showing 36 of ~574560 from 574555 documents
Triiodothyronine alongside levothyroxine in the management of hypothyroidism?
2021
The current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the level of thyrotropin within a euthyroid reference range. This has been successful for most people with hypothyroidism, but a substantial minority still report symptoms of hypothyroidism unexplained by a comorbid medical condition. LT4 is essentially a prodrug for triiodothyronine (T3), the thyroid hormone that acts on target tissues in the brain and the periphery. Thyroid hormone replacement with LT4 alone does not restore physiological tissue levels of thyroid hormones, particularly T3. During the last two decades, much interest has focussed on the potential of…
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2021
Lyme borreliosis is a multisystemic disease caused by the pleomorphic bacteria of theBorrelia burgdorferi sensu latocomplex. The exact mechanisms for the infection to progress into a prolonged sequelae of the disease are currently unknown, although immune evasion and persistence of the bacteria in the host are thought to be major contributors. The current study investigatedB. burgdorferiinfection processes in two human cell lines, both non-immune and non-phagocytic, to further understand the mechanisms of infection of this bacterium. By utilizing light, confocal, helium ion, and transmission electron microscopy, borrelial infection of chondrosarcoma (SW1353) and dermal fibroblast (BJ) cells…
Opening a Conversation on Open Communication Research
2021
Abstract Many disciplines have been debating and enacting a range of policies, procedures, and practices that fall under the umbrella term “open research” or “open science.” Following the publication of “An Agenda for Open Science in Communication”, we invited communication scholars to continue the conversation on what open research practices broadly might mean for our diverse field. Specifically, we sought work that: looked empirically at the need for and impact of open research practices; considered the unintended consequences of calls for open research practices broadly; and that reflected on what such a move would mean for qualitative and humanistic communication research. We hope the c…
Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population.
2021
Lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC) represent a major health problem in the global scenario. In South America, the highest incidence rates are seen in Brazil. Therefore, the epidemiological and clinical profile and survival outcomes of lip, oral cavity, and oropharyngeal SCC was studied in São Paulo State, Brazil. The clinicopathological data of 12,099 patients with lip, oral cavity, and oropharyngeal SCC were obtained from hospital cancer registries of the Fundação Oncocentro de São Paulo, Brazil (2010?2015). Survival rates and other analyses were performed using SPSS software. A clear male predominance was observed, particularly for patients with oropharyngea…
A European survey of management approaches in chronic urticaria in children: EAACI Paediatric Urticaria Taskforce
2021
Background: Although well described in adults, there are scarce and heterogeneous data on the diagnosis and management of chronic urticaria (CU) in children (0-18 years) throughout Europe. Our aim was to explore country differences and identify the extent to which the EAACI/GA²LEN/EDF/WAO guideline recommendations for paediatric urticaria are implemented. Methods: The EAACI Taskforce for paediatric CU disseminated an online clinical survey among EAACI paediatric section members. Members were asked to answer 35 multiple choice questions on current practices in their respective centres. Results: The survey was sent to 2,773 physicians of whom 358 (13.8%) responded, mainly paediatric allergist…
Évaluation scolaire et climat motivationnel : l'apport d'une analyse des interactions évaluatives orales à l'école élémentaire
2021
International audience
Three-Dimensional Heterocycles by 5-exo-dig Cyclizations of S-Methyl-N-ynonylsulfoximines
2021
Upon treatment with Cs2CO3, S-methyl-N-ynonylsulfoximines undergo 5-exo-dig cyclizations to give three-dimensional heterocycles. The reactions proceed at ambient temperature with a wide range of substrates affording the corresponding products in good to excellent yields.
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2021
The study aims were to 1) examine profiles of perception of motor competence (PMC) in relation to actual motor competence (AMC), i.e. under-estimators (UEs), realistic estimators (REs) and over-estimators (OEs) and 2) investigate associations between the profiles and selected socioecological factors at the individual, family and environmental levels. PMC (Pictorial Scale of Perceived Movement Skill Competence) and AMC (Test of Gross Motor Development-Third Edition) were administered to a representative sample of children from 37 childcare centres in Finland (n=441;6.2±0.6yrs;52% boys). Socioecological factors were investigated using a parental questionnaire. The three profiles were formed b…
Prises de décisions et dilemmes en situation d'interaction évaluative orale dans trois classes de CP
2021
International audience
Which is the best ultrasound parameter for the prediction of adverse perinatal outcome within 1 day of delivery?
