Is maternal thyroid hormone deposition subject to a trade-off between self and egg because of iodine?

2021

ABSTRACT Maternal hormones constitute a key signalling pathway for mothers to shape offspring phenotype and fitness. Thyroid hormones (THs; triiodothyronine, T3; and thyroxine, T4) are metabolic hormones known to play crucial roles in embryonic development and survival in all vertebrates. During early developmental stages, embryos exclusively rely on exposure to maternal THs, and maternal hypothyroidism can cause severe embryonic maldevelopment. The TH molecule includes iodine, an element that cannot be synthesised by the organism. Therefore, TH production may become costly when environmental iodine availability is low. This may yield a trade-off for breeding females between allocating the …

Industry 4.0 and Digital Supply-Chain Management : ERP-SCM Implementation

2021

International audience

false

2021

Background: The current COVID-19 coronavirus pandemic is an emergency on a global scale, with huge swathes of the population required to remain indoors for prolonged periods to tackle the virus. In this new context, individuals' health-promoting routines are under greater strain, contributing to poorer mental and physical health. Additionally, individuals are required to keep up to date with latest health guidelines about the virus, which may be confusing in an age of social-media disinformation and shifting guidelines. To tackle these factors, we developed Elena+, a smartphone-based and conversational agent (CA) delivered pandemic lifestyle care intervention.Methods: Elena+ utilizes varied…

The Influence Mechanism of Supervisor Developmental Feedback on the Enactment of Employees’ Creative Ideas: A Moderated Chain Mediation Model Based o…

2021

Employees’ creative idea enactment is critical for organizational creativity assessment and innovation implementation. In the paper, we want to develop and verify a moderated chain mediation model to explore the impact of supervisor developmental feedback on the enactment of employees’ creative ideas, and to investigate the moderating role of psychological empowerment further. Hierarchical regression analyses of the multi-time data from 375 employees in China indicate that positive emotions and work engagement, respectively mediate the relationship between supervisor developmental feedback and employees’ creative idea enactment. Simultaneously, positive emotions and work engagement form cha…

Abatellis: Un punto sull’Allestimento di Scarpa 1953-54

2021

Palazzo Abatellis, ultimato alla fine del XV secolo, subì profondi rimaneggiamenti in seguito alla sua trasformazione in convento. Il visitatore si trova di fronte a uno straordinario palinsesto progettuale, composto tra il 1490 e il 1953, dall'inizio dei lavori di Matteo Carnilivari alla conclusione dei lavori della Galleria Nazionale di Sicilia su disegno di Carlo Scarpa. Tutto questo va salvaguardato o forse è necessario fare degli “aggiustamenti” per esigenze temporanee e transitorie? Palazzo Abatellis, completed at the end of the 15th century, underwent profound alterations following its transformation into a convent. The visitor is faced with an extraordinary planning schedule, compos…

Gaming as a Key Approach for the Recovery Process of a Public Space: The Case Study of the Old Chemical Plant ‘Chimica Arenella’ in Palermo

2021

This poster describes the FORGE (FactOry of uRban GamEs) project, a proposal that our research group launched in partnership with the Municipality of Palermo (Italy) and other local stakeholders in 2019. FORGE will be hosted in what was previously a chemical plant (the former 'Chimica Arenella') and is an open factory designed to collect needs and to generate interventions for urban innovation. The four key terms we have used for the project are urban, game, factory and participation. In fact, FORGE employs a participatory methodological model based on the concept of game, aimed at supporting social and economic development through a platform for participatory co-design. FORGE plays also a …

Multidimensional Sexual Well-being Scale for Older Adults: Validity Evidence from a Polish Sample

2021

Here, we report the results of a Polish adaptation of the Multidimensional Sexual Well-being Scale (MSWBS) for older adults. The MSWBS is a short self-report scale for assessing the five dimensions of an individual's sexual well-being: frequency of caressing, sexual intimacy, sexual compliance, sexual satisfaction, and sexual distress. The aim of our adaptation was to examine the utility of the scale in a country with conservative views on the sexuality of older people, which will help health care providers and researchers to better understand the sexual needs of older people. The study included 507 participants, aged 60-92. We found the reliability of the scale to be satisfactory (Cronbach…

Social disparities in students’ trajectories to French « grandes écoles »

2021

International audience

Finance, Digital Disruption, and Sustainability : Issues, Challenges, and Future Directions

