showing 36 of ~574560 from 574555 documents
Coordinatively Unsaturated Amidotitanocene Cations with Inverted σ and π Bond Strengths: Controlled Release of Aminyl Radicals and Hydrogenation/Dehy…
2021
Cationic amidotitanocene complexes [Cp2 Ti(NPhAr)][B(C6 F5 )4 ] (Cp=η5 -C5 H5 ; Ar=phenyl (1 a), p-tolyl (1 b), p-anisyl (1 c)) were isolated. The bonding situation was studied by DFT (Density Functional Theory) using EDA-NOCV (Energy Decomposition Analysis with Natural Orbitals for Chemical Valence). The polar Ti-N bond in 1 a-c features an unusual inversion of σ and π bond strengths responsible for the balance between stability and reactivity in these coordinatively unsaturated species. In solution, 1 a-c undergo photolytic Ti-N cleavage to release Ti(III) species and aminyl radicals ⋅NPhAr. Reaction of 1 b with H3 BNHMe2 results in fast homolytic Ti-N cleavage to give [Cp2 Ti(H3 BNHMe2 )…
Searching Silk Fabrics by Images Leveraging on Knowledge Graph and Domain Expert Rules
2021
The production of European silk textile is an endangered intangible cultural heritage. Digital tools can nowadays be developed to help preserving it, or even to make it more accessible for the public and the fashion industry. In this paper, we propose an image-based retrieval tool that leverages on a knowledge graph describing the silk textile production as well as rules formulated by experts of this domain. Out of several possible similarity scenarios, two have proven to work best and have been integrated into an exploratory search engine.
Some Previously Relevant Aspects of Academic Life: Venia Legendi and the Status of a Private Docent in the World and in Riga Polytechnicum (1862–1896)
2021
The study examines the status of a private docent, the academic position which was introduced across the world in the 18th century and which also existed in Latvia from the second half of the 19th century until the end of World War II. The status of the private docent as it used to be understood in Latvia is compared with other countries, mainly considering German-type universities. Definition of the terms «venia legendi» and «private docent» providing examples of academic activity of the lecturers of Riga Polytechnicum (RP) allow considering these concepts from various perspectives in order to make their meaning and usage in the previous centuries transparent for the users in the 21st cent…
« Mettre en scène un fruit ancien : châtaignes et castanéiculteurs, de l’Ardèche aux Cévennes. »
2021
International audience
Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach
2021
(1) Background: Prostate-specific membrane antigen (PSMA) has been extensively studied in the last decade. It became a promising biological target in the diagnosis and therapy of PSMA-expressing cancer diseases. Although there are several radiolabeled PSMA inhibitors available, the search for new compounds with improved pharmacokinetic properties and simplified synthesis is still ongoing. In this study, we developed PSMA ligands with two different hybrid chelators and a modified linker. Both compounds have displayed a promising pharmacokinetic profile. (2) Methods: DATA5m.SA.KuE and AAZTA5.SA.KuE were synthesized. DATA5m.SA.KuE was labeled with gallium-68 and radiochemical yields of various…
Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?
2021
Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads to retinal ganglion cell (RGC) damage in glaucoma. Substances with anti-inflammatory properties could decrease these cytokines and chemokines and thus prevent RGC death. The authors of this study analysed the anti-inflammatory effect of a hydrophilic saffron extract standardized to 3% crocin content, focusing on the regulation of cytokine and chemokine production, in a mouse model of unilateral laser-induced ocular hypertension (OHT). We demonstrated that following saffron treatment, most of the concentration of proinflammatory cytokines (IL-1β, IFN-γ, TNF-α, and IL-17), anti-inflammatory cyt…
Predictive Role of the p16 Immunostaining Pattern in Atypical Cervical Biopsies with Less Common High Risk HPV Genotypes
2021
P16 immunostaining is considered a useful surrogate of transcriptionally active high-risk (hr) HPV infection. Only strong and widespread “block-like” immunoreactivity is considered specific, whereas weak/focal p16 positive immunostaining is considered not specific, and follow-up and HPV molecular detection is not indicated. The aim of the study was to evaluate the presence of HPV DNA and Ki67 immunostaining in 40 cervical atypical biopsies (CALs) with mild and focal histological features suggestive of HPV infection—20 cases with weak/focal p16 positive immunoreactivity and 20 cases negative for p16 expression. In 16/20 weak/focal p16 positive CALs (80%), the INNO-LiPA HPV genotyping detecte…
Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients.
