showing 36 of ~574560 from 574555 documents
The Conservatives’ representation of Socialism and Liberalism during parliamentary debates since the 90s.
2021
International audience; The Conservatives’ representation of Liberalism through the mirror image of Socialism (in parliamentary discourse)This paper aims to analyse the way the Conservatives have represented socialism and liberalism in the Westminster parliamentary debates since John Major (especially during Prime Minister’s Question Time).Since Margaret Thatcher’s adoption of neo-liberal policies the conservative MPs and leaders have relentlessly depicted socialism as a threat to the country, both from an economic and social perspective. In their view, socialism is the arch-enemy to fight aginst, it is associated with regimes that would kill democracy and freedom in the UK. Its principles …
L'abeille : animal médiatique, animal de l'anthropocène
2021
National audience
Nonunitary neutrino mixing in short and long-baseline experiments
2021
Non-unitary neutrino mixing in the light neutrino sector is a direct consequence of type-I seesaw neutrino mass models. In these models, light neutrino mixing is described by a sub-matrix of the full lepton mixing matrix and, then, it is not unitary in general. In consequence, neutrino oscillations are characterized by additional parameters, including new sources of CP violation. Here we perform a combined analysis of short and long-baseline neutrino oscillation data in this extended mixing scenario. We did not find a significant deviation from unitary mixing, and the complementary data sets have been used to constrain the non-unitarity parameters. We have also found that the T2K and NOvA t…
false
2021
IntroductionImmune checkpoint inhibitors (ICI) are increasingly being used to treat numerous cancer types. Together with improved recognition of toxicities, this has led to more frequent identification of rare immune-related adverse events (irAE), for which specific treatment strategies are needed. Neutropenia is a rare hematological irAE that has a potential for a high mortality rate because of its associated risk of sepsis. Prompt recognition and timely treatment of this life-threatening irAE are therefore critical to the outcome of patients with immune-related neutropenia.MethodsThis multicenter international retrospective study was conducted at 17 melanoma centers to evaluate the clinic…
Analysis of the Standard Definition of Cosmopolitanism
2021
This chapter investigates the traditional definition of cosmopolitanism which understands cosmopolitanism as moral egalitarianism. It sets out in detail how the three core elements (individualism, universality, and generality) allow so much room for interpretation that the definition hardly provides any information on what moral egalitarianism means. It confirms that cosmopolitanism as moral egalitarianism includes almost all theories of global justice, even such that are commonly seen as opposing positions.
Smoking a Dangerous Addiction: A Systematic Review on an Underrated Risk Factor for Oral Diseases
2021
Despite growing knowledge of the adverse effects of cigarette smoking on general health, smoking is one of the most widely prevalent addictions around the world. Globally, about 1.1 billion smokers and over 8 million people die each year because of cigarette smoking. Smoking acts as a source for a variety of oral and systemic diseases. Various periodontal issues such as increased pocket depth, loss of alveolar bone, tooth mobility, oral lesions, ulcerations, halitosis, and stained teeth are more common among smokers. This systematic review was conducted according to the guidelines from PRISMA, and research articles were retrieved from the Web database sources on 31 May 2021. The quality of …
Refuting the Relationist Challenge: Room for Partiality Rather Than Advocating Special Duties
2021
Building on the responsibility framework developed in the previous chapter, this chapter completes the argument. It refutes the relationist challenge that personal relations require special responsibilities qualifying as relevant for matters of justice. The argument focuses Scheffler’s relationist arguments and demonstrates how his critique of nonrelationism can be resolved by differentiating between different types of responsibility.