2021
To compare the accuracies of several sonographic parameters for the prediction of adverse perinatal outcome (APO) prior to delivery.This was a prospective study of fetuses attending the day hospital unit of a tertiary referral hospital that were scanned at 34-41 weeks and gave birth within 24 h of examination. APO was defined as a composite of abnormal intrapartum fetal heart rate or intrapartum fetal scalp pH7.20 requiring urgent cesarean section, neonatal umbilical cord pH7.10, 5' Apgar score7 and postpartum admission to neonatal or pediatric intensive care units. The accuracies of the middle cerebral, vertebral and umbilical arteries pulsatility index multiples of the median (MoM), the c…
Repeatability and sensitivity of passive mechanical stiffness measurements in the triceps surae muscle‐tendon complex
2021
Measurements of muscle-tendon unit passive mechanical properties are often used to illustrate acute and chronic responses to a training stimulus. The purpose of this study was to quantify the inter-session repeatability of triceps surae passive stiffness measurements in athletic and non-athletic populations, with the view to discussing its usefulness both as a muscle-tendon profiling tool and a control measure for studies with multiple data collection sessions. The study also aimed to observe the effects of quiet standing on passive stiffness parameters. Twenty-nine men (10 cyclists, nine triathletes, 10 controls) visited the laboratory on three separate occasions, where passive stiffness t…
The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis.
2021
Sepsis represents an important global health burden due to its high mortality and morbidity. The rapid detection of sepsis is crucial in order to prevent adverse outcomes and reduce mortality. However, the diagnosis of sepsis is still challenging and many efforts have been made to identify reliable biomarkers. Unfortunately, many investigated biomarkers have several limitations that do not support their introduction in clinical practice, such as moderate diagnostic and prognostic accuracy, long turn-around time, and high-costs. Complete blood count represents instead a precious test that provides a wealth of information on individual health status. It can guide clinicians to early-identify …
Vinylcyclopropane [3+2] Cycloaddition with Acetylenic Sulfones Based on Visible Light Photocatalysis
2021
We describe the first intermolecular visible light [3+2] cycloaddition reaction being performed on a meta photocycloadduct employing acetylenic sulfones. The developed methodology exploits the advantages of combining UV and Visible light in a two-step sequence that provides a photogenerated cyclopropane which, through a strain-release process, generates a new cyclopentane ring while increasing significally the molecular complexity. This strategy could be extended to simpler vinylcyclopropanes.
A machine learning application to predict early lung involvement in scleroderma: A feasibility evaluation
2021
Introduction: Systemic sclerosis (SSc) is a systemic immune-mediated disease, featuring fibrosis of the skin and organs, and has the greatest mortality among rheumatic diseases. The nervous system involvement has recently been demonstrated, although actual lung involvement is considered the leading cause of death in SSc and, therefore, should be diagnosed early. Pulmonary function tests are not sensitive enough to be used for screening purposes, thus they should be flanked by other clinical examinations
Roadmap on digital holography [Invited]
2021
This Roadmap article on digital holography provides an overview of a vast array of research activities in the field of digital holography. The paper consists of a series of 25 sections from the prominent experts in digital holography presenting various aspects of the field on sensing, 3D imaging and displays, virtual and augmented reality, microscopy, cell identification, tomography, label-free live cell imaging, and other applications. Each section represents the vision of its author to describe the significant progress, potential impact, important developments, and challenging issues in the field of digital holography.
A Deployment Model to Extend Ethically Aligned AI Implementation Method ECCOLA
2021
There is a struggle in Artificial intelligence (AI) ethics to gain ground in actionable methods and models to be utilized by practitioners while developing and implementing ethically sound AI systems. AI ethics is a vague concept without a consensus of definition or theoretical grounding and bearing little connection to practice. Practice involving primarily technical tasks like software development is not aptly equipped to process and decide upon ethical considerations. Efforts to create tools and guidelines to help people working with AI development have been concentrating almost solely on the technical aspects of AI. A few exceptions do apply, such as the ECCOIA method for creating ethic…
Potential of Automated Digital Hemispherical Photography and Wireless Quantum Sensors for Routine Canopy Monitoring and Satellite Product Validation
2021
To better characterize the temporal dynamics of vegetation biophysical variables, a variety of automated in situ measurement techniques have been developed in recent years. In this study, we investigated automated digital hemispherical photography (DHP) and wireless quantum sensors, which were installed at two sites under the Copernicus Ground Based Observations for Validation (GBOV) project. Daily estimates of plant area index (PAI) and the fraction of absorbed photosynthetically active radiation (FAPAR) were obtained, which realistically described expected vegetation dynamics. Good correspondence with manual DHP and LAI-2000 data (RMSE = 0.39 to 0.90 for PAI, RMSE = 0.07 for FAPAR) provid…
Older and Younger Adults Perform Similarly in an Iterated Trust Game
2021
This work was supported by the Spanish Ministry of Education, Culture and Sports, with pre-doctoral FPU fellowship FPU14/07106 to MT, and the Spanish Ministry of Economy and Competitiveness, with research projects PSI2014-52764-P and PSI2017-84926-P to JL. This research is part of MT’s thesis dissertation under the supervision of JL.