2021
Abstract In the midst of the COVID-19 pandemic, different vaccines in front of SARS-CoV-2 have been approved and administered in different vulnerable populations. As patients with cancer were excluded from pivotal trials of vaccination, little is known on their immunogenic response to these vaccines, particularly in patients with severely impaired immune system. In response to that uncertainty, the Spanish Society of Hematology and Hemotherapy launched an initiative aimed to provide recommendations for vaccination of the main hematological conditions. This document is based on the available information on COVID-19 outcomes, prior knowledge on vaccination in hematological patients, recent pu…
MOF-Stabilized Perfluorinated Palladium Cages Catalyze the Additive-Free Aerobic Oxidation of Aliphatic Alcohols to Acids
2021
Extremely high electrophilic metal complexes, composed by a metal cation and very electron poor σ-donor ancillary ligands, are expected to be privileged catalysts for oxidation reactions in organic chemistry. However, their low lifetime prevents any use in catalysis. Here we show the synthesis of fluorinated pyridine-Pd coordinate cages within the channels of an anionic tridimensional metal-organic framework (MOF), and their use as efficient metal catalysts for the aerobic oxidation of aliphatic alcohols to carboxylic acids without any additive. Mechanistic studies strongly support that the MOF-stabilized coordination cage with perfluorinated ligands unleashes the full electrophilic potenti…
An annotated checklist and bibliography of the diaptomidae (copepoda, calanoida) of Italy, Corsica, and the maltese islands
2021
Calanoids of the family Diaptomidae are the most widespread copepods in the lentic inland waters of the Palearctic region. In Italy, studies on the family date back to the end of 19th century. Since then, several papers contributed to increasing the knowledge on their presence, distribution, and ecological preferences. Nevertheless, new records for the area and the discovery of putative new species stress that the current knowledge on these inland water crustaceans is still far from being exhaustive. This paper presents an updated and annotated checklist and bibliography of the Diaptomidae of the Italian peninsula and surrounding islands, including Corsica and the Maltese islands, compiled …
Does the nuclear family affect social trust? Longitudinal evidence from Germany
2021
While research indicates that social trust might benefit societies’ political and economic development, the sources of social trust are subject to debate. This article investigates a less investiga...
