Portugal. A multi-group analysis with PLS-SEM was performed to analyze the data. The results show that sports sciences students have favorable attitudes towards entrepreneurship and a supportive closed enviro…