Airway epithelial dysfunction and mesenchymal transition in chronic obstructive pulmonary disease: Role of Oct-4
2021
Abstract The airway epithelium is a dynamic tissue that undergoes slow but constant renewal. Dysregulation of airway epithelial function related to cigarette smoke exposure plays an important role in the pathophysiology of COPD. Oct4 is a transcription factor responsible for maintaining cellular self-renewal and regeneration, and CD146 and CD105/Endoglin are adhesion molecules involved in cell proliferation, differentiation, epithelial-mesenchymal-transition and tissue remodeling. Bronchial biopsy specimens (BBs) were obtained from 7 healthy controls (HC) and 10 COPD and subjected to paraffin embedding; BBs from HC were also used for epithelial cell expansion and pHBEC/ALI (air-liquid inter…
Mesurer l’efficacité des enseignements par l’étude des rendements
2021
International audience; Le champ des recherches concernant les pratiques enseignantes en étude de la langue demeure peu fertile (on citera entre autres : Bulea Bronckart et al. , 2018 ; Riou, 2017) et supporte peu de généralisations, la portée statistique semblant difficilement atteignable, pour des raisons pragmatiques. Par ailleurs, l’importante recherche Lire – Écrire menée par l’Ifé en 2010-2013 (Goigoux, 2015) a ouvert la voie méthodologique à des études quantitatives dans le domaine de la didactique. C’est dans ce cadre que la recherche REAlang1 s’est donné comme objectif, entre autres, d’évaluer la performance des classes de CE2, CM1 et CM22 concernant des savoirs grammaticaux et ort…
Increased Phospholipid Transfer Protein Activity Is Associated With Markers of Enhanced Lipopolysaccharide Clearance in Human During Cardiopulmonary …
2021
Introduction: Lipopolysaccharide (LPS) is a component of gram-negative bacteria, known for its ability to trigger inflammation. The main pathway of LPS clearance is the reverse lipopolysaccharide transport (RLT), with phospholipid transfer protein (PLTP) and lipoproteins playing central roles in this process in experimental animal models. To date, the relevance of this pathway has never been studied in humans. Cardiac surgery with cardiopulmonary bypass is known to favor LPS digestive translocation. Our objective was to determine whether pre-operative PLTP activity and triglyceride or cholesterol-rich lipoprotein concentrations were associated to LPS concentrations in patients undergoing ca…
GameStop im Lichte der MAR
2021
Zusammenfassung In sozialen Medien koordinierter Aktien- und Optionshandel von Privatanlegern hat den Kurs der GameStop-Aktie im Januar 2021 in schwindelerregende Höhen getrieben, insbesondere, weil die im sozialen Netzwerk Reddit kommunizierenden Anleger durch ihre Zukäufe vor allem Leerverkäufer in GameStop „in die Ecke drängen“ konnten (sog. short squeeze). Auf dem Höhepunkt der Rallye erließen dann mehrere Broker in den USA aber auch in Deutschland Kaufbeschränkungen, was einen vorübergehenden beträchtlichen Kursverlust zur Folge hatte. Der Beitrag bewertet vergleichbare Geschehnisse im Lichte der MAR. Dabei zeigt sich, dass das europäische Marktmissbrauchsrecht dem – durchaus Marktverw…
La mixité scolaire facilite-t-elle la progression des élèves les plus faibles en lecture ?
2021
International audience
Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism
2021
ABSTRACTMutualistic interactions with the commensal microbiota are enforced through a range of immune responses that confer metabolic benefits for the host and ensure tissue health and homeostasis. Immunoglobulin (Ig)A responses directly determine the composition of commensal species that colonize the intestinal tract but require significant metabolic resources to fuel antibody production by tissue-resident plasma cells. Here we demonstrate IgA responses are subject to diurnal regulation by dietary-derived metabolic cues and a cell-intrinsic circadian clock. Rhythmicity in IgA secretion conferred oscillatory patterns on the commensal microbial community and its associated metabolic activity…
Measurement of the doubly Cabibbo-suppressed decay D+→K+π+π−π0 with semileptonic tags
2021
Faire égalité en éducation physique (et sportive). De la formation aux pratiques à l’école primaire
2021
International audience
Study of the chlorfenvinphos pesticide removal under different anodic materials and different reactor configuration.