2021

International audience

Coupled-channel meson-meson scattering in the diabatic framework

2021

We apply the diabatic framework, a QCD-based formalism for the unified study of quarkoniumlike systems in terms of heavy quark-antiquark and open-flavor meson-meson components, to the description of coupled-channel meson-meson scattering. For this purpose, we first introduce a numerical scheme to find the solutions of the diabatic Schr\"odinger equation for energies in the continuum, then we derive a general formula for calculating the meson-meson scattering amplitudes from these solutions. We thus obtain a completely nonperturbative procedure for the calculation of open-flavor meson-meson scattering cross sections from the diabatic potential, which is directly connected to lattice QCD calc…

Violencia y cambio político: el caso paradójico del modelo español de Transición

2021

International audience

The Symmetry of Lower Back Pain as a Potential Screening Factor for Serious Pathology: A Survey Study

2021

Background: Pain maps provide reliable information on pain location in various conditions. This study explored the feasibility of pain maps as a screening tools for serious underlying conditions. The pain symmetry was evaluated as the possible distinguishing feature. Methods: A Web-based survey on the correlation of pain-related disability and pain pattern was developed. Respondents with lower back pain were asked to mark the exact location of their pain over the pain chart. The symmetry index was calculated and used to divide subjects into two groups that were then compared in terms of the prevalence of red flags for serious pathologies, as well as the pain-related disability measured with…

Cell adhesion on UV-crosslinked polyurethane gels with adjustable mechanical strength and thermoresponsiveness

2021

Temperature-responsive polyurethane (PU) hydrogels represent a versatile material platform for modern tissue engineering and biomedical applications. However, besides intrinsic advantages such as high mechanical strength and a hydrolysable backbone composition, plain PU materials are generally lacking bio-adhesive properties. To overcome this shortcoming, the authors focus on the synthesis of thermoresponsive PU hydrogels with variable mechanical and cell adhesive properties obtained from linear precursor PUs based on poly(ethylene glycol)s (pEG) with different molar masses, isophorone diisocyanate, and a dimerizable dimethylmaleimide (DMMI)-diol. The cloud point temperatures of the dilute,…

Chronic venous insufficiency, cardiovascular disease, and mortality: a population study

2021

Abstract Aims  Evidence regarding the health burden of chronic venous insufficiency (CVI), its clinical determinants, and impact on outcome is scarce. Methods and results  Systematic phenotyping of CVI according to established CEAP (Clinical-Etiologic-Anatomic-Pathophysiologic) classification was performed in 12 423 participants (age range: 40–80 years) of the Gutenberg Health Study from April 2012 to April 2017. Prevalence was calculated age- and sex-specifically. Multivariable Poisson regression models were calculated to evaluate the relation of CVI with cardiovascular comorbidities. Survival analyses were carried out to assess the CVI-associated risk of death. Replication of findings was…

Unsymmetrically Substituted Bis(phosphino)Ferrocenes Triggering Through-Space 31(P, P′)-Nuclear Spin Couplings and Encapsulating Coinage Metal Cations

2021

International audience; We describe unsymmetrically substituted di-tert-butylated 1,1'-bis(phosphino)ferrocenes, with phosphino substituents R = [5-methyl]-2-furyl = Fu, and R' = phenyl (4a), i-propyl (4b). A modular synthetic approach was applied from the di-tert-butylated ferrocene platform (1), which lead to the formation of new diphosphines by using 1,1'bis(diiodo)-3,3'-bis(tert-butyl)ferrocene (2) as synthetic precursor. In contrast to the cousin non-alkylated unsymmetrically substituted diphosphino-ferrocenes which were reported up to now, these diphosphines showed strong (31 P, P')nonbonded (" ug-p e") nuclear spin-spin coupling. The strength of such internuclear spin-spin coupling c…

Valorization of Wastewater from Table Olives: NMR Identification of Antioxidant Phenolic Fraction and Microwave Single-Phase Reaction of Sugary Fract…

2021

The table olive industry is producing a huge amount of wastewater, which is a post-processing cost and an environmental concern. The present study aims to valorize this processing by-product to obtain a value-added product, thereby enhancing resource efficiency and contributing to achieving sustainable development goals (SDGs). In this sense, a chemical reaction-based platform was developed to obtain valuable components, such as levulinic acid (LA) and 5-hydromethylfurfural (HMF). The products were then analyzed using NMR identification of the antioxidant phenolic fraction and microwave single-phase reaction of the sugary fraction. According to the results, the highest concentration of phen…

The relationship between stress and vitiligo during COVID‐19 pandemic

2021

Rich band structure and multiple long-lived isomers in the odd-odd Cs118 nucleus

2021

Recurrent missense variant in the nuclear export signal of FMR1 associated with FXS-like phenotype including intellectual disability, ASD, facial abn…

