showing 36 of ~574560 from 574555 documents
The COVID-19 pandemic and its global effects on dental practice. An International survey
2021
OBJECTIVES: A multicentre survey was designed to evaluate the impact of COVID-19 outbreak on dental practice worldwide, estimate the COVID-19 related symptoms/signs, work attitudes and behaviour and the routine use of protective measures and Personal Protective Equipment (PPE). METHODS: A global survey using a standardized questionnaire with research groups from 36 countries was designed. The questionnaire was developed and pretested during April 2020 and contained three domains: 1) Personal data; 2) COVID-19 positive rate and symptoms/signs presumably related to the coronavirus; 3) Working conditions and PPE adopted after the outbreak. Countries' data were grouped by the Country Positive R…
Molecular Approaches Fighting Nonsense
2021
Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...]
B and T cell immune responses elicited by the Comirnaty® COVID-19 vaccine in nursing home residents
2021
Objectives The immunogenicity of the Comirnaty® COVID-19 vaccine is understudied in elderly people with comorbidities. SARS-CoV-2-S-targeted antibody and T cell responses following full vaccination were assessed in nursing home residents. Methods Sixty nursing home residents (44 female; age, 53-100 years), of whom 10 had previously been diagnosed of COVID-19, and 18 healthy controls (15 female; age, 27-54 years) were recruited. Pre- and post-vaccination blood specimens were available for quantitation of total antibodies binding SARS-CoV-2 S protein and enumeration of SARS-CoV-2-S-reactive IFN-γ CD4+ and CD8+ T cells by flow cytometry. Results The seroconversion rate in presumably SARS-CoV-2…
Il gesto comparativo negli studi urbani critici
2021
Non tutte le città sono uguali tra loro, ma i processi che si verificano al loro interno sono assimilabili e analizzabili grazie a modelli più o meno universali. O almeno, per molti anni così si è sostenuto: più anni di quanti forse pensiamo, se consideriamo che ancor oggi diversi studiosi di fatti urbani sostengono posizioni universalistiche. Il confronto tra due testi, un classico di Ernest W. Burgess e una lettura più recente e alternativa di Jennifer Robinson, ha come scopo la messa in discussione di questo tema all’interno degli studi urbani critici. Not all cities are the same, but the processes that occur within them can be assimilated and analyzed thanks to more or less universal mo…
Differences in Perceived Occupational Stress by Demographic Characteristics, of European Emergency Medical Services Personnel during the COVID-19 Vir…
2021
Objectives: The outbreak of the COVID-19 pandemic has brought commercial, social, and economic consequences in every country that has experienced substantial SARS-CoV-2 infection rates. The complete change in the environment that took place due to the outbreak of the pandemic can lead to stressful situations, especially among healthcare personnel. Material and methods: The research were conducted during the COVID-19 pandemic between the 27 March 2020 and the 20 April 2020. The research included 1984 employees of emergency medical systems in seven European countries. An internet-based questionnaire format was adopted for the study (ΩMc-Donald >
L'action des services pour la protection du patrimoine archéologique
2021
National audience
Lung ultrasound in outpatients with heart failure: the wet‐to‐dry HF study
2021
The Nancy team is supported by the RHU Fight-HF, a public grant overseen by the French National Research Agency (ANR) as part of the second 'Investissements d'Avenir' programme (reference: ANR-15-RHUS-0004), by the French PIA project 'Lorraine Université d'Excellence' (reference: ANR-15-IDEX-04-LUE), the ANR FOCUS-MR (reference: ANR-15-CE14-0032-01), ERA-CVD EXPERT (reference: ANR-16-ECVD-0002-02), the Contrat de Plan Etat Lorraine IT2MP, and FEDER Lorraine. Aims: In ambulatory patients with chronic heart failure (HF), congestion and decongestion assessment may be challenging. The aim of this study is to assess the value of lung ultrasound (LUS) in outpatients with HF in characterizing deco…
Degree of conversion and microhardness of resin cements photoactivated through glass ceramic
2021
Background To assess whether glass-ceramic shade, thickness and translucency affect degree of conversion (DC) and Knoop microhardness (KHN) of resin cements photoactivated using light-emitting diode (LED) or quartz-tungsten-halogen (QTH) units. Material and Methods Glass-ceramic blocks were cut (2, 3 and 4mm) and sintered. For DC FT Raman spectroscopy (n=3), film specimens of cements (RelyX ARC, U200, Veneer, C&B) were obtained. For KHN test (n=3), cements were inserted in cylindrical matrix and covered by polyester strip. Specimens were photoactivated (30s) using LED or QTH according to each group: direct photoactivation (DP), interposing ceramic specimens or no photoactivation (NP). Data …
Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides.