Intercultural Dialogue via Music: Translating the Beatles’ Legacy into Contemporary Pop Culture
2021
Abstract Cultural translation phenomena are per se an intercultural product. Exchange and interaction take place every day in our globalized world. Especially with respect to music, a translational perspective can broaden the horizon of research projects in a very fruitful way. Music always combines elements from different cultures, periods and styles and can, in that way, serve as a medium of intercultural dialogue, which affects the participants of the dialogue not only on a rational, but also on an emotional level – and helps to cross borders and build bridges between different cultures. In my analysis, I take a look at the legacy of the Beatles and how it is performatively unfolded by t…
Geolocators reveal variation and sex‐specific differences in the migratory strategies of a long‐distance migrant
2021
A Comparison of 2D Magnetohydrodynamic Supernova Simulations with the CoCoNuT-FMT and Aenus-Alcar Codes
2021
Code comparisons are a valuable tool for the verification of supernova simulation codes and the quantification of model uncertainties. Here we present a first comparison of axisymmetric magnetohydrodynamic (MHD) supernova simulations with the CoCoNuT-FMT and Aenus-Alcar codes, which use distinct methods for treating the MHD induction equation and the neutrino transport. We run two sets of simulations of a rapidly rotating 35M gamma-ray burst progenitor model with different choices for the initial field strength, namely 10^12 G for the maximum poloidal and toroidal field in the strong-field case and 10^10 G in the weak-field case. We also investigate the influence of the Riemann solver and t…
false
2021
Arginine-glycine(-glycine) (RG/RGG) regions are highly abundant in RNA-binding proteins and involved in numerous physiological processes. Aberrant liquid-liquid phase separation (LLPS) and stress granule (SGs) association of RG/RGG regions in the cytoplasm have been implicated in several neurodegenerative disorders. LLPS and SG association of these proteins is regulated by the interaction with nuclear import receptors, such as transportin-1 (TNPO1), and by post-translational arginine methylation. Strikingly, many RG/RGG proteins harbour potential phosphorylation sites within or close to their arginine methylated regions, indicating a regulatory role. Here, we studied the role of phosphoryla…
Device-measured sedentary time in Norwegian children and adolescents in the era of ubiquitous internet access: secular changes between 2005, 2011 and…
2021
Abstract Background Access to screen-based media has been revolutionized during the past two decades. How this has affected sedentary time (ST) accumulation in children is poorly understood. Methods This study, based on the Physical Activity among Norwegian Children Study (PANCS), uses accelerometer data from population-based samples of 9- and 15-year-olds, collected in 2005 (n = 1722), 2011 (n = 1587) and 2018 (n = 1859). Secular changes between surveys were analysed using random-effects linear regression models adjusted for survey-specific factors. Data on ST were collected using hip-worn ActiGraphs and ST was defined using a threshold equivalent to <100 counts/min. Sedentary bouts…
HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Exper…
2021
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have therapeutic potential in the treatment of several immune disorders, including ulcerative colitis, owing to their regenerative and immunosuppressive properties. We recently showed that MSCs engineered to overexpress hypoxia-inducible factor 1-alpha and telomerase (MSC-T-HIF) and conditioned with pro-inflammatory stimuli release EVs (EVMSC-T-HIFC) with potent immunomodulatory activity. We tested the efficacy of EVMSC-T-HIFC to repolarize M1 macrophages (Mφ1) to M2-like macrophages (Mφ2-like) by analyzing surface markers and cytokines and performing functional assays in co-culture, including efferocytosis and T-cel…
The Potsdam Open Source Radio Interferometry Tool (PORT)
2021
The Potsdam Open Source Radio Interferometry Tool (PORT) is the very long baseline interferometry (VLBI) analysis software developed and maintained at the GFZ German Research Centre for Geosciences. Chiefly, PORT is tasked with the timely processing of VLBI sessions and post-processing activities supporting the generation of celestial and terrestrial reference frames. In addition, it serves as a framework for research and development within the GFZ's VLBI working group and is part of the tool set employed in educating young researchers. Starting out from VLBI group delays, PORT estimates station and radio sources positions, as well as Earth orientation parameters, tropospheric parameters, a…
En vingt ans, l’apport des historiennes du sport et de l’EPS
2021
International audience
Demasiada felicidad. Sobre la teoria de los afectos en Descartes y Leibniz
2021
Descartes y Leibniz figuran como pensadores opuestos en el ámbito de la filosofía moderna. Tras un período de influencia inicial, el pensador alemán habría sido un crítico severo de las tesis filosóficas del filósofo francés. Sin embargo, una lectura cuidadosa de las dispersas declaraciones leibnizianas a propósito de los afectos y su dimensión moral nos permitirán hacernos cargo de la distancia y cercanía entre el pensamiento de ambos. Para Descartes la felicidad está ligada a la voluntad, mientras que Leibniz será más fiel a la tradición intelectualista aristotélica, aunque su concepción de las emociones es, en muchos sentidos, asombrosamente similar.