2021

Fragile X syndrome (FXS; MIM 300624) is an X-linked genetic disorder characterized by physical abnormalities associated with intellectual disability and a wide spectrum of neurological and psychiatric impairments. FXS occurs more frequently in males, 1 in 5000 males and 1 in 8000 females accounting for 1-2% of overall intellectual disability (ID). In more than 99% of patients, FXS results from expansions of a CGG triplet repeat (>200 in male) of the FMR1 gene. In the last years an increasing number, albeit still limited, of FXS subjects carrying FMR1 mutations including deletions, splicing errors, missense, and nonsense variants was reported. Nevertheless, the studies concerning the func…

Elena+ care for COVID-19, a pandemic lifestyle care intervention : intervention design and study protocol

2021

Background: The current COVID-19 coronavirus pandemic is an emergency on a global scale, with huge swathes of the population required to remain indoors for prolonged periods to tackle the virus. In this new context, individuals' health-promoting routines are under greater strain, contributing to poorer mental and physical health. Additionally, individuals are required to keep up to date with latest health guidelines about the virus, which may be confusing in an age of social-media disinformation and shifting guidelines. To tackle these factors, we developed Elena+, a smartphone-based and conversational agent (CA) delivered pandemic lifestyle care intervention. Methods: Elena+ utilizes varie…

Technical design of the phase I Mu3e experiment

2021

Nuclear instruments & methods in physics research / A 1014, 165679 (2021). doi:10.1016/j.nima.2021.165679

Editorial: On the Nature and Scope of Habits and Model-Free Control

2021

Gut Microbiota, Microbial Metabolites and Human Physical Performance

2021

Trillions of microbes inhabiting the gut modulate the metabolism of the host. Cross-sectional studies have reported associations between physical performance and the gut microbiota (GM). Physical activity seems to increase GM diversity and the abundance of certain health-beneficial microbes. We reviewed the evidence from longitudinal studies on the connection between physically active lifestyle or long-term exercise interventions and the GM. We made literature searches using databases of Web of Science and PubMed Medline to collect human studies showing or not the associations between the GM and exercise. Many controversies exist in the studies. However, the longitudinal studies show that f…

The Conservatives’ representation of Socialism and Liberalism during parliamentary debates since the 90s.

2021

International audience; The Conservatives’ representation of Liberalism through the mirror image of Socialism (in parliamentary discourse)This paper aims to analyse the way the Conservatives have represented socialism and liberalism in the Westminster parliamentary debates since John Major (especially during Prime Minister’s Question Time).Since Margaret Thatcher’s adoption of neo-liberal policies the conservative MPs and leaders have relentlessly depicted socialism as a threat to the country, both from an economic and social perspective. In their view, socialism is the arch-enemy to fight aginst, it is associated with regimes that would kill democracy and freedom in the UK. Its principles …

[Protein intake in community-dwelling postmenopausal women and its relationship with sarcopenia].

2021

Objectives: the general aging of the population is related to the increase in the prevalence of sarcopenic disease; especially among older women, this pathology is closely related to nutrition and specifically to protein consumption in older adults. The aim of our study was to evaluate the possible relationship between a low protein intake and a higher prevalence of sarcopenic disease, a worse dietary pattern, and lower physical performance in postmenopausal women living in the community. Material and methods: the study was carried out in a total of 164 independent women over 65 years of age, recruited from a municipal social center in Valencia (Benimaclet). The presence of sarcopenic patho…

Role of microglia in blood pressure and respiratory responses to acute hypoxic exposure in rats

2021

AbstractMicroglia modulate cardiorespiratory activities during chronic hypoxia. It has not been clarified whether microglia are involved in the cardiorespiratory responses to acute hypoxia. Here we investigated this issue by comparing cardiorespiratory responses to two levels of acute hypoxia (13% O2 for 4 min and 7% O2 for 5 min) in conscious unrestrained rats before and after systemic injection of minocycline (MINO), an inhibitor of microglia activation. MINO increased blood pressure but not lung ventilation in the control normoxic condition. Acute hypoxia stimulated cardiorespiratory responses in MINO-untreated rats. MINO failed to significantly affect the magnitude of hypoxia-induced bl…

Evidence for a conserved queen-worker genetic toolkit across slave-making ants and their ant hosts

2021

AbstractThe ecological success of social Hymenoptera (ants, bees, wasps) depends on the division of labour between the queen and workers. Each caste is highly specialised in its respective function in morphology, behaviour and life-history traits, such as lifespan and fecundity. Despite strong defences against alien intruders, insect societies are vulnerable to social parasites, such as workerless inquilines or slave-making (dulotic) ants. Here, we investigate whether gene expression varies in parallel ways between lifestyles (slave-making versus host ants) across five independent origins of ant slavery in the “Formicoxenus-group” of the ant tribe Crematogastrini. As caste differences are o…

Des pesticides aux maladies thyroïdiennes : la place des liens entre les perturbateurs endocriniens et les maladies thyroïdiennes dans la presse écri…

2021

International audience

Treatment of COVID-19 with MSCs: how does it work?