2021
The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. On the basis of genetic evidence, it has been postulated that the FHIT protein may function as tumor suppressor, implying a role for the FHIT protein in carcinogenesis. Recently, Gaudio et al. reported that FHIT binds and delocalizes annexin A4 (ANXA4) from plasma membrane to cytosol in paclitaxel-resistant lung cancer cells, thus restoring their chemosensitivity to the drug. They also identified the smallest protein sequence of the FHIT still interacting with ANXA4, ranging from position 7 to 13: QHLIKPS. This short sequence of FHIT protein was not only able to bind …
Zinc Finger Proteins in Neuro-Related Diseases Progression
2021
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, zinc finger proteins can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many zinc finger proteins are associated with neurological diseases. The purpose of this review is to summarize the types and roles of zinc finger proteins in neuropsychiatric disorders. We will describe the structure and classification of zinc finger proteins, then focus on the pathophysiological role of zinc finge…
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
2021
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…
Chitin Deacetylase, a Novel Target for the Design of Agricultural Fungicides
2021
Fungicide resistance is a serious problem for agriculture. This is particularly apparent in the case of powdery mildew fungi. Therefore, there is an urgent need to develop new agrochemicals. Chitin is a well-known elicitor of plant immunity, and fungal pathogens have evolved strategies to overcome its detection. Among these strategies, chitin deacetylase (CDA) is responsible for modifying immunogenic chitooligomers and hydrolysing the acetamido group in the N-acetylglucosamine units to avoid recognition. In this work, we tested the hypothesis that CDA can be an appropriate target for antifungals using the cucurbit powdery mildew pathogen Podosphaera xanthii. According to our hypothesis, RNA…
Slacking with the Bot: Programmable Social Bot in Virtual Team Interaction
2021
Nonhuman communicators are challenging the prevailing conceptualizations of technology-mediated team communication. Slackbot is a social bot that can be configured to respond to trigger words and, thus, take part in discussions on the platform. A set of 84 bot-related communication episodes were identified from a journalistic team's Slack messages (N=45,940) and analyzed utilizing both qualitative content analysis and interaction process analysis (IPA). This integrated mixed-methods analysis revealed novel insights into the micro-level dynamics of human-machine communication in organizational teams. In response to Slackbot's greetings, acclamations, work-related messages, and relational mes…
Combined endoscopical treatments for tracheo‐esophageal fistula developed during V‐V ECMO for severe COVID‐19: A case series
2021
Microstructure and phase composition of bronze Montefortino helmets discovered Mediterranean seabed to explain an unusual corrosion
2021
AbstractTwo Monterfortino helmets, recovered in the Mediterranean seabed, show unusual features with respect to the more common helmets of the same period and found in underwater environments. Hence, they were investigated by a multi-analytical approach, which allowed us to identify the compounds constituting the helmets and to make some considerations about their metallurgy, although all the metal was converted to degradation products. The helmets, originally made in bronze, have maintained their original shape because of copper sulphides formation. The observed differences in composition between the two helmets were attributed to the position modification, of one of them, into the seabed …
Predicting entrepreneurial intentions of sports sciences students: A cross-cultural approach
2021
Abstract The importance of entrepreneurship in the sports sector has risen recently. However, few studies analyze the determinants of entrepreneurial intentions with sport sciences students using a cross-cultural approach. This study aims to determine the entrepreneurial potential of sports sciences students and analyze the influence of national culture on sports sciences students' entrepreneurial intentions determinants. The sample is composed of 356 university students from Spain and Portugal. A multi-group analysis with PLS-SEM was performed to analyze the data. The results show that sports sciences students have favorable attitudes towards entrepreneurship and a supportive closed enviro…
Effects of motor imagery on strength, range of motion, physical function, and pain intensity in patients with total knee arthroplasty: A systematic r…
2021
Abstract Background In the early stages of total knee arthroplasty (TKA) rehabilitation, in which physical function in general can be affected, motor imagery (MI) might play a relevant role. Objective To assess the impact of MI on strength, active range of motion (ROM), pain intensity, and physical function in patients with TKA. Methods We conducted a systematic review and meta-analysis of randomised controlled trials. Pooled effects were calculated as standardised mean differences (SMDs) and 95% confidence intervals (CIs) for the relevant outcomes using random effects model. The certainty of evidence was assessed with GRADE approach. Results This review included 7 articles. The addition of…
