showing 36 of ~574560 from 574555 documents
Can adjunctive corticosteroid therapy improve patient-centered outcomes following third molar surgery? A systematic review
2021
Third molar surgery is frequently associated with postoperative discomfort such as pain, edema and trismus. We aimed to evaluate the current evidence on the efficacy of adjunctive corticosteroid therapy in improving patient-centered outcomes following third molar surgery.This systematic review assessed and searched PubMed, Google scholar, Scopus, web of science, clinicaltrials.gov and Cochrane central for controlled trials, up to May 2021. The primary outcome measures were patient-centered outcomes such as quality of life following the use of adjunctive corticosteroid therapy in third molar removal. Only randomized controlled trials published in English language were included.A total of 355…
Construction of Metatranscriptomic Libraries for 5′ End Sequencing of rRNAs for Microbiome Research
2021
Metatranscriptomic sequencing enables studying community-wide gene expression profiles of microbial samples and getting functional insight on their up- or downregulated pathways. However, shotgun sequencing is not the most efficient way to study expression of ribosomal RNA genes or to compare lot of samples in experimental setups. Here we describe an efficient primer-independent method for processing and barcoding libraries for directional sequencing of the 5' end region of the RNA. When applying size selection of the original RNA, the method forms an optimal solution for the simultaneous analysis of bacterial, archaeal, and eukaryotic rRNA diversity.
Validity and reliability of an inertial sensor device for specific running patterns in soccer
2021
Electronic performance tracking devices are largely employed in team sports to monitor performance and improve training. To date, global positioning system (GPS) based devices are those mainly used in soccer training. The aim of this study was to analyse the validity and reliability of the inertial sensor device (ISD) in monitoring distance and speed in a soccer-specific circuit and how their performance compare to a GPS system. 44 young male soccer players (age: 14.9 ± 1.1, range 9–16, years, height: 1.65 ± 0.10 m, body mass: 56.3 ± 8.9 kg) playing in a non-professional soccer team in Italy, participated in the study. We assessed the players trough a soccer running sport-specific circuit. …
Vironkielisten osallistujien kielitaito Yleisten kielitutkintojen suomen kielen testissä
2021
Tarkastelemme tässä artikkelissa vironkielisten suomen oppijoiden osallistumista Suomen kansallisen kielitestin, Yleisten kielitutkintojen, keskitason tutkintoon ja heidän kielitaitoprofiiliaan tutkintotulosten valossa. Vertaamme tuloksia yleiseen tutkintomenestykseen sekä osallistujien taustaan ja pohdimme suomen kielen asemaa oppimisen kohteena vironkielisten näkökulmasta. Analyysimetodina käytämme kuvailevaa tilastollista analyysia sekä tilastollista päättelyä. Tulokset osoittavat, että vironkieliset osallistujat menestyvät tutkinnossa hyvin ja erityisesti ymmärtämistaidot ovat tutkitussa ryhmässä vahvat. Vaikka aiemman tutkimuksen valossa suomen kielen taidon tason onkin nähty riippuvan…
Non-competitive Elections at the Local Level and the Incumbency Advantage of Mayors – Research Experiences from Poland
2021
The objective of this paper is an attempt to answer if non-competitive elections to commune councils in Poland may be the result of incumbency advantage of mayors. The author assumes, that the effects of incumbency advantage of mayors in influence not only the competition for the office of mayor, but also the entire local political scene. These effects may weaken the competitiveness of elections and lead to the cartelisation of local political scenes. In extreme cases, it may even cause the degeneration of political pluralism and lead to non-competitive elections at both the executive and legislative levels. The paper analyses relationships between the competitiveness of elections at the lo…
Fertility-sparing approach in women affected by stage i and low-grade endometrial carcinoma: An updated overview
2021
Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol …
Optical Plasmonic Nanoantenna-MWCNT diode Energy Harvester for Solar Powered Wireless Sensors
2021
This paper presents the design of an optical energy-harvester (EH) to power wireless IoT sensors. For the first time, the simulation results of the complete nanorectenna-electronic system are reported, consisting of an N*M Ag-Ti arrow bowtie nanoantenna - MWCNT-I-M diode array, a low-pass filter, and a DC-DC converter. An output voltage value of 3.3 V and an output current of 10 mA were obtained with a 49498*14286 optical array with an area of about 63, 64 mm2. The proposed optical EH paves the way for the replacement of batteries with solar energy, overcoming the limit of photovoltaic applications in wireless IoT sensors.