2021

The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II clinical trial to validate previous findings and explore the potential mechanisms. Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay (P = 0.0198) and less time required for symptoms remission (P = 0.0194) than those who received placebo. Based on chest images, both severe and critical patients treated with MSCs showed improvement by day 7 (P = 0.0099) and day 21 (P = 0.0084). MSC-treated pat…

Schoolyard affordances for physical activity: a pilot study in 6 Nordic–Baltic countries

2021

Environmental settings influence children’s and adolescents’ physical activity (PA) in neighborhoods and schoolyards. This study aimed to explore the main characteristics of schoolyards in six Nordic–Baltic countries, to document how those facilities provide affordances for PA in 7–18 year–old schoolchildren, and how the schoolyard meets children’s preferences. One schoolyard was studied in each included country: Iceland, Norway, Finland, Lithuania, Latvia, and Estonia. The affordances, facilities, and equipment for PA in schoolyards were identified through orthophoto maps and standard registration forms. Children’s preferences were collected through group interviews at each participating s…

Dynamic Structural Changes and Thermodynamics in Phase Separation Processes of an Intrinsically Disordered–Ordered Protein Model

2021

Elastin-like proteins (ELPs) are biologically important proteins and models for intrinsically disordered proteins (IDPs) and dynamic structural transitions associated with coacervates and liquid-liquid phase transitions. However, the conformational status below and above coacervation temperature and its role in the phase separation process is still elusive. Employing matrix least-squares global Boltzmann-fitting of the circular dichroism spectra of the ELPs (VPGVG) 20 , (VPGVG) 40 and (VPGVG) 60 , we found that coacervation occurs sharply when a certain number of repeat units has acquired β-turn conformation (in our sequence setting a threshold of ~20 repeat units). The differential scatter…

Lipas-aineistot

2021

Lipas on valtakunnallinen paikkatietokanta liikuntapaikoista, ulkoilureiteistä ja virkistysalueista. Lipas-tietokantaan kerätään tiedot Suomen julkisista, erityisesti kuntien omistamista liikuntapaikoista. Myös yksityisten yritysten ja yhdistysten hallinnoimia paikkoja löytyy tietokannasta. Tiedon tuottajina toimivat kuntien liikuntatoimen asiantuntijat yhteistyössä kunnan muiden toimialojen kanssa sekä virkistysalueyhdistykset ja lajiliitot. Lisäksi Lipas-projektissa tehdään aineiston kattavuuden ja laadun seurantaa ja tietojen täydennystä. Hankkeesta löytyy lisätietoa lipas.fi ja lipasinfo.fi. Hankkeesta julkaistaan säännöllisin väliajoin otoksia. Aineisto on ladattavissa myös hankkeen om…

Katsaus : Heroines-antologia, Karoliina Maanmieli ja Katri Kluukeri (toim.) ja Heroines-työryhmä, Suomen kirjallisuusterapia-yhdistys ry, 2021

2021

Comment on "Universal Origin of Boson Peak Vibrational Anomalies in Ordered Crystals and in Amorphous Materials".

2021

22nd International Scientific Conference “EcoBalt 2021”: Book of Abstracts (Riga, Latvia, October 21–23, 2021)

2021

The abstract book contains abstracts of the participants of the 22nd International Scientific Conference "EcoBalt 2021".

Nonunitary neutrino mixing in short and long-baseline experiments

2021

Non-unitary neutrino mixing in the light neutrino sector is a direct consequence of type-I seesaw neutrino mass models. In these models, light neutrino mixing is described by a sub-matrix of the full lepton mixing matrix and, then, it is not unitary in general. In consequence, neutrino oscillations are characterized by additional parameters, including new sources of CP violation. Here we perform a combined analysis of short and long-baseline neutrino oscillation data in this extended mixing scenario. We did not find a significant deviation from unitary mixing, and the complementary data sets have been used to constrain the non-unitarity parameters. We have also found that the T2K and NOvA t…