The widespread presence of a family of fish virulence plasmids in Vibrio vulnificus stresses its relevance as a zoonotic pathogen linked to fish farms
2021
Vibrio vulnificus is a pathogen of public health concern that causes either primary septicemia after ingestion of raw shellfish or secondary septicemia after wound exposure to seawater. In consequence, shellfish and seawater are considered its main reservoirs. However, there is one aspect of its biology that is systematically overlooked: its association with fish in its natural environment. This association led in 1975 to the emergence of a zoonotic clade within phylogenetic lineage 2 following successive outbreaks of vibriosis in farmed eels. Although this clade is now worldwide distributed, no new zoonotic clades were subsequently reported. In this work, we have performed phylogenetic, ge…
Introduction to Special Issue: Brand Equity, Satisfaction, and Word of Mouth
2021
The COVID-19 pandemic has generated an incredible change in the global economy that will likely have long-term consequences on consumer behavior, markets, business models, market regulation, and public policies, among others [1,2]. We are only at the beginning of seeing these effects, and this new scenario offers opportunities to articulate research in the area of marketing aligned with the urgency of recovering customer trust and reactivating sales [3]. The five contributions presented in this Special Issue, “Brand Equity, Satisfaction, and Word of Mouth”, aim at being incorporated into the dynamics of methodological and thematic innovation in marketing, in reply to some of the research pr…
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis
2021
Abstract Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool. Here, we evaluate whether hFwe‐Lose gene expression can outperform conventional methods in predicting outcomes (e.g., death and hospitalization) in COVID‐19 patients. We performed a post‐mortem examination of infected lung tissue in deceased COVID‐19 patients to determine hFwe‐Lose’s biological role in acute lung injury. We then performed an observational study (n = 283) to evaluate whether hFwe‐Lose expression (in nasopharyngeal samples) could accu…
Book review: Kristin Enola Gilbert and Gregory Matoesian, Multimodal Performance and Interaction in Focus Groups
2021
Radiation effects on stress evolution and dimensional stability of large fusion energy structures
2021
Abstract We assess the effects of neutron irradiation on the deformation and stress evolution of large-scale fusion energy structures. This is accomplished through non-linear finite element structural analysis of the coupled thermal and mechanical fields at the Beginning-Of-Life (BOL), at 45 dpa, and at 90 dpa. Radiation effects include volumetric swelling and the influence of radiation on the mechanical properties. The system studied here is a large section of a full inboard module of an integrated structure comprising the First Wall and Blanket (FW/B) of a Dual Cooled Lithium-Lead (DCLL) energy conversion unit in the Fusion Nuclear Science Facility (FNSF). The structural material is the f…
Spectroscopic studies of Cr3+ ions in natural single crystal of magnesium aluminate spinel MgAl2O4
2021
Abstract The natural spinel crystal MgAl2O4 containing the Cr3+ ions was studied experimentally and theoretically in this paper. The absorption and emission spectra at room and low temperatures were recorded. The experimental spectroscopic results were aided with the crystal field calculations, which returned the energy level schemes of the Cr3+ ions at the Al sites with the local D3d symmetry. Effects of the trigonal crystal field were clearly seen in the calculated results, which were compared with the experimental spectra to yield a good agreement between both data sets.
The role of noninvasive brain oximetry in adult critically ill patients without primary non-anoxic brain injury.
2021
A primary objective in intensive care and perioperative settings is to promote an adequate supply and delivery of oxygen to tissues and organs, particularly to the brain. Cerebral near infrared spectroscopy (NIRS) is a noninvasive, continuous monitoring technique, that can be used to assess cerebral oxygenation. Using NIRS to monitor cerebral oximetry is not new and has been in widespread use in neonates and cardiac surgery for decades. In addition, it has become common to see NIRS being used in adult and pediatric cardiac surgery, acute neurological diseases, neurosurgical procedures, vascular surgery, severe trauma and other acute medical diseases. Furthermore, recent evidence suggests a …
Le témoin face au défi de la vraisemblance. L’usage de l’ekphrasis chez une rescapée du génocide des Tutsi au Rwanda
2021
Cet article part du constat suivant : même si penser le génocide n’est pas nouveau, chaque massacre de cette nature reste un événement inédit dans sa singularité. Or, comment faire pour raconter un événement qui est, par essence, unique, un événement qui, littéralement, ne ressemble à rien de connu ? Ce défi-ci, est d’un ordre particulier : il n’est ni juridique, ni historique, il est rhétorique. Le défi rhétorique que constitue l’expression d’un fait ineffable, ici génocidaire, a notamment été étudié par Marc Dominicy et Emmanuelle Danblon qui, dans leurs travaux sur les témoignages des rescapés de la Shoah, ont souligné deux points. Ils remarquent le recours aux figures pour exprimer l’in…