The Development of Vaccines from Synthetic Tumor‐Associated Mucin Glycopeptides and their Glycosylation‐Dependent Immune Response
2021
Tumor-associated carbohydrate antigens are overexpressed as altered-self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been developing anti-cancer vaccines based on mucin glycopeptides, yet the interplay of delivery system, adjuvant and tumor associated MUC epitopes in the induced immune response is not well understood. The current state of the art suggests that the identity, abundancy and location of the glycans on the MUC backbone are all key parameters in the cellular and humoral response. This review shares lessons learned by us in over two decades of research in glycopeptide vac…
Editorial misconduct: the case of online predatory journals.
2021
The number of publishers that offer academics, researchers, and postgraduate students the opportunity to publisharticles and book chapters quickly and easily has been growing steadily in recent years. This can be ascribed to avariety of factors, e.g., increasing Internet use, the Open Access movement, academic pressure to publish, and theemergence of publishers with questionable interests that cast doubt on the reliability and the scientific rigor of thearticles they publish.All this has transformed the scholarly and scientific publishing scene and has opened the door to theappearance of journals whose editorial procedures differ from those of legitimate journals. These publishers arecalled…
Salute e cultura alimentare globalizzata
2021
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Water Splitting on Multifaceted SrTiO3 Nanocrystals: Computational Study
2021
The financial support of M-ERA.NET2 Sun2Chem project is greatly acknowledged by E.K. Authors thank Dr. Marjeta Ma?ek Kr?manc and prof. Chi-Sheng Wu, for the fruitful discussions. The financial support of FLAG-ERA JTC project To2Dox is acknowledged by Y.A.M. This paper is based upon the work from COST Action 18234, supported by COST (European Cooperation in Science and Technology). The support is greatly acknowledged by Y.A.M. and V.K. The grant No. 1.1.1.2/VIAA/l/16/147 (1.1.1.2/16/I/001) under the activity of Post-doctoral research aid is greatly acknowledged by M.S. and D.B. The Institute of Solid State Physics, University of Latvia (Latvia) as the Centre of Excellence has received fundin…
Collaborative professional practice for strengthening teacher educator identities in Eritrea
2021
Strengthening the identities of teacher educators is critical to quality teacher education and implementing change in the education sector. This study examines the professional identities of Eritrean teacher educators and how these identities can be strengthened through collaborative professional practice in a challenging context currently under reform. The focus is on the professional capacity building activities at the College of Education in Eritrea, which were implemented in collaboration with Finnish education partners. The paper reports on findings from an action-research informed study of a semester-long series of professional development seminars and an interview study with individu…
Progetto di restauro, per la fruizione e la valorizzazione della chiesa di San Sebastiano
2021
Il saggio presenta l’iter metodologico utilizzato per l’analisi dello stato di conservazione e delle problematiche di accessibilità presenti nella chiesa di San Sebastiano di Palermo, edificata alla fine del sec. XV. Inoltre nel saggio si mostra una proposta di restauro e di accessibilità alla stessa chiesa che nel passato aveva un sagrato eliminato dopo la metà del Novecento (e i danni subiti dai bombardamenti della seconda guerra mondiale) per raccordare i livelli della strada. La ricerca è stata condotta all’interno del Laboratorio di restauro e Teoria e storia del restauro e ha visto protagonisti le allievi e gli allievi del corso LM4 in Architettura del Dipartimento di Palermo. La solu…
Progetto di restauro, per la fruizione e la valorizzazione della chiesa di Sant’Antonio Abate
2021
Il saggio presenta l’iter metodologico utilizzato per l’analisi dello stato di conservazione e delle problematiche di accessibilità presenti nella chiesa parrocchiale di Sant’Antonio Abate di Palermo, già esistente all’inizio del sec. XIII. Inoltre nel saggio si mostra una proposta di restauro e di accessibilità alla stessa chiesa. Oggi esiste un elevato dislivello (creato con l’apertura della via Roma) tra il piano della via Roma e l’accesso alla chiesa. La ricerca è stata condotta all’interno del Laboratorio di restauro e Teoria e storia del restauro e ha visto protagonisti le allievi e gli allievi del corso LM4 in Architettura del Dipartimento di Palermo. La soluzione suggerita è stata q…
Engel, Christine; Pohlan, Irina; Walter, Stephan (Hgg.). Russland übersetzen/Russia in Translation/Россия в переводе. Festschrift für Birgit Menzel. …
2021