International Multicentre Study of Candida auris Infections
2021
Background:Candida auris has emerged globally as a multi-drug resistant yeast and is commonly associated with nosocomial outbreaks in ICUs. Methods: We conducted a retrospective observational multicentre study to determine the epidemiology of C. auris infections, its management strategies, patient outcomes, and infection prevention and control practices across 10 centres from five countries. Results: Significant risk factors for C. auris infection include the age group of 61–70 years (39%), recent history of ICU admission (63%), diabetes (63%), renal failure (52%), presence of CVC (91%) and previous history of antibiotic treatment (96%). C. auris was commonly isolated from blood (76%). Echi…
Measurement of the Absolute Branching Fraction of Ds+→τ+ντ via τ+→e+νeν¯τ
2021
Using a dataset of 6.32 fb^{-1} of e^{+}e^{-} annihilation data collected with the BESIII detector at center-of-mass energies between 4178 and 4226 MeV, we have measured the absolute branching fraction of the leptonic decay D_{s}^{+}→τ^{+}ν_{τ} via τ^{+}→e^{+}ν_{e}ν[over ¯]_{τ}, and find B_{D_{s}^{+}→τ^{+}ν_{τ}}=(5.27±0.10±0.12)×10^{-2}, where the first uncertainty is statistical and the second is systematic. The precision is improved by a factor of 2 compared to the previous best measurement. Combining with f_{D_{s}^{+}} from lattice quantum chromodynamics calculations or the |V_{cs}| from the CKMfitter group, we extract |V_{cs}|=0.978±0.009±0.012 and f_{D_{s}^{+}}=(251.1±2.4±3.0) MeV, r…
Impact of Thermal Treatment on the Surface of Na0.5Bi0.5TiO3-Based Ceramics
2021
This research was funded by the European Regional Development Fund, grant number 1.1.1.2/VIAA/3/19/558. The Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme, grant number 739508.
Religiosity and social support in Polish older adults: the mediating role of wisdom. Perspectives on Lars Tornstam’s theory of gerotranscendence
2021
Objectives: The purpose of this study was to examine whether wisdom is a mediator in the relation-ships between religious meaning system and social support among older adults. According to the theory of gerotranscendence, associations of religiousness and social support are complex and sug- gest the existence of wisdom in their internal structures. Method: The study included 466 persons aged 50–75. Three measures were used: Religious Meaning System Scale (RMSS), Three-Dimensional Wisdom Scale (3D-WS) and Berlin Social Support Scales (BSSS). Results: The analyses allowed for a partial verification of the hypothesis that wisdom is a mediator in the relationship between the religious meaning s…
Une start-up communicationnelle en santé : l'expérience Nuvee
2021
Unveiling the Substituent Effects in the Stereochemistry of [3+2] Cycloaddition Reactions of Aryl‐ and Alkyldiazomethylphosphonates with Norbornadien…
2021
Transition 8: 800-1200. Emergence of enduring, concentrated and hierarchised settlement patterns in rural regions of North-Western Europe
2021
Chapter 11 : https://books.openedition.org/pufr/19927; International audience
L'émergence du référentiel marchand dans la tarification des cliniques privées algériennes : privatisation du financement et changement de paradigme
2021
La convergence tarifaire participe à la privatisation progressive du système de santé algérien amorcée depuis la fin des années 80. Le passage d’une logique de gratuité à une logique marchande pour accéder aux soins représente un bouleversement pour les patients. Afin d’appréhender la formation des tarifs dans le secteur de l’hospitalisation privée, nous avons mixé une enquête qualitative par entretiens semi-directifs auprès de 16 fondateurs de cliniques privées et l’administration d’un questionnaire auprès de 40 médecins permanents de ces cliniques disposant d’une activité à plein temps. Nos résultats montrent que l’absence d’une grille officielle de tarification des prestations de soins a…
The Holy Sinful Church: Towards a More Realistic Catholic Ecclesiology
2021
Abstract This article demonstrates that in Roman Catholic ecclesiology, it would be more justifiable and realistic to fully accept the concept of the sinfulness of the Church as a whole, not only that of its individual members. The piece begins with a short review and commentary on the doctrinal position of the Second Vatican Council (1962–1965) that provides a doctrinal basis for adopting and developing the notion of a ‘sinful Church’. Then, two contemporary activities of the Roman Catholic Church are analysed in which the notion of the ‘sinful Church’ has played an important role: the Great Jubilee act of confession, with the related explanations and commentaries, and the ecumenical dialo…
The systemic vision of the environment through drawing of young Spanish children
2021
Many current environmental problems occur on a planetary scale and their interrelationships are becoming increasingly complex. In order to solve these environmental problems, citizens must be aware...