Versatile Pedagogical and Social Activities of a Graduate of Riga Polytechnic Institute Jānis Stiprais (1870–1946)
2021
The research discusses continuous effort of a pedagogue, economist and journalist Jānis Stiprais (1870–1946) in his pursuit to obtain education and his versatile pedagogical activities in Tomsk (Russia), Tukums, Valka and Riga, as well as the contribution he made in such areas as journalism, folklore and social work. J. Stiprais shared his knowledge of economics gained at Riga Polytechnic Institute (RPI) with the students at the University of Latvia (UL), Latvia People’s University and Vilis Olavs Commercial School; in the first half of the 20th century he was the principal of educational institutions in Tukums, Valka and Riga, he also was one of the signatories of the Memorandum of the Cen…
Modelling the Interaction between Air Pollutant Emissions and Their Key Sources in Poland
2021
The main purpose of this study is to investigate the relationships between key sources of air pollutant emissions (sources of energy production, factories which are particularly harmful to the environment, the fleets of cars, environmental protection expenditure) and the main environmental air pollution (SO2, NOx, CO and PM) in Poland. Models based on MLP neural networks were used as predictive models. Global sensitivity analysis was used to demonstrate the significant impact of individual network input variables on the output variable. To verify the effectiveness of the models created, the actual data were compared with the data obtained through modelling. Projected courses of changes in t…
Kohti traumainformoidun kirjallisuusterapian käytäntöä
2021
Artikkelissa käsitellyn traumainformoidun toiminnan keskiössä on uudelleen traumatisoitumisen ehkäiseminen. Traumainformoituja työtapoja tarkastellaan kahdesssa eri kirjallisuusterapiaryhmässä. 1) Monikansallisessa Heroines-hankkeessa (2021) keskeiseksi nousivat turvallinen toimintaympäristö, sekä osallistujien kokemukset kirjallisesta ilmaisusta. 2) Rintasyöpää sairastavien kirjoittajaryhmän tarkastelussa nousee puolestaan esiin etäännyttäminen kirjoittamisen keinona. Rintasyövästä kirjoittavien teksteissä metaforat olivat keskeisiä, samoin asioiden personifiointi. Uudelleen traumatisoitumisen välttämisessä keskeisessä roolissa on ohjaaja, joka toimillaan luo ja ylläpitää turvallista toimi…
Trends in hospitalizations and deaths in HIV-infected patients in Spain over two decades.
2021
Background The prognosis of HIV infection dramatically improved after the introduction of triple antiretroviral therapy 25 years ago. Herein, we report the impact of further improvements in HIV management since then, looking at all hospitalizations in persons living with HIV (PLWH) in Spain. Methods Retrospective study using the Spanish National Registry of Hospital Discharges. Information was retrieved since 1997 to 2018. Results From 79,647,783 nationwide hospital admissions recorded during the study period, 532,668 (0.67%) included HIV as diagnosis. The mean age of PLWH hospitalized increased from 33 to 51 years-old (p < 0.001). The rate of HIV hospitalizations significantly declined aft…
Searching Silk Fabrics by Images Leveraging on Knowledge Graph and Domain Expert Rules
2021
The production of European silk textile is an endangered intangible cultural heritage. Digital tools can nowadays be developed to help preserving it, or even to make it more accessible for the public and the fashion industry. In this paper, we propose an image-based retrieval tool that leverages on a knowledge graph describing the silk textile production as well as rules formulated by experts of this domain. Out of several possible similarity scenarios, two have proven to work best and have been integrated into an exploratory search engine.
Reconfigurable nonlinear response of dielectric and semiconductor metasurfaces
2021
Abstract Optically resonant dielectric and semiconductor metasurfaces are an emerging and promising area of nanophotonics and light–matter interaction at the nanoscale. Recently, active tuning of the linear response and nonlinear effects of these components has received an increasing amount of interest. However, so far these research directions have remained separated with only few sporadic works that study their combination beginning to appear in the literature. The evolution of nonlinear metasurfaces based on dielectric and semiconductor materials toward reconfigurable and dynamic components could potentially answer the demand of integrated on-chip components that realize essential functi…
Valorization of Marine Waste: Use of Industrial By-Products and Beach Wrack Towards the Production of High Added-Value Products
2021
Biomass is defined as organic matter from living organisms represented in all kingdoms. It is recognized to be an excellent source of proteins, polysaccharides and lipids and, as such, embodies a tailored feedstock for new products and processes to apply in green industries. The industrial processes focused on the valorization of terrestrial biomass are well established, but marine sources still represent an untapped resource. Oceans and seas occupy over 70% of the Earth’s surface and are used intensively in worldwide economies through the fishery industry, as logistical routes, for mining ores and exploitation of fossil fuels, among others. All these activities produce waste. The other sou…
Platelets Contribution to Thrombin Generation in Philadelphia-Negative Myeloproliferative Neoplasms: The "Circulating Wound" Model.