Progetto di restauro, per la fruizione e la valorizzazione della chiesa di San Domenico
2021
The essay illustrates the methodological process used to analyze the state of conservation and accessibility issues of the church of San Domenico in Palermo, built from scratch from the 17th century. XVII, on medieval pre-existences. Furthermore, the essay presents a proposal for the restoration and accessibility of the church itself, where there is a difference in height between the floor of the church and that of the square of several steps. The research was conducted within the Restoration and Theory and History of Restoration Laboratory and involved the students of the LM4 course in Architecture of the Palermo Department. The suggested solution was to insert an inclined ramp for everyon…
Identification, Characterization and Synthesis of Natural Parasitic Cysteine Protease Inhibitors – More Potent Falcitidin Analogs
2021
ABSTRACTProtease inhibitors represent a promising therapeutic option for the treatment of parasitic diseases such as malaria and human African trypanosomiasis. Falcitidin was the first member of a new class of inhibitors of falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. Using a metabolomics dataset of 25 Chitinophaga strains for molecular networking enabled identification of over 30 natural analogs of falcitidin. Based on MS/MS spectra, they vary in their amino acid chain length, sequence, acyl residue, and C-terminal functionalization; therefore, they were grouped into the four falcitidin peptide families A-D. The isolation, characterization and absolute st…
Europeanisation as a driver of dependent financialisation in East-Central Europe: insights from the Baltic states
2021
The aim of this paper is to contribute to advancing the academic debate on dependent financialisation through a focus on East-Central Europe. In doing so, the paper identifies the role of Europeanisation as a driver of dependent financialisation using the Baltic States of Estonia, Latvia and Lithuania as case studies. The paper makes two main contributions to the literature on dependent financialisation. First, it argues that, through the establishment of 'financial chains', dependent financialisation creates asymmetric co-dependencies and bilateral risks between the 'dependent' economies in the (semi-)periphery and the financial actors in core countries. While the (semi-)peripheral economi…
Procedural characteristics and outcomes following chronic total occlusion coronary intervention: pooled analysis from 5 registries.
2021
Background Recent improvement in clinical skills, technology and hardware has resulted in improved success rates with chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We performed a study level pooled analysis from the five largest registries of percutaneous coronary intervention (PCI) of CTO. Research design and methods We conducted pooled analysis of 9500 patients in registries and data on procedural characteristics, technical success, and MACCE was collected. Results A total of 9500 patients were included in the analysis. Mean age was 65.4 years with previous CABG in 24.8%, reattempt procedure in 24.8% and mean JCTO score was 2.2. Final wiring strategy in hybrid al…
Pienamente conservare per pienamente fruire: il paradigma della Vucciria di Palermo nel Progetto I-Access
2021
Già dal nome la città di Palermo rivela una delle sue peculiarità più significative, ovvero la capacità di accogliere: dal greco «Pan ormos» - tutto porto. In generale, consapevole della vocazione di Palermo, il mercato della Vucciria è stato scelto per illustrare i contenuti del Progetto Interreg Italia-Malta, I-Access di Implementare l'accessibilità alla fruizione e alla conoscenza del centro storico urbano e per le somiglianze e le differenze riscontrate nel La Valletta e Palermo. Il progetto I-ACCESS ha verificato un metodo per promuovere l'accessibilità in senso culturale e fisico e questa esperienza può essere ripetuta in altri centri storici. La conoscenza della realtà materiale del …
Prognostic implications of surgical specimen quality on the oncological outcomes of open and laparoscopic surgery in mid and low rectal cancer
2021
Abstract Purpose Determine differences in pathologic outcomes between laparoscopic (LAP) and open surgery (OPEN) for mid and low rectal cancer and its influence in long-term oncological outcomes. Methods Retrospective case matched study at a tertiary institution. Adults with rectal cancer below 12 cm from the anal verge operated between January 2005 and September 2018 were included. Primary outcomes were quality of specimen, overall survival (OS), disease-free survival (DFS), and local recurrence (LR). Results The study included 311 patients, LAP = 108 (34.7%), OPEN = 203 (65,3%). A successful resection was accomplished in 81% of the LAP group and in 84.5% of the OPEN (p = 0.505). No differ…
One year after the ESC/EAS guidelines on cholesterol control. What's the new evidence? What's missing?