EPV145/#82 Multicentric predictive score validation for nodal assessment in endometrial cancer patients: preliminary data
2021
Stairway to heaven, L'irrésistible ascension de Led Zeppelin (1969-1971)
2021
International audience
Alimentazione ed insulina-resistenza. In Salute e cultura alimentare globalizzata
2021
NA
Water Splitting on Multifaceted SrTiO3 Nanocrystals: Computational Study
2021
The financial support of M-ERA.NET2 Sun2Chem project is greatly acknowledged by E.K. Authors thank Dr. Marjeta Ma?ek Kr?manc and prof. Chi-Sheng Wu, for the fruitful discussions. The financial support of FLAG-ERA JTC project To2Dox is acknowledged by Y.A.M. This paper is based upon the work from COST Action 18234, supported by COST (European Cooperation in Science and Technology). The support is greatly acknowledged by Y.A.M. and V.K. The grant No. 1.1.1.2/VIAA/l/16/147 (1.1.1.2/16/I/001) under the activity of Post-doctoral research aid is greatly acknowledged by M.S. and D.B. The Institute of Solid State Physics, University of Latvia (Latvia) as the Centre of Excellence has received fundin…
Healthcare professionals on the move: Investing in learning a new language for work
2021
Artikkelissa tarkastellaan maahanmuuton kielikysymyksiä Unkarista Suomeen ja Ruotsiin työllistyneiden terveydenhuollon ammattilaisten näkökulmasta. Neksusanalyyttisessä viitekehyksessä tutkitaan sitä investointia, jonka nämä työntekijät tekevät oppiakseen uutta, työssä tarvitsemaansa kieltä eli suomea tai ruotsia. Tutkimusasetelma on pitkittäinen, ja analyysi perustuu terveydenhuollon ammattilaisten sekä muutamien kielikoulutuksesta ja rekrytoinnista vastaavien henkilöiden haastatteluihin. Kirjoittajat aloittivat omat tutkimuksesta itsenäisesti mutta yhdistivät voimansa ennen toista aineistonkeruukierrosta. Tämän myötä analyysissa voitiin kattaa useampia kulttuurisia ja ajallisia ulottuvuuk…
Salute e cultura alimentare globalizzata - Prefazione
2021
NA
Dieta, cura e società multietnica. In: Salute e cultura alimentare globalizzata
2021
NA
Contents of the Sexual and Reproductive Health Subject in the Undergraduate Nursing Curricula of Spanish Universities: A Cross-Sectional Study
2021
Background: Nursing students must receive adequate training in Sexual and Reproductive Health (SRH), which could allow them to acquire sufficient knowledge to solve the future SRH needs of everyone. In this study, the contents of the SRH subject in the undergraduate nursing curricula of 77 Spanish universities were examined to determine what SRH training nursing students are receiving. Methods: The contents of the SRH subject of all the curricula that were available online were reviewed. The distribution of the contents (topics) in the two areas (reproductive health and sexual health) was analyzed, and the prevalence of each topic was established. It was also determined whether there were d…
Simplified feedback control system for scanning tunneling microscopy
2021
A Scanning Tunneling Microscope (STM) is one of the most important scanning probe tools available to study and manipulate matter at the nanoscale. In a STM, a tip is scanned on top of a surface with a separation of a few \AA. Often, the tunneling current between tip and sample is maintained constant by modifying the distance between the tip apex and the surface through a feedback mechanism acting on a piezoelectric transducer. This produces very detailed images of the electronic properties of the surface. The feedback mechanism is nearly always made using a digital processing circuit separate from the user computer. Here we discuss another approach, using a computer and data acquisition thr…
Can adjunctive corticosteroid therapy improve patient-centered outcomes following third molar surgery? A systematic review
2021
Third molar surgery is frequently associated with postoperative discomfort such as pain, edema and trismus. We aimed to evaluate the current evidence on the efficacy of adjunctive corticosteroid therapy in improving patient-centered outcomes following third molar surgery.This systematic review assessed and searched PubMed, Google scholar, Scopus, web of science, clinicaltrials.gov and Cochrane central for controlled trials, up to May 2021. The primary outcome measures were patient-centered outcomes such as quality of life following the use of adjunctive corticosteroid therapy in third molar removal. Only randomized controlled trials published in English language were included.A total of 355…
The Beneficial Effects of Essential Oils in Anti-Obesity Treatment
2021
Obesity is a complex disease caused by an excessive amount of body fat. Obesity is a medical problem and represents an important risk factor for the development of serious diseases such as insulin resistance, type 2 diabetes, cardiovascular disease, and some types of cancer. Not to be overlooked are the psychological issues that, in obese subjects, turn into very serious pathologies, such as depression, phobias, anxiety, and lack of self-esteem. In addition to modifying one’s lifestyle, the reduction of body mass can be promoted by different natural compounds such as essential oils (EOs). EOs are mixtures of aromatic substances produced by many plants, particularly in medicinal and aromatic…