2021
Current cytoreductive and antithrombotic strategies in MPNs are mostly based on cell counts and on patient’s demographic and clinical history. Despite the numerous studies conducted on platelet function and on the role of plasma factors, an accurate and reliable method to dynamically quantify the hypercoagulability states of these conditions is not yet part of clinical practice. Starting from our experience, and after having sifted through the literature, we propose an in-depth narrative report on the contribution of the clonal platelets of MPNs—rich in tissue factor (TF)—in promoting a perpetual procoagulant mechanism. The whole process results in an unbalanced generation of thrombin and i…
false
2021
During the early months of the COVID-19 pandemic, there was an unusually high submission rate of scholarly articles. Given that most academics were forced to work from home, the competing demands for familial duties may have penalized the scientific productivity of women. To test this hypothesis, we looked at submitted manuscripts and peer review activities for all Elsevier journals between February and May 2018-2020, including data on over 5 million authors and referees. Results showed that during the first wave of the pandemic, women submitted proportionally fewer manuscripts than men. This deficit was especially pronounced among more junior cohorts of women academics. The rate of the pee…
How to assess the risks associated with the usage of a medical device based on predictive modeling: the case of an anemia control model certified as …
2021
Background The successful application of Machine Learning (ML) to many clinical problems can lead to its implementation as medical devices (MD), being important to assess the associated risks. Methods An anemia control model (ACM), certified as MD may face adverse events as the result of wrong predictions that are translated into suggestions of doses of erythropoietic stimulating agents to dialysis patients. Risks are assessed as the combination of severity and probability of a given hazard. While severities are typically assessed by clinicians, probabilities are tightly related to the performance of the predictive model. Results A post-marketing dataset formed by all adult patients registe…
Climate signals in stable carbon and hydrogen isotopes of lignin methoxy groups from southern German beech trees
2021
Stable hydrogen and carbon isotope ratios of wood lignin methoxy groups (δ13CLM and δ2HLM values) have been shown to be reliable proxies of past temperature variations. Previous studies showed that δ2HLM values even work in temperate environments where classical tree-ring width and maximum latewood density measurements are less successful for climate reconstructions. Here, we analyse the annually resolved δ13CLM values from 1916–2015 of four beech trees (Fagus sylvatica) from a temperate site near Hohenpeißenberg in southern Germany and compare these data with regional- to continental-scale climate observations. Initial δ13CLM values were corrected for the Suess effect (a decrease of δ13C i…
Interpretation of gut microbiota data in the ‘eye of the beholder’: A commentary and re‐evaluation of data from ‘Impacts of radiation exposure on the…
2021
1.Evidence that exposure to environmental pollutants can alter the gut microbiota composition of wildlife includes studies of rodents exposed to radionuclides. 2.Antwis et al. (2021) used amplicon sequencing to characterise the gut microbiota of four species of rodent (Myodes glareolus, Apodemus agrarius, A. flavicollis and A. sylvaticus) inhabiting the Chernobyl Exclusion Zone (CEZ) to examine possible changes in gut bacteria (microbiota) and gut fungi (mycobiota) associated with exposure to radionuclides and whether the sample type (from caecum or faeces) affected the analysis. 3.The conclusions derived from the analyses of gut mycobiota are based on data that represent a mixture of inges…
Cosmopolitanism as Nonrelationism and Relevant Duties of Justice
2021
This chapter clarifies the new concept of cosmopolitanism as nonrelationism and embeds it in the academic debate. In defence of the new concept, it clarifies how personal relationships can be valued without treating them as a basis for justifying special responsibilities between related individuals. The argument distinguishes between different kinds of responsibilities based on a responsibility framework developed from conceptual considerations of Hart and O’Neill as well as Pettit and Goodin. It reveals that not all kinds of responsibilities are equally relevant with regard to matters of justice.