2021
The recent ESC/EAS 2019 Guidelines for the management of dyslipidaemias are centred on the causal role of low density lipoprotein (LDL), or more generally apolipoprotein B (apoB)-containing lipoproteins, in atherosclerosis as an essential principle. Despite updated goals and recommendations, that have further highlighted the importance of a powerful reduction in LDL-C levels to reduce the individual CV risk, some challenges remain to be addressed in view of future guideline elaboration. In this review, we will summarize the new evidence from clinical trials since 2019 guideline release and discuss the possible challenges for the future.
Le triomphe des vins d'AOC à l'issue des Trente Glorieuses et l'invention de la dégustation sensorielle
2021
International audience
Rap and politics: a special focus on Tunisian rappers
2021
This paper deals with the topic of conflict and peace in the field of rap. In the first part, we tried to collect some interdisciplinary research around the world in a short review of the state of the art focusing on the communicative and political aspects of the rap of the origin and of its different evolutions. In the second part of our article, we describe the development of rap music in Tunisia over the time. The leitmotiv is the use of the rap as a form of political communication, using lyrics for claiming for a different society with the aim of addressing the performance to politics and to citizens, both in a local and a global perspective.
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2021
Abstract Pantomime has a long tradition in clinical neuropsychology of apraxia. It has been much more used by researchers and clinicians to assess tool-use disorders than real tool use. Nevertheless, it remains incompletely understood and has given rise to controversies, such as the involvement of the left inferior parietal lobe or the nature of the underlying cognitive processes. The present article offers a comprehensive framework, with the aim of specifying the neural and cognitive bases of pantomime. To do so, we conducted a series of meta-analyses of brain-lesion, neuroimaging, and behavioral studies about pantomime and other related tasks (i.e., real tool use, imitation of meaningless…
Glucosamine Supplementation Improves Physical Performance in Trained Mice
2021
Introduction D-Glucosamine (GlcN) is one of the most widely consumed dietary supplements and complementary medicines in the world and has been traditionally used to attenuate osteoarthritis in humans. GlcN extends lifespan in different animal models. In humans, its supplementation has been strongly associated with decreased total mortality and improved vascular endothelial function. GlcN acts as a suppressor of inflammation and by inhibiting glycolysis, it can activate the metabolism of stored fat and mitochondrial respiration. Methods The conventional human GlcN dose is 1,500 mg x day-1 but extensive evidence indicates that much higher doses are well tolerated. GlcN is one of the supplemen…
Progetti di restauro e accessibilità per il quartiere della Loggia di Palermo
2021
Il tema dell’accessibilità ai monumenti è stato il tema fondante all’interno del Laboratorio di restauro dei monumenti e Teoria e storia del restauro, Lm-4 Architettura, Darch, Unipa, tra il 2018 e il 2020. È stata un’occasione di analisi sul campo e di sperimentazione che ha coinvolto studenti e congiuntamente sia la prof. Renata Prescia che il prof. Rosario Scaduto, con il supporto del Phd arch. Zaira Barone, oggi Rtd B in Restauro. Il lavoro ha coordinato un percorso di indagine sull’area del centro storico di Palermo che comprende l’itinerario I-Access. In parallelo alla ricerca che il progetto sperimentava sul campo, attraverso il dialogo e l’organizzazione di incontri con le associazi…
Robustness of PET Radiomics Features: Impact of Co-Registration with MRI
2021
Radiomics holds great promise in the field of cancer management. However, the clinical application of radiomics has been hampered by uncertainty about the robustness of the features extracted from the images. Previous studies have reported that radiomics features are sensitive to changes in voxel size resampling and interpolation, image perturbation, or slice thickness. This study aims to observe the variability of positron emission tomography (PET) radiomics features under the impact of co-registration with magnetic resonance imaging (MRI) using the difference percentage coefficient, and the Spearman’s correlation coefficient for three groups of images: (i) original PET, (ii) PET after co-…
Progetto di restauro, per la fruizione e la valorizzazione della chiesa di Santa Maria in Valverde
2021
The essay presents the methodological process used for the analysis of the state of conservation and of the accessibility problems present in the church of Santa Maria in Valverde in Palermo, built in the 17th century. XVII, above previous stratifications. Furthermore, the essay shows a proposal for restoration and accessibility to the same church which in the past had a churchyard that was eliminated after the mid-twentieth century to connect the street levels. The research was conducted within the Restoration and Theory and History of Restoration Laboratory and involved the students of the LM4 course in Architecture of the Palermo Department. The suggested solution was to rebuild a new ch…
Integrity measures take its toll: Introducing a complete supplement issue with retractions only.