Tracking migration of black‐headed buntings Emberiza melanocephala reveals the Iranian Plateau as an ecological barrier along the Indo‐European flyway
2021
The black-headed bunting is one of the few species that migrate along the Indo-European flyway, and its migration routes and phenology are poorly understood. We provide the first individual-based year-round tracking study describing route choice and timing of black-headed buntings migrating from a breeding site in Croatia to a 6000 km distant non-breeding region in Maharashtra, central India. To evaluate landscapes important for the black-headed bunting migration, we quantified land covers and climates along the migration corridor. Stopover areas during the post-breeding migration were concentrated in four distinct regions: the Balkan Peninsula, central Anatolia, along with the Zagros mount…
Global Initiative for Asthma (GINA) Strategy 2021 - Executive summary and rationale for key changes
2021
Funder: Global Initiative for Asthma
Le diplôme et la profession : deux composantes de la classe sociale en France et en Allemagne
2021
A travers une comparaison franco-allemande, cet article s’attache a montrer comment les classements scolaires et professionnels s’articulent, et quelles nuances nationales cela produit dans les modalites d’acces et d’identification aux classes superieures. L’analyse se fonde sur un usage reflexif de la nomenclature socio-economique europeenne ESeG et des Labour Force Surveys conduits en 2011. En France, l’allongement des etudes associe a l’instabilite du marche du travail a conduit a un affaiblissement du lien entre le diplome et la profession chez les femmes, ainsi qu’a une accumulation de titres scolaires par les cadres des deux sexes. En Allemagne au contraire, les femmes et les hommes d…
Enablers and Constraints of STEM Programme Implementation: an External Change Agent Perspective from a National STEM Programme in Finland
2021
AbstractAn international need exists for effective programmes that will enhance learners’ interest in studies and careers related to science, technology, engineering and mathematics, i.e. STEM. When considering the impact of STEM programmes, it is important to identify what can enable or constrain effective programme implementation. As such, enablers can be systematically supported and constraints tackled to maximise a programme’s impact. This study considers a nationwide STEM programme in Finland that involved 450 teachers and their learning communities. The study followed an interpretative paradigm, collecting data through semi-structured interviews and analysed with data-driven thematic …
Integrating Decomposers, Methane-Cycling Microbes and Ecosystem Carbon Fluxes Along a Peatland Successional Gradient in a Land Uplift Region
2021
AbstractPeatlands are carbon dioxide (CO2) sinks that, in parallel, release methane (CH4). The peatland carbon (C) balance depends on the interplay of decomposer and CH4-cycling microbes, vegetation, and environmental conditions. These interactions are susceptible to the changes that occur along a successional gradient from vascular plant-dominated systems to Sphagnum moss-dominated systems. Changes similar to this succession are predicted to occur from climate change. Here, we investigated how microbial and plant communities are interlinked with each other and with ecosystem C cycling along a successional gradient on a boreal land uplift coast. The gradient ranged from shoreline to meadows…
Les traditions techniques de la céramique dans la région des Trois-Lacs (Suisse) entre 3650 et 3000 av. n. è.
2021
International audience