Frequency and prognostic impact of ALK amplifications and mutations in the European Neuroblastoma Study Group (SIOPEN) high-risk neuroblastoma trial …
2021
Purpose: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated through activating point mutations or genomic amplification. We studied ALK genetic alterations in high-risk (HR) patients on the HR-NBL1/SIOPEN trial to determine their frequency, correlation with clinical parameters, and prognostic impact. Materials and methods: Diagnostic tumor samples were available from 1,092 HR-NBL1/SIOPEN patients to determine ALK amplification status (n = 330), ALK mutational profile (n = 191), or both (n = 571). Results: Genomic ALK amplification (ALKa) was detected in 4.5% of cases (41 out of 901), all except one with MYCN amplification (MNA). ALKa was associated with …
Genetic Evidence of the Black Death in the Abbey of San Leonardo (Apulia Region, Italy): Tracing the Cause of Death in Two Individuals Buried with Co…
2021
The Abbey of San Leonardo in Siponto (Apulia, Southern Italy) was an important religious and medical center during the Middle Ages. It was a crossroads for pilgrims heading along the Via Francigena to the Sanctuary of Monte Sant’Angelo and for merchants passing through the harbor of Manfredonia. A recent excavation of Soprintendenza Archeologica della Puglia investigated a portion of the related cemetery, confirming its chronology to be between the end of the 13th and beginning of the 14th century. Two single graves preserved individuals accompanied by numerous coins dating back to the 14th century, hidden in clothes and in a bag tied to the waist. The human remains of the individuals were …
Some Previously Relevant Aspects of Academic Life: Venia Legendi and the Status of a Private Docent in the World and in Riga Polytechnicum (1862–1896)
2021
The study examines the status of a private docent, the academic position which was introduced across the world in the 18th century and which also existed in Latvia from the second half of the 19th century until the end of World War II. The status of the private docent as it used to be understood in Latvia is compared with other countries, mainly considering German-type universities. Definition of the terms «venia legendi» and «private docent» providing examples of academic activity of the lecturers of Riga Polytechnicum (RP) allow considering these concepts from various perspectives in order to make their meaning and usage in the previous centuries transparent for the users in the 21st cent…
Treatment options for leishmaniasis.
2021
Leishmaniasis is broadly classified into three types: cutaneous, mucocutaneous and visceral. The visceral form is most dangerous and can result in death. Although leishmaniasis is an ancient disease, its treatment is still challenging. Several drugs, differing in their cost, toxicity, treatment duration and emergence of drug resistance, are used for different types of leishmaniasis. To overcome these limitations, the search for newer drugs and other treatments continues. In this article, we discuss conventional drugs, other treatments, including newer options such as immunotherapy and immunochemotherapy, and future prospects for leishmaniasis treatment.
Antibiotics accelerate growth at the expense of immunity
2021
Antibiotics have long been used in the raising of animals for agricultural, industrial or laboratory use. The use of subtherapeutic doses in diets of terrestrial and aquatic animals to promote growth is common and highly debated. Despite their vast application in animal husbandry, knowledge about the mechanisms behind growth promotion is minimal, particularly at the molecular level. Evidence from evolutionary research shows that immunocompetence is resource-limited, and hence expected to trade off with other resource-demanding processes, such as growth. Here, we ask if accelerated growth caused by antibiotics can be explained by genome-wide trade-offs between growth and costly immunocompete…
Early psychosis in Thauvin‐Robinet‐Faivre syndrome, a complication of the disease?
2021
Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants.
2021
The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant?s surface at the early stages of osseointegration. Sixty tapered acid-etched titanium implants were divided into four groups: i) Collagen, used as a control group; and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations: ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6- and 12-weeks of healing samples were harvested, histologically processed,…
Valerijs Bitenieks – From a Student of Riga Polytechnic Institute to a Construction Contractor in the Independent Latvia
2021
A paper on Valerijs Bitenieks, a graduate (1986) of the Faculty of Architecture and Civil Engineering of Riga Polytechnic Institute (RPI), reflects on the daily life of the Soviet students in the 1980s, the work of a young engineer while he was trying various opportunities in the labour market and the engineer’s growth as a successful contractor in the independent Latvia in the 21st century. It traces the life of V. Bitenieks from his childhood to the present day, paying attention to his professional activities. The research provides an insight into students’ internships and extracurricular activities during the Soviet era. Unpublished photographic material unknown to the general public has…
Coordinatively Unsaturated Amidotitanocene Cations with Inverted σ and π Bond Strengths: Controlled Release of Aminyl Radicals and Hydrogenation/Dehy…
2021
Cationic amidotitanocene complexes [Cp2 Ti(NPhAr)][B(C6 F5 )4 ] (Cp=η5 -C5 H5 ; Ar=phenyl (1 a), p-tolyl (1 b), p-anisyl (1 c)) were isolated. The bonding situation was studied by DFT (Density Functional Theory) using EDA-NOCV (Energy Decomposition Analysis with Natural Orbitals for Chemical Valence). The polar Ti-N bond in 1 a-c features an unusual inversion of σ and π bond strengths responsible for the balance between stability and reactivity in these coordinatively unsaturated species. In solution, 1 a-c undergo photolytic Ti-N cleavage to release Ti(III) species and aminyl radicals ⋅NPhAr. Reaction of 1 b with H3 BNHMe2 results in fast homolytic Ti-N cleavage to give [Cp2 Ti(H3 BNHMe2 )…
Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Resear…
2021
Abstract Background Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse the differential clinical course. Methods We performed a hierarchical cluster analysis based on Ward’s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results A total of 9363 were available for this analysis. We identified three …
Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?