2021
Progetto di restauro, per la fruizione e la valorizzazione dell’Oratorio del Santissimo Rosario in San Domenico
2021
Il saggio illustra l’iter metodologico utilizzato per l’analisi dello stato di conservazione e delle problematiche di accessibilità presenti nell’Oratorio del Santissimo Rosario in San Domenico di Palermo, edificata nel sec. XVII, e caratterizzato da notevoli opere d’arte e ricco delle decorazioni realizzate, con stucco, da Giacomo Serpotta nel sec. XVIII. Inoltre nel saggio si presenta una proposta di restauro e di accessibilità allo stesso oratorio che è particolarmente difficile in quanto l’accesso è separato dalla strada da un dislivello di 1,30 metri. La ricerca è stata condotta all’interno del Laboratorio di restauro e Teoria e storia del restauro e ha visto protagonisti le allievi e …
Progetto di restauro, per la fruizione e la valorizzazione dell'Oratorio del Santissimo Rosario in Santa Cita
2021
Il saggio presenta l’iter metodologico utilizzato per l’analisi dello stato di conservazione e delle problematiche di accessibilità presenti nell’Oratorio del Santissimo Rosario di Palermo, edificato nel sec. XVII, con la ricca decorazioni di stucchi, opera pregevolissima di Giacomo Serpotta, per giungere ad una proposta di restauro e di accessibilità allo stesso. La ricerca è stata condotta all’interno del Laboratorio di restauro e Teoria e storia del restauro e ha visto protagonisti le allievi e gli allievi del corso LM4 in Architettura del Dipartimento di Palermo. La soluzione suggerita privilegia l’uso di materiali lapidei della tradizione storica di Palermo, che si pone come soluzione …
Progetto di restauro, per la fruizione e la valorizzazione della chiesa di San Giorgio dei Genovesi
2021
Il saggio presenta l’iter metodologico utilizzato per l’analisi dello stato di conservazione e delle problematiche di accessibilità presenti nella chiesa di San Giorgio dei Genovesi di Palermo, edificata nel sec. XVI, per giungere ad una proposta di restauro e di accessibilità alla stessa. La ricerca è stata condotta all’interno del Laboratorio di restauro e Teoria e storia del restauro e ha visto protagonisti le allievi e gli allievi del corso LM4 in Architettura del Dipartimento di Palermo. La soluzione suggerita privilegia l’uso di materiali lapidei della tradizione storica di Palermo, che si pone come soluzione stabile, non provvisoria, con uso di materiali di pregio, che si confrontano…
Importance of force feedback for following uneven virtual paths with a stylus
2021
It is commonly known that a physical textured path can be followed by indirect touch through a probe also in absence of vision if sufficiently informative cues are delivered by the other sensory channels, but prior research indicates that the level of performance while following a virtual path on a touchscreen depends on the type and channel such cues belong to. The re-enactment of oriented forces, as they are induced by localized obstacles in probe-based exploration, may be important to equalize the performance between physical and virtual path following. Using a stylus attached to a force-feedback arm, an uneven path marked by virtual bars was traversed while time and positions were measu…
SPECIAL ISSUE: The clinical relevance of exosomes in cancer
2021
Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study…
2021
Background Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex and age group in people aged 10–24 years in 204 countries and territories from 1950 to 2019 by use of estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We report trends in estimated total numbers of deaths and mortality rate per 100 000 population in young people aged 10–24 years by age group (10–14 y…