2021
The present manuscript focuses on the study of the electrochemical oxidation of the insecticide Chlorfenvinphos (CVP). The assays were carried out under galvanostatic conditions using boron-doped diamond (BDD) and low-cost tin dioxide doped with antimony (Sb-doped SnO2) as anodes. The influence of the operating variables, such as applied current density, presence or absence of a cation-exchange membrane and concentration of supporting electrolyte, was discussed. The results revealed that the higher applied current density the higher degradation and mineralization of the insecticide for both anodes. The presence of the membrane and the highest concentration of Na2SO4 studied (0.1 M) as a sup…
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2021
Atomic layer deposition (ALD) technology has unlocked new ways of manipulating the growth of inorganic materials. The fine control at the atomic level allowed by ALD technology creates the perfect conditions for the inclusion of new cationic or anionic elements of the already-known materials. Consequently, novel material characteristics may arise with new functions for applications. This is especially relevant for inorganic luminescent materials where slight changes in the vicinity of the luminescent centers may originate new emission properties. Here, we studied the luminescent properties of CaS:Eu by introducing europium with oxygen ions by ALD, resulting in a novel CaS:EuO thin film. We …
Direct atomic layer deposition of ultrathin aluminium oxide on monolayer $MoS_2$ exfoliated on gold: the role of the substrate
2021
In this paper we demonstrated the thermal Atomic Layer Deposition (ALD) growth at 250 {\deg}C of highly homogeneous and ultra-thin ($\approx$ 3.6 nm) $Al_2O_3$ films with excellent insulating properties directly onto a monolayer (1L) $MoS_2$ membrane exfoliated on gold. Differently than in the case of 1L $MoS_2$ supported by a common insulating substrate ($Al_2O_3/Si$), a better nucleation process of the high-k film was observed on the 1L $MoS_2/Au$ system since the ALD early stages. Atomic force microscopy analyses showed a $\approx 50\%$ $Al_2O_3$ surface coverage just after 10 ALD cycles, its increasing up to $>90\%$ (after 40 cycles), and an uniform $\approx$ 3.6 nm film, after 80 cycle…
Getting into the Same Boat – Enabling the Realization of the Disabled Child’s Agency in Adult–Child Play Interaction
2021
The purpose of this study was to find out how an adult can enable or hinder the realization of a disabled child’s agency in play interaction. We focused on the child’s play invitations, which were constructed as dispreferred by the adult. The data consisted of nine videotaped playing situations with five nurses and five disabled children in a children’s neurological ward. The microanalysis with interventionist applied conversation analysis focused on one playing situation between one nurse and one three-year-old boy with no spoken language. The nurse responded to the child’s play invitations constructed as dispreferred by her in three different ways. Two of them were about trying to control…
L'accès aux archives couvertes par le secret défense dans la tourmente
2021
International audience
Responses to Developmental Temperature Fluctuation in Life History Traits of Five Drosophila Species (Diptera: Drosophilidae) from Different Thermal …
2021
Simple Summary Most laboratory experiments on insects to date have been conducted using constant temperature settings. Even when the purpose of the study was to investigate effects of temperature, insects have mostly been kept at different but constant temperatures ignoring natural variation in temperature. Here we investigated effects of simple daily temperature fluctuation (22.5/27.5 °C and 20/30 °C) on some development characteristics in five species of fruit flies (Drosophila) originating from areas with different temperature profiles. We demonstrated how species of the same genus can show substantial differences when developing at fluctuating temperatures not always predictable by deve…
“Developing Capabilities”. Inclusive Extracurricular Enrichment Programs to Improve the Well-Being of Gifted Adolescents
2021
The educational inclusion of gifted students requires not only equity but also emotional accessibility and social participation. However, different studies indicate that gifted students constitute a vulnerable group (for example, the incidence of bullying is higher). Psychosocial variables are determinants for the development and expression of giftedness, particularly during adolescence. This study analyzes the impact of an inclusive extracurricular enrichment program for gifted secondary school students on the well-being of adolescents. The program was based on the enrichment model of Renzulli and Reis (2016). The objective was to develop a cluster to facilitate high-achieving learning in …
Validation des modèles de connectivité issus de la théorie des graphes en utilisant des données génétiques
2021
National audience; Modéliser la connectivité fonctionnelle des habitats est déterminant pour la conservation de la biodiversité. Les graphes paysagers, en modélisant des taches d’habitat reliées par des chemins de dispersion potentiels, permettent de quantifier la connectivité du paysage. Si cette approche semble prometteuse, sa validité écologique reste à démontrer. Tester sa validité implique de confronter des données de connectivité issues d’un graphe à des données reflétant la dispersion des individus, telles que des données génétiques. Dans cet objectif, nous avons modélisé la connectivité de l’habitat d’une espèce d’oiseau forestière, la Paruline caféiette (Setophaga plumbea), en Guad…