2021
Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads to retinal ganglion cell (RGC) damage in glaucoma. Substances with anti-inflammatory properties could decrease these cytokines and chemokines and thus prevent RGC death. The authors of this study analysed the anti-inflammatory effect of a hydrophilic saffron extract standardized to 3% crocin content, focusing on the regulation of cytokine and chemokine production, in a mouse model of unilateral laser-induced ocular hypertension (OHT). We demonstrated that following saffron treatment, most of the concentration of proinflammatory cytokines (IL-1β, IFN-γ, TNF-α, and IL-17), anti-inflammatory cyt…
Ultrafast Interface Charge Separation in Carbon Nanodot-Nanotube Hybrids
2021
Carbon dots are an emerging family of zero-dimensional nanocarbons behaving as tunable light harvesters and photoactivated charge donors. Coupling them to carbon nanotubes, which are well-known electron acceptors with excellent charge transport capabilities, is very promising for several applications. Here, we first devised a route to achieve the stable electrostatic binding of carbon dots to multi- or single-walled carbon nanotubes, as confirmed by several experimental observations. The photoluminescence of carbon dots is strongly quenched when they contact either semiconductive or conductive nanotubes, indicating a strong electronic coupling to both. Theoretical simulations predict a favo…
Seven-Weeks Gait-Retraining in Minimalist Footwear Has No Effect on Dynamic Stability Compared With Conventional Footwear.
2021
Purpose: To investigate the effects of two different running footwear conditions (transition to minimalist footwear and conventional running footwear) on dynamic postural stability before and after 7 weeks of gait retraining program, and to evaluate the effect of fatigue on dynamic stability. Method: This randomized controlled clinical trial was carried out by 42 recreational male runners, who were randomly divided into two groups; Conventional Footwear Group (CFG) (n = 22) and Minimalist Footwear Group (MFG) (n = 20). Dynamic Postural Stability Index (DPSI), in a fatigued and non-fatigued state, were assessed before and after a gait retraining program. The gait retraining program consisted…
Role de la Recherche et l’Innovation dans le développement économique d’un pays
2021
National audience
Cosmopolitanism About Culture: Specifying Individualism
2021
Still drawing on the classical distinction between moderate and extreme cosmopolitanism, this chapter analyses different specifications of the individualism element providing different answers to what it means to respect individuals as moral equals. The analysis eventually presents eight types of specification but rejects all of them as either still too broad or untenable. Only a hybrid type, which is composed of assumptions of different specification types, appears more promising. This defines the new concept of cosmopolitanism: cosmopolitanism as nonrelationism.
Lavoro e sicurezza sociale dei migranti economici: l'eguaglianza imperfetta
2021
Il saggio analizza i diritti dei migranti economici in Italia alla luce dei principi di eguaglianza e non discriminazione in chiave multilivello, in relazione ad accesso al lavoro, esecuzione del contratto e prestazioni di sicurezza sociale. Nella prospettiva dei diritti fondamentali del lavoratore il quadro normativo non è per nulla confortante: è estremamente difficile un ingresso regolare dei migranti sul territorio nazionale in virtù della legislazione di riferimento. Inoltre, sul versante dell’assistenza sociale il principio paritario soffre numerose eccezioni che di recente sono state avallate da un revirement del Giudice delle leggi nella sentenza 50/2019 in materia